Article
Urology & Nephrology
Isabelle Ayoub, Bethany J. Wolf, Linyu Geng, Huijuan Song, Aastha Khatiwada, Betty P. Tsao, Jim C. Oates, Brad H. Rovin
Summary: A machine learning approach combining traditional clinical data and novel urine biomarkers was used to develop prediction models for one-year treatment response in lupus nephritis. The models showed good predictive value, with the best performance seen in predicting eGFR response. The inclusion of both traditional clinical data and novel urine biomarkers, including cytokines, chemokines, and markers of kidney damage, was found to improve the prediction accuracy.
KIDNEY INTERNATIONAL
(2022)
Article
Immunology
Jeremy S. Tilstra, Minjung Kim, Rachael A. Gordon, Claire Leibler, Haylee A. Cosgrove, Sheldon Bastacky, Kevin M. Nickerson, Mark J. Shlomchik
Summary: Studies have shown that MyD88 in B cells plays a crucial role in the onset and progression of lupus in mice, and its deficiency can improve disease symptoms and reduce autoantibody production. Therefore, targeting MyD88 or its upstream activators may be an effective option for treating lupus.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Chenzhu Zhang, Tsz Wai Tam, Mel K. M. Chau, Cristina Alexandra Garcia Cordoba, Susan Yung, Tak Mao Chan
Summary: In murine lupus nephritis, combined treatment of mycophenolate and rapamycin improves kidney fibrosis through their distinct effects on mTOR and ERK signaling in mesangial cells.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Rheumatology
Stephen McDonald, Sean Yiu, Li Su, Caroline Gordon, Matt Truman, Laura Lisk, Neil Solomons, Ian N. Bruce
Summary: This study aimed to identify baseline predictors of 6-month responses in patients with lupus. The predictors included age, haemoglobin level, lupus activity, baseline damage, and urine protein. The results showed that these predictors can help identify patients who may require novel treatment strategies.
LUPUS SCIENCE & MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Chun-Ling Liang, Weihui Lu, Feifei Qiu, Dan Li, Huazhen Liu, Fang Zheng, Qunfang Zhang, Yuchao Chen, Chuanjian Lu, Bin Li, Zhenhua Dai
Summary: PF can ameliorate lupus nephritis by reducing proteinuria, serum creatinine, anti-dsDNA levels, and renal cellular infiltration, as well as by improving renal immunopathology. It also has the potential to promote Treg differentiation and proliferation mediated by M2 macrophages, suggesting it may be used as a possible treatment for lupus nephritis.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Plant Sciences
Ying Zhang, Zhaojun Li, Haijie Wu, Jing Wang, Sen Zhang
Summary: The study evaluates the renal protective effect of esculetin against the progression of lupus nephritis and finds that esculetin can significantly improve renal function and pathology. It exhibits antioxidant and anti-inflammatory properties and acts on LN through multiple pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Zhifeng Zhao, Xiaoke Xu, Haochen Jiang, Kirk W. Foster, Zhenshan Jia, Xin Wei, Ningrong Chen, Steven R. Goldring, Mary K. Crow, Dong Wang
Summary: This study established the optimal dose-response relationships for ZSJ-0228 in treating LN in NZB/W F1 mice, showing that the most effective dose range is between 1.0 and 3.0 mg/kg/day Dex equivalent, with excellent safety profile. The resolution of proteinuria, improvement in renal histological scores, and lack of typical GC-associated side effects further support the therapeutic potential of ZSJ-0228 in LN management.
MOLECULAR PHARMACEUTICS
(2021)
Article
Pediatrics
Sai Sudha Mannemuddhu, Lawrence R. Shoemaker, Shahab Bozorgmehri, R. Ezequiel Borgia, Nirupama Gupta, William L. Clapp, Xu Zeng, Renee F. Modica
Summary: This study compared the characteristics and outcomes of pediatric Silent lupus nephritis (SLN) with overt lupus nephritis (OLN) and identified associated risk factors and biochemical markers. Lower complement levels were associated with proliferative lesions in both SLN and OLN. Non-African Americans had higher odds of having proliferative nephritis than African Americans. Prospective, randomized, long-term follow-up is needed to determine the benefits of early diagnosis and treatment.
PEDIATRIC NEPHROLOGY
(2023)
Review
Immunology
Jiaxuan Chen, Shuzhen Liao, Huimin Zhou, Lawei Yang, Fengbiao Guo, Shuxian Chen, Aifen Li, Quanren Pan, Chen Yang, Hua-feng Liu, Qingjun Pan
Summary: Animal models play a crucial role in understanding human diseases, but they cannot fully simulate the occurrence and progression of diseases due to genetic and disease-specific differences. Humanized immune system mice, developed from immunodeficient mice, provide a partial reconstruction of the human immune system and mimic the in vivo microenvironment. However, there are challenges in developing humanized mice models for systemic lupus erythematosus (SLE), including improving immune response reconstruction efficiency, extending observation period, and improving model development and utilization.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Sylvia Xie, Anto Sam Crosslee Louis Sam Titus, Chandra Mohan
Summary: Lupus nephritis (LN) is a highly heterogeneous disease, and diagnosis is difficult due to the varied clinical manifestations. Recent proteomic studies have identified several urinary proteins which are also cell-surface receptors. This study found that EGFR, TFRC, FOLR2, and PDGF-RB are hyperexpressed in LN kidneys, suggesting their potential as drug targets.
CLINICAL IMMUNOLOGY
(2023)
Article
Immunology
Marc Xipell, Gema M. Lledo, Allyson C. Egan, Farah Tamirou, Cristina Serrano del Castillo, Jordi Rovira, Jose A. Gomez-Puerta, Adriana Garcia-Herrera, Ricard Cervera, Andreas Kronbichler, David R. W. Jayne, Hans-Joachim Anders, Frederic Houssiau, Gerard Espinosa, Luis F. Quintana
Summary: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by loss of tolerance against nuclear and cytoplasmic self-antigens, induction of immunity, and tissue inflammation. Lupus nephritis (LN) is a common complication of SLE, affecting around 30% of patients at disease onset and up to 50-60% within the first 10 years. This review focuses on the pathogenic mechanisms of SLE, the immunological pathways of kidney damage in LN, and the rationale for the treatment of LN.
AUTOIMMUNITY REVIEWS
(2023)
Article
Medicine, Research & Experimental
Yunjung Choi, Ji-Hyun Jung, Eun-Gyeong Lee, Kyoung Min Kim, Wan-Hee Yoo
Summary: The study found that attenuating ER stress can reduce disease activity in an experimental lupus model, primarily by enhancing the suppressive capacity of Tregs. This suggests that reducing ER stress may be a beneficial therapeutic strategy for SLE.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Immunology
Masashi Morita, Masayuki Mizui, Satoshi Masuyama, George C. Tsokos, Yoshitaka Isaka
Summary: The study compares the efficacy and mechanisms of action of conventional anti-CD3 antibodies and non-mitogenic anti-CD3 antibodies. It demonstrates that non-mitogenic anti-CD3 antibodies can effectively suppress the development of lupus by reducing surface TCR.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Erica Moore, Michelle W. Huang, Cara A. Reynolds, Fernando Macian, Chaim Putterman
Summary: Objective T cells play a critical role in neuropsychiatric systemic lupus erythematosus (NPSLE) and their modulation may be a potential therapeutic strategy for targeted treatment of NPSLE.
ARTHRITIS & RHEUMATOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Marta Monticolo, Krzysztof Mucha, Bartosz Foroncewicz
Summary: Lupus nephritis is a common and serious complication of systemic lupus erythematosus, with genetic and environmental factors, including dysbiosis, playing a role in its development. The relationship between the human microbiome, genetic determinants, individual variability, and clinical consequences needs further investigation. Bacterial metabolites that mimic autoantigens and stimulate autoimmune responses may be a potential target for future interventions in Lupus nephritis.
Article
Immunology
Anne Davidson, Ramalingam Bethunaickan, Celine Berthier, Ranjit Sahu, Weijia Zhang, Matthias Kretzler
IMMUNOLOGIC RESEARCH
(2015)
Review
Rheumatology
Anne Davidson
NATURE REVIEWS RHEUMATOLOGY
(2016)
Editorial Material
Rheumatology
Anne Davidson, David Polsky
ARTHRITIS CARE & RESEARCH
(2015)
Review
Immunology
Megan Woods, Yong-Rui Zou, Anne Davidson
FRONTIERS IN IMMUNOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Alexis Boneparth, Megan Woods, Weiqing Huang, Meredith Akerman, Martin Lesser, Anne Davidson
MOLECULAR MEDICINE
(2016)
Article
Immunology
K. Worthmann, F. Gueler, S. von Vietinghoff, A. Davalos-Militz, F. Wiehler, A. Davidson, T. Witte, H. Haller, M. Schiffer, C. S. Falk, L. Schiffer
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2014)
Article
Immunology
Chao Dai, Hongyang Wang, Sun-Sang J. Sung, Rahul Sharma, Carol Kannapell, Wei Han, Qian Wang, Anne Davidson, Felicia Gaskin, Shu Man Fu
CLINICAL IMMUNOLOGY
(2014)
Article
Multidisciplinary Sciences
Ramalingam Bethunaickan, Celine C. Berthier, Weijia Zhang, Matthias Kretzler, Anne Davidson
Article
Multidisciplinary Sciences
Alexis Boneparth, Weiqing Huang, Ramalingam Bethunaickan, Megan Woods, Ranjit Sahu, Shitij Arora, Meredith Akerman, Martin Lesser, Anne Davidson
Meeting Abstract
Rheumatology
Ramalingam Bethunaickan, Celine C. Berthier, Weijia Zhang, Ridvan Eksi, Hong-Dong Li, Yuanfang Guan, Matthias Kretzler, Anne Davidson
ARTHRITIS RESEARCH & THERAPY
(2014)
Article
Rheumatology
Ramalingam Bethunaickan, Celine C. Berthier, Weijia Zhang, Ridvan Eksi, Hong-Dong Li, Yuanfang Guan, Matthias Kretzler, Anne Davidson
ARTHRITIS & RHEUMATOLOGY
(2014)
Editorial Material
Rheumatology
Anne Davidson
ARTHRITIS & RHEUMATOLOGY
(2014)
Article
Rheumatology
Ranjit Sahu, Ramalingam Bethunaickan, Satwinder Singh, Anne Davidson
ARTHRITIS & RHEUMATOLOGY
(2014)
Article
Immunology
Celine C. Berthier, Matthias Kretzler, Anne Davidson
CLINICAL IMMUNOLOGY
(2017)
Article
Urology & Nephrology
Hans-Joachim Anders, Brad Rovin, David Jayne, Paul Brunetta, Rosanna Coppo, Anne Davidson, Satish Kumar Devarapu, Dick de Zeeuw, Jeremy Duffield, Dirk Eulberg, Alberto Fierro, Juergen Floege, Steffen Frese, Loic Guillevin, Stephen Holdsworth, Jeremy Hughes, Ralph Kettritz, Malte Kluger, Christian Krebs, Larissa Lapteva, Adeera Levin, Jinhua Li, Liz Lightstone, Matthias Mack, Ladan Mansouri, Stephen McAdoo, Eoin McKinney, Ulf Panzer, Samir Parikh, Charles Pusey, Chaim Putterman, Ton Rabelink, Andreas Radbruch, Andrew Rees, Mary Reilly, Marlies Reinders, Giuseppe Remuzzi, Piero Ruggenenti, Steven Sacks, Thomas J. Schall, Catherine Meyer-Schwesinger, Kumar Sharma, Yusuke Suzuki, Nicola M. Tomas, Ming-Hui Zhao
KIDNEY INTERNATIONAL REPORTS
(2016)