Advances in Targeting Voltage-Gated Sodium Channels with Small Molecules

Discovery and hit-to-lead optimization of pyrrolopyrimidines as potent, state-dependent Nav1.7 antagonists

(2012) Nagasree Chakka et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The discovery of aminopyrazines as novel, potent Nav1.7 antagonists: Hit-to-lead identification and SAR

(2012) Howard Bregman et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Binding Modes of μ-Conotoxin to the Bacterial Sodium Channel (NaVAb)

(2012) Rong Chen et al.   BIOPHYSICAL JOURNAL

Voltage-Gated Sodium Channel Blockers for the Treatment of Chronic Pain

(2012) Mark Matulenko et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Recent Advances in the Medicinal Chemistry of Sodium Channel Blockers and their Therapeutic Potential

(2012) Valentina Zuliani et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Sodium Channel Blockers as Therapeutic Target for Treating Epilepsy: Recent Updates

(2012) Valentina Zuliani et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Biophysical characterization of M1476I, a sodium channel founder mutation associated with cold-induced myotonia in French Canadians

(2012) Juan Zhao et al.   JOURNAL OF PHYSIOLOGY-LONDON

Tetrodotoxin (TTX) as a Therapeutic Agent for Pain

(2012) Francisco Rafael Nieto et al.   Marine Drugs

China must provide education on HIV

(2012) Jian Zhang et al.   NATURE

Block of Na+ currents and suppression of action potentials in embryonic rat dorsal root ganglion neurons by ranolazine

(2012) Ryoko Hirakawa et al.   NEUROPHARMACOLOGY

Spider-venom peptides that target voltage-gated sodium channels: Pharmacological tools and potential therapeutic leads

(2012) Julie K. Klint et al.   TOXICON

The Differential Effect of Intrathecal Nav1.8 Blockers on the Induction and Maintenance of Capsaicin- and Peripheral Ischemia-Induced Mechanical Allodynia and Thermal Hyperalgesia

(2011) Ji-Young Moon et al.   ANESTHESIA AND ANALGESIA

Validation of a Patch Clamp Screening Protocol That Simultaneously Measures Compound Activity in Multiple States of the Voltage-Gated Sodium Channel Nav1.2

(2011) Yi Liu et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Phenyl isoxazole voltage-gated sodium channel blockers: Structure and activity relationship

(2011) Istvan Macsari et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of XEN907, a spirooxindole blocker of NaV1.7 for the treatment of pain

(2011) Sultan Chowdhury et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery and optimization of aminopyrimidinones as potent and state-dependent Nav1.7 antagonists

(2011) Hanh Nho Nguyen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Antillatoxin is a sodium channel activator that displays unique efficacy in heterologously expressed rNav1.2, rNav1.4 and rNav1.5 alpha subunits

(2011) Zhengyu Cao et al.   BMC NEUROSCIENCE

Deletion mutation of sodium channel NaV1.7 in inherited erythromelalgia: enhanced slow inactivation modulates dorsal root ganglion neuron hyperexcitability

(2011) X. Cheng et al.   BRAIN

The ‘overly-sensitive’ heart: sodium channel block and QRS interval prolongation

(2011) Gary A Gintant et al.   BRITISH JOURNAL OF PHARMACOLOGY

On the relationship between block of the cardiac Na+channel and drug-induced prolongation of the QRS complex

(2011) AR Harmer et al.   BRITISH JOURNAL OF PHARMACOLOGY

Pain Disorders and Erythromelalgia Caused by Voltage-Gated Sodium Channel Mutations

(2011) Ron Dabby   Current Neurology and Neuroscience Reports

Targeting Voltage-Gated Sodium Channels for Treating Neuropathic and Inflammatory Pain

(2011) Charles J. Cohen   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Cardiac ion channel gene mutations in Greek long QT syndrome patients

(2011) C -M. Kotta et al.   JOURNAL OF APPLIED GENETICS

Elucidation of the Molecular Basis of Selective Recognition Uncovers the Interaction Site for the Core Domain of Scorpion α-Toxins on Sodium Channels

(2011) Maya Gur et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Common Molecular Determinants of Tarantula Huwentoxin-IV Inhibition of Na+Channel Voltage Sensors in Domains II and IV

(2011) Yucheng Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of New Batrachotoxin-sensing Residues in Segment IIIS6 of the Sodium Channel

(2011) Yuzhe Du et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure-Function Map of the Receptor Site for β-Scorpion Toxins in Domain II of Voltage-gated Sodium Channels

(2011) Joel Z. Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A sodium channel knockin mutant (NaV1.4-R669H) mouse model of hypokalemic periodic paralysis

(2011) Fenfen Wu et al.   JOURNAL OF CLINICAL INVESTIGATION

Functional properties and toxin pharmacology of a dorsal root ganglion sodium channel viewed through its voltage sensors

(2011) Frank Bosmans et al.   JOURNAL OF GENERAL PHYSIOLOGY

Identification of a Potent, State-Dependent Inhibitor of Nav1.7 with Oral Efficacy in the Formalin Model of Persistent Pain

(2011) Howard Bregman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Resurgent currents turn painfully exciting

(2011) Angelika Lampert   JOURNAL OF PHYSIOLOGY-LONDON

Tetrodotoxin-Bupivacaine-Epinephrine Combinations for Prolonged Local Anesthesia

(2011) Charles B. Berde et al.   Marine Drugs

Are Voltage-Gated Sodium Channels on the Dorsal Root Ganglion Involved in the Development of Neuropathic Pain?

(2011) Wei Wang et al.   Molecular Pain

Inhibition of Nav 4 Peptide-Mediated Resurgent Sodium Currents in Nav1.7 Channels by Carbamazepine, Riluzole, and Anandamide

(2011) J. W. Theile et al.   MOLECULAR PHARMACOLOGY

Loss-of-function mutations in sodium channel Nav1.7 cause anosmia

(2011) Jan Weiss et al.   NATURE

The crystal structure of a voltage-gated sodium channel

(2011) Jian Payandeh et al.   NATURE

Molecular determinants for the subtype specificity of μ-conotoxin SIIIA targeting neuronal voltage-gated sodium channels

(2011) Enrico Leipold et al.   NEUROPHARMACOLOGY

A novel slow-inactivation-specific ion channel modulator attenuates neuropathic pain

(2011) Michael E. Hildebrand et al.   PAIN

Treatment of Nav1.7-mediated pain in inherited erythromelalgia using a novel sodium channel blocker

(2011) Yigal Paul Goldberg et al.   PAIN

The Roles of Sodium Channels in Nociception: Implications for Mechanisms of Neuropathic Pain

(2011) Min Liu et al.   PAIN MEDICINE

Blockade of Persistent Sodium Currents Contributes to the Riluzole-Induced Inhibition of Spontaneous Activity and Oscillations in Injured DRG Neurons

(2011) Rou-Gang Xie et al.   PLoS One

Nav1.9 Channel Contributes to Mechanical and Heat Pain Hypersensitivity Induced by Subacute and Chronic Inflammation

(2011) Stéphane Lolignier et al.   PLoS One

Severe case and literature review of primary erythromelalgia: Novel SCN9A gene mutation

(2011) Nedaa Skeik et al.   VASCULAR MEDICINE

Fever-triggered ventricular arrhythmias in Brugada syndrome and type 2 long-QT syndrome

(2011) A. S. Amin et al.   Netherlands Heart Journal

Recent Developments Regarding Voltage-Gated Sodium Channel Blockers for the Treatment of Inherited and Acquired Neuropathic Pain Syndromes

(2011) Jonathan W. Theile et al.   Frontiers in Pharmacology

Neurotoxins and Their Binding Areas on Voltage-Gated Sodium Channels

(2011) Marijke Stevens et al.   Frontiers in Pharmacology

Y1767C, a novel SCN5A mutation, induces a persistent Na+ current and potentiates ranolazine inhibition of Nav1.5 channels

(2010) Hai Huang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Sodium Channels in Normal and Pathological Pain

(2010) Sulayman D. Dib-Hajj et al.   Annual Review of Neuroscience

Discovery and biological evaluation of potent, selective, orally bioavailable, pyrazine-based blockers of the Nav1.8 sodium channel with efficacy in a model of neuropathic pain

(2010) Marc J.C. Scanio et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Subtype-selective Nav1.8 sodium channel blockers: Identification of potent, orally active nicotinamide derivatives

(2010) Michael E. Kort et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Substituted biaryl oxazoles, imidazoles, and thiazoles as sodium channel blockers

(2010) Sriram Tyagarajan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Substituted biaryl pyrazoles as sodium channel blockers

(2010) Sriram Tyagarajan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of a novel class of biphenyl pyrazole sodium channel blockers for treatment of neuropathic pain

(2010) Sriram Tyagarajan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

F 15845, a new blocker of the persistent sodium current prevents consequences of hypoxia in rat femoral artery

(2010) A Bocquet et al.   BRITISH JOURNAL OF PHARMACOLOGY

Selective inhibition of persistent sodium current by F 15845 prevents ischaemia-induced arrhythmias

(2010) C Pignier et al.   BRITISH JOURNAL OF PHARMACOLOGY

Ranolazine selectively blocks persistent current evoked by epilepsy-associated NaV1.1 mutations

(2010) Kristopher M Kahlig et al.   BRITISH JOURNAL OF PHARMACOLOGY

REVIEW: Sodium Channel (Dys)Function and Cardiac Arrhythmias

(2010) Carol Ann Remme et al.   Cardiovascular Therapeutics

Block of Tetrodotoxin-sensitive, Nav1.7, and Tetrodotoxin-resistant, Nav1.8, Na+channels by Ranolazine

(2010) Sridharan Rajamani et al.   Channels

Riluzole, Neuroprotection and Amyotrophic Lateral Sclerosis

(2010) B.C. Cheah et al.   CURRENT MEDICINAL CHEMISTRY

Genetics of Brugada syndrome

(2010) Oscar Campuzano et al.   CURRENT OPINION IN CARDIOLOGY

A Nonsense Mutation in the SCN9A Gene in Congenital Insensitivity to Pain

(2010) Mazen Kurban et al.   DERMATOLOGY

Sodium channel SCN1A and epilepsy: Mutations and mechanisms

(2010) Andrew Escayg et al.   EPILEPSIA

Two novel mutations of SCN9A (Nav1.7) are associated with partial congenital insensitivity to pain

(2010) Roland Staudl et al.   EUROPEAN JOURNAL OF PAIN

Block of sensory neuronal Na+ channels by the secreolytic ambroxol is associated with an interaction with local anesthetic binding sites

(2010) Andreas Leffler et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Lacosamide for pain

(2010) Gary McCleane   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Isoform-selective voltage-gated Na+channel modulators as next-generation analgesics

(2010) Steve England et al.   Future Medicinal Chemistry

Congenital insensitivity to pain: novel SCN9A missense and in-frame deletion mutations

(2010) James J. Cox et al.   HUMAN MUTATION

Human voltage-gated sodium channel mutations that cause inherited neuronal and muscle channelopathies increase resurgent sodium currents

(2010) Brian W. Jarecki et al.   JOURNAL OF CLINICAL INVESTIGATION

Cooccupancy of the Outer Vestibule of Voltage-Gated Sodium Channels by μ-Conotoxin KIIIA and Saxitoxin or Tetrodotoxin

(2010) Min-Min Zhang et al.   JOURNAL OF NEUROPHYSIOLOGY

NaV1.1 channels and epilepsy

(2010) William A. Catterall et al.   JOURNAL OF PHYSIOLOGY-LONDON

Sodium channel gene family: epilepsy mutations, gene interactions and modifier effects

(2010) Miriam H. Meisler et al.   JOURNAL OF PHYSIOLOGY-LONDON

Voltage-gated sodium channels as therapeutic targets in epilepsy and other neurological disorders

(2010) Massimo Mantegazza et al.   LANCET NEUROLOGY

The Tetrodotoxin Binding Site Is within the Outer Vestibule of the Sodium Channel

(2010) Harry A. Fozzard et al.   Marine Drugs

Molecular genetics of long QT syndrome

(2010) Nilesh J. Bokil et al.   MOLECULAR GENETICS AND METABOLISM

Effects of Ranolazine on Wild-Type and Mutant hNav1.7 Channels and on DRG Neuron Excitability

(2010) Mark Estacion et al.   Molecular Pain

Molecular Model of Anticonvulsant Drug Binding to the Voltage-Gated Sodium Channel Inner Pore

(2010) G. M. Lipkind et al.   MOLECULAR PHARMACOLOGY

The Tarantula Toxins ProTx-II and Huwentoxin-IV Differentially Interact with Human Nav1.7 Voltage Sensors to Inhibit Channel Activation and Inactivation

(2010) Y. Xiao et al.   MOLECULAR PHARMACOLOGY

Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction

(2010) Nona Sotoodehnia et al.   NATURE GENETICS

Paroxysmal extreme pain disorder: a molecular lesion of peripheral neurons

(2010) Jin-Sung Choi et al.   Nature Reviews Neurology

Temporal lobe epilepsy induces intrinsic alterations in Na channel gating in layer II medial entorhinal cortex neurons

(2010) Nicholas J. Hargus et al.   NEUROBIOLOGY OF DISEASE

A-887826 is a structurally novel, potent and voltage-dependent Nav1.8 sodium channel blocker that attenuates neuropathic tactile allodynia in rats

(2010) Xu-Feng Zhang et al.   NEUROPHARMACOLOGY

Ranolazine Attenuation of CFA-induced Mechanical Hyperalgesia

(2010) Gregory P. Casey et al.   PAIN MEDICINE

Antinociceptive effect of ambroxol in rats with neuropathic spinal cord injury pain

(2010) Aldric T. Hama et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Control of transient, resurgent, and persistent current by open-channel block by Na channel  4 in cultured cerebellar granule neurons

(2010) J. S. Bant et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the full-length Shaker potassium channel Kv1.2 by normal-mode-based X-ray crystallographic refinement

(2010) X. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting voltage sensors in sodium channels with spider toxins

(2010) Frank Bosmans et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Fast- or Slow-inactivated State Preference of Na+ Channel Inhibitors: A Simulation and Experimental Study

(2010) Robert Karoly et al.   PLoS Computational Biology

A Peripherally Acting Nav1.7 Sodium Channel Blocker Reverses Hyperalgesia and Allodynia on Rat Models of Inflammatory and Neuropathic Pain

(2009) Erin McGowan et al.   ANESTHESIA AND ANALGESIA

A novel Nav1.7 mutation producing carbamazepine-responsive erythromelalgia

(2009) Tanya Z. Fischer et al.   ANNALS OF NEUROLOGY

Familial pain syndromes from mutations of the Nav1.7 sodium channel

(2009) Tanya Z. Fischer et al.   Annals of the New York Academy of Sciences

Exploring the role of nociceptor-specific sodium channels in pain transmission using Nav1.8 and Nav1.9 knockout mice

(2009) Sandra Leo et al.   BEHAVIOURAL BRAIN RESEARCH

Ranolazine attenuates behavioral signs of neuropathic pain

(2009) Harry J. Gould et al.   BEHAVIOURAL PHARMACOLOGY

Identification of a cluster of residues in transmembrane segment 6 of domain III of the cockroach sodium channel essential for the action of pyrethroid insecticides

(2009) Yuzhe Du et al.   BIOCHEMICAL JOURNAL

Discovery of a novel class of isoxazoline voltage gated sodium channel blockers

(2009) Pengcheng P. Shao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of isoxazole voltage gated sodium channel blockers for treatment of chronic pain

(2009) Pengcheng P. Shao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Subtype-selective targeting of voltage-gated sodium channels

(2009) Steve England et al.   BRITISH JOURNAL OF PHARMACOLOGY

Hoiamide A, a Sodium Channel Activator of Unusual Architecture from a Consortium of Two Papua New Guinea Cyanobacteria

(2009) Alban Pereira et al.   CHEMISTRY & BIOLOGY

Automated Planar Electrode Electrophysiology in Drug Discovery: Examples of the Use of QPatch in Basic Characterization and High Content Screening on Nav, KCa2.3, and Kv11.1 Channels

(2009) Mads Korsgaard et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Sodium Channel Inhibitor Drug Discovery Using Automated High Throughput Electrophysiology Platforms

(2009) Neil Castle et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

The relationship between sodium channel inhibition and anticonvulsant activity in a model of generalised seizure in the rat

(2009) Charles H. Large et al.   EPILEPSY RESEARCH

Myocardial protection by F 15845, a persistent sodium current blocker, in an ischemia-reperfusion model in the pig

(2009) Robert Létienne et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Targeting voltage-gated sodium channels for pain therapy

(2009) Jeffrey J Clare   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Cardiac ion channels in health and disease

(2009) Ahmad S. Amin et al.   HEART RHYTHM

The genetic basis of Brugada syndrome: A mutation update

(2009) Paula L. Hedley et al.   HUMAN MUTATION

Structural Determinants of Drugs Acting on the Nav1.8 Channel

(2009) Liam E. Browne et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cardiac sodium channel Nav1.5 and interacting proteins: Physiology and pathophysiology

(2009) Hugues Abriel   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Antillatoxin, a Novel Lipopeptide, Enhances Neurite Outgrowth in Immature Cerebrocortical Neurons through Activation of Voltage-Gated Sodium Channels

(2009) S. V. Jabba et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

3-(R)-[3-(2-Methoxyphenylthio-2-(S)-methylpropyl]amino-3,4-dihydro-2H-1,5-benzoxathiepine Bromhydrate (F 15845) Prevents Ischemia-Induced Heart Remodeling by Reduction of the Intracellular Na+ Overload

(2009) B. Vie et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Gabapentin selectively reduces persistent sodium current in injured type-A dorsal root ganglion neurons

(2009) Rui-Hua Yang et al.   PAIN

State-dependent modification of voltage-gated sodium channels by pyrethroids

(2009) David M. Soderlund   PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY

Cardiac sodium channelopathies

(2009) Ahmad S. Amin et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Persistent Na-channels: Origin and function

(2008) T. Kiss   ACTA BIOLOGICA HUNGARICA

Function and role of voltage-gated sodium channel NaV1.7 expressed in aortic smooth muscle cells

(2008) Kentaro Meguro et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Imidazopyridines: A novel class of hNav1.7 channel blockers

(2008) Clare London et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Cardiac Sodium Channel ( SCN5A ) Variants Associated with Atrial Fibrillation

(2008) Dawood Darbar et al.   CIRCULATION

Clinical Impact of Genetic Studies in Lethal Inherited Cardiac Arrhythmias

(2008) Wataru Shimizu   CIRCULATION JOURNAL

Cardiac sodium channels and inherited electrophysiologic disorders: a pharmacogenetic overview

(2008) Jeroen PP Smits et al.   EXPERT OPINION ON PHARMACOTHERAPY

Tarantula Huwentoxin-IV Inhibits Neuronal Sodium Channels by Binding to Receptor Site 4 and Trapping the Domain II Voltage Sensor in the Closed Configuration

(2008) Yucheng Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sodium Late Current Blockers in Ischemia Reperfusion: Is the Bullet Magic?

(2008) Bruno Le Grand et al.   JOURNAL OF MEDICINAL CHEMISTRY

NaV1.7 Gain-of-Function Mutations as a Continuum: A1632E Displays Physiological Changes Associated with Erythromelalgia and Paroxysmal Extreme Pain Disorder Mutations and Produces Symptoms of Both Disorders

(2008) M. Estacion et al.   JOURNAL OF NEUROSCIENCE

Differential Block of Sensory Neuronal Voltage-Gated Sodium Channels by Lacosamide [(2R)-2-(Acetylamino)-N-benzyl-3-methoxypropanamide], Lidocaine, and Carbamazepine

(2008) P. L. Sheets et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Persistent pain: the contribution of NaV1.9

(2008) Ewan St. John Smith et al.   JOURNAL OF PHYSIOLOGY-LONDON

Navigating the channels and beyond: unravelling the genetics of the epilepsies

(2008) Ingo Helbig et al.   LANCET NEUROLOGY

ProTx-II, a Selective Inhibitor of NaV1.7 Sodium Channels, Blocks Action Potential Propagation in Nociceptors

(2008) W. A. Schmalhofer et al.   MOLECULAR PHARMACOLOGY

How membrane proteins sense voltage

(2008) Francisco Bezanilla   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ralfinamide administered orally before hindpaw neurectomy or postoperatively provided long-lasting suppression of spontaneous neuropathic pain-related behavior in the rat

(2008) Shi-Hong Zhang et al.   PAIN

C-fiber spontaneous discharge evoked by chronic inflammation is suppressed by a long-term infusion of lidocaine yielding nanogram per milliliter plasma levels

(2008) Wen Hua Xiao et al.   PAIN

Tetrodotoxin

(2008) Toshio NARAHASHI   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

L’insensibilité congénitale à la douleur

(2008) N. Danziger et al.   REVUE NEUROLOGIQUE

Two novel sodium channel inhibitors from Heriaeus melloteei spider venom differentially interacting with mammalian channel's isoforms

(2008) Bert Billen et al.   TOXICON

The cardiac persistent sodium current: an appealing therapeutic target?

(2007) D A Saint   BRITISH JOURNAL OF PHARMACOLOGY

Sodium channels and nociception: recent concepts and therapeutic opportunities

(2007) D KRAFTE et al.   CURRENT OPINION IN PHARMACOLOGY

Conotoxin modulation of voltage-gated sodium channels

(2007) J. Ekberg et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

GTP up-regulated persistent Na+current and enhanced nociceptor excitability require NaV1.9

(2007) Johan A. R. Östman et al.   JOURNAL OF PHYSIOLOGY-LONDON

Synthesis and characterization of huwentoxin-IV, a neurotoxin inhibiting central neuronal sodium channels

(2007) Yucheng Xiao et al.   TOXICON