Article
Immunology
Andrea R. Daamen, Hongyang Wang, Prathyusha Bachali, Nan Shen, Kathryn M. Kingsmore, Robert D. Robl, Amrie C. Grammer, Shu Man Fu, Peter E. Lipsky
Summary: This study characterized the molecular profiles of lupus nephritis (LN) development using gene expression analysis in lupus-prone NZM2328 mice. Different stages of LN exhibited distinct molecular characteristics, and it was found that NZM2328.R27 mice had resistance to chronic nephritis. The gene expression profiles in human LN were similar to those in NZM2328 mice, suggesting comparable disease stages.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Mengdi Liu, Lei Zhang, Yixin Wang, Weijie Hu, Chunhong Wang, Zhenke Wen
Summary: Lupus nephritis is a severe renal disease caused by the deposition of immune complexes in renal tissue, leading to damage and excessive proliferation of mesangial cells. In addition to their structural role, mesangial cells are involved in immune regulation and inflammatory responses, contributing to immune-mediated renal damage.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Liu Liu, Lei Zhang, Ming Li
Summary: Lupus nephritis is a renal disease caused by systemic lupus erythematosus and has serious implications for patients. Traditional Chinese medicine has shown promising effects in alleviating the symptoms and improving the prognosis of LN patients. This review provides supplementary evidence for the development of TCM treatment for LN and serves as a reference for future research and clinical practice.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Chang Seong Kim, Ansuja Pulickal Mathew, Arathy Vasukutty, Saji Uthaman, Soo Yeon Joo, Eun Hui Bae, Seong Kwon Ma, In-Kyu Park, Soo Wan Kim
Summary: The treatment with HGC-TAC nanomicelles significantly reduces kidney injury in lupus nephritis mice by targeting inflammation, fibrosis, and apoptosis, showing potential for improved therapeutic outcomes.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Urology & Nephrology
Isabelle Ayoub, Bethany J. Wolf, Linyu Geng, Huijuan Song, Aastha Khatiwada, Betty P. Tsao, Jim C. Oates, Brad H. Rovin
Summary: A machine learning approach combining traditional clinical data and novel urine biomarkers was used to develop prediction models for one-year treatment response in lupus nephritis. The models showed good predictive value, with the best performance seen in predicting eGFR response. The inclusion of both traditional clinical data and novel urine biomarkers, including cytokines, chemokines, and markers of kidney damage, was found to improve the prediction accuracy.
KIDNEY INTERNATIONAL
(2022)
Article
Urology & Nephrology
Suchun Li, Qimei Luo, Yuting Fan, Chen Zhao, Fengxian Huang, Xi Xia, Wei Chen
Summary: This study found that lupus nephritis patients with acute kidney injury (AKI) had poorer long-term renal outcomes and patient survival. Early identification and management of AKI in these patients is crucial.
AMERICAN JOURNAL OF NEPHROLOGY
(2023)
Article
Medicine, General & Internal
Yiyao Deng, Ying Zheng, Delun Li, Quan Hong, Min Zhang, Qinggang Li, Bo Fu, Lingling Wu, Xu Wang, Wanjun Shen, Yingjie Zhang, Jiakai Chang, Kangkang Song, Xiaomin Liu, Shunlai Shang, Guangyan Cai, Xiangmei Chen
Summary: Through single-cell RNA sequencing analysis, it was found that monocytes, B cells, dendritic cells, and granulocytes were significantly increased in SLE patients, while subsets of T cells were significantly decreased. Neutrophils and low-density granulocytes exhibited the highest ISG activity. 31 common ISGs were found expressed in both PBMCs and kidneys, and these ISGs were also most active in neutrophils and LDGs.
Article
Biochemistry & Molecular Biology
Rakesh Mishra, Ramalingam Bethunaickan, Celine C. Berthier, Zhengzi Yi, Joshua J. Strohl, Patricio T. Huerta, Weijia Zhang, Anne Davidson
Summary: The study found significant disruption of renal circadian rhythms in mice with lupus nephritis, affecting multiple renal pathways including homeostasis, metabolism, and blood pressure regulation. Induction of remission therapy partially reversed this circadian dysregulation.
MOLECULAR MEDICINE
(2021)
Article
Immunology
Fei-fei Chen, Xiao-tian Liu, Juan Tao, Zhao-min Mao, Hui Wang, Ying Tan, Zhen Qu, Feng Yu
Summary: The current study aimed to evaluate the activation of renal NLRP3 inflammasome pathway in Chinese lupus nephritis (LN) patients and its clinicopathological significances. It was found that expressions of NLRP3, ASC, caspase-1, IL-1 beta and IL-18 were significantly higher in the kidneys of LN patients, mainly in glomerular mesangial cells, podocytes, renal tubular epithelial cells, and macrophages. The expressions of NLRP3, ASC, caspase-1, and IL-1 beta were positively correlated with SLEDAI scores and renal pathological activity indices, while NLRP3 expression was negatively associated with chronicity scores. Furthermore, glomerular caspase-1 levels were positively correlated with foot process width, and podocyte injury markers were decreased significantly in LN patients with higher caspase-1 expression. The findings suggest that renal NLRP3 inflammasome is activated in LN patients and correlated with disease activity, which warrants further exploration.
CLINICAL IMMUNOLOGY
(2023)
Article
Immunology
Jingquan He, Chiyu Ma, Donge Tang, Shaoyun Zhong, Xiaofang Yuan, Fengping Zheng, Zhipeng Zeng, Yumei Chen, Dongzhou Liu, Xiaoping Hong, Weier Dai, Lianghong Yin, Yong Dai
Summary: This study investigated the alteration of oxylipins in the serum of systemic lupus erythematosus (SLE) patients and identified potential biomarkers for SLE classification. The results showed that certain oxylipins were correlated with lupus nephritis (LN) and SLE disease activity. Additionally, a combination of 5 oxylipins was found to have high accuracy in classifying SLE patients. The findings provide insights into the characteristics of SLE and the development of new tools for classification.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Camila Barbosa Oliveira, Camilla Albertina Dantas Lima, Gisele Vajgel, Paula Sandrin-Garcia
Summary: This review manuscript discusses the relationship between the NLRP3 inflammasome, SLE, and LN, emphasizing the impact of genetic susceptibility of NLRP3 polymorphisms on the disease and exploring NLRP3 inhibition mechanisms for the development of potential therapeutic drugs for LN.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Meiying Wang, Snehin Rajkumar, Yupeng Lai, Xingjiao Liu, Jing He, Tatsuya Ishikawa, Dhiraj Nallapothula, Ram Raj Singh
Summary: This article describes the potential role of tertiary lymphoid structures (TLS) in the pathogenesis of autoimmune diseases, focusing on lupus nephritis. The presence of TLS in the kidneys is associated with severe inflammation, higher disease activity, and poor response to treatment. TLS may contribute to the development of lupus nephritis by increasing local immune response and supporting the production of autoantibodies. However, the mechanisms underlying TLS formation and their exact role in lupus nephritis are not fully understood.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Chen Yu, Ping Li, Xin Dang, Xuan Zhang, Yonghui Mao, Xiangmei Chen
Summary: This review focuses on lupus nephritis (LN), a common manifestation of systemic lupus erythematosus (SLE), and discusses the challenges in its diagnosis and treatment as well as the potential targets for future management.
JOURNAL OF AUTOIMMUNITY
(2022)
Review
Biochemistry & Molecular Biology
Marta Monticolo, Krzysztof Mucha, Bartosz Foroncewicz
Summary: Lupus nephritis is a common and serious complication of systemic lupus erythematosus, with genetic and environmental factors, including dysbiosis, playing a role in its development. The relationship between the human microbiome, genetic determinants, individual variability, and clinical consequences needs further investigation. Bacterial metabolites that mimic autoantigens and stimulate autoimmune responses may be a potential target for future interventions in Lupus nephritis.
Article
Biology
Xingzhong Liu, Jie Chen, Lu Liu
Summary: One of the most severe side effects of systemic lupus erythematosus (SLE) is lupus nephritis (LN). In this study, DUSP2 was found to reduce proteinuria, urea nitrogen, dsDNA and TNF-alpha, IL-6, and IL-1 beta levels in mice with LN and improve renal tissue injury. Mechanistically, DUSP2 inhibited STAT3 phosphorylation. These findings suggest that DUSP2 could serve as a potential therapeutic target for LN research.
OPEN LIFE SCIENCES
(2023)
