Latest in vitro and in vivo models of celiac disease

Immunogenicity of monococcum wheat in celiac patients

(2012) Carmen Gianfrani et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Variable activation of immune response by quinoa (Chenopodium quinoa Willd.) prolamins in celiac disease

(2012) Victor F Zevallos et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

A Randomized, Double-Blind Study of Larazotide Acetate to Prevent the Activation of Celiac Disease During Gluten Challenge

(2012) Daniel A Leffler et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Discerning the Role of Bacteroides fragilis in Celiac Disease Pathogenesis

(2012) E. Sánchez et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Reintroduction of Gluten Following Flour Transamidation in Adult Celiac Patients: A Randomized, Controlled Clinical Study

(2012) Giuseppe Mazzarella et al.   Clinical & Developmental Immunology

In vitro models for gluten toxicity: relevance for celiac disease pathogenesis and development of novel treatment options

(2012) Katri Lindfors et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

A Phase I Study to Determine Safety, Tolerability and Bioactivity of Nexvax2® in HLA DQ2+ Volunteers With Celiac Disease Following a Long-Term, Strict Gluten-Free Diet

(2012) Gregor J. Brown et al.   GASTROENTEROLOGY

Interactions Among Secretory Immunoglobulin A, CD71, and Transglutaminase-2 Affect Permeability of Intestinal Epithelial Cells to Gliadin Peptides

(2012) Corinne Lebreton et al.   GASTROENTEROLOGY

Modulation of phenotypic and functional maturation of dendritic cells by intestinal bacteria and gliadin: relevance for celiac disease

(2012) G. De Palma et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Oral administration of Bifidobacterium longum CECT 7347 modulates jejunal proteome in an in vivo gliadin-induced enteropathy animal model

(2012) Marta Olivares et al.   Journal of Proteomics

Gluten induces coeliac-like disease in sensitised mice involving IgA, CD71 and transglutaminase 2 interactions that are prevented by probiotics

(2012) Christina Papista et al.   LABORATORY INVESTIGATION

Larazotide acetate regulates epithelial tight junctions in vitro and in vivo

(2012) Shobha Gopalakrishnan et al.   PEPTIDES

Bifidobacterium longum CECT 7347 Modulates Immune Responses in a Gliadin-Induced Enteropathy Animal Model

(2012) José Moisés Laparra et al.   PLoS One

Activation and Inhibition of Transglutaminase 2 in Mice

(2012) Laila Dafik et al.   PLoS One

Gliadin Peptides Induce Tissue Transglutaminase Activation and ER-Stress through Ca2+ Mobilization in Caco-2 Cells

(2012) Ivana Caputo et al.   PLoS One

Interactions Between the Microbiota and the Immune System

(2012) L. V. Hooper et al.   SCIENCE

Gluten-dependent antibodies in horses with inflammatory small bowel disease (ISBD)

(2012) J.H. van der Kolk et al.   VETERINARY QUARTERLY

Ascorbate-dependent decrease of the mucosal immune inflammatory response to gliadin in coeliac disease patients

(2011) D. Bernardo et al.   ALLERGOLOGIA ET IMMUNOPATHOLOGIA

IL-15 Interferes With Suppressive Activity of Intestinal Regulatory T Cells Expanded in Celiac Disease

(2011) Delia Zanzi et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Integration of Genetic and Immunological Insights into a Model of Celiac Disease Pathogenesis

(2011) Valérie Abadie et al.   Annual Review of Immunology

Safety, Tolerability, and Activity of ALV003: Results from Two Phase 1 Single, Escalating-Dose Clinical Trials

(2011) Matthew Siegel et al.   DIGESTIVE DISEASES AND SCIENCES

Increased Bacterial Translocation in Gluten-Sensitive Mice Is Independent of Small Intestinal Paracellular Permeability Defect

(2011) Manuel A. Silva et al.   DIGESTIVE DISEASES AND SCIENCES

Impairment of protein trafficking by direct interaction of gliadin peptides with actin

(2011) Yvonne Reinke et al.   EXPERIMENTAL CELL RESEARCH

Tolerance to Ingested Deamidated Gliadin in Mice is Maintained by Splenic, Type 1 Regulatory T Cells

(2011) M. Fleur Du Pré et al.   GASTROENTEROLOGY

The Copolymer P(HEMA-co-SS) Binds Gluten and Reduces Immune Response in Gluten-Sensitized Mice and Human Tissues

(2011) Maud Pinier et al.   GASTROENTEROLOGY

T-Cell Response to Gluten in Patients With HLA-DQ2.2 Reveals Requirement of Peptide-MHC Stability in Celiac Disease

(2011) Michael Bodd et al.   GASTROENTEROLOGY

Influence of Bifidobacterium longum CECT 7347 and Gliadin Peptides on Intestinal Epithelial Cell Proteome

(2011) Marta Olivares et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Transgenic Mice that Overexpress Human IL-15 in Enterocytes Recapitulate Both B and T Cell-Mediated Pathologic Manifestations of Celiac Disease

(2011) Seiji Yokoyama et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Sensitization to Gliadin Induces Moderate Enteropathy and Insulitis in Nonobese Diabetic-DQ8 Mice

(2011) Heather J. Galipeau et al.   JOURNAL OF IMMUNOLOGY

Conjugated linoleic acid protects against gliadin-induced depletion of intestinal defenses

(2011) Paolo Bergamo et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens

(2011) R. W. DePaolo et al.   NATURE

Zonulin and Its Regulation of Intestinal Barrier Function: The Biological Door to Inflammation, Autoimmunity, and Cancer

(2011) Alessio Fasano   PHYSIOLOGICAL REVIEWS

Effect of Hookworm Infection on Wheat Challenge in Celiac Disease – A Randomised Double-Blinded Placebo Controlled Trial

(2011) A. James Daveson et al.   PLoS One

Gliadin-Mediated Proliferation and Innate Immune Activation in Celiac Disease Are Due to Alterations in Vesicular Trafficking

(2011) M. Vittoria Barone et al.   PLoS One

Role of Intestinal Bacteria in Gliadin-Induced Changes in Intestinal Mucosa: Study in Germ-Free Rats

(2011) Jana Cinova et al.   PLoS One

Suppression of Inflammatory Immune Responses in Celiac Disease by Experimental Hookworm Infection

(2011) Henry J. McSorley et al.   PLoS One

Immunogenicity of two oat varieties, in relation to their safety for celiac patients

(2011) Mariantonia Maglio et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Immunomodulatory Effects of Lactobacillus casei Administration in a Mouse Model of Gliadin-Sensitive Enteropathy

(2011) R. D’Arienzo et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Long-term and acute effects of gliadin on small intestine of patients on potentially pathogenic networks in celiac disease

(2010) Ainara Castellanos-Rubio et al.   AUTOIMMUNITY

Safety for Patients With Celiac Disease of Baked Goods Made of Wheat Flour Hydrolyzed During Food Processing

(2010) Luigi Greco et al.   Clinical Gastroenterology and Hepatology

Monocytes differentiated with IL-15 support Th17 and Th1 responses to wheat gliadin: Implications for celiac disease

(2010) Kristina M. Harris et al.   CLINICAL IMMUNOLOGY

Searching for wheat plants with low toxicity in celiac disease: Between direct toxicity and immunologic activation

(2010) Antonio Carroccio et al.   DIGESTIVE AND LIVER DISEASE

IL-15 triggers an antiapoptotic pathway in human intraepithelial lymphocytes that is a potential new target in celiac disease–associated inflammation and lymphomagenesis

(2010) Georgia Malamut et al.   JOURNAL OF CLINICAL INVESTIGATION

Gluten-free Sourdough Wheat Baked Goods Appear Safe for Young Celiac Patients: A Pilot Study

(2010) Raffaella Di Cagno et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Characterization of CCX282-B, an Orally Bioavailable Antagonist of the CCR9 Chemokine Receptor, for Treatment of Inflammatory Bowel Disease

(2010) M. J. Walters et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Gliadin Peptide P31-43 Localises to Endocytic Vesicles and Interferes with Their Maturation

(2010) Maria Vittoria Barone et al.   PLoS One

Removing celiac disease-related gluten proteins from bread wheat while retaining technological properties: a study with Chinese Spring deletion lines

(2009) Hetty C van den Broeck et al.   BMC PLANT BIOLOGY

The effects of ALV003 pre-digestion of gluten on immune response and symptoms in celiac disease in vivo

(2009) Jason A. Tye-Din et al.   CLINICAL IMMUNOLOGY

Modulation of the immune response by probiotic strains in a mouse model of gluten sensitivity

(2009) Rossana D’Arienzo et al.   CYTOKINE

A deregulated immune response to gliadin causes a decreased villus height in DQ8 transgenic mice

(2009) Rossana D'Arienzo et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

In vitroandin vivomodels of celiac disease

(2009) Eric Vincent Marietta et al.   Expert Opinion on Drug Discovery

355 Immune Tolerance Induced By Peptide Immunotherapy in An HLA Dq2-Dependent Mouse Model of Gluten Immunity

(2009) Catherine L. Keech et al.   GASTROENTEROLOGY

Increased Prevalence and Mortality in Undiagnosed Celiac Disease

(2009) Alberto Rubio–Tapia et al.   GASTROENTEROLOGY

Gliadin-primed CD4+CD45RBlowCD25- T cells drive gluten-dependent small intestinal damage after adoptive transfer into lymphopenic mice

(2009) T. L. Freitag et al.   GUT

Endocytotic segregation of gliadin peptide 31-49 in enterocytes

(2009) K.-P. Zimmer et al.   GUT

Resistance to Celiac Disease in Humanized HLA-DR3-DQ2-Transgenic Mice Expressing Specific Anti-Gliadin CD4+ T Cells

(2009) A. L. de Kauwe et al.   JOURNAL OF IMMUNOLOGY

Induction of Antigen-Specific Tolerance by Oral Administration of Lactococcus lactis Delivered Immunodominant DQ8-Restricted Gliadin Peptide in Sensitized Nonobese Diabetic Ab  Dq8 Transgenic Mice

(2009) I. L. Huibregtse et al.   JOURNAL OF IMMUNOLOGY

Host Responses to Intestinal Microbial Antigens in Gluten-Sensitive Mice

(2009) Jane M. Natividad et al.   PLoS One

A Food-Grade Enzyme Preparation with Modest Gluten Detoxification Properties

(2009) Jennifer Ehren et al.   PLoS One

Antibody-mediated blockade of IL-15 reverses the autoimmune intestinal damage in transgenic mice that overexpress IL-15 in enterocytes

(2009) S. Yokoyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systematic review: tolerable amount of gluten for people with coeliac disease

(2008) A. K. AKOBENG et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Effects of gliadin stimulation on bone marrow-derived dendritic cells from HLA-DQ8 transgenic MICE

(2008) R. Ciccocioppo et al.   DIGESTIVE AND LIVER DISEASE

Polymeric Binders Suppress Gliadin-Induced Toxicity in the Intestinal Epithelium

(2008) Maud Pinier et al.   GASTROENTEROLOGY

Adjuvant effect of Lactobacillus casei in a mouse model of gluten sensitivity

(2008) Rossana D’Arienzo et al.   IMMUNOLOGY LETTERS

Specific duodenal and faecal bacterial groups associated with paediatric coeliac disease

(2008) M C Collado et al.   JOURNAL OF CLINICAL PATHOLOGY

The role of HLA-DQ8 β57 polymorphism in the anti-gluten T-cell response in coeliac disease

(2008) Zaruhi Hovhannisyan et al.   NATURE

Transepithelial Transport and Enzymatic Detoxification of Gluten in Gluten-Sensitive Rhesus Macaques

(2008) Michael T. Bethune et al.   PLoS One

A Non-Human Primate Model for Gluten Sensitivity

(2008) Michael T. Bethune et al.   PLoS One

Gliadin-dependent neuromuscular and epithelial secretory responses in gluten-sensitive HLA-DQ8 transgenic mice

(2007) E. F. Verdu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY