Subtype-selective targeting of voltage-gated sodium channels

Identification of a cluster of residues in transmembrane segment 6 of domain III of the cockroach sodium channel essential for the action of pyrethroid insecticides

(2009) Yuzhe Du et al.   BIOCHEMICAL JOURNAL

Structure of the Analgesic μ-Conotoxin KIIIA and Effects on the Structure and Function of Disulfide Deletion†‡

(2009) Keith K. Khoo et al.   BIOCHEMISTRY

Early- and late-onset inherited erythromelalgia: genotype–phenotype correlation

(2009) Chongyang Han et al.   BRAIN

Structural Determinants of Drugs Acting on the Nav1.8 Channel

(2009) Liam E. Browne et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ataxia3 Mutation in the N-Terminal Cytoplasmic Domain of Sodium Channel Nav1.6 Disrupts Intracellular Trafficking

(2009) L. M. Sharkey et al.   JOURNAL OF NEUROSCIENCE

Primary Erythermalgia as a Sodium Channelopathy

(2008) Joost P. H. Drenth et al.   ARCHIVES OF DERMATOLOGY

Specificity, affinity and efficacy of iota-conotoxin RXIA, an agonist of voltage-gated sodium channels NaV1.2, 1.6 and 1.7

(2008) Brian Fiedler et al.   BIOCHEMICAL PHARMACOLOGY

Tetrameric Bacterial Sodium Channels: Characterization of Structure, Stability, and Drug Binding†

(2008) Ghasem Nurani et al.   BIOCHEMISTRY

Discovery of potent furan piperazine sodium channel blockers for treatment of neuropathic pain

(2008) Irene Drizin et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Imidazopyridines: A novel class of hNav1.7 channel blockers

(2008) Clare London et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Models of the Structure and Gating Mechanisms of the Pore Domain of the NaChBac Ion Channel

(2008) Yinon Shafrir et al.   BIOPHYSICAL JOURNAL

Models of Voltage-Dependent Conformational Changes in NaChBac Channels

(2008) Yinon Shafrir et al.   BIOPHYSICAL JOURNAL

How do mutant Nav1.1 sodium channels cause epilepsy?

(2008) David S. Ragsdale   BRAIN RESEARCH REVIEWS

Voltage-gated sodium channels in pain states: Role in pathophysiology and targets for treatment

(2008) Sulayman D. Dib-Hajj et al.   BRAIN RESEARCH REVIEWS

Guide to Receptors and Channels (GRAC), 3rd edition

(2008) S P H Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

First Mutation in the Voltage-Gated Nav1.1 Subunit Gene SCN1A with Co-Occurring Familial Hemiplegic Migraine and Epilepsy

(2008) M-J Castro et al.   CEPHALALGIA

Impaired NaV1.2 function and reduced cell surface expression in benign familial neonatal-infantile seizures

(2008) Sunita N. Misra et al.   EPILEPSIA

Tarantula Huwentoxin-IV Inhibits Neuronal Sodium Channels by Binding to Receptor Site 4 and Trapping the Domain II Voltage Sensor in the Closed Configuration

(2008) Yucheng Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery and Biological Evaluation of 5-Aryl-2-furfuramides, Potent and Selective Blockers of the Nav1.8 Sodium Channel with Efficacy in Models of Neuropathic and Inflammatory Pain

(2008) Michael E. Kort et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inherited Neuronal Ion Channelopathies: New Windows on Complex Neurological Diseases

(2008) W. A. Catterall et al.   JOURNAL OF NEUROSCIENCE

Paroxysmal extreme pain disorder mutations within the D3/S4-S5 linker of Nav1.7 cause moderate destabilization of fast inactivation

(2008) Brian W. Jarecki et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mutation I136V Alters Electrophysiological Properties of the NaV1.7 Channel in a Family with Onset of Erythromelalgia in the Second Decade

(2008) Xiaoyang Cheng et al.   Molecular Pain

ProTx-II, a Selective Inhibitor of NaV1.7 Sodium Channels, Blocks Action Potential Propagation in Nociceptors

(2008) W. A. Schmalhofer et al.   MOLECULAR PHARMACOLOGY

Structure of a β1-adrenergic G-protein-coupled receptor

(2008) Tony Warne et al.   NATURE

Reduced expression of Nav1.6 sodium channels and compensation by Nav1.2 channels in mice heterozygous for a null mutation in Scn8a

(2008) Ana V. Vega et al.   NEUROSCIENCE LETTERS

Tetrodotoxin

(2008) Toshio NARAHASHI   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

SCN5A channelopathies – An update on mutations and mechanisms

(2008) Thomas Zimmer et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Trafficking and Cellular Distribution of Voltage-Gated Sodium Channels

(2008) Fiona S. Cusdin et al.   TRAFFIC