Copper complexes as therapeutic agents

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Copper complexes of bis(thiosemicarbazones): from chemotherapeutics to diagnostic and therapeutic radiopharmaceuticals

(2011) Brett M. Paterson et al.   CHEMICAL SOCIETY REVIEWS

Clioquinol – A Novel Copper-Dependent and Independent Proteasome Inhibitor

(2011) A. D. Schimmer   CURRENT CANCER DRUG TARGETS

Transition Metal Based Anticancer Drugs

(2011) K. Benjamin Garbutcheon-Singh et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Biphasic effects of copper on neurotransmission in rat hippocampal neurons

(2011) Christian Peters et al.   JOURNAL OF NEUROCHEMISTRY

Photoaging and chronological aging profile: Understanding oxidation of the skin

(2011) P.S. Peres et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Metal Ionophore Treatment Restores Dendritic Spine Density and Synaptic Protein Levels in a Mouse Model of Alzheimer's Disease

(2011) Paul A. Adlard et al.   PLoS One

Iron, zinc and copper in the Alzheimer's disease brain: A quantitative meta-analysis. Some insight on the influence of citation bias on scientific opinion

(2011) Matthew Schrag et al.   PROGRESS IN NEUROBIOLOGY

Metallothioneins and copper metabolism are candidate therapeutic targets in Huntington's disease

(2010) Sarah L. Hands et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Cell cycle arrest in cultured neuroblastoma cells exposed to a bis(thiosemicarbazonato) metal complex

(2010) Laura Bica et al.   BIOMETALS

Evaluation of a Schiff base copper complex compound as potent anticancer molecule with multiple targets of action

(2010) Ajanta Chakraborty et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A copper chelate of thiosemicarbazone NSC 689534 induces oxidative/ER stress and inhibits tumor growth in vitro and in vivo

(2010) Chad N. Hancock et al.   FREE RADICAL BIOLOGY AND MEDICINE

Huntington's disease: From molecular basis to therapeutic advances

(2010) Sylvia Krobitsch et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Significant anti-inflammatory properties of a copper(II) fenoprofenate complex compared with its parent drug: Physical and chemical characterization of the complex

(2010) Mariela A. Agotegaray et al.   JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY

TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia

(2010) Ian RA Mackenzie et al.   LANCET NEUROLOGY

Copper−Doxorubicin as a Nanoparticle Cargo Retains Efficacy with Minimal Toxicity

(2010) Azadeh Kheirolomoom et al.   MOLECULAR PHARMACEUTICS

Potent anticancer activity of pyrrolidine dithiocarbamate–copper complex against cisplatin-resistant neuroblastoma cells

(2009) Haiyuan Zhang et al.   ANTI-CANCER DRUGS

Synthesis, characterization and evaluation of antileishmanial activity of copper(II) with fluorinated α-hydroxycarboxylate ligands

(2009) Rodrigo da Silva Maffei et al.   BIOMETALS

Novel Complex of Copper and a Salicylaldehyde Pyrazole Hydrazone Derivative Induces Apoptosis through Up-Regulating Integrin β4 in Vascular Endothelial Cells

(2009) Chuandong Fan et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Copper chelation in cancer therapy using tetrathiomolybdate: an evolving paradigm

(2009) Gazala Khan et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Metal ionophores – An emerging class of anticancer drugs

(2009) Wei-Qun Ding et al.   IUBMB LIFE

Tumor cellular proteasome inhibition and growth suppression by 8-hydroxyquinoline and clioquinol requires their capabilities to bind copper and transport copper into cells

(2009) Shumei Zhai et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Antimalarial evaluation of copper(II) nanohybrid solids: inhibition of plasmepsin II, a hemoglobin-degrading malarial aspartic protease from Plasmodium falciparum

(2009) Subash Chandra Mohapatra et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Cerebral bioimaging of Cu, Fe, Zn, and Mn in the MPTP mouse model of Parkinson’s disease using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS)

(2009) Andreas Matusch et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Copper reduces striatal protein nitration and tyrosine hydroxylase inactivation induced by MPP+ in rats

(2009) M. Rubio-Osornio et al.   NEUROCHEMISTRY INTERNATIONAL

Increasing Cu bioavailability inhibits A  oligomers and tau phosphorylation

(2009) P. J. Crouch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Copper accumulation and compartmentalization in mouse fibroblast lacking metallothionein and copper chaperone, Atox1

(2009) Takamitsu Miyayama et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Bonding and structure trends of thiosemicarbazone derivatives of metals—An overview

(2008) Tarlok S. Lobana et al.   COORDINATION CHEMISTRY REVIEWS

Ammonium tetrathiomolybdate delays onset, prolongs survival, and slows progression of disease in a mouse model for amyotrophic lateral sclerosis

(2008) Eiichi Tokuda et al.   EXPERIMENTAL NEUROLOGY

Safety, efficacy, and biomarker findings of PBT2 in targeting Aβ as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial

(2008) Lars Lannfelt et al.   LANCET NEUROLOGY

Clioquinol inhibits the proteasome and displays preclinical activity in leukemia and myeloma

(2008) X Mao et al.   LEUKEMIA

Free Copper, Ferroxidase and SOD1 Activities, Lipid Peroxidation and NO x Content in the CSF. A Different Marker Profile in Four Neurodegenerative Diseases

(2008) Marie-Catherine Boll et al.   NEUROCHEMICAL RESEARCH

Rapid Restoration of Cognition in Alzheimer's Transgenic Mice with 8-Hydroxy Quinoline Analogs Is Associated with Decreased Interstitial Aβ

(2008) Paul A. Adlard et al.   NEURON

Improvement of Aging-Associated Cardiovascular Dysfunction by the Orally Administered Copper(II)-Aspirinate Complex

(2008) Tamás Radovits et al.   REJUVENATION RESEARCH

The toxicology of Clioquinol☆

(2008) X MAO et al.   TOXICOLOGY LETTERS