Topology of active, membrane-embedded Bax in the context of a toroidal pore

BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis

(2018) Kate McArthur et al.   SCIENCE

The membrane activity of BOK involves formation of large, stable toroidal pores and is promoted by cBID

(2017) Yuniel Fernández-Marrero et al.   FEBS Journal

Sickle Cell Disease

(2017) Frédéric B. Piel et al.   NEW ENGLAND JOURNAL OF MEDICINE

BAK α6 permits activation by BH3-only proteins and homooligomerization via the canonical hydrophobic groove

(2017) Mark Xiang Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative interactome of a membrane Bcl-2 network identifies a hierarchy of complexes for apoptosis regulation

(2017) Stephanie Bleicken et al.   Nature Communications

Membrane insertion of the BAX core, but not latch domain, drives apoptotic pore formation

(2017) Hector Flores-Romero et al.   Scientific Reports

Inactivation of prosurvival Bcl-2 proteins activates Bax/Bak through the outer mitochondrial membrane

(2016) Katelyn L. O'Neill et al.   GENES & DEVELOPMENT

Water accessibility in a membrane-inserting peptide comparing Overhauser DNP and pulse EPR methods

(2016) Takuya F. Segawa et al.   JOURNAL OF CHEMICAL PHYSICS

Bax transmembrane domain interacts with prosurvival Bcl-2 proteins in biological membranes

(2016) Vicente Andreu-Fernández et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

cBid, Bax and Bcl-xL exhibit opposite membrane remodeling activities

(2016) S Bleicken et al.   Cell Death & Disease

Bak apoptotic pores involve a flexible C-terminal region and juxtaposition of the C-terminal transmembrane domains

(2015) S Iyer et al.   CELL DEATH AND DIFFERENTIATION

BH3-in-groove dimerization initiates and helix 9 dimerization expands Bax pore assembly in membranes

(2015) Z. Zhang et al.   EMBO JOURNAL

Membrane curvature at a glance

(2015) H. T. McMahon et al.   JOURNAL OF CELL SCIENCE

Visual and functional demonstration of growing Bax-induced pores in mitochondrial outer membranes

(2015) Laura A Gillies et al.   MOLECULAR BIOLOGY OF THE CELL

The EMBL-EBI bioinformatics web and programmatic tools framework

(2015) Weizhong Li et al.   NUCLEIC ACIDS RESEARCH

Dissociation of Bak α1 helix from the core and latch domains is required for apoptosis

(2015) Amber E. Alsop et al.   Nature Communications

Measuring membrane penetration with depth-dependent fluorescence quenching: Distribution analysis is coming of age

(2014) Alexey S. Ladokhin   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Bax targets mitochondria by distinct mechanisms before or during apoptotic cell death: a requirement for VDAC2 or Bak for efficient Bax apoptotic function

(2014) S B Ma et al.   CELL DEATH AND DIFFERENTIATION

Differential retrotranslocation of mitochondrial Bax and Bak

(2014) F. Todt et al.   EMBO JOURNAL

Conformational Rearrangements in the Pro-apoptotic Protein, Bax, as It Inserts into Mitochondria

(2014) Robert F. Gahl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bak Core and Latch Domains Separate during Activation, and Freed Core Domains Form Symmetric Homodimers

(2014) Jason M. Brouwer et al.   MOLECULAR CELL

Structural Model of Active Bax at the Membrane

(2014) Stephanie Bleicken et al.   MOLECULAR CELL

Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membrane

(2014) Dana Westphal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple partners can kiss-and-run: Bax transfers between multiple membranes and permeabilizes those primed by tBid

(2014) A Shamas-Din et al.   Cell Death & Disease

Residue mutations and their impact on protein structure and function: detecting beneficial and pathogenic changes

(2013) Romain A. Studer et al.   BIOCHEMICAL JOURNAL

Mechanistic Differences in the Membrane Activity of Bax and Bcl-xL Correlate with Their Opposing Roles in Apoptosis

(2013) Stephanie Bleicken et al.   BIOPHYSICAL JOURNAL

Bax Crystal Structures Reveal How BH3 Domains Activate Bax and Nucleate Its Oligomerization to Induce Apoptosis

(2013) Peter E. Czabotar et al.   CELL

Multimodal Interaction with BCL-2 Family Proteins Underlies the Proapoptotic Activity of PUMA BH3

(2013) Amanda L. Edwards et al.   CHEMISTRY & BIOLOGY

Organization of the Mitochondrial Apoptotic BAK Pore

(2013) Sreevidya Aluvila et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proapoptotic Bax and Bak Proteins Form Stable Protein-permeable Pores of Tunable Size

(2013) Stephanie Bleicken et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Single color FRET based measurements of conformational changes of proteins resulting from translocation inside cells

(2013) Robert F. Gahl et al.   METHODS

Bax Exists in a Dynamic Equilibrium between the Cytosol and Mitochondria to Control Apoptotic Priming

(2013) Barbara Schellenberg et al.   MOLECULAR CELL

A cost–benefit analysis of the physical mechanisms of membrane curvature

(2013) Jeanne C. Stachowiak et al.   NATURE CELL BIOLOGY

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

(2013) Peter E. Czabotar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

BID-induced structural changes in BAK promote apoptosis

(2013) Tudor Moldoveanu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

BIM-Mediated Membrane Insertion of the BAK Pore Domain Is an Essential Requirement for Apoptosis

(2013) Kathrin Weber et al.   Cell Reports

The secrets of the Bcl-2 family

(2012) A J García-Sáez   CELL DEATH AND DIFFERENTIATION

Translocation of a Bak C-Terminus Mutant from Cytosol to Mitochondria to Mediate Cytochrome c Release: Implications for Bak and Bax Apoptotic Function

(2012) Pedro Eitz Ferrer et al.   PLoS One

Bak Conformational Changes Induced by Ligand Binding: Insight into BH3 Domain Binding and Bak Homo-Oligomerization

(2012) Yuan-Ping Pang et al.   Scientific Reports

Bax dimerizes via a symmetric BH3:groove interface during apoptosis

(2011) G Dewson et al.   CELL DEATH AND DIFFERENTIATION

Mitochondria in Apoptosis: Bcl-2 Family Members and Mitochondrial Dynamics

(2011) Jean-Claude Martinou et al.   DEVELOPMENTAL CELL

Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases

(2011) Andreas Strasser et al.   EMBO JOURNAL

Molecular biology of Bax and Bak activation and action

(2010) Dana Westphal et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Conformational Changes in BAK, a Pore-forming Proapoptotic Bcl-2 Family Member, upon Membrane Insertion and Direct Evidence for the Existence of BH3-BH3 Contact Interface in BAK Homo-oligomers

(2010) Kyoung Joon Oh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bax Forms an Oligomer via Separate, Yet Interdependent, Surfaces

(2010) Zhi Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BH3-Triggered Structural Reorganization Drives the Activation of Proapoptotic BAX

(2010) Evripidis Gavathiotis et al.   MOLECULAR CELL

Pulsed EPR Determination of Water Accessibility to Spin-Labeled Amino Acid Residues in LHCIIb

(2009) A. Volkov et al.   BIOPHYSICAL JOURNAL

Conformational changes and protein stability of the pro-apoptotic protein Bax

(2009) Stephanie Bleicken et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Molecular Details of Bax Activation, Oligomerization, and Membrane Insertion

(2009) Stephanie Bleicken et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Outer Membrane Proteins Assist Bid in Bax-mediated Lipidic Pore Formation

(2009) Blanca Schafer et al.   MOLECULAR BIOLOGY OF THE CELL

Bak Activation for Apoptosis Involves Oligomerization of Dimers via Their α6 Helices

(2009) Grant Dewson et al.   MOLECULAR CELL

Stepwise Activation of BAX and BAK by tBID, BIM, and PUMA Initiates Mitochondrial Apoptosis

(2009) Hyungjin Kim et al.   MOLECULAR CELL

Membrane Binding by tBid Initiates an Ordered Series of Events Culminating in Membrane Permeabilization by Bax

(2008) Jonathan F. Lovell et al.   CELL

Bax targeting to mitochondria occurs via both tail anchor-dependent and -independent mechanisms

(2008) A J Valentijn et al.   CELL DEATH AND DIFFERENTIATION

To Trigger Apoptosis, Bak Exposes Its BH3 Domain and Homodimerizes via BH3:Groove Interactions

(2008) Grant Dewson et al.   MOLECULAR CELL

BAX activation is initiated at a novel interaction site

(2008) Evripidis Gavathiotis et al.   NATURE

Structure of transmembrane pore induced by Bax-derived peptide: Evidence for lipidic pores

(2008) S. Qian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY