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PTPN22 in Autoimmunity: Different Cell and Different Way

IMMUNITY (2013)

期刊

IMMUNITY

卷 39, 期 1, 页码 91-93

出版社

CELL PRESS

DOI: 10.1016/j.immuni.2013.07.007

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Immunology

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NIAID NIH HHS [R01 AI046712] Funding Source: Medline
NIAMS NIH HHS [R01 AR050401, R01 AR046713] Funding Source: Medline

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摘要

The tyrosine phosphatase PTPN22 regulates T cell receptor signaling. In this issue of Immunity, Wang et al. (2013) show that in myeloid cells PTPN22 potentiates TLR-induced type I interferon production and that autoimmunity-associated allele PTPN22W encodes a reduced-function variant.

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