Modeling human neurodegenerative diseases in transgenic systems

Altering Presenilin Gene Activity in Zebrafish Embryos Causes Changes in Expression of Genes with Potential Involvement in Alzheimer's Disease Pathogenesis

(2017) Morgan Newman et al.   JOURNAL OF ALZHEIMERS DISEASE

A Novel Transgenic Rat Model with a Full Alzheimer's-Like Amyloid Pathology Displays Pre-Plaque Intracellular Amyloid-β-Associated Cognitive Impairment

(2017) Wanda Carolina Leon et al.   JOURNAL OF ALZHEIMERS DISEASE

Behavioral Phenotyping of a Transgenic Caenorhabditis Elegans Expressing Neuronal Amyloid-β

(2017) Laura E. Dosanjh et al.   JOURNAL OF ALZHEIMERS DISEASE

Transgenic Mouse Models of Parkinsons Disease and Huntingtons Disease

(2012) Stephen D. Skaper et al.   CNS & Neurological Disorders-Drug Targets

Developing tTA Transgenic Rats for Inducible and Reversible Gene Expression

(2012) Hongxia Zhou et al.   International Journal of Biological Sciences

Parkinson's Disease: Genetics and Pathogenesis

(2011) Joshua M. Shulman et al.   Annual Review of Pathology-Mechanisms of Disease

One step forward: The use of transgenic zebrafish tumor model in drug screens

(2011) Xiaoqian Huang et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

The expanding reach of the GAL4/UAS system into the behavioral neurobiology of Drosophila

(2011) Walton D. Jones   BMB Reports

ZFNGenome: A comprehensive resource for locating zinc finger nuclease target sites in model organisms

(2011) Deepak Reyon et al.   BMC GENOMICS

The use of RNAi technologies for gene knockdown in zebrafish

(2011) A. Kelly et al.   Briefings in Functional Genomics

A Rapid and Scalable System for Studying Gene Function in Mice Using Conditional RNA Interference

(2011) Prem K. Premsrirut et al.   CELL

FTD and ALS: A Tale of Two Diseases

(2011) R. Ferrari et al.   Current Alzheimer Research

Modeling Neurodegeneration in Zebrafish

(2011) Yanwei Xi et al.   Current Neurology and Neuroscience Reports

Genetic manipulations in the rat: progress and prospects

(2011) Guanyi Huang et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Circadian dysfunction in a mouse model of Parkinson's disease

(2011) Takashi Kudo et al.   EXPERIMENTAL NEUROLOGY

Mitochondrial redox signalling by p66Shc mediates ALS-like disease through Rac1 inactivation

(2011) M. G. Pesaresi et al.   HUMAN MOLECULAR GENETICS

Annual Research Review: Transgenic mouse models of childhood-onset psychiatric disorders

(2011) Holly R. Robertson et al.   JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY

Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice

(2011) Lionel M. Igaz et al.   JOURNAL OF CLINICAL INVESTIGATION

A tale on animal models of Parkinson's disease

(2011) Erwan Bezard et al.   MOVEMENT DISORDERS

In vivo genome editing restores haemostasis in a mouse model of haemophilia

(2011) Hojun Li et al.   NATURE

Adult hippocampal neurogenesis buffers stress responses and depressive behaviour

(2011) Jason S. Snyder et al.   NATURE

A decade’s perspective on DNA sequencing technology

(2011) Elaine R. Mardis   NATURE

Heritable gene targeting in zebrafish using customized TALENs

(2011) Peng Huang et al.   NATURE BIOTECHNOLOGY

Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription

(2011) Feng Zhang et al.   NATURE BIOTECHNOLOGY

Knockout rats generated by embryo microinjection of TALENs

(2011) Laurent Tesson et al.   NATURE BIOTECHNOLOGY

Generating gene knockout rats by homologous recombination in embryonic stem cells

(2011) Chang Tong et al.   Nature Protocols

Pathophysiology of Huntington's disease: time-dependent alterations in synaptic and receptor function

(2011) L.A. Raymond et al.   NEUROSCIENCE

Multiple new site-specific recombinases for use in manipulating animal genomes

(2011) A. Nern et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficient generation of a biallelic knockout in pigs using zinc-finger nucleases

(2011) J. Hauschild et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted Genome Editing Across Species Using ZFNs and TALENs

(2011) Andrew J. Wood et al.   SCIENCE

Sirt1’s beneficial roles in neurodegenerative diseases - a chaperonin containing TCP-1 (CCT) connection?

(2010) Bin Qi Gan et al.   AGING CELL

Circadian regulation of cell cycle: Molecular connections between aging and the circadian clock

(2010) Rohini V. Khapre et al.   ANNALS OF MEDICINE

Transgenic mice in the study of drug addiction and the effects of psychostimulant drugs

(2010) Ichiro Sora et al.   Annals of the New York Academy of Sciences

Genomic Screening with RNAi: Results and Challenges

(2010) Stephanie Mohr et al.   Annual Review of Biochemistry

XanthomonasAvrBs3 Family-Type III Effectors: Discovery and Function

(2010) Jens Boch et al.   Annual Review of Phytopathology

A short upstream promoter region mediates transcriptional regulation of the mouse doublecortin gene in differentiating neurons

(2010) Marie Piens et al.   BMC NEUROSCIENCE

Characterization of the 3xTg-AD mouse model of Alzheimer's disease: Part 2. Behavioral and cognitive changes

(2010) Roxanne Sterniczuk et al.   BRAIN RESEARCH

Transgenic zebrafish models of neurodegenerative diseases

(2010) Jonathan J. Sager et al.   Brain Structure & Function

Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions

(2010) Aaron D. Goldberg et al.   CELL

Cellular mechanisms of posterior neural tube morphogenesis in the zebrafish

(2010) Michael J. Harrington et al.   DEVELOPMENTAL DYNAMICS

Ascidians: an invertebrate chordate model to study Alzheimer's disease pathogenesis

(2010) M. J. Virata et al.   Disease Models & Mechanisms

Dysfunctions in circadian behavior and physiology in mouse models of Huntington's disease

(2010) Takashi Kudo et al.   EXPERIMENTAL NEUROLOGY

Targeted Genome Modification in Mice Using Zinc-Finger Nucleases

(2010) I. D. Carbery et al.   GENETICS

Targeting DNA Double-Strand Breaks with TAL Effector Nucleases

(2010) M. Christian et al.   GENETICS

RNA Interference in Ageing Research – A Mini-Review

(2010) Nadège Minois et al.   GERONTOLOGY

Neurotoxic effects of TDP-43 overexpression in C. elegans

(2010) Peter E.A. Ash et al.   HUMAN MOLECULAR GENETICS

Expression of Huntington's disease protein results in apoptotic neurons in the brains of cloned transgenic pigs

(2010) Dongshan Yang et al.   HUMAN MOLECULAR GENETICS

Transgenic animal models of neurodegeneration based on human genetic studies

(2010) Brandon K. Harvey et al.   JOURNAL OF NEURAL TRANSMISSION

Clinical, genetic and pathological heterogeneity of frontotemporal dementia: a review

(2010) H. Seelaar et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Enhanced Striatal Dopamine Transmission and Motor Performance with LRRK2 Overexpression in Mice Is Eliminated by Familial Parkinson's Disease Mutation G2019S

(2010) X. Li et al.   JOURNAL OF NEUROSCIENCE

Wild-Type Human TDP-43 Expression Causes TDP-43 Phosphorylation, Mitochondrial Aggregation, Motor Deficits, and Early Mortality in Transgenic Mice

(2010) Y.-F. Xu et al.   JOURNAL OF NEUROSCIENCE

Model organisms — A historical perspective

(2010) Bruno Müller et al.   Journal of Proteomics

Genetic screens using the piggyBac transposon

(2010) Su Kit Chew et al.   METHODS

Sleeping Beauty transposon mutagenesis of the rat genome in spermatogonial stem cells

(2010) Zoltán Ivics et al.   METHODS

Transgenic Mouse Models of Alzheimer's Disease

(2010) Gregory A. Elder et al.   MOUNT SINAI JOURNAL OF MEDICINE

Amyloid-β Oligomers: Possible Roles as Key Neurotoxins in Alzheimer's Disease

(2010) Alex L. Lublin et al.   MOUNT SINAI JOURNAL OF MEDICINE

Production of p53 gene knockout rats by homologous recombination in embryonic stem cells

(2010) Chang Tong et al.   NATURE

Gamma-secretase activating protein is a therapeutic target for Alzheimer’s disease

(2010) Gen He et al.   NATURE

Targeted integration in rat and mouse embryos with zinc-finger nucleases

(2010) Xiaoxia Cui et al.   NATURE BIOTECHNOLOGY

Generating knockout rats by transposon mutagenesis in spermatogonial stem cells

(2010) Zsuzsanna Izsvák et al.   NATURE METHODS

Rapid selection of transgenic C. elegans using antibiotic resistance

(2010) Jennifer I Semple et al.   NATURE METHODS

Nicotine addiction and nicotinic receptors: lessons from genetically modified mice

(2010) Jean-Pierre Changeux   NATURE REVIEWS NEUROSCIENCE

Progressive motor weakness in transgenic mice expressing human TDP-43

(2010) Nancy R. Stallings et al.   NEUROBIOLOGY OF DISEASE

Transgenic Zebrafish as a Novel Animal Model to Study Tauopathies and Other Neurodegenerative Disorders in vivo

(2010) Dominik Paquet et al.   Neurodegenerative Diseases

TDP-43-Based Animal Models of Neurodegeneration: New Insights into ALS Pathology and Pathophysiology

(2010) Iga Wegorzewska et al.   Neurodegenerative Diseases

Promoter elements of rice susceptibility genes are bound and activated by specific TAL effectors from the bacterial blight pathogen, Xanthomonas oryzae pv. oryzae

(2010) Patrick Römer et al.   NEW PHYTOLOGIST

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

(2010) Patricia Spilman et al.   PLoS One

Transgenic rhesus monkeys produced by gene transfer into early-cleavage–stage embryos using a simian immunodeficiency virus-based vector

(2010) Yuyu Niu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dually inducible TetON systems for tissue-specific conditional gene expression in zebrafish

(2010) F. Knopf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conversion of a yeast prion protein to an infectious form in bacteria

(2010) S. J. Garrity et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for the glucan phosphatase activity of Starch Excess4

(2010) C. W. Vander Kooi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene targeting by homologous recombination in mouse zygotes mediated by zinc-finger nucleases

(2010) M. Meyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Altered distributions of Gemini of coiled bodies and mitochondria in motor neurons of TDP-43 transgenic mice

(2010) X. Shan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration

(2010) Hans Wils et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Presenilin mouse and zebrafish models for dementia: Focus on neurogenesis

(2010) Paula van Tijn et al.   PROGRESS IN NEUROBIOLOGY

PiggyBac Transposon Mutagenesis: A Tool for Cancer Gene Discovery in Mice

(2010) R. Rad et al.   SCIENCE

Generating a Prion with Bacterially Expressed Recombinant Prion Protein

(2010) F. Wang et al.   SCIENCE

FLPe functions in zebrafish embryos

(2010) Andrew C. Wong et al.   TRANSGENIC RESEARCH

Transgenic Rat Model of Neurodegeneration Caused by Mutation in the TDP Gene

(2010) Hongxia Zhou et al.   PLoS Genetics

In vivo gene regulation using tetracycline-regulatable systems

(2009) Knut Stieger et al.   ADVANCED DRUG DELIVERY REVIEWS

Age-Related Vascular Pathology in Transgenic Mice Expressing Presenilin 1-Associated Familial Alzheimer's Disease Mutations

(2009) Miguel A. Gama Sosa et al.   AMERICAN JOURNAL OF PATHOLOGY

A simplified, robust, and streamlined procedure for the production of C. elegans transgenes via recombineering

(2009) Yue Zhang et al.   BMC DEVELOPMENTAL BIOLOGY

Presenilin transgenic mice as models of Alzheimer’s disease

(2009) Gregory A. Elder et al.   Brain Structure & Function

Understanding the molecular basis of Alzheimer’s disease using a Caenorhabditis elegans model system

(2009) Collin Y. Ewald et al.   Brain Structure & Function

Immunotherapeutic approaches for Alzheimer’s disease in transgenic mouse models

(2009) Thomas Wisniewski et al.   Brain Structure & Function

Animal transgenesis: an overview

(2009) Miguel A. Gama Sosa et al.   Brain Structure & Function

APP transgenic modeling of Alzheimer’s disease: mechanisms of neurodegeneration and aberrant neurogenesis

(2009) Leslie Crews et al.   Brain Structure & Function

Beyond the Rat Models of Human Neurodegenerative Disorders

(2009) Ondrej Bugos et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Resveratrol and Neurodegenerative Diseases: Activation of SIRT1 as the Potential Pathway towards Neuroprotection

(2009) Merce Pallas et al.   CURRENT NEUROVASCULAR RESEARCH

Inactivation of Drosophila Huntingtin affects long-term adult functioning and the pathogenesis of a Huntington's disease model

(2009) S. Zhang et al.   Disease Models & Mechanisms

Dre recombinase, like Cre, is a highly efficient site-specific recombinase in E. coli, mammalian cells and mice

(2009) K. Anastassiadis et al.   Disease Models & Mechanisms

Independent and cooperative action of Psen2 with Psen1 in zebrafish embryos

(2009) Svanhild Nornes et al.   EXPERIMENTAL CELL RESEARCH

The Evolutionary Theories of Aging Revisited – A Mini-Review

(2009) Predrag Ljubuncic et al.   GERONTOLOGY

Gain and loss of function of ALS-related mutations of TARDBP (TDP-43) cause motor deficits in vivo

(2009) Edor Kabashi et al.   HUMAN MOLECULAR GENETICS

Drosophila melanogaster as a Model Organism of Brain Diseases

(2009) Astrid Jeibmann et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Divalent Metal Transporter Homologues SMF-1/2 Mediate Dopamine Neuron Sensitivity in Caenorhabditis elegans Models of Manganism and Parkinson Disease

(2009) Raja Settivari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation

(2009) Dominik Paquet et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of independent APP locus duplication in Japanese patients with early-onset Alzheimer disease

(2009) K Kasuga et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

In Vivo Evidence for NMDA Receptor-Mediated Excitotoxicity in a Murine Genetic Model of Huntington Disease

(2009) M. Y. Heng et al.   JOURNAL OF NEUROSCIENCE

Bacterial Artificial Chromosome Transgenic Mice Expressing a Truncated Mutant Parkin Exhibit Age-Dependent Hypokinetic Motor Deficits, Dopaminergic Neuron Degeneration, and Accumulation of Proteinase K-Resistant  -Synuclein

(2009) X.-H. Lu et al.   JOURNAL OF NEUROSCIENCE

Transposon-mediated mutagenesis of somatic