Glucose activates free fatty acid receptor 1 gene transcription via phosphatidylinositol-3-kinase-dependent O-GlcNAcylation of pancreas-duodenum homeobox-1

O-GlcNAcylation Increases ChREBP Protein Content and Transcriptional Activity in the Liver

(2011) C. Guinez et al.   DIABETES

Targetedin Vivo O-GlcNAc Sensors Reveal Discrete Compartment-specific Dynamics during Signal Transduction

(2010) Luz D. Carrillo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear phosphoinositide signaling regulates messenger RNA export

(2010) Masashi Okada et al.   RNA Biology

Deletion of GPR40 Impairs Glucose-Induced Insulin Secretion In Vivo in Mice Without Affecting Intracellular Fuel Metabolism in Islets

(2009) T. Alquier et al.   DIABETES

Overexpression of GPR40 in Pancreatic  -Cells Augments Glucose-Stimulated Insulin Secretion and Improves Glucose Tolerance in Normal and Diabetic Mice

(2009) K. Nagasumi et al.   DIABETES

Progress in the discovery and development of small-molecule modulators of G-protein-coupled receptor 40 (GPR40/FFA1/FFAR1): an emerging target for type 2 diabetes

(2009) Sandip B Bharate et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Glucose Effects on Beta-Cell Growth and Survival Require Activation of Insulin Receptors and Insulin Receptor Substrate 2

(2009) A. Assmann et al.   MOLECULAR AND CELLULAR BIOLOGY

The Fatty Acid Receptor GPR40 Plays a Role in Insulin Secretion In Vivo After High-Fat Feeding

(2008) M. Kebede et al.   DIABETES

Gpr40 Is Expressed in Enteroendocrine Cells and Mediates Free Fatty Acid Stimulation of Incretin Secretion

(2008) S. Edfalk et al.   DIABETES

Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance

(2008) Xiaoyong Yang et al.   NATURE

O-GlcNAc modification of transcription factors, glucose sensing and glucotoxicity

(2008) Tarik Issad et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Nuclear phosphoinositide signaling

(2007) Keqiang Ye   Frontiers in Bioscience-Landmark