Isoform-selective voltage-gated Na+channel modulators as next-generation analgesics

Human voltage-gated sodium channel mutations that cause inherited neuronal and muscle channelopathies increase resurgent sodium currents

(2010) Brian W. Jarecki et al.   JOURNAL OF CLINICAL INVESTIGATION

Treatment of Neuropathic Pain: An Overview of Recent Guidelines

(2009) Alec B. O'Connor et al.   AMERICAN JOURNAL OF MEDICINE

A Peripherally Acting Nav1.7 Sodium Channel Blocker Reverses Hyperalgesia and Allodynia on Rat Models of Inflammatory and Neuropathic Pain

(2009) Erin McGowan et al.   ANESTHESIA AND ANALGESIA

Subtype-selective targeting of voltage-gated sodium channels

(2009) Steve England et al.   BRITISH JOURNAL OF PHARMACOLOGY

Structural Determinants of Drugs Acting on the Nav1.8 Channel

(2009) Liam E. Browne et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Voltage-Gated Sodium Channels: Therapeutic Targets for Pain

(2009) Sulayman D. Dib-Hajj et al.   PAIN MEDICINE

Primary Erythermalgia as a Sodium Channelopathy

(2008) Joost P. H. Drenth et al.   ARCHIVES OF DERMATOLOGY

Discovery of potent furan piperazine sodium channel blockers for treatment of neuropathic pain

(2008) Irene Drizin et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Imidazopyridines: A novel class of hNav1.7 channel blockers

(2008) Clare London et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Voltage-gated sodium channels: the search for subtype-selective analgesics

(2008) Steve England   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Tarantula Huwentoxin-IV Inhibits Neuronal Sodium Channels by Binding to Receptor Site 4 and Trapping the Domain II Voltage Sensor in the Closed Configuration

(2008) Yucheng Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery and Biological Evaluation of 5-Aryl-2-furfuramides, Potent and Selective Blockers of the Nav1.8 Sodium Channel with Efficacy in Models of Neuropathic and Inflammatory Pain

(2008) Michael E. Kort et al.   JOURNAL OF MEDICINAL CHEMISTRY

ProTx-II, a Selective Inhibitor of NaV1.7 Sodium Channels, Blocks Action Potential Propagation in Nociceptors

(2008) W. A. Schmalhofer et al.   MOLECULAR PHARMACOLOGY

High-throughput electrophysiology: an emerging paradigm for ion-channel screening and physiology

(2008) John Dunlop et al.   NATURE REVIEWS DRUG DISCOVERY

Synthesis and characterization of huwentoxin-IV, a neurotoxin inhibiting central neuronal sodium channels

(2007) Yucheng Xiao et al.   TOXICON