Targeting voltage-gated sodium channels for pain therapy

Voltage-Gated Sodium Channel Blockers for the Treatment of Chronic Pain

(2012) Mark Matulenko et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Recent Advances in the Medicinal Chemistry of Sodium Channel Blockers and their Therapeutic Potential

(2012) Valentina Zuliani et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

QX-314 Produces Long-lasting Local Anesthesia Modulated by Transient Receptor Potential Vanilloid Receptors in Mice

(2009) Craig R. Ries et al.   ANESTHESIOLOGY

Coapplication of Lidocaine and the Permanently Charged Sodium Channel Blocker QX-314 Produces a Long-lasting Nociceptive Blockade in Rodents

(2009) Alexander M. Binshtok et al.   ANESTHESIOLOGY

Use of Planar Array Electrophysiology for the Development of Robust Ion Channel Cell Lines

(2009) Jeffrey Clare et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Port-a-Patch and Patchliner: High Fidelity Electrophysiology for Secondary Screening and Safety Pharmacology

(2009) Niels Fertig et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

QPatch: The Missing Link Between HTS and Ion Channel Drug Discovery

(2009) Yi Liu et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Sodium Channel Inhibitor Drug Discovery Using Automated High Throughput Electrophysiology Platforms

(2009) Neil Castle et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Structural Determinants of Drugs Acting on the Nav1.8 Channel

(2009) Liam E. Browne et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional and pharmacological properties of human and rat NaV1.8 channels

(2009) Liam E. Browne et al.   NEUROPHARMACOLOGY

Capsaicin Combined with Local Anesthetics Preferentially Prolongs Sensory/Nociceptive Block in Rat Sciatic Nerve

(2008) Peter Gerner et al.   ANESTHESIOLOGY

Structure, Dynamics, and Selectivity of the Sodium Channel Blocker μ-Conotoxin SIIIA†‡

(2008) Shenggen Yao et al.   BIOCHEMISTRY

Imidazopyridines: A novel class of hNav1.7 channel blockers

(2008) Clare London et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Production of a specific extracellular inhibitor of TRPM3 channels

(2008) J Naylor et al.   BRITISH JOURNAL OF PHARMACOLOGY

Impact of Novel Screening Technologies on Ion Channel Drug Discovery

(2008) Qiang Lu et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Tarantula Huwentoxin-IV Inhibits Neuronal Sodium Channels by Binding to Receptor Site 4 and Trapping the Domain II Voltage Sensor in the Closed Configuration

(2008) Yucheng Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery and Biological Evaluation of 5-Aryl-2-furfuramides, Potent and Selective Blockers of the Nav1.8 Sodium Channel with Efficacy in Models of Neuropathic and Inflammatory Pain

(2008) Michael E. Kort et al.   JOURNAL OF MEDICINAL CHEMISTRY

ProTx-II, a Selective Inhibitor of NaV1.7 Sodium Channels, Blocks Action Potential Propagation in Nociceptors

(2008) W. A. Schmalhofer et al.   MOLECULAR PHARMACOLOGY

High-throughput electrophysiology: an emerging paradigm for ion-channel screening and physiology

(2008) John Dunlop et al.   NATURE REVIEWS DRUG DISCOVERY

Anti-Ca2+ channel antibody attenuates Ca2+ currents and mimics cerebellar ataxia in vivo

(2008) Y. J. Liao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular HTS Assays for Pharmacological Characterization of NaV1.7 Modulators

(2007) Shephali Trivedi et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Sodium channels and nociception: recent concepts and therapeutic opportunities

(2007) D KRAFTE et al.   CURRENT OPINION IN PHARMACOLOGY

Optimisation and validation of a medium-throughput electrophysiology-based hNav1.5 assay using IonWorks™

(2007) A.R. Harmer et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS