Epigenetics in autoimmune diseases with focus on type 1 diabetes

Genetics of Type 1 Diabetes

(2013) J. A. Noble et al.   Cold Spring Harbor Perspectives in Medicine

DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients

(2012) Michael Volkmar et al.   EMBO JOURNAL

A functional methylome map of ulcerative colitis

(2012) R. Hasler et al.   GENOME RESEARCH

Association of the CpG Methylation Pattern of the Proximal Insulin Gene Promoter with Type 1 Diabetes

(2012) Delphine Fradin et al.   PLoS One

Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients

(2012) Kaleb M Pauley et al.   ARTHRITIS RESEARCH & THERAPY

Histone deacetylase inhibitors suppress rheumatoid arthritis fibroblast-like synoviocyte and macrophage IL-6 production by accelerating mRNA decay

(2011) Aleksander M Grabiec et al.   ANNALS OF THE RHEUMATIC DISEASES

Histone deacetylases are dysregulated in rheumatoid arthritis and a novel histone deacetylase 3-selective inhibitor reduces interleukin-6 production by peripheral blood mononuclear cells from rheumatoid arthritis patients

(2011) Justin Gillespie et al.   ARTHRITIS AND RHEUMATISM

MicroRNAs in  -Cell Biology, Insulin Resistance, Diabetes and Its Complications

(2011) S. L. Fernandez-Valverde et al.   DIABETES

Increased expression of microRNA miR-326 in type 1 diabetic patients with ongoing islet autoimmunity

(2011) Guido Sebastiani et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Pro- and anti-inflammatory cytokines in latent autoimmune diabetes in adults, type 1 and type 2 diabetes patients: Action LADA 4

(2011) M. N. Pham et al.   DIABETOLOGIA

The DNA methyltranferase Dnmt2 participates in RNA processing during cellular stress

(2011) Devi Thiagarajan et al.   Epigenetics

Genome-wide DNA methylation patterns in CD4+ T cells from patients with systemic lupus erythematosus

(2011) Matlock Jeffries et al.   Epigenetics

DNA methylation regulates the expression of CXCL12 in rheumatoid arthritis synovial fibroblasts

(2011) E Karouzakis et al.   GENES AND IMMUNITY

The role of oxidative stress and innate immunity in O3 and endotoxin-induced human allergic airway disease

(2011) David B. Peden   IMMUNOLOGICAL REVIEWS

Histone modifications and methyl-CpG-binding domain protein levels at the TNFSF7 (CD70) promoter in SLE CD4+ T cells

(2011) Y Zhou et al.   LUPUS

Hypomethylation of the HTR1A promoter region and high expression of HTR1A in the peripheral blood lymphocytes of patients with systemic lupus erythematosus

(2011) J Xu et al.   LUPUS

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(2011) Eli Lewis et al.   MOLECULAR MEDICINE

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(2011) Jelena Vojinovic et al.   MOLECULAR MEDICINE

Heterogeneity of T1DM raises questions for therapy

(2011) Paolo Pozzilli   Nature Reviews Endocrinology

Detection of   cell death in diabetes using differentially methylated circulating DNA

(2011) E. M. Akirav et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The microRNA-21-PDCD4 axis prevents type 1 diabetes by blocking pancreatic   cell death

(2011) Q. Ruan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNAs: Emerging Regulators of Immune-Mediated Diseases

(2011) T. Tomankova et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

A twin approach to unraveling epigenetics

(2011) Jordana T. Bell et al.   TRENDS IN GENETICS

Identification of Type 1 Diabetes–Associated DNA Methylation Variable Positions That Precede Disease Diagnosis

(2011) Vardhman K. Rakyan et al.   PLoS Genetics

The Role of MicroRNAs in Regulatory T Cells and in the Immune Response

(2011) Tai-You Ha   Immune Network

MicroRNA-125a contributes to elevated inflammatory chemokine RANTES levels via targeting KLF13 in systemic lupus erythematosus

(2010) Xia Zhao et al.   ARTHRITIS AND RHEUMATISM

MicroRNA-126 regulates DNA methylation in CD4+ T cells and contributes to systemic lupus erythematosus by targeting DNA methyltransferase 1

(2010) Sha Zhao et al.   ARTHRITIS AND RHEUMATISM

Genome-wide DNA methylation analysis for diabetic nephropathy in type 1 diabetes mellitus

(2010) Christopher G Bell et al.   BMC Medical Genomics

Enterovirus RNA in Blood Is Linked to the Development of Type 1 Diabetes

(2010) S. Oikarinen et al.   DIABETES

A polymorphism in the 3’-UTR of interleukin-1 receptor-associated kinase (IRAK1), a target gene of miR-146a, is associated with rheumatoid arthritis susceptibility

(2010) Anthoula Chatzikyriakidou et al.   JOINT BONE SPINE

Epigenetics and autoimmunity

(2010) Wesley H. Brooks et al.   JOURNAL OF AUTOIMMUNITY

Hypomethylation ofIL10andIL13Promoters in CD4+T Cells of Patients with Systemic Lupus Erythematosus

(2010) Ming Zhao et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

MicroRNA-21 and MicroRNA-148a Contribute to DNA Hypomethylation in Lupus CD4+ T Cells by Directly and Indirectly Targeting DNA Methyltransferase 1

(2010) W. Pan et al.   JOURNAL OF IMMUNOLOGY

Serum and Urinary Cell-free MiR-146a and MiR-155 in Patients with Systemic Lupus Erythematosus

(2010) G. WANG et al.   JOURNAL OF RHEUMATOLOGY

Global DNA methylation, DNMT1, and MBD2 in patients with systemic lupus erythematosus

(2010) CC Liu et al.   LUPUS

Epigenetics as a unifying principle in the aetiology of complex traits and diseases

(2010) Arturas Petronis   NATURE

Genetics, pathogenesis and clinical interventions in type 1 diabetes

(2010) Jeffrey A. Bluestone et al.   NATURE

Altered microRNA expression profile with miR-146a upregulation in CD4+ T cells from patients with rheumatoid arthritis

(2010) Jingyi Li et al.   ARTHRITIS RESEARCH & THERAPY

Natural history and immunopathogenesis of type 1 diabetes

(2010) Paolo Pozzilli et al.   Endocrinologia y Nutricion

MicroRNA-124a is a key regulator of proliferation and monocyte chemoattractant protein 1 secretion in fibroblast-like synoviocytes from patients with rheumatoid arthritis

(2009) Yuji Nakamachi et al.   ARTHRITIS AND RHEUMATISM

MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1 responses

(2009) Shigeru Miyaki et al.   ARTHRITIS AND RHEUMATISM

Induction of apoptosis in the synovium of mice with autoantibody-mediated arthritis by the intraarticular injection of double-stranded MicroRNA-15a

(2009) Yoshihiko Nagata et al.   ARTHRITIS AND RHEUMATISM

DNA hypomethylation in rheumatoid arthritis synovial fibroblasts

(2009) Emmanuel Karouzakis et al.   ARTHRITIS AND RHEUMATISM

MicroRNA-146a contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteins

(2009) Yuanjia Tang et al.   ARTHRITIS AND RHEUMATISM

microRNA-342, microRNA-191 and microRNA-510 are differentially expressed in T regulatory cells of type 1 diabetic patients

(2009) Renata Hezova et al.   CELLULAR IMMUNOLOGY

Hyperglycemia Induces a Dynamic Cooperativity of Histone Methylase and Demethylase Enzymes Associated With Gene-Activating Epigenetic Marks That Coexist on the Lysine Tail

(2009) D. Brasacchio et al.   DIABETES

Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus

(2009) B. M. Javierre et al.   GENOME RESEARCH

miR-223 is overexpressed in T-lymphocytes of patients affected by rheumatoid arthritis

(2009) Valerio Fulci et al.   HUMAN IMMUNOLOGY

The genetics and epigenetics of autoimmune diseases

(2009) Anura Hewagama et al.   JOURNAL OF AUTOIMMUNITY

The epidemiology of Graves' disease: Evidence of a genetic and an environmental contribution

(2009) Kari Hemminki et al.   JOURNAL OF AUTOIMMUNITY

Histone deacetylase inhibitors: Potential in cancer therapy

(2009) P.A. Marks et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores

(2009) Rafael A Irizarry et al.   NATURE GENETICS

Analysis of skewed X-chromosome inactivation in females with rheumatoid arthritis and autoimmune thyroid diseases

(2009) Ghazi Chabchoub et al.   ARTHRITIS RESEARCH & THERAPY

Methylation status of a single CpG site in theIL6promoter is related toIL6messenger RNA levels and rheumatoid arthritis

(2008) Christoper J. Nile et al.   ARTHRITIS AND RHEUMATISM

Change in post-translational modifications of histone H3, heat-shock protein-27 and MAP kinase p38 expression by curcumin in streptozotocin-induced type I diabetic nephropathy

(2008) K Tikoo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Distinct Monocyte Gene-Expression Profiles in Autoimmune Diabetes

(2008) R. C. Padmos et al.   DIABETES

Lymphocytes From Patients With Type 1 Diabetes Display a Distinct Profile of Chromatin Histone H3 Lysine 9 Dimethylation: An Epigenetic Study in Diabetes

(2008) F. Miao et al.   DIABETES

Joint Genetic Susceptibility to Type 1 Diabetes and Autoimmune Thyroiditis: from Epidemiology to Mechanisms

(2008) Amanda Huber et al.   ENDOCRINE REVIEWS

Epigenetic clues to rheumatoid arthritis

(2008) Olga Sánchez-Pernaute et al.   JOURNAL OF AUTOIMMUNITY