Topology of active, membrane-embedded Bax in the context of a toroidal pore
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Title
Topology of active, membrane-embedded Bax in the context of a toroidal pore
Authors
Keywords
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Journal
CELL DEATH AND DIFFERENTIATION
Volume -, Issue -, Pages -
Publisher
Springer Nature America, Inc
Online
2018-09-05
DOI
10.1038/s41418-018-0184-6
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Note: Only part of the references are listed.- BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis
- (2018) Kate McArthur et al. SCIENCE
- The membrane activity of BOK involves formation of large, stable toroidal pores and is promoted by cBID
- (2017) Yuniel Fernández-Marrero et al. FEBS Journal
- Sickle Cell Disease
- (2017) Frédéric B. Piel et al. NEW ENGLAND JOURNAL OF MEDICINE
- BAK α6 permits activation by BH3-only proteins and homooligomerization via the canonical hydrophobic groove
- (2017) Mark Xiang Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Quantitative interactome of a membrane Bcl-2 network identifies a hierarchy of complexes for apoptosis regulation
- (2017) Stephanie Bleicken et al. Nature Communications
- Membrane insertion of the BAX core, but not latch domain, drives apoptotic pore formation
- (2017) Hector Flores-Romero et al. Scientific Reports
- Inactivation of prosurvival Bcl-2 proteins activates Bax/Bak through the outer mitochondrial membrane
- (2016) Katelyn L. O'Neill et al. GENES & DEVELOPMENT
- Water accessibility in a membrane-inserting peptide comparing Overhauser DNP and pulse EPR methods
- (2016) Takuya F. Segawa et al. JOURNAL OF CHEMICAL PHYSICS
- Bax transmembrane domain interacts with prosurvival Bcl-2 proteins in biological membranes
- (2016) Vicente Andreu-Fernández et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- cBid, Bax and Bcl-xL exhibit opposite membrane remodeling activities
- (2016) S Bleicken et al. Cell Death & Disease
- Bak apoptotic pores involve a flexible C-terminal region and juxtaposition of the C-terminal transmembrane domains
- (2015) S Iyer et al. CELL DEATH AND DIFFERENTIATION
- BH3-in-groove dimerization initiates and helix 9 dimerization expands Bax pore assembly in membranes
- (2015) Z. Zhang et al. EMBO JOURNAL
- Membrane curvature at a glance
- (2015) H. T. McMahon et al. JOURNAL OF CELL SCIENCE
- Visual and functional demonstration of growing Bax-induced pores in mitochondrial outer membranes
- (2015) Laura A Gillies et al. MOLECULAR BIOLOGY OF THE CELL
- The EMBL-EBI bioinformatics web and programmatic tools framework
- (2015) Weizhong Li et al. NUCLEIC ACIDS RESEARCH
- Dissociation of Bak α1 helix from the core and latch domains is required for apoptosis
- (2015) Amber E. Alsop et al. Nature Communications
- Measuring membrane penetration with depth-dependent fluorescence quenching: Distribution analysis is coming of age
- (2014) Alexey S. Ladokhin BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Bax targets mitochondria by distinct mechanisms before or during apoptotic cell death: a requirement for VDAC2 or Bak for efficient Bax apoptotic function
- (2014) S B Ma et al. CELL DEATH AND DIFFERENTIATION
- Differential retrotranslocation of mitochondrial Bax and Bak
- (2014) F. Todt et al. EMBO JOURNAL
- Conformational Rearrangements in the Pro-apoptotic Protein, Bax, as It Inserts into Mitochondria
- (2014) Robert F. Gahl et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Bak Core and Latch Domains Separate during Activation, and Freed Core Domains Form Symmetric Homodimers
- (2014) Jason M. Brouwer et al. MOLECULAR CELL
- Structural Model of Active Bax at the Membrane
- (2014) Stephanie Bleicken et al. MOLECULAR CELL
- Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membrane
- (2014) Dana Westphal et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Multiple partners can kiss-and-run: Bax transfers between multiple membranes and permeabilizes those primed by tBid
- (2014) A Shamas-Din et al. Cell Death & Disease
- Residue mutations and their impact on protein structure and function: detecting beneficial and pathogenic changes
- (2013) Romain A. Studer et al. BIOCHEMICAL JOURNAL
- Mechanistic Differences in the Membrane Activity of Bax and Bcl-xL Correlate with Their Opposing Roles in Apoptosis
- (2013) Stephanie Bleicken et al. BIOPHYSICAL JOURNAL
- Bax Crystal Structures Reveal How BH3 Domains Activate Bax and Nucleate Its Oligomerization to Induce Apoptosis
- (2013) Peter E. Czabotar et al. CELL
- Multimodal Interaction with BCL-2 Family Proteins Underlies the Proapoptotic Activity of PUMA BH3
- (2013) Amanda L. Edwards et al. CHEMISTRY & BIOLOGY
- Organization of the Mitochondrial Apoptotic BAK Pore
- (2013) Sreevidya Aluvila et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Proapoptotic Bax and Bak Proteins Form Stable Protein-permeable Pores of Tunable Size
- (2013) Stephanie Bleicken et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Single color FRET based measurements of conformational changes of proteins resulting from translocation inside cells
- (2013) Robert F. Gahl et al. METHODS
- Bax Exists in a Dynamic Equilibrium between the Cytosol and Mitochondria to Control Apoptotic Priming
- (2013) Barbara Schellenberg et al. MOLECULAR CELL
- A cost–benefit analysis of the physical mechanisms of membrane curvature
- (2013) Jeanne C. Stachowiak et al. NATURE CELL BIOLOGY
- Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy
- (2013) Peter E. Czabotar et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- BID-induced structural changes in BAK promote apoptosis
- (2013) Tudor Moldoveanu et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- BIM-Mediated Membrane Insertion of the BAK Pore Domain Is an Essential Requirement for Apoptosis
- (2013) Kathrin Weber et al. Cell Reports
- The secrets of the Bcl-2 family
- (2012) A J García-Sáez CELL DEATH AND DIFFERENTIATION
- Translocation of a Bak C-Terminus Mutant from Cytosol to Mitochondria to Mediate Cytochrome c Release: Implications for Bak and Bax Apoptotic Function
- (2012) Pedro Eitz Ferrer et al. PLoS One
- Bak Conformational Changes Induced by Ligand Binding: Insight into BH3 Domain Binding and Bak Homo-Oligomerization
- (2012) Yuan-Ping Pang et al. Scientific Reports
- Bax dimerizes via a symmetric BH3:groove interface during apoptosis
- (2011) G Dewson et al. CELL DEATH AND DIFFERENTIATION
- Mitochondria in Apoptosis: Bcl-2 Family Members and Mitochondrial Dynamics
- (2011) Jean-Claude Martinou et al. DEVELOPMENTAL CELL
- Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases
- (2011) Andreas Strasser et al. EMBO JOURNAL
- Molecular biology of Bax and Bak activation and action
- (2010) Dana Westphal et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Conformational Changes in BAK, a Pore-forming Proapoptotic Bcl-2 Family Member, upon Membrane Insertion and Direct Evidence for the Existence of BH3-BH3 Contact Interface in BAK Homo-oligomers
- (2010) Kyoung Joon Oh et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Bax Forms an Oligomer via Separate, Yet Interdependent, Surfaces
- (2010) Zhi Zhang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- BH3-Triggered Structural Reorganization Drives the Activation of Proapoptotic BAX
- (2010) Evripidis Gavathiotis et al. MOLECULAR CELL
- Pulsed EPR Determination of Water Accessibility to Spin-Labeled Amino Acid Residues in LHCIIb
- (2009) A. Volkov et al. BIOPHYSICAL JOURNAL
- Conformational changes and protein stability of the pro-apoptotic protein Bax
- (2009) Stephanie Bleicken et al. JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
- Molecular Details of Bax Activation, Oligomerization, and Membrane Insertion
- (2009) Stephanie Bleicken et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mitochondrial Outer Membrane Proteins Assist Bid in Bax-mediated Lipidic Pore Formation
- (2009) Blanca Schafer et al. MOLECULAR BIOLOGY OF THE CELL
- Bak Activation for Apoptosis Involves Oligomerization of Dimers via Their α6 Helices
- (2009) Grant Dewson et al. MOLECULAR CELL
- Stepwise Activation of BAX and BAK by tBID, BIM, and PUMA Initiates Mitochondrial Apoptosis
- (2009) Hyungjin Kim et al. MOLECULAR CELL
- Membrane Binding by tBid Initiates an Ordered Series of Events Culminating in Membrane Permeabilization by Bax
- (2008) Jonathan F. Lovell et al. CELL
- Bax targeting to mitochondria occurs via both tail anchor-dependent and -independent mechanisms
- (2008) A J Valentijn et al. CELL DEATH AND DIFFERENTIATION
- To Trigger Apoptosis, Bak Exposes Its BH3 Domain and Homodimerizes via BH3:Groove Interactions
- (2008) Grant Dewson et al. MOLECULAR CELL
- BAX activation is initiated at a novel interaction site
- (2008) Evripidis Gavathiotis et al. NATURE
- Structure of transmembrane pore induced by Bax-derived peptide: Evidence for lipidic pores
- (2008) S. Qian et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The BCL-2 protein family: opposing activities that mediate cell death
- (2007) Richard J. Youle et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
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