Copper as a key regulator of cell signalling pathways

The role of Nrf1 and Nrf2 in the regulation of copper-responsive transcription

(2014) Min Ok Song et al.   EXPERIMENTAL CELL RESEARCH

Phosphorylation of Amyloid Precursor Protein at Threonine 668 Is Essential for Its Copper-responsive Trafficking in SH-SY5Y Neuroblastoma Cells

(2014) Karla M. Acevedo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tuning NF-κB activity: A touch of COMMD proteins

(2013) Paulina Bartuzi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Metals and movement disorders

(2013) Pille Taba   CURRENT OPINION IN NEUROLOGY

Metal binding ability of curcumin derivatives: a theoretical vs. experimental approach

(2013) Erika Ferrari et al.   DALTON TRANSACTIONS

Overcoming endocrine resistance in breast cancer: role of the PI3K and the mTOR pathways

(2013) Aaron Provenzano et al.   Expert Review of Anticancer Therapy

The mammalian copper transporters CTR1 and CTR2 and their roles in development and disease

(2013) Natalie K.Y. Wee et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Rho Kinases in Cardiovascular Physiology and Pathophysiology

(2013) Jianjian Shi et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Towards an understanding of cell-specific functions of signal-dependent transcription factors

(2013) Dawn X Zhang et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Protein kinase C (PKC) as a drug target in chronic lymphocytic leukemia

(2013) Julhash U. Kazi et al.   MEDICAL ONCOLOGY

Recent Developments of Small Molecule PI3K/mTOR Dual Inhibitors

(2013) Yan-Na Liu et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

SLC31 (CTR) family of copper transporters in health and disease

(2013) Heejeong Kim et al.   MOLECULAR ASPECTS OF MEDICINE

Existing and potential therapeutic uses for N-acetylcysteine: The need for conversion to intracellular glutathione for antioxidant benefits

(2013) Gordon F. Rushworth et al.   PHARMACOLOGY & THERAPEUTICS

Amyloid-β induced signaling by cellular prion protein and Fyn kinase in Alzheimer disease

(2013) Ji Won Um et al.   Prion

Structure of FGFR3 Transmembrane Domain Dimer: Implications for Signaling and Human Pathologies

(2013) Eduard V. Bocharov et al.   STRUCTURE

Zinc Biochemistry: From a Single Zinc Enzyme to a Key Element of Life

(2013) Wolfgang Maret   Advances in Nutrition

Therapeutic effects of CuII(atsm) in the SOD1-G37R mouse model of amyotrophic lateral sclerosis

(2013) Erin J. McAllum et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Therapeutic Redistribution of Metal Ions To Treat Alzheimer’s Disease

(2012) Peter J. Crouch et al.   ACCOUNTS OF CHEMICAL RESEARCH

Deregulated Cdk5 Activity Is Involved in Inducing Alzheimer’s Disease

(2012) Varsha Shukla et al.   ARCHIVES OF MEDICAL RESEARCH

Copper influx transporter 1 is required for FGF, PDGF and EGF-induced MAPK signaling

(2012) Cheng-Yu Tsai et al.   BIOCHEMICAL PHARMACOLOGY

Charting the travels of copper in eukaryotes from yeast to mammals

(2012) Tracy Nevitt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Copper compound induces autophagy and apoptosis of glioma cells by reactive oxygen species and jnk activation

(2012) Cristina Trejo-Solís et al.   BMC CANCER

Cytotoxic effect of disulfiram/copper on human glioblastoma cell lines and ALDH-positive cancer-stem-like cells

(2012) P Liu et al.   BRITISH JOURNAL OF CANCER

Copper, BDNF and Its N-terminal Domain: Inorganic Features and Biological Perspectives

(2012) Alessio Travaglia et al.   CHEMISTRY-A EUROPEAN JOURNAL

Chelating Agents for Neurodegenerative Diseases

(2012) R. J. Ward et al.   CURRENT MEDICINAL CHEMISTRY

Novel metal-based anticancer drugs: a new challenge in drug delivery

(2012) Anne-Laure Lainé et al.   CURRENT OPINION IN PHARMACOLOGY

Prevention of iron- and copper-mediated DNA damage by catecholamine and amino acid neurotransmitters, l-DOPA, and curcumin: metal binding as a general antioxidant mechanism

(2012) Carla R. García et al.   DALTON TRANSACTIONS

Axonal degeneration in Alzheimer's disease: When signaling abnormalities meet the axonal transport system

(2012) Nicholas M. Kanaan et al.   EXPERIMENTAL NEUROLOGY

Involvement and interplay of Parkin, PINK1, and DJ1 in neurodegenerative and neuroinflammatory disorders

(2012) Micha M.M. Wilhelmus et al.   FREE RADICAL BIOLOGY AND MEDICINE

Metallostasis in Alzheimer's disease

(2012) Scott Ayton et al.   FREE RADICAL BIOLOGY AND MEDICINE

The hypoxia imaging agent Cu II (atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson’s disease

(2012) Lin W. Hung et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Metal imaging in neurodegenerative diseases

(2012) Megan W. Bourassa et al.   Metallomics

A Novel Role for Copper in Ras/Mitogen-Activated Protein Kinase Signaling

(2012) M. L. Turski et al.   MOLECULAR AND CELLULAR BIOLOGY

Phosphatidylinositol 4-Kinases and PI4P Metabolism in the Nervous System: Roles in Psychiatric and Neurological Diseases

(2012) Emma L. Clayton et al.   MOLECULAR NEUROBIOLOGY

The mTOR Signaling Pathway in the Brain: Focus on Epilepsy and Epileptogenesis

(2012) Emilio Russo et al.   MOLECULAR NEUROBIOLOGY

Copper(ii) oxide nanoparticles penetrate into HepG2 cells, exert cytotoxicity via oxidative stress and induce pro-inflammatory response

(2012) Jean-Pascal Piret et al.   Nanoscale

Metal dyshomeostasis and oxidative stress in Alzheimer’s disease

(2012) Mark A. Greenough et al.   NEUROCHEMISTRY INTERNATIONAL

Disruption of copper homeostasis due to a mutation of Atp7a delays the onset of prion disease

(2012) O. M. Siggs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The challenges of using a copper fluorescent sensor (CS1) to track intracellular distributions of copper in neuronal and glial cells

(2012) Katherine A. Price et al.   Chemical Science

Curcumin inhibition of JNKs prevents dopaminergic neuronal loss in a mouse model of Parkinson’s disease through suppressing mitochondria dysfunction

(2012) Jing Pan et al.   Translational Neurodegeneration

Activation of Nuclear Factor Erythroid 2-Related Factor 2 Cytoprotective Signaling by Curcumin Protect Primary Spinal Cord Astrocytes against Oxidative Toxicity

(2011) Hong Jiang et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Transition metal abnormalities in progressive dementias

(2011) Hiroyasu Akatsu et al.   BIOMETALS

Disulfiram/copper complex activated JNK/c-jun pathway and sensitized cytotoxicity of doxorubicin in doxorubicin resistant leukemia HL60 cells

(2011) Bing Xu et al.   BLOOD CELLS MOLECULES AND DISEASES

Potent and selective inhibition of T-cell proteintyrosine phosphatase (TCPTP) by a dinuclear copper(ii) complex

(2011) Caixia Yuan et al.   CHEMICAL COMMUNICATIONS

The Inorganic Perspective of Nerve Growth Factor: Interactions of Cu2+ and Zn2+ with the N-Terminus Fragment of Nerve Growth Factor Encompassing the Recognition Domain of the TrkA Receptor

(2011) Alessio Travaglia et al.   CHEMISTRY-A EUROPEAN JOURNAL

Diacetylbis(N(4)-methylthiosemicarbazonato) Copper(II) (CuII(atsm)) Protects against Peroxynitrite-induced Nitrosative Damage and Prolongs Survival in Amyotrophic Lateral Sclerosis Mouse Model

(2011) Cynthia P. W. Soon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Alzheimer’s therapeutic PBT2 promotes amyloid-β degradation and GSK3 phosphorylation via a metal chaperone activity

(2011) Peter J. Crouch et al.   JOURNAL OF NEUROCHEMISTRY

A Targetable Fluorescent Sensor Reveals That Copper-DeficientSCO1andSCO2Patient Cells Prioritize Mitochondrial Copper Homeostasis

(2011) Sheel C. Dodani et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dynamic action of neurometals at the synapse

(2011) Haruna Tamano et al.   Metallomics

Copper complexes as therapeutic agents

(2011) Clare Duncan et al.   Metallomics

Curcumin protects against A53T alpha-synuclein-induced toxicity in a PC12 inducible cell model for Parkinsonism

(2011) Zhaohui Liu et al.   PHARMACOLOGICAL RESEARCH

Iron, zinc and copper in the Alzheimer's disease brain: A quantitative meta-analysis. Some insight on the influence of citation bias on scientific opinion

(2011) Matthew Schrag et al.   PROGRESS IN NEUROBIOLOGY

Involvement of oxidative stress-induced ERK/JNK activation in the Cu2+/pyrrolidine dithiocarbamate complex-triggered mitochondria-regulated apoptosis in pancreatic β-cells

(2011) Chin-Ching Wu et al.   TOXICOLOGY LETTERS

Beyond the cell surface: New mechanisms of receptor function

(2010) Carlos F. Ibáñez   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Curcumin reduces α-synuclein induced cytotoxicity in Parkinson's disease cell model

(2010) Min S Wang et al.   BMC NEUROSCIENCE

N-Acetylcysteine interacts with copper to generate hydrogen peroxide and selectively induce cancer cell death

(2010) Jie Zheng et al.   CANCER LETTERS

Cellular copper distribution: a mechanistic systems biology approach

(2010) Lucia Banci et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Potent inhibition of protein tyrosine phosphatase 1B by copper complexes: implications for copper toxicity in biological systems

(2010) Qingming Wang et al.   CHEMICAL COMMUNICATIONS

Activation of the NRF2 Signaling Pathway by Copper-Mediated Redox Cycling of Para- and Ortho-Hydroquinones

(2010) Xiu Jun Wang et al.   CHEMISTRY & BIOLOGY

Human copper homeostasis: a network of interconnected pathways

(2010) Svetlana Lutsenko   CURRENT OPINION IN CHEMICAL BIOLOGY

2,2′-Bipyridyl based copper complexes down regulate expression of pro-inflammatory cytokines and suppress MAPKs in mitogen induced Peripheral blood mononuclear cells

(2010) K.R. Rupesh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A novel copper complex of salicylaldehyde pyrazole hydrazone induces apoptosis through up-regulating integrin β4 in H322 lung carcinoma cells

(2010) ChuanDong Fan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Cognitive Loss in Zinc Transporter-3 Knock-Out Mice: A Phenocopy for the Synaptic and Memory Deficits of Alzheimer's Disease?

(2010) P. A. Adlard et al.   JOURNAL OF NEUROSCIENCE

The puzzle posed by COMMD1, a newly discovered protein binding Cu(ii)

(2010) Bibudhendra Sarkar et al.   Metallomics

Pyrrolidine dithiocarbamate (PDTC)/Cu complex induces lung epithelial cell apoptosis through mitochondria and ER-stress pathways

(2010) Ya-Wen Chen et al.   TOXICOLOGY LETTERS

Direct Measurement of Free Copper in Serum or Plasma Ultrafiltrate

(2009) Gwendolyn A. McMillin et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Copper–GHK increases integrin expression and p63 positivity by keratinocytes

(2009) Youn-A Kang et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

p38 and ERK, but not JNK, are involved in copper-induced apoptosis in cultured cerebellar granule neurons

(2009) Xiaohong Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Copper(II) complexes of methimazole, an anti Grave’s disease drug. Synthesis, characterization and its potential biological behavior as alkaline phosphatase inhibitor

(2009) Nora M. Urquiza et al.   BIOMETALS

Synthesis and pharmacological exploitation of clioquinol-derived copper-binding apoptosis inducers triggering reactive oxygen species generation and MAPK pathway activation

(2009) Hui-Ling Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Role of copper and manganese in prion disease progression

(2009) Gerda Mitteregger et al.   BRAIN RESEARCH

The isatin-Schiff base copper(II) complex Cu(isaepy) 2 acts as delocalized lipophilic cation, yields widespread mitochondrial oxidative damage and induces AMP-activated protein kinase-dependent apoptosis

(2009) Giuseppe Filomeni et al.   CARCINOGENESIS

Copper-induced regression of cardiomyocyte hypertrophy is associated with enhanced vascular endothelial growth factor receptor-1 signalling pathway

(2009) Y. Zhou et al.   CARDIOVASCULAR RESEARCH

Novel Complex of Copper and a Salicylaldehyde Pyrazole Hydrazone Derivative Induces Apoptosis through Up-Regulating Integrin β4 in Vascular Endothelial Cells

(2009) Chuandong Fan et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Sustained Activation of Glial Cell Epidermal Growth Factor Receptor by Bis(thiosemicarbazonato) Metal Complexes Is Associated with Inhibition of Protein Tyrosine Phosphatase Activity

(2009) Katherine Ann Price et al.   JOURNAL OF MEDICINAL CHEMISTRY

Copper Activation of NF-κB Signaling in HepG2 Cells

(2009) Matthew K. McElwee et al.   JOURNAL OF MOLECULAR BIOLOGY

Chronic copper exposure exacerbates both amyloid and tau pathology and selectively dysregulates cdk5 in a mouse model of AD

(2009) Masashi Kitazawa et al.   JOURNAL OF NEUROCHEMISTRY

Trientine, a Copper-Chelating Agent, Induced Apoptosis in Murine Fibrosarcoma Cells by Activation of the p38 MAPK Pathway

(2009) Shingo KADOWAKI et al.   JOURNAL OF VETERINARY MEDICAL SCIENCE

Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper

(2009) Min Ok Song et al.   PHYSIOLOGICAL GENOMICS

Increasing Cu bioavailability inhibits A  oligomers and tau phosphorylation

(2009) P. J. Crouch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nickel and copper ion-induced stress signaling in human hepatoma cells: analysis of phosphoinositide 3′-kinase/Akt signaling

(2008) Anna Eckers et al.   BIOMETALS

The release of fibroblast growth factor-1 from melanoma cells requires copper ions and is mediated by phosphatidylinositol 3-kinase/Akt intracellular signaling pathway

(2008) Claudia Di Serio et al.   CANCER LETTERS

Elevated copper and oxidative stress in cancer cells as a target for cancer treatment

(2008) Anshul Gupte et al.   CANCER TREATMENT REVIEWS

Involvement of activating transcription factors JNK, NF-κB, and AP-1 in apoptosis induced by pyrrolidine dithiocarbamate/Cu complex

(2008) Sung-Ho Chen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Activation of epidermal growth factor receptor by metal-ligand complexes decreases levels of extracellular amyloid beta peptide

(2008) Katherine A. Price et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

ATOX1: A novel copper-responsive transcription factor in mammals?

(2008) Patricia A.J. Muller et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Antioxidant and Iron-Binding Properties of Curcumin, Capsaicin, andS-Allylcysteine Reduce Oxidative Stress in Rat Brain Homogenate

(2008) Amichand Dairam et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The Copper Binding Domain of SPARC Mediates Cell Survivalin Vitrovia Interaction with Integrin β1 and Activation of Integrin-linked Kinase

(2008) Matt S. Weaver et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Prion Gene Expression by Transcription Factors SP1 and Metal Transcription Factor-1

(2008) Shayne A. Bellingham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Role of Antioxidant-1 (Atox1) as a Copper-dependent Transcription Factor Involved in Cell Proliferation

(2008) Shinichi Itoh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism of Copper-Activated Transcription: Activation of AP-1, and the JNK/SAPK and p38 Signal Transduction Pathways

(2008) Michael D. Mattie et al.   JOURNAL OF MOLECULAR BIOLOGY

Metallo-complex activation of neuroprotective signalling pathways as a therapeutic treatment for Alzheimer’s disease

(2008) Laura Bica et al.   Molecular BioSystems

Transcription Factor Sp1 Plays an Important Role in the Regulation of Copper Homeostasis in Mammalian Cells

(2008) I.-S. Song et al.   MOLECULAR PHARMACOLOGY

Synthetic fluorescent sensors for studying the cell biology of metals

(2008) Dylan W Domaille et al.   Nature Chemical Biology

Clioquinol inhibits peroxide-mediated toxicity through up-regulation of phosphoinositol-3-kinase and inhibition of p53 activity

(2007) Gulay Filiz et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY