Opposing functions of Fbxw7 in keratinocyte growth, differentiation and skin tumorigenesis mediated through negative regulation of c-Myc and Notch

Fbxw7-dependent Degradation of Notch Is Required for Control of “Stemness” and Neuronal-Glial Differentiation in Neural Stem Cells

(2011) Akinobu Matsumoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation

(2011) Roya Babaei-Jadidi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Complex regulation of cell-cycle inhibitors by Fbxw7 in mouse embryonic fibroblasts

(2009) K Masuda et al.   ONCOGENE

The FoxO3a gene is a key negative target of canonical Notch signalling in the keratinocyte UVB response

(2008) Anna Mandinova et al.   EMBO JOURNAL

Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL

(2008) S. Matsuoka et al.   GENES & DEVELOPMENT

Skin stem cells: rising to the surface

(2008) Elaine Fuchs   JOURNAL OF CELL BIOLOGY

Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7

(2008) Benjamin J. Thompson et al.   JOURNAL OF EXPERIMENTAL MEDICINE