Genetic susceptibility to lupus: the biological basis of genetic risk found in B cell signaling pathways

A meta-analysis of the association ofSTAT4polymorphism with systemic lupus erythematosus

(2014) Hui Yuan et al.   Modern Rheumatology

Evaluation ofTRAF6in a large multiancestral lupus cohort

(2012) Bahram Namjou et al.   ARTHRITIS AND RHEUMATISM

Efficacy and safety of rituximab in patients with active proliferative lupus nephritis: The lupus nephritis assessment with rituximab study

(2012) Brad H. Rovin et al.   ARTHRITIS AND RHEUMATISM

Genetic association of miRNA-146a with systemic lupus erythematosus in Europeans through decreased expression of the gene

(2012) S E Löfgren et al.   GENES AND IMMUNITY

Regulation of NF-κB by deubiquitinases

(2012) Edward W. Harhaj et al.   IMMUNOLOGICAL REVIEWS

The mystery of missing heritability: Genetic interactions create phantom heritability

(2012) O. Zuk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Replication of recently identified systemic lupus erythematosus genetic associations: a case–control study

(2012) Marian Suarez-Gestal et al.   ARTHRITIS RESEARCH & THERAPY

Replicated associations of TNFAIP3, TNIP1 and ETS1 with systemic lupus erythematosus in a southwestern Chinese population

(2012) Hua Zhong et al.   ARTHRITIS RESEARCH & THERAPY

Integrating Autoimmune Risk Loci with Gene-Expression Data Identifies Specific Pathogenic Immune Cell Subsets

(2011) Xinli Hu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A common SNP in the CD40 region is associated with systemic lupus erythematosus and correlates with altered CD40 expression: implications for the pathogenesis

(2011) V. M. Vazgiourakis et al.   ANNALS OF THE RHEUMATIC DISEASES

Genetic and physical interaction of the B-cell systemic lupus erythematosus-associated genesBANK1andBLK

(2011) Casimiro Castillejo-López et al.   ANNALS OF THE RHEUMATIC DISEASES

Fine-mapping and transethnic genotyping establish IL2/IL21 genetic association with lupus and localize this genetic effect to IL21

(2011) Travis Hughes et al.   ARTHRITIS AND RHEUMATISM

Identification of novel genetic susceptibility loci in African American lupus patients in a candidate gene association study

(2011) Elena Sánchez et al.   ARTHRITIS AND RHEUMATISM

Gene-gene interaction of BLK, TNFSF4, TRAF1, TNFAIP3, and REL in systemic lupus erythematosus

(2011) Xu-jie Zhou et al.   ARTHRITIS AND RHEUMATISM

A phase III, randomized, placebo-controlled study of belimumab, a monoclonal antibody that inhibits B lymphocyte stimulator, in patients with systemic lupus erythematosus

(2011) Richard Furie et al.   ARTHRITIS AND RHEUMATISM

B cells and autoimmunity

(2011) Shiv Pillai et al.   CURRENT OPINION IN IMMUNOLOGY

Elevated BCR signaling and decreased survival of Lyn-deficient transitional and follicular B cells

(2011) Andrew J. Gross et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Two missense variants in UHRF1BP1 are independently associated with systemic lupus erythematosus in Hong Kong Chinese

(2011) Y Zhang et al.   GENES AND IMMUNITY

The dual effect of the lupus-associated polymorphism rs10516487 on BANK1 gene expression and protein localization

(2011) S V Kozyrev et al.   GENES AND IMMUNITY

Evaluation of the TREX1 gene in a large multi-ancestral lupus cohort

(2011) B Namjou et al.   GENES AND IMMUNITY

The association between BANK1 and TNFAIP3 gene polymorphisms and systemic lupus erythematosus: a meta-analysis

(2011) Y. Fan et al.   International Journal of Immunogenetics

ABIN1 Protein Cooperates with TAX1BP1 and A20 Proteins to Inhibit Antiviral Signaling

(2011) Linlin Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans

(2011) Laurence Menard et al.   JOURNAL OF CLINICAL INVESTIGATION

Polyubiquitin binding to ABIN1 is required to prevent autoimmunity

(2011) Sambit K. Nanda et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Altered B Cell Homeostasis Is Associated with Type I Diabetes and Carriers of the PTPN22 Allelic Variant

(2011) T. Habib et al.   JOURNAL OF IMMUNOLOGY

Direct, Noncatalytic Mechanism of IKK Inhibition by A20

(2011) Brian Skaug et al.   MOLECULAR CELL

Initial impact of the sequencing of the human genome

(2011) Eric S. Lander   NATURE

Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease

(2011) Gosia Trynka et al.   NATURE GENETICS

Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus

(2011) Indra Adrianto et al.   NATURE GENETICS

Systemic Lupus Erythematosus

(2011) George C. Tsokos   NEW ENGLAND JOURNAL OF MEDICINE

Lupus-associated causal mutation in neutrophil cytosolic factor 2 (NCF2) brings unique insights to the structure and function of NADPH oxidase

(2011) C. O. Jacob et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interferon regulatory factors in human lupus pathogenesis

(2011) Rafah Salloum et al.   Translational Research

A Functional Variant in MicroRNA-146a Promoter Modulates Its Expression and Confers Disease Risk for Systemic Lupus Erythematosus

(2011) Xiaobing Luo et al.   PLoS Genetics

A Comprehensive Analysis of Shared Loci between Systemic Lupus Erythematosus (SLE) and Sixteen Autoimmune Diseases Reveals Limited Genetic Overlap

(2011) Paula S. Ramos et al.   PLoS Genetics

Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with Systemic Lupus Erythematosus

(2011) Deborah S. Cunninghame Graham et al.   PLoS Genetics

Identification of a Systemic Lupus Erythematosus Susceptibility Locus at 11p13 between PDHX and CD44 in a Multiethnic Study

(2010) Christopher J. Lessard et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Exon 6 variants carried on systemic lupus erythematosus (SLE) risk haplotypes modulate IRF5 function

(2010) Feng Wen et al.   AUTOIMMUNITY

B cells lacking the tumor suppressor TNFAIP3/A20 display impaired differentiation and hyperactivation and cause inflammation and autoimmunity in aged mice

(2010) Y. Chu et al.   BLOOD

The association between single-nucleotide polymorphisms of NCF2 and systemic lupus erythematosus in Chinese mainland population

(2010) Bo Yu et al.   CLINICAL RHEUMATOLOGY

Genetic variations associated with psoriasis and psoriatic arthritis found by genome-wide association

(2010) Kristina Callis Duffin et al.   Dermatologic Therapy

Evidence for both copy number and allelic (NA1/NA2) risk at the FCGR3B locus in systemic lupus erythematosus

(2010) David L Morris et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Replication of past candidate loci for common diseases and phenotypes in 100 genome-wide association studies

(2010) Konstantinos C M Siontis et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles

(2010) M L Budarf et al.   GENES AND IMMUNITY

ELF1 is associated with systemic lupus erythematosus in Asian populations

(2010) J. Yang et al.   HUMAN MOLECULAR GENETICS

Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects

(2010) Kai Wang et al.   HUMAN MOLECULAR GENETICS

The Ubiquitin Modifying Enzyme A20 Restricts B Cell Survival and Prevents Autoimmunity

(2010) Rita M. Tavares et al.   IMMUNITY

Autoimmune-associated PTPN22 R620W Variation Reduces Phosphorylation of Lymphoid Phosphatase on an Inhibitory Tyrosine Residue

(2010) Edoardo Fiorillo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myeloid cells, BAFF, and IFN-γ establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice

(2010) Patrizia Scapini et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A BAFF-R mutation associated with non-Hodgkin lymphoma alters TRAF recruitment and reveals new insights into BAFF-R signaling

(2010) Joanne M. Hildebrand et al.   JOURNAL OF EXPERIMENTAL MEDICINE

African-Derived Genetic Polymorphisms in TNFAIP3 Mediate Risk for Autoimmunity

(2010) J. P. Lodolce et al.   JOURNAL OF IMMUNOLOGY

Polymorphisms at 16p13 are associated with systemic lupus erythematosus in the Chinese population

(2010) Z. Zhang et al.   JOURNAL OF MEDICAL GENETICS

Promoter Insertion/Deletion in the IRF5 Gene Is Highly Associated with Susceptibility to Systemic Lupus Erythematosus in Distinct Populations, But Exerts a Modest Effect on Gene Expression in Peripheral Blood Mononuclear Cells

(2010) S. E. LOFGREN et al.   JOURNAL OF RHEUMATOLOGY

The A20 Deubiquitinase Activity Negatively Regulates LMP1 Activation of IRF7

(2010) S. Ning et al.   JOURNAL OF VIROLOGY

Interleukin 4 and STAT6 gene polymorphisms are associated with systemic lupus erythematosus in Chinese patients

(2010) H-H. Yu et al.   LUPUS

The association between the PTPN22 C1858T polymorphism and systemic lupus erythematosus: a meta-analysis update

(2010) WW Lea et al.   LUPUS

TNIP1, SLC15A4, ETS1, RasGRP3 and IKZF1 are associated with clinical features of systemic lupus erythematosus in a Chinese Han population

(2010) C-F. He et al.   LUPUS

Receptors, subcellular compartments and the regulation of peripheral B cell responses: The illuminating state of anergy

(2010) Marcus R. Clark et al.   MOLECULAR IMMUNOLOGY

Genetic susceptibility to systemic lupus erythematosus in the genomic era

(2010) Yun Deng et al.   Nature Reviews Rheumatology

Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus

(2010) N. Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Follow-up study identifies two novel susceptibility loci PRKCB and 8p11.21 for systemic lupus erythematosus

(2010) Y.-J. Sheng et al.   RHEUMATOLOGY

Association of TNFAIP3 interacting protein 1, TNIP1 with systemic lupus erythematosus in a Japanese population: a case-control association study

(2010) Aya Kawasaki et al.   ARTHRITIS RESEARCH & THERAPY

Genome-Wide Association Study in Asian Populations Identifies Variants in ETS1 and WDFY4 Associated with Systemic Lupus Erythematosus

(2010) Wanling Yang et al.   PLoS Genetics

B Cell Signaling and Fate Decision

(2009) Tomohiro Kurosaki et al.   Annual Review of Immunology

Replication of the association between theC8orf13-BLKregion and systemic lupus erythematosus in a Japanese population

(2009) Ikue Ito et al.   ARTHRITIS AND RHEUMATISM

Variants withinMECP2, a key transcription regulator, are associated with increased susceptibility to lupus and differential gene expression in patients with systemic lupus erythematosus

(2009) Ryan Webb et al.   ARTHRITIS AND RHEUMATISM

High-density genotyping of STAT4 reveals multiple haplotypic associations with systemic lupus erythematosus in different racial groups

(2009) Bahram Namjou et al.   ARTHRITIS AND RHEUMATISM

Efficacy and safety of rituximab in moderately-to-severely active systemic lupus erythematosus: The randomized, double-blind, phase ii/iii systemic lupus erythematosus evaluation of rituximab trial

(2009) Joan T. Merrill et al.   ARTHRITIS AND RHEUMATISM

Genetic associations of LYN with systemic lupus erythematosus

(2009) R Lu et al.   GENES AND IMMUNITY

Replication of the BANK1 genetic association with systemic lupus erythematosus in a European-derived population

(2009) L Guo et al.   GENES AND IMMUNITY

Admixture in Hispanic Americans: its impact on ITGAM association and implications for admixture mapping in SLE

(2009) J E Molineros et al.   GENES AND IMMUNITY

Recent insights into the genetic basis of systemic lupus erythematosus

(2009) K L Moser et al.   GENES AND IMMUNITY

Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF- B signalling

(2009) G. Trynka et al.   GUT

PTPN22 Deficiency Cooperates with the CD45 E613R Allele to Break Tolerance on a Non-Autoimmune Background

(2009) J. Zikherman et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: The PTPN22 Allelic Variant Associated with Autoimmunity Impairs B Cell Signaling

(2009) A. F. Arechiga et al.   JOURNAL OF IMMUNOLOGY

Developmental Acquisition of the Lyn-CD22-SHP-1 Inhibitory Pathway Promotes B Cell Tolerance

(2009) A. J. Gross et al.   JOURNAL OF IMMUNOLOGY

A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus

(2009) Vesela Gateva et al.   NATURE GENETICS

Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus

(2009) Jian-Wen Han et al.   NATURE GENETICS

Genetic susceptibility to SLE: new insights from fine mapping and genome-wide association studies

(2009) Isaac T. W. Harley et al.   NATURE REVIEWS GENETICS

High-Density SNP Screening of the Major Histocompatibility Complex in Systemic Lupus Erythematosus Demonstrates Strong Evidence for Independent Susceptibility Regions

(2009) Lisa F. Barcellos et al.   PLoS Genetics

STAT4 associates with systemic lupus erythematosus through two independent effects that correlate with gene expression and act additively with IRF5 to increase risk

(2008) A-K Abelson et al.   ANNALS OF THE RHEUMATIC DISEASES

Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus

(2008) E Y M G Fung et al.   GENES AND IMMUNITY

Estimation of the multiple testing burden for genomewide association studies of nearly all common variants

(2008) Itsik Pe'er et al.   GENETIC EPIDEMIOLOGY

Genetic variation in the CRP promoter: association with systemic lupus erythematosus

(2008) Jeffrey C. Edberg et al.   HUMAN MOLECULAR GENETICS

Fas Receptor Expression in Germinal-Center B Cells Is Essential for T and B Lymphocyte Homeostasis

(2008) Zhenyue Hao et al.   IMMUNITY

Homeostatic MyD88-dependent signals cause lethal inflamMation in the absence of A20

(2008) Emre E. Turer et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PTPN22 R620W promotes production of anti-AChR autoantibodies and IL-2 in myasthenia gravis

(2008) Ann Kari Lefvert et al.   JOURNAL OF NEUROIMMUNOLOGY

A nonsynonymous functional variant in integrin-αM (encoded by ITGAM) is associated with systemic lupus erythematosus

(2008) Swapan K Nath et al.   NATURE GENETICS

Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci

(2008) John B Harley et al.   NATURE GENETICS

Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus

(2008) Sergey V Kozyrev et al.   NATURE GENETICS

Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus

(2008) Robert R Graham et al.   NATURE GENETICS

Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus

(2008) Stacy L Musone et al.   NATURE GENETICS

Association of Systemic Lupus Erythematosus withC8orf13–BLKandITGAM–ITGAX

(2008) Geoffrey Hom et al.   NEW ENGLAND JOURNAL OF MEDICINE

Common Variants within MECP2 Confer Risk of Systemic Lupus Erythematosus

(2008) Amr H. Sawalha et al.   PLoS One