Revisiting the metabolic syndrome and paving the way for microRNAs in non-alcoholic fatty liver disease

c-Jun N-Terminal Kinase 1/c-Jun Activation of the p53/MicroRNA 34a/Sirtuin 1 Pathway Contributes to Apoptosis Induced by Deoxycholic Acid in Rat Liver

(2014) D. M. S. Ferreira et al.   MOLECULAR AND CELLULAR BIOLOGY

Elevated microRNA-34a in obesity reduces NAD+levels and SIRT1 activity by directly targeting NAMPT

(2013) Sung-E Choi et al.   AGING CELL

High-Fat-Fed Obese Glutathione Peroxidase 1-Deficient Mice Exhibit Defective Insulin Secretion but Protection from Hepatic Steatosis and Liver Damage

(2013) Troy L. Merry et al.   ANTIOXIDANTS & REDOX SIGNALING

MicroRNA-1 and microRNA-206 suppress LXRα-induced lipogenesis in hepatocytes

(2013) Dan Zhong et al.   CELLULAR SIGNALLING

Associations between circulating microRNAs (miR-21, miR-34a, miR-122 and miR-451) and non-alcoholic fatty liver

(2013) Hiroya Yamada et al.   CLINICA CHIMICA ACTA

Pharmacological Inhibition of Protein Tyrosine Phosphatase 1B: A Promising Strategy for the Treatment of Obesity and Type 2 Diabetes Mellitus

(2013) E. Panzhinskiy et al.   CURRENT MEDICINAL CHEMISTRY

Upregulation of miR-15b in NAFLD models and in the serum of patients with fatty liver disease

(2013) Yuhao Zhang et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Inducible liver-specific knockdown of protein tyrosine phosphatase 1B improves glucose and lipid homeostasis in adult mice

(2013) C. Owen et al.   DIABETOLOGIA

Regulation of cholesterol and bile acid homeostasis by the cholesterol 7α-hydroxylase/steroid response element-binding protein 2/microRNA-33a axis in mice

(2013) Tiangang Li et al.   HEPATOLOGY

Free cholesterol accumulation in hepatic stellate cells: Mechanism of liver fibrosis aggravation in nonalcoholic steatohepatitis in mice

(2013) Kengo Tomita et al.   HEPATOLOGY

Role of the intestinal microbiome in liver disease

(2013) Jorge Henao-Mejia et al.   JOURNAL OF AUTOIMMUNITY

Enhanced hepatic delivery of siRNA and microRNA using oleic acid based lipid nanoparticle formulations

(2013) Xinmei Wang et al.   JOURNAL OF CONTROLLED RELEASE

Expression of genes for microRNA-processing enzymes is altered in advanced non-alcoholic fatty liver disease

(2013) Haveesh Sharma et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

The burden of liver disease in Europe: A review of available epidemiological data

(2013) Martin Blachier et al.   JOURNAL OF HEPATOLOGY

Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome

(2013) Shin Yoshimoto et al.   NATURE

MiR-155 Has a Protective Role in the Development of Non-Alcoholic Hepatosteatosis in Mice

(2013) Ashley M. Miller et al.   PLoS One

CEACAM1 loss links inflammation to insulin resistance in obesity and non-alcoholic steatohepatitis (NASH)

(2013) Sonia M. Najjar et al.   Seminars in Immunopathology

MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice

(2013) Takahiro Horie et al.   Nature Communications

Fanconi Anemia Links Reactive Oxygen Species to Insulin Resistance and Obesity

(2012) Jie Li et al.   ANTIOXIDANTS & REDOX SIGNALING

Increased Hepatic Synthesis and Dysregulation of Cholesterol Metabolism Is Associated with the Severity of Nonalcoholic Fatty Liver Disease

(2012) Hae-Ki Min et al.   Cell Metabolism

miR-33 controls the expression of biliary transporters, and mediates statin- and diet-induced hepatotoxicity

(2012) Ryan M. Allen et al.   EMBO Molecular Medicine

PTP1B and TCPTP - nonredundant phosphatases in insulin signaling and glucose homeostasis

(2012) Tony Tiganis   FEBS Journal

MicroRNA-221/222 upregulation indicates the activation of stellate cells and the progression of liver fibrosis

