cBid, Bax and Bcl-xL exhibit opposite membrane remodeling activities

Distinct lipid effects on tBid and Bim activation of membrane permeabilization by pro-apoptotic Bax

(2015) Aisha Shamas-Din et al.   BIOCHEMICAL JOURNAL

A Single Herpesvirus Protein Can Mediate Vesicle Formation in the Nuclear Envelope

(2015) Michael Lorenz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane curvature at a glance

(2015) H. T. McMahon et al.   JOURNAL OF CELL SCIENCE

More Than a Pore: The Interplay of Pore-Forming Proteins and Lipid Membranes

(2015) Uris Ros et al.   JOURNAL OF MEMBRANE BIOLOGY

Visual and functional demonstration of growing Bax-induced pores in mitochondrial outer membranes

(2015) Laura A Gillies et al.   MOLECULAR BIOLOGY OF THE CELL

Architecture of the synaptotagmin–SNARE machinery for neuronal exocytosis

(2015) Qiangjun Zhou et al.   NATURE

Bax monomers form dimer units in the membrane that further self-assemble into multiple oligomeric species

(2015) Yamunadevi Subburaj et al.   Nature Communications

Automated analysis of giant unilamellar vesicles using circular Hough transformation

(2014) Eduard Hermann et al.   BIOINFORMATICS

Mechanisms shaping cell membranes

(2014) Michael M Kozlov et al.   CURRENT OPINION IN CELL BIOLOGY

Dynamin-related Protein 1 (Drp1) Promotes Structural Intermediates of Membrane Division

(2014) Begoña Ugarte-Uribe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Model of Active Bax at the Membrane

(2014) Stephanie Bleicken et al.   MOLECULAR CELL

Endophilin-A2 functions in membrane scission in clathrin-independent endocytosis

(2014) Henri-François Renard et al.   NATURE

Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membrane

(2014) Dana Westphal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple partners can kiss-and-run: Bax transfers between multiple membranes and permeabilizes those primed by tBid

(2014) A Shamas-Din et al.   Cell Death & Disease

Membranes in motion: mitochondrial dynamics and their role in apoptosis

(2013) Begoña Ugarte-Uribe et al.   BIOLOGICAL CHEMISTRY

Mechanistic Differences in the Membrane Activity of Bax and Bcl-xL Correlate with Their Opposing Roles in Apoptosis

(2013) Stephanie Bleicken et al.   BIOPHYSICAL JOURNAL

Bax Crystal Structures Reveal How BH3 Domains Activate Bax and Nucleate Its Oligomerization to Induce Apoptosis

(2013) Peter E. Czabotar et al.   CELL

Lipid Segregation and Membrane Budding Induced by the Peripheral Membrane Binding Protein Annexin A2

(2013) Patrick Drücker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proapoptotic Bax and Bak Proteins Form Stable Protein-permeable Pores of Tunable Size

(2013) Stephanie Bleicken et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

tBid Undergoes Multiple Conformational Changes at the Membrane Required for Bax Activation

(2013) Aisha Shamas-Din et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Insights of tBid, the Caspase-8-activated Bid, and Its BH3Domain

(2013) Yu Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bax Exists in a Dynamic Equilibrium between the Cytosol and Mitochondria to Control Apoptotic Priming

(2013) Barbara Schellenberg et al.   MOLECULAR CELL

A Bcl-xL–Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis

(2013) Hongmei Li et al.   NATURE CELL BIOLOGY

A cost–benefit analysis of the physical mechanisms of membrane curvature

(2013) Jeanne C. Stachowiak et al.   NATURE CELL BIOLOGY

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

(2013) Peter E. Czabotar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Membrane Fission Is Promoted by Insertion of Amphipathic Helices and Is Restricted by Crescent BAR Domains

(2012) Emmanuel Boucrot et al.   CELL

The C-terminal helix of Bcl-xL mediates Bax retrotranslocation from the mitochondria

(2012) F Todt et al.   CELL DEATH AND DIFFERENTIATION

The secrets of the Bcl-2 family

(2012) A J García-Sáez   CELL DEATH AND DIFFERENTIATION

Molecular machines governing exocytosis of synaptic vesicles

(2012) Reinhard Jahn et al.   NATURE

Dynamic Interaction of cBid with Detergents, Liposomes and Mitochondria

(2012) Stephanie Bleicken et al.   PLoS One

Membrane Fusion Intermediates via Directional and Full Assembly of the SNARE Complex

(2012) J. M. Hernandez et al.   SCIENCE

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

Synaptic proteins promote calcium-triggered fast transition from point contact to full fusion

(2012) Jiajie Diao et al.   eLife

Less than perfect divorces: dysregulated mitochondrial fission and neurodegeneration

(2011) Björn Oettinghaus et al.   ACTA NEUROPATHOLOGICA

Mitochondrial outer membrane permeabilization during apoptosis: The role of mitochondrial fission

(2011) Thomas Landes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Bcl-xL Retrotranslocates Bax from the Mitochondria into the Cytosol

(2011) Frank Edlich et al.   CELL

Mitochondria in Apoptosis: Bcl-2 Family Members and Mitochondrial Dynamics

(2011) Jean-Claude Martinou et al.   DEVELOPMENTAL CELL

A lipocentric view of peptide-induced pores

(2011) Gustavo Fuertes et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Reconstitution of Proapoptotic BAK Function in Liposomes Reveals a Dual Role for Mitochondrial Lipids in the BAK-driven Membrane Permeabilization Process

(2011) Olatz Landeta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Unified Model of Mammalian BCL-2 Protein Family Interactions at the Mitochondria

(2011) Fabien Llambi et al.   MOLECULAR CELL

Lipid Polymorphisms and Membrane Shape

(2011) V. A. Frolov et al.   Cold Spring Harbor Perspectives in Biology

Membrane Remodeling Induced by the Dynamin-Related Protein Drp1 Stimulates Bax Oligomerization

(2010) Sylvie Montessuit et al.   CELL

Cooperative elastic stresses, the hydrophobic effect, and lipid tilt in membrane remodeling

(2010) Vadim A. Frolov et al.   FEBS LETTERS

Molecular mechanism of multivesicular body biogenesis by ESCRT complexes

(2010) Thomas Wollert et al.   NATURE

Molecular mechanism of the synaptotagmin–SNARE interaction in Ca2+-triggered vesicle fusion

(2010) Marija Vrljic et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Protein-driven membrane stresses in fusion and fission

(2010) Michael M. Kozlov et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mitochondrial outer-membrane permeabilization and remodelling in apoptosis

(2009) Alexis Jourdain et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Molecular Details of Bax Activation, Oligomerization, and Membrane Insertion

(2009) Stephanie Bleicken et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bcl-xLincreases mitochondrial fission, fusion, and biomass in neurons

(2009) Sarah B. Berman et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial Outer Membrane Proteins Assist Bid in Bax-mediated Lipidic Pore Formation

(2009) Blanca Schafer et al.   MOLECULAR BIOLOGY OF THE CELL

Membrane promotes tBID interaction with BCLXL

(2009) Ana J García-Sáez et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Membrane Binding by tBid Initiates an Ordered Series of Events Culminating in Membrane Permeabilization by Bax

(2008) Jonathan F. Lovell et al.   CELL

Chemical Inhibition of the Mitochondrial Division Dynamin Reveals Its Role in Bax/Bak-Dependent Mitochondrial Outer Membrane Permeabilization

(2008) Ann Cassidy-Stone et al.   DEVELOPMENTAL CELL

A Chemical Inhibitor of DRP1 Uncouples Mitochondrial Fission and Apoptosis

(2008) Atsushi Tanaka et al.   MOLECULAR CELL

Mechanics of membrane fusion

(2008) Leonid V Chernomordik et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of transmembrane pore induced by Bax-derived peptide: Evidence for lipidic pores

(2008) S. Qian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bcl-xL induces Drp1-dependent synapse formation in cultured hippocampal neurons

(2008) H. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bcl-XL Inhibits Membrane Permeabilization by Competing with Bax

(2008) Lieven P Billen et al.   PLOS BIOLOGY

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY