Review
Immunology
Swayanka Biswas, Katja Bieber, Rudolf Armin Manz
Summary: IL-10 is a cytokine that has pleiotropic effects on immune cells, including both suppressive and activating functions. It plays a dual role in Systemic lupus Erythematosus (SLE), inhibiting pro-inflammatory effector functions while also promoting extrafollicular antibody response. IL-10 is produced by B cells, myeloid cells, and certain T cell subsets, and it drives B cell responses, proliferation, class switching, and plasma cell formation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Renata Rocha da Silva, Fernanda de Santana Fontes Vasconcelos, Debora dos Santos Tavares, Priscila Lima dos Santos
Summary: This study conducted a systematic review and meta-analysis to investigate the association between IL-10 single nucleotide polymorphisms (SNPs) and the progression of leishmaniasis. The results showed that IL-10 SNPs were not significantly associated with leishmaniasis progression and were not considered a risk factor.
SCIENTIFIC REPORTS
(2022)
Article
Rheumatology
E. Rzeszotarska, A. Sowinska, B. Stypinska, A. Lutkowska, A. Felis-Giemza, M. Olesinska, M. Puszczewicz, D. Majewski, P. P. Jagodzinski, E. Haladyj, A. Paradowska-Gorycka
Summary: Our study revealed that IL-1#-511, IL-1# +3953, IL-10-592, IL-10-1082, and TNF-alpha-308 polymorphisms may affect SLE risk and phenotype. Specifically, certain genotypes were found to be associated with the SLE phenotype and serum concentrations of TNF-alpha, IL-1#, and IL-10.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2022)
Article
Rheumatology
Young Ho Lee, Gwan Gyu Song
Summary: This study found that circulating IL-33 levels were significantly higher in patients with SLE, suggesting a relationship between IL-33 and SLE. Additionally, the research identified an association between the IL-33 rs1891385 polymorphism and SLE susceptibility.
Review
Medicine, Research & Experimental
Hamidreza Ebrahimiyan, Shayan Mostafaei, Saeed Aslani, Seyedeh Tahereh Faezi, Elham Farhadi, Ahmadreza Jamshidi, Mahdi Mahmoudi
Summary: In this study, a meta-analysis was performed to investigate the association between ITGAM gene rs1143679 SNP and MBL gene rs1800451 SNP with SLE risk. The results showed a significant positive association between rs1143679 and SLE risk, while rs1800451 was significantly associated with decreased susceptibility to SLE.
CLINICAL AND EXPERIMENTAL MEDICINE
(2022)
Article
Allergy
Zongqing Liu, Tong Sun, Linjian Song, Xiaoxing Xue, Shuang Liu, Huihui Kuang, Liyuan Tian, Zheng Xiao
Summary: This meta-analysis found that interleukin polymorphisms, particularly IL-1, IL-4, IL-6, and IL-10, may impact the predisposition of SLE. The results varied among different ethnicities, with positive findings observed in Asians for certain polymorphisms and in Caucasians for others.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Yu-Xin Fan, Li -Rong Chen, Run-Xin Gan, Sun-Jun Yin, Ping Wang, Rui Meng, Yan-Hua Huang, Fang-Fang Jiang, Gong-Hao He
Summary: This meta-analysis found that IL-10 polymorphisms, specifically rs1800896 and rs1800872, were associated with increased risk of acute leukemia.
Article
Immunology
Melissa Northcott, Linden J. Gearing, Julie Bonin, Rachel Koelmeyer, Alberta Hoi, Paul J. Hertzog, Eric F. Morand
Summary: The effects of medication on gene module expression in SLE patients are significant, emphasizing the need to control for medication exposure in studies of gene expression in SLE.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Qi Huang, Wang-Dong Xu, Lin-Chong Su, Xiao-Yan Liu, An-Fang Huang
Summary: This study investigated CD40 gene polymorphisms in Chinese Han population with SLE and RA, finding associations between certain genotypes and alleles with susceptibility to the diseases. The findings suggest a potential role of CD40 gene polymorphisms in the pathogenesis of SLE and RA.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, General & Internal
Ning Chen, Yijun Dai, Juanjuan He, Meng Zhou, Hong Sun, Ling Lin, Fei Gao, He Lin, Qing Yan
Summary: This meta-analysis investigated the relationship between TGF-beta 1 gene polymorphisms and systemic lupus erythematosus (SLE), and found that TGF-beta 1 C509T, G915C, and T869C polymorphisms were not associated with SLE risk.
Article
Allergy
Lin Zhu, Peng Chen, Xuanjing Sun, Shuo Zhang
Summary: This meta-analysis suggests that IL-1A +4845G/T and IL-1B +3954C/T polymorphisms may influence the risk of RA, whereas IL-1A -889C/T, IL-1B -31T/C, and IL-1B -511C/T polymorphisms may influence the risk of SLE.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2021)
Review
Medicine, General & Internal
Napoleon Bellua Sam, Shi-Yang Guan, Peng Wang, Xiao-Mei Li, De-Guang Wang, Hai-Feng Pan, Dong-Qing Ye
Summary: This study revealed significantly higher MIF levels in SLE patients compared to healthy controls, with Asians and younger patients showing even higher MIF levels. The association between SLE and MIF-173 C/G was supported, while no significant relationship was found between MIF-794 CATT and SLE.
ARCHIVES OF MEDICAL SCIENCE
(2021)
Article
Multidisciplinary Sciences
Mengmeng Xiang, Yang Feng, Yilun Wang, Jie Wang, Zhixiong Zhang, Jun Liang, Jinhua Xu
Summary: This meta-analysis revealed that the circulating level of interleukin-18 is significantly higher in systemic lupus erythematosus (SLE) patients compared to healthy controls. Patients with higher SLEDAI scores, Asian, White, Arab, or mixed ethnicity tend to have elevated levels of IL-18, indicating the potential role of IL-18 in the pathogenesis of SLE.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Yantong Zhu, Xiaojun Tang, Yang Xu, Si Wu, Weilin Liu, Linyu Geng, Xiaolei Ma, Betty P. Tsao, Xuebing Feng, Lingyun Sun
Summary: Systemic lupus erythematosus (SLE) is characterized by the production of pathogenic autoantibodies. This study found that Ribonuclease A family member 2 (RNase2) is highly expressed in SLE patients and is associated with the increase of autoreactive B cells known as age-associated B cells (ABCs). Reduction of RNASE2 expression led to a decrease in ABCs, accompanied by a reduction in total IgG and IL-10 levels. It was also found that both RNASE2 and IL-10 in SLE patients were mainly derived from monocytes. The study concluded that RNASE2 might induce the production of ABCs via IL-10 secreted from monocytes, contributing to the pathogenesis of SLE.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Zhi-Chao Yuan, Wang-Dong Xu, You-Yu Lan, Jia-Min Wang, Qian Wu, Jie Zhou, An-Fang Huang
Summary: This study suggests that the A\B and A\O polymorphisms of the MBL2 gene are associated with SLE susceptibility, and the allele H may act as a protective factor for SLE.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2021)