(2012) Tomohiro Ogawa et al.   GUT

Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice

(2012) Kouichi Miura et al.   HEPATOLOGY

Regulation of intracellular signalling through cysteine oxidation by reactive oxygen species

(2012) H. Miki et al.   JOURNAL OF BIOCHEMISTRY

Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver

(2012) Shu-hao Hsu et al.   JOURNAL OF CLINICAL INVESTIGATION

MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis

(2012) Wei-Chih Tsai et al.   JOURNAL OF CLINICAL INVESTIGATION

Prevalence and risk factors of non-alcoholic fatty liver disease in the elderly: Results from the Rotterdam study

(2012) Edith M. Koehler et al.   JOURNAL OF HEPATOLOGY

Inhibition of p53 attenuates steatosis and liver injury in a mouse model of non-alcoholic fatty liver disease

(2012) Zoltan Derdak et al.   JOURNAL OF HEPATOLOGY

miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease

(2012) Rui E. Castro et al.   JOURNAL OF HEPATOLOGY

Atf6α-null mice are glucose intolerant due to pancreatic β-cell failure on a high-fat diet but partially resistant to diet-induced insulin resistance

(2012) Masahiro Usui et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Plasma MicroRNA Profiles in Rat Models of Hepatocellular Injury, Cholestasis, and Steatosis

(2012) Yu Yamaura et al.   PLoS One

Liver and Muscle in Morbid Obesity: The Interplay of Fatty Liver and Insulin Resistance

(2012) Mariana Verdelho Machado et al.   PLoS One

Aberrantly elevated microRNA-34a in obesity attenuates hepatic responses to FGF19 by targeting a membrane coreceptor  -Klotho

(2012) T. Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nonalcoholic Fatty Liver Disease: Pathologic Patterns and Biopsy Evaluation in Clinical Research

(2012) David Kleiner et al.   SEMINARS IN LIVER DISEASE

Plasma microRNAs are sensitive indicators of inter-strain differences in the severity of liver injury induced in mice by a choline- and folate-deficient diet

(2012) Volodymyr P. Tryndyak et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

miR-34 – a microRNA replacement therapy is headed to the clinic

(2012) Andreas G. Bader   Frontiers in Genetics

High fat diet induced downregulation of microRNA-467b increased lipoprotein lipase in hepatic steatosis

(2011) Jiyun Ahn et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ER stress modulates cellular metabolism

(2011) Xiaoli Wang et al.   BIOCHEMICAL JOURNAL

Metabolically healthy and unhealthy obesity phenotypes in the general population: the FIN-D2D Survey

(2011) Pia Pajunen et al.   BMC PUBLIC HEALTH

Prevalence of and Risk Factors for Hepatic Steatosis and Nonalcoholic Fatty Liver Disease in People With Type 2 Diabetes: the Edinburgh Type 2 Diabetes Study

(2011) R. M. Williamson et al.   DIABETES CARE

Apoptosis and insulin resistance in liver and peripheral tissues of morbidly obese patients is associated with different stages of non-alcoholic fatty liver disease

(2011) D. M. S. Ferreira et al.   DIABETOLOGIA

The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis

(2011) Kezhong Zhang et al.   EMBO JOURNAL

Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis

(2011) Anabela P. Rolo et al.   FREE RADICAL BIOLOGY AND MEDICINE

MicroRNA therapeutics

(2011) J A Broderick et al.   GENE THERAPY

Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells

(2011) Timea Csak et al.   HEPATOLOGY

Effect of adipose tissue insulin resistance on metabolic parameters and liver histology in obese patients with nonalcoholic fatty liver disease

(2011) Romina Lomonaco et al.   HEPATOLOGY

Regulation of protein tyrosine phosphatases by reversible oxidation

(2011) Arne Östman et al.   JOURNAL OF BIOCHEMISTRY

Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress

(2011) R. Bravo et al.   JOURNAL OF CELL SCIENCE

Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis

(2011) Katey J. Rayner et al.   JOURNAL OF CLINICAL INVESTIGATION

A role for miR-296 in the regulation of lipoapoptosis by targeting PUMA

(2011) Sophie C. Cazanave et al.   JOURNAL OF LIPID RESEARCH

Nonalcoholic fatty liver disease is associated with an altered hepatocyte microRNA profile in LDL receptor knockout mice

(2011) Menno Hoekstra et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides

(2011) Katey J. Rayner et al.   NATURE

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

(2011) Ira Tabas et al.   NATURE CELL BIOLOGY

MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins

(2011) Kasey C. Vickers et al.   NATURE CELL BIOLOGY

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

(2011) Haitao Wen et al.   NATURE IMMUNOLOGY

MicroRNAs in body fluids—the mix of hormones and biomarkers

(2011) Maria Angelica Cortez et al.   Nature Reviews Clinical Oncology

MicroRNAs in Development and Disease

(2011) Danish Sayed et al.   PHYSIOLOGICAL REVIEWS

Circulating MicroRNAs in Patients with Chronic Hepatitis C and Non-Alcoholic Fatty Liver Disease

(2011) Silvia Cermelli et al.   PLoS One

miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling

(2011) A. Davalos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma

(2011) J. D. Arroyo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Fatty Liver Disease: Old Questions and New Insights

(2011) J. C. Cohen et al.   SCIENCE

H2S-Induced Sulfhydration of the Phosphatase PTP1B and Its Role in the Endoplasmic Reticulum Stress Response

(2011) N. Krishnan et al.   Science Signaling

Propensity to high-fat diet-induced obesity in rats is associated with changes in the gut microbiota and gut inflammation

(2010) Claire Barbier de La Serre et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Regulation of mRNA Translation and Stability by microRNAs

(2010) Marc Robert Fabian et al.   Annual Review of Biochemistry

Irs1 Serine 307 Promotes Insulin Sensitivity in Mice

(2010) Kyle D. Copps et al.   Cell Metabolism

Plasma MicroRNA-122 as a Biomarker for Viral-, Alcohol-, and Chemical-Related Hepatic Diseases

(2010) Y. Zhang et al.   CLINICAL CHEMISTRY

Epidemiology of Non-Alcoholic Fatty Liver Disease

(2010) Stefano Bellentani et al.   DIGESTIVE DISEASES

Gender-specific differences in adipose distribution and adipocytokines influence adolescent nonalcoholic fatty liver disease

(2010) Oyekoya T. Ayonrinde et al.   HEPATOLOGY

A Pathway Involving Farnesoid X Receptor and Small Heterodimer Partner Positively Regulates Hepatic Sirtuin 1 Levels via MicroRNA-34a Inhibition

(2010) Jiyoung Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of p53 enhances apoptosis and insulin resistance in a rat model of alcoholic liver disease

(2010) Zoltan Derdak et al.   JOURNAL OF HEPATOLOGY

A putative role of micro RNA in regulation of cholesterol 7α-hydroxylase expression in human hepatocytes

(2010) Kwang-Hoon Song et al.   JOURNAL OF LIPID RESEARCH

Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155 and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice

(2010) Igor P Pogribny et al.   LABORATORY INVESTIGATION

Mirnome analysis reveals novel molecular determinants in the pathogenesis of diet-induced nonalcoholic fatty liver disease

(2010) Anna Alisi et al.   LABORATORY INVESTIGATION

Induction of Liver Steatosis and Lipid Droplet Formation in ATF6α-Knockout Mice Burdened with Pharmacological Endoplasmic Reticulum Stress

(2010) Keisuke Yamamoto et al.   MOLECULAR BIOLOGY OF THE CELL

The role of the gut microbiota in nonalcoholic fatty liver disease

(2010) Ahmed Abu-Shanab et al.   Nature Reviews Gastroenterology & Hepatology

MicroRNA-33 and the SREBP Host Genes Cooperate to Control Cholesterol Homeostasis

(2010) S. H. Najafi-Shoushtari et al.   SCIENCE

MicroRNA Expression Profile in Lieber-DeCarli Diet-Induced Alcoholic and Methionine Choline Deficient Diet-Induced Nonalcoholic Steatohepatitis Models in Mice

(2009) Angela Dolganiuc et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Therapeutic microRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model

(2009) Janaiah Kota et al.   CELL

Origin, Biogenesis, and Activity of Plant MicroRNAs

(2009) Olivier Voinnet   CELL

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Origins and Mechanisms of miRNAs and siRNAs

(2009) Richard W. Carthew et al.   CELL

Reactive Oxygen Species Enhance Insulin Sensitivity

(2009) Kim Loh et al.   Cell Metabolism

Hepatocyte-Specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation

(2009) Aparna Purushotham et al.   Cell Metabolism

Harmonizing the Metabolic Syndrome

(2009) K.G.M.M. Alberti et al.   CIRCULATION

Non-Alcoholic Fatty Liver Disease in Older People

(2009) James Frith et al.   GERONTOLOGY

Role of microRNA-155 at early stages of hepatocarcinogenesis induced by choline-deficient and amino acid-defined diet in C57BL/6 mice

(2009) Bo Wang et al.   HEPATOLOGY

Ultrasonographic hepatic steatosis increases prediction of mortality risk from elevated serum gamma-glutamyl transpeptidase levels

(2009) Robin Haring et al.   HEPATOLOGY

JNK1-dependent PUMA Expression Contributes to Hepatocyte Lipoapoptosis

(2009) Sophie C. Cazanave et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatic Lipid Partitioning and Liver Damage in Nonalcoholic Fatty Liver Disease

(2009) Zheng Zheng Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toward unraveling the complexity of simple epithelial keratins in human disease

(2009) M. Bishr Omary et al.   JOURNAL OF CLINICAL INVESTIGATION

Apoptosis in experimental NASH is associated with p53 activation and TRAIL receptor expression

(2009) Geoffrey C Farrell et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Effect of miRNA-10b in regulating cellular steatosis level by targeting PPAR-α expression, a novel mechanism for the pathogenesis of NAFLD

(2009) Lin Zheng et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Differential expression of microRNAs in mouse liver under aberrant energy metabolic status

(2009) Shengjie Li et al.   JOURNAL OF LIPID RESEARCH

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

(2009) Michael R. Elliott et al.   NATURE

Decreased levels of microRNA miR-122 in individuals with hepatitis C responding poorly to interferon therapy

(2009) Magdalena Sarasin-Filipowicz et al.   NATURE MEDICINE

Therapeutic Silencing of MicroRNA-122 in Primates with Chronic Hepatitis C Virus Infection

(2009) R. E. Lanford et al.   SCIENCE

A robust methodology to study urine microRNA as tumor marker: microRNA-126 and microRNA-182 are related to urinary bladder cancer

(2009) Merle Hanke et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Liver-Specific Deletion of Protein-Tyrosine Phosphatase 1B (PTP1B) Improves Metabolic Syndrome and Attenuates Diet-Induced Endoplasmic Reticulum Stress

(2008) M. Delibegovic et al.   DIABETES

Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice

(2008) P. D. Cani et al.   DIABETES

Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance

(2008) Rajat Singh et al.   HEPATOLOGY

Nonalcoholic steatohepatitis is associated with altered hepatic MicroRNA expression

(2008) Onpan Cheung et al.   HEPATOLOGY

Unsaturated fatty acids inhibit the expression of tumor suppressor phosphatase and tensin homolog (PTEN) via microRNA-21 up-regulation in hepatocytes

(2008) Manlio Vinciguerra et al.   HEPATOLOGY

SIRT1 Exerts Anti-Inflammatory Effects and Improves Insulin Sensitivity in Adipocytes

(2008) T. Yoshizaki et al.   MOLECULAR AND CELLULAR BIOLOGY

MicroRNA-21 Targets Sprouty2 and Promotes Cellular Outgrowths

(2008) Danish Sayed et al.   MOLECULAR BIOLOGY OF THE CELL

Detection of microRNA Expression in Human Peripheral Blood Microvesicles

(2008) Melissa Piper Hunter et al.   PLoS One

PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation

(2008) E. Bobrovnikova-Marjon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CELL SIGNALING: Fat Stress and Liver Resistance

(2008) W. Ogawa et al.   SCIENCE

Impact of Fatty Liver Disease on Health Care Utilization and Costs in a General Population: A 5-Year Observation

(2007) Sebastian E. Baumeister et al.   GASTROENTEROLOGY