In vitro models for gluten toxicity: relevance for celiac disease pathogenesis and development of novel treatment options

IL-15 Interferes With Suppressive Activity of Intestinal Regulatory T Cells Expanded in Celiac Disease

(2011) Delia Zanzi et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Epithelial transport and deamidation of gliadin peptides: a role for coeliac disease patient immunoglobulin A

(2011) T. Rauhavirta et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Tolerance to Ingested Deamidated Gliadin in Mice is Maintained by Splenic, Type 1 Regulatory T Cells

(2011) M. Fleur Du Pré et al.   GASTROENTEROLOGY

Influence of Bifidobacterium longum CECT 7347 and Gliadin Peptides on Intestinal Epithelial Cell Proteome

(2011) Marta Olivares et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Novel therapies for coeliac disease

(2011) L. M. Sollid et al.   JOURNAL OF INTERNAL MEDICINE

Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens

(2011) R. W. DePaolo et al.   NATURE

Correction of Gliadin Transport Within Enterocytes Through Celiac Disease Serum

(2011) Nico Lübbing et al.   PEDIATRIC RESEARCH

Gliadin-Mediated Proliferation and Innate Immune Activation in Celiac Disease Are Due to Alterations in Vesicular Trafficking

(2011) M. Vittoria Barone et al.   PLoS One

Transglutaminase 2-targeted autoantibodies in celiac disease: Pathogenetic players in addition to diagnostic tools?

(2010) Katri Lindfors et al.   AUTOIMMUNITY REVIEWS

Celiac anti-tissue transglutaminase antibodies interfere with the uptake of alpha gliadin peptide 31–43 but not of peptide 57–68 by epithelial cells

(2010) Ivana Caputo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Live probiotic Bifidobacterium lactis bacteria inhibit the toxic effects induced by wheat gliadin in epithelial cell culture

(2010) K. Lindfors et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Degradation of coeliac disease-inducing rye secalin by germinating cereal enzymes: diminishing toxic effects in intestinal epithelial cells

(2010) S. M. Stenman et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Single-chain recombinant HLA-DQ2.5/peptide molecules block α2-gliadin-specific pathogenic CD4+ T-cell proliferation and attenuate production of inflammatory cytokines: a potential therapy for celiac disease

(2010) J Huan et al.   Mucosal Immunology

Gliadin Peptide P31-43 Localises to Endocytic Vesicles and Interferes with Their Maturation

(2010) Maria Vittoria Barone et al.   PLoS One

Enzymatic detoxification of gluten by germinating wheat proteases: Implications for new treatment of celiac disease

(2009) Satumarja M. Stenman et al.   ANNALS OF MEDICINE

Anti-transglutaminase antibodies in non-coeliac children suffering from infectious diseases

(2009) F. Ferrara et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

A deregulated immune response to gliadin causes a decreased villus height in DQ8 transgenic mice

(2009) Rossana D'Arienzo et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Gliadin-primed CD4+CD45RBlowCD25- T cells drive gluten-dependent small intestinal damage after adoptive transfer into lymphopenic mice

(2009) T. L. Freitag et al.   GUT

Lysosomal accumulation of gliadin p31-43 peptide induces oxidative stress and tissue transglutaminase-mediated PPAR  downregulation in intestinal epithelial cells and coeliac mucosa

(2009) A. Luciani et al.   GUT

Resistance to Celiac Disease in Humanized HLA-DR3-DQ2-Transgenic Mice Expressing Specific Anti-Gliadin CD4+ T Cells

(2009) A. L. de Kauwe et al.   JOURNAL OF IMMUNOLOGY

Pivotal Advance: Bifidobacteria and Gram-negative bacteria differentially influence immune responses in the proinflammatory milieu of celiac disease

(2009) G. De Palma et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Interferon-  Released by Gluten-Stimulated Celiac Disease-Specific Intestinal T Cells Enhances the Transepithelial Flux of Gluten Peptides

(2009) M. T. Bethune et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Identification of human zonulin, a physiological modulator of tight junctions, as prehaptoglobin-2

(2009) A. Tripathi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of epithelial growth factor receptor signalling does not preserve epithelial barrier function afterin vitrogliadin insult

(2009) Kati Juuti-Uusitalo et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Higher constitutive IL15Rα expression and lower IL-15 response threshold in coeliac disease patients

(2008) D. Bernardo et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Polymeric Binders Suppress Gliadin-Induced Toxicity in the Intestinal Epithelium

(2008) Maud Pinier et al.   GASTROENTEROLOGY

Mechanisms of epithelial translocation of the  2-gliadin-33mer in coeliac sprue

(2008) M Schumann et al.   GUT

A Non-Human Primate Model for Gluten Sensitivity

(2008) Michael T. Bethune et al.   PLoS One

Design of azidoproline containing gluten peptides to suppress CD4+ T-cell responses associated with Celiac disease

(2007) Varsha V. Kapoerchan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Interleukin 21 contributes to the mucosal T helper cell type 1 response in coeliac disease

(2007) D Fina et al.   GUT

Anti-idiotypic response in mice expressing human autoantibodies

(2007) Roberto Di Niro et al.   MOLECULAR IMMUNOLOGY