Common Molecular Determinants of Tarantula Huwentoxin-IV Inhibition of Na+Channel Voltage Sensors in Domains II and IV

The Tarantula Toxins ProTx-II and Huwentoxin-IV Differentially Interact with Human Nav1.7 Voltage Sensors to Inhibit Channel Activation and Inactivation

(2010) Y. Xiao et al.   MOLECULAR PHARMACOLOGY

Targeting voltage sensors in sodium channels with spider toxins

(2010) Frank Bosmans et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Molecular Requirements for Recognition of Brain Voltage-gated Sodium Channels by Scorpion α-Toxins

(2009) Roy Kahn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tarantula Huwentoxin-IV Inhibits Neuronal Sodium Channels by Binding to Receptor Site 4 and Trapping the Domain II Voltage Sensor in the Closed Configuration

(2008) Yucheng Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ProTx-II, a Selective Inhibitor of NaV1.7 Sodium Channels, Blocks Action Potential Propagation in Nociceptors

(2008) W. A. Schmalhofer et al.   MOLECULAR PHARMACOLOGY

Deconstructing voltage sensor function and pharmacology in sodium channels

(2008) Frank Bosmans et al.   NATURE

Synthesis and characterization of huwentoxin-IV, a neurotoxin inhibiting central neuronal sodium channels

(2007) Yucheng Xiao et al.   TOXICON