Article
Biochemistry & Molecular Biology
Ying Kong, Han-Dong Li, Dan Wang, Xiaolin Gao, Chunsheng Yang, Minshu Li, Ting Chang, Qiang Liu
Summary: The study found a correlation between the reduction of ILC2 and disease severity in neuromyelitis optica spectrum disorder (NMOSD), and expanding ILC2 could alleviate the pathological conditions.
Review
Immunology
Qian Chen, Jie Wang, Mengmeng Xiang, Yilun Wang, Zhixiong Zhang, Jun Liang, Jinhua Xu
Summary: This review summarizes the potential links between ferroptosis and systemic lupus erythematosus (SLE), elucidates the role of ferroptosis in SLE pathogenesis, and proposes a new therapeutic strategy for SLE.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, Research & Experimental
Urshila Naithani, Priyanjal Jain, Aastha Sachan, Prachi Khare, Reema Gabrani
Summary: This paper discusses the challenges in the clinical classification of systemic lupus erythematosus (SLE) due to its multifactorial nature and complex pathogenesis. It also highlights the importance of microRNAs (miRNAs) in the development and treatment of SLE, suggesting their potential as therapeutic targets.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Cell Biology
Tong Zhu, Rongli Wang, Heather Miller, Lisa S. Westerberg, Lu Yang, Fei Guan, Pamela Lee, Quan Gong, Yan Chen, Chaohong Liu
Summary: This article provides a comprehensive overview of the interaction between invariant natural killer T cells (iNKTs) and B cells, discussing their roles in infections, autoimmunity, and cancers. It also explores potential immunotherapies based on iNKTs and possible treatments for infectious, autoimmune, and other diseases.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Review
Immunology
Umut Can Kucuksezer, Esin Aktas Cetin, Fehim Esen, Ilhan Tahrali, Nilgun Akdeniz, Metin Yusuf Gelmez, Gunnur Deniz
Summary: NK cells are a subset of innate lymphoid cells that play important roles in anti-tumor immune responses and immune regulation, with different subgroups showing cytotoxic functions or cytokine production. Their activation is influenced by a variety of factors, including cell surface receptors and cytokines, and their dysregulation can contribute to various immune-mediated diseases. Further research on NK cell biology and their potential therapeutic applications is necessary for better understanding and treatment of inflammatory disorders.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Chemistry, Medicinal
Mieke Metzemaekers, Bert Malengier-Devlies, Mieke Gouwy, Lien De Somer, Fernando de Queiroz Cunha, Ghislain Opdenakker, Paul Proost
Summary: Neutrophils are powerful effector cells that play crucial roles in fighting pathogens and modulating immune responses. Recent evidence suggests that these cells are more versatile and heterogeneous than previously thought, and are involved in various diseases including cancer and autoimmune disorders. This review discusses the kinetics of neutrophils and their activation products, as well as their multifaceted functions in health and disease, focusing on studies using primary human cells.
MEDICINAL RESEARCH REVIEWS
(2023)
Review
Medicine, Research & Experimental
Jamshid Gholizadeh Navashenaq, Arezoo Gowhari Shabgah, Mahdiyeh Hedayati-Moghadam, Nazila Ariaee, Hamed Mohammadi, Maryam Hemmatzadeh, Sara Azhdari, Tannaz Jamialahmadi, Thozhukat Sathyapalan, Amirhossein Sahebkar
Summary: Rheumatoid arthritis (RA) is an autoimmune disease affecting joints, with unclear etiology but involving immune mechanisms. Immune cells migrate to the joints during disease onset, and the shift to Th1 and Th17 immune responses is crucial in RA development. Myeloid-derived suppressor cells (MDSCs) regulate immune system, their specific functions in RA need further investigation.
Review
Immunology
Leonardo Martin Calderon, Janet E. Pope
Summary: The pathogenesis of connective tissue diseases involves immune system derangements, chronic inflammation, and autoimmunity. Pre-clinical states with biochemical and autoimmune abnormalities can increase the risk of developing established connective tissue diseases. Early identification and treatment in these states can limit disease progression and improve prognosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Larisa Dubrovsky, Beda Brichacek, N. M. Prashant, Tatiana Pushkarsky, Nigora Mukhamedova, Andrew J. Fleetwood, Yangsong Xu, Dragana Dragoljevic, Michael Fitzgerald, Anelia Horvath, Andrew J. Murphy, Dmitri Sviridov, Michael I. Bukrinsky
Summary: A possible explanation for chronic inflammation in HIV-infected individuals treated with anti-retroviral therapy is hyperreactivity of myeloid cells due to a phenomenon called trained immunity. Here, we demonstrate that human monocyte-derived macrophages originating from monocytes initially treated with extracellular vesicles containing HIV-1 protein Nef (exNef), but differentiating in the absence of exNef, release increased levels of pro-inflammatory cytokines after lipopolysaccharide stimulation. This effect is associated with chromatin changes at the genes involved in inflammation and cholesterol metabolism pathways and upregulation of the lipid rafts and is blocked by methyl-beta-cyclodextrin, statin, and an inhibitor of the lipid raft-associated receptor IGF1R. Bone-marrow-derived macrophages from exNef-injected mice, as well as from mice trans-planted with bone marrow from exNef-injected animals, produce elevated levels of tumor necrosis factor alpha (TNF-alpha) upon stimulation. These phenomena are consistent with exNef-induced trained immunity that may contribute to persistent inflammation and associated co-morbidities in HIV-infected individuals with unde-tectable HIV load.
Article
Immunology
Sofia Gargani, Niki Lourou, Christina Arapatzi, Dimitris Tzanos, Marania Saridaki, Esmeralda Dushku, Margarita Chatzimike, Nikolaos D. Sidiropoulos, Margarita Andreadou, Vasileios Ntafis, Pantelis Hatzis, Vassiliki Kostourou, Dimitris L. Kontoyiannis
Summary: The RNA-binding protein hnRNPD/AUF1 does not act as a general anti-inflammatory factor in innate immune cells, but rather plays more specialized roles in regulating specific innate immune cell transitions to support tissue infiltration and remodeling processes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Yuen Ping Chong, Evelyn Priya Peter, Feon Jia Ming Lee, Chu Mun Chan, Shereen Chai, Lorni Poh Chou Ling, Eng Lai Tan, Sook Han Ng, Atsushi Masamune, Siti Aisyah Abd Ghafar, Norsharina Ismail, Ket Li Ho
Summary: Pancreatic cancer cells and pancreatic stellate cells together form the immunosuppressive tumor microenvironment of pancreatic cancer. This study found that co-culture of these two cell types resulted in a reduction in lymphocyte population. Proteomic analysis revealed differentially expressed proteins in two different stages of tumor-derived PCC lines. Additionally, it was found that the conditioned medium containing proteins secreted by PCC and/or PSC enhanced the viability of lymphocyte subtypes, while CM-induced MDSCs decreased the viability of certain T cells.
SCIENTIFIC REPORTS
(2022)
Review
Dermatology
J. Michelle Kahlenberg
Summary: Recent research on cutaneous lupus has identified key abnormalities in nonlesional skin of patients with systemic lupus, including an elevated type I interferon signature, overproduction of interferons, and absence of Langerhans cells. These abnormalities likely contribute to a propensity for inflammation in response to disease triggers like UV light.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Immunology
Mohamed L. Sobah, Aimee C. Scott, Miranda Laird, Cassandra Koole, Clifford Liongue, Alister C. Ward
Summary: By investigating the zebrafish socs3b gene, it was found that socs3b gene plays a critical role in regulating neutrophil production and macrophage activation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Miguel Reyes, Samantha M. Leff, Matteo Gentili, Nir Hacohen, Paul C. Blainey
Summary: Cells respond to various signals by adopting complex transcriptional states. Most single-cell profiling is done at baseline, ignoring cells' potential functional responses. Single-cell genomics combined with multiplexing techniques provide a useful tool for characterizing cell states across experimental conditions.
Review
Biochemistry & Molecular Biology
Sandra Winning, Joachim Fandrey
Summary: Oxygen deprivation is a common feature at inflamed sites, and immune cells adapt to this condition by activating HIF. HIF plays a significant role in regulating the inflammatory phenotype of immune cells, including migration, phagocytosis, and induction of inflammatory cytokines. However, further research is needed to understand the specific roles of HIF-1 and HIF-2 in different cell types.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Immunology
Jacob J. Orme, Yong Du, Kamala Vanarsa, Jessica Mayeux, Li Li, Azza Mutwally, Cristina Arriens, Soyoun Min, Jack Hutcheson, Laurie S. Davis, Benjamin F. Chong, Anne B. Satterthwaite, Tianfu Wu, Chandra Mohan
CLINICAL IMMUNOLOGY
(2016)
Article
Immunology
S-Y. Min, M. Yan, Y. Du, T. Wu, E. Khobahy, S-R. Kwon, V. Taneja, A. Bashmakov, S. Nukala, Y. Ye, J. Orme, D. Sajitharan, H-Y. Kim, C. Mohan
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2013)
Editorial Material
Medicine, General & Internal
Jacob J. Orme, Surbhi Sidana, Wilson I. Gonsalves
MAYO CLINIC PROCEEDINGS
(2018)
Article
Multidisciplinary Sciences
Jacob J. Orme, Yong Du, Kamala Vanarsa, Tianfu Wu, Anne B. Satterthwaite, Chandra Mohan
Editorial Material
Oncology
Jacob J. Orme, Haojie Huang
Article
Oncology
Jacob J. Orme, Elizabeth Ann L. Enninga, Fabrice Lucien-Matteoni, Heather Dale, Edwin Burgstaler, Susan M. Harrington, Matthew K. Ball, Aaron S. Mansfield, Sean S. Park, Mathew S. Block, Svetomir N. Markovic, Yiyi Yan, Haidong Dong, Roxana S. Dronca, Jeffrey L. Winters
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2020)
Article
Medicine, General & Internal
Renate Pichler, Andrea Katharina Lindner, Georg Schaefer, Gennadi Tulchiner, Nina Staudacher, Martin Mayr, Eva Comperat, Jacob J. Orme, Gert Schachtner, Martin Thurnher
Summary: Despite the low expression of PD-L1 in both tumor regions and cell types, high expression of ADAM17 was found in RC specimens obtained after BCG failure. Additionally, increased expression of GATA3, IL-10, and IL-10R suggested an immunosuppressive tumor microenvironment in BCG failure patients. This study highlights the potential role of ADAM proteases in cleaving PD-L1 from bladder tumor cells and immune cells in BCG failure cases, indicating the necessity of supplementing PD-L1 assessment with ADAM10/17.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Andrea Katharina Lindner, Tobias Furlan, Jacob J. Orme, Gennadi Tulchiner, Nina Staudacher, David D'Andrea, Zoran Culig, Renate Pichler
Summary: HUS1 may act as an oncogene in urothelial cancer and might be a key determinant of the cellular response to cisplatin-based chemotherapy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Jacob J. Orme, Khalid A. Jazieh, Tiancheng Xie, Susan Harrington, Xin Liu, Matthew Ball, Benjamin Madden, M. Cristine Charlesworth, Tariq U. Azam, Fabrice Lucien, Bharath Wootla, Yanli Li, Jose Caetano Villasboas, Aaron S. Mansfield, Roxana S. Dronca, Haidong Dong
Meeting Abstract
Rheumatology
Michael Richter, Jacob Orme, Heidi Finnes, Uma Thanarajasingam
ARTHRITIS & RHEUMATOLOGY
(2019)
Meeting Abstract
Oncology
Aaron Mansfield, Jacob Orme, Roxana Dronca, Haidong Dong
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2019)
Meeting Abstract
Hematology
Jacob Orme, Ronald S. Go, Shaji K. Kumar, Angela Dispenzieri, Morie A. Gertz, Francis K. Buadi, David Dingli, Nelson Leung, Martha Q. Lacy, Prashant Kapoor, John A. Lust, Yi Lin, Stephen J. Russell, Suzanne R. Hayman, Steven Zeldenrust, Taxiarchis Kourelis, Rahma Warsame, Robert A. Kyle, S. Vincent Rajkumar, Wilson I. Gonsalves
Letter
Medicine, General & Internal
Jacob Orme, Diana Purushotham
AMERICAN JOURNAL OF MEDICINE
(2017)
Article
Medicine, Research & Experimental
Jacob Orme, Chandra Mohan
DISCOVERY MEDICINE
(2012)
Article
Rheumatology
Yuyuan Guo, Jacob Orme, Chandra Mohan
CURRENT RHEUMATOLOGY REVIEWS
(2013)