Article
Neurosciences
Zoja Selimi, Jean-Sebastien Rougier, Hugues Abriel, Jan P. P. Kucera
Summary: Cardiac voltage-gated sodium (Na+) channels play a crucial role in myocardial electrical excitation. Single-channel recordings indicate that these channels exhibit functional interactions and coupled gating. However, the analysis of such recordings often involves manual interventions, leading to potential bias. In this study, an automated pipeline was developed to de-trend and idealize single-channel currents, revealing weak or no functional interactions in wild-type Na(v)1.5 channels.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Biology
Christian J. G. Tessier, Raymond M. Sturgeon, Johnathon R. Emlaw, Gregory D. McCluskey, F. Javier Perez-Areales, Corrie J. B. daCosta
Summary: Human adult muscle-type acetylcholine receptors are heteropentameric ion channels formed from different subunits, but they share a common ancestral homopentameric origin. A reconstructed ancestral muscle-type beta-subunit can form spontaneously open homopentameric ion channels, demonstrating that the function of the receptor is independent of agonist and does not require complex heteropentameric architecture.
Article
Chemistry, Medicinal
Juan Antonio Contreras Vite, Carlos Vega Valle, Happi Biekeu Mbem, Sarah-Maude Boivin, Robert Dumaine
Summary: Lamotrigine is commonly used for treating bipolar disorder and epilepsy. The US FDA has recently issued a warning regarding the drug's potential to cause conduction anomalies and Brugada syndrome in epileptic patients. In this study, researchers used patch clamp technique on rat cardiomyocytes to investigate the effect of Lamotrigine on cardiac sodium current (I-Na). The results showed that Lamotrigine inhibited I-Na peak amplitude, reduced cardiac excitability, and prolonged the action potential refractory period in epileptic rats.
Review
Multidisciplinary Sciences
Federico Bertagna, Rebecca Lewis, S. Ravi P. Silva, Johnjoe McFadden, Kamalan Jeevaratnam
Summary: Research in recent decades has focused on the effects of different electromagnetic fields on the electrical properties of neurons, particularly voltage-gated ion channels. Changes in voltage-gated calcium channels have been found to be the most commonly reported result of electromagnetic field exposure. The effects of electromagnetic fields on the neuronal landscape appear to be diverse and highly dependent on factors such as the field's frequency, exposure time, and intrinsic properties of the irradiated tissue.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Dandan Yang, Xiaoping Wan, Adrienne T. Dennis, Emre Bektik, Zhihua Wang, Mauricio G. S. Costa, Charline Fagnen, Catherine Venien-Bryan, Xianyao Xu, Daniel H. Gratz, Thomas J. Hund, Peter J. Mohler, Kenneth R. Laurita, Isabelle Deschenes, Ji-Dong Fu
Summary: This study reveals a novel biophysical action of endogenous miRs in modulating cardiac electrophysiology through noncanonical mechanisms. Endogenous miR1 physically binds with cardiac membrane protein Kir2.1, suppressing I-K1 and affecting action potential of cardiomyocytes. The findings suggest that miRs may be involved in the pathogenesis of cardiac arrhythmias by regulating ion channel physiology and pathology.
Review
Biology
Carol Ann Remme
Summary: The influx of sodium ions through voltage-gated sodium channels is crucial for proper electrical conduction in the heart. Dysfunction of sodium channels can lead to life-threatening arrhythmias in acquired conditions and inherited disorders. Recent research has revealed the complex nature of sodium channel distribution and function, as well as its impact on cardiac structural integrity. Moreover, sodium channels and their role in various extracardiac tissues are being increasingly recognized. This review provides an overview of these novel insights and their contribution to our understanding of sodium channelopathies and dysfunction.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Loryn J. Bohne, Hailey J. Jansen, Tristan W. Dorey, Irene M. Daniel, K. Lockhart Jamieson, Darrell D. Belke, Megan D. Mcrae, Robert A. Rose
Summary: This study demonstrates that GLP-1 and its analogues can reduce the incidence of atrial fibrillation and prevent atrial remodeling in patients with type 2 diabetes.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Ji-Yue Wen, Jie Zhang, Shuo Chen, Ye Chen, Yang Zhang, Zi-Yao Ma, Fang Zhang, Wei-Ming Xie, Yi-Fei Fan, Jing-Si Duan, Zhi-Wu Chen
Summary: This study demonstrates that hydrogen sulfide acts as endothelium-derived hyperpolarizing factor (EDHF) and exerts neuroprotective effects by activating BKCa channels in hippocampal neurons.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Spela Gubic, Zan Toplak, Xiaoyi Shi, Jaka Dernovsek, Louise Antonia Hendrickx, Ernesto Lopes Pinheiro-Junior, Steve Peigneur, Jan Tytgat, Luis A. Pardo, Lucija Peterlin Masic, Tihomir Tomasic
Summary: Expression of K(V)10.1 has been detected in human cancers, making it a potential target for anticancer drugs. New inhibitors with improved potency and selectivity were developed through structural optimisation.
Review
Biochemistry & Molecular Biology
Yevheniia Kravenska, Vanessa Checchetto, Ildiko Szabo
Summary: Potassium ions can enter and exit mitochondria through various channels in the outer and inner membranes, with the ATP-dependent potassium channel being the most studied and playing a crucial role in protecting cells against ischemic and neuronal damage.
Article
Cardiac & Cardiovascular Systems
Pietro Mesirca, Shu Nakao, Sarah Dalgas Nissen, Gabriella Forte, Cali Anderson, Tariq Trussell, Jue Li, Charlotte Cox, Min Zi, Sunil Logantha, Sana Yaar, Helena Cartensen, Isabelle Bidaud, Luke Stuart, Luca Soattin, Gwilym M. Morris, Paula A. da Costa Martins, Elizabeth J. Cartwright, Delvac Oceandy, Matteo E. Mangoni, Thomas Jespersen, Rikke Buhl, Halina Dobrzynski, Mark R. Boyett, Alicia D'Souza
Summary: The study found that atrioventricular block in athletes is mainly caused by electrical remodeling. Trained animals and mice showed atrioventricular node dysfunction, characterized by prolonged PR intervals and reduced expression of key ion channels. miRNAs such as miR-211-5p and miR-432 were identified as direct regulators of Ca(V)1.2 and HCN4.
CIRCULATION RESEARCH
(2021)
Review
Neurosciences
Deepanjali Dwivedi, Upinder S. Bhalla
Summary: SK, HCN, and M channels are medium afterhyperpolarization (mAHP)-mediating ion channels that co-express in various brain regions, influencing cellular excitability. Biophysical properties, signaling pathways, chemical modulators, and therapeutic potential are discussed, emphasizing their collective behavior and specialized roles in treating neurological anomalies. The modulation of mAHP channels also plays a role in alleviating symptoms of various neurological diseases.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Can Wu, Yaojie Lei, Laura Simonelli, Dino Tonti, Ashley Black, Xinxin Lu, Wei-Hong Lai, Xiaolan Cai, Yun-Xiao Wang, Qinfen Gu, Shu-Lei Chou, Hua-Kun Liu, Guoxiu Wang, Shi-Xue Dou
Summary: Porous carbon is used as a host to encapsulate highly active sulfur in Li-S and Na-S batteries. The study focuses on designing continuous carbonaceous pores that serve as multifunctional channels to encapsulate sulfur and provide pathways for sodium ions. The carbon-hosted sulfur cathode demonstrates superior cycling performance, high capacity retention, and outstanding rate capability in room-temperature sodium-sulfur batteries.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Physical
Fermin Cuevas, Barbara Laik, Junxian Zhang, Mickaël Mateos, Jean-Pierre Pereira-Ramos, Michel Latroche
Summary: In this study, Ti1-xVxH2 compounds were synthesized by mechanochemistry, and their electrochemical properties as anodes in LiBs and NaBs were investigated. It was found that the compounds have a highly nanostructured fluorite-type structure, and the lattice parameter decreases with the increase of V content, leading to material destabilization. Electrochemical studies in Li-ion half cells showed that the potential of the conversion reaction varies with the vanadium content. Na-ion half cell measurements revealed significant kinetic limitations in the reactivity between (V, Ti)H2 hydrides and sodium.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Chemistry, Physical
Hiram Kwak, Jeyne Lyoo, Juhyoun Park, Yoonjae Han, Ryo Asakura, Arndt Remhof, Corsin Battaglia, Hansu Kim, Seung-Tae Hong, Yoon Seok Jung
Summary: Halide solid electrolytes show promise in all-solid-state batteries, with Na2ZrCl6 demonstrating both high chemical stability and mechanical sinterability. Despite its low Na+ conductivity, Na2ZrCl6 exhibits exceptional electrochemical stability when used in Na-ion batteries, showcasing high Coulombic efficiency and reversible capacity.
ENERGY STORAGE MATERIALS
(2021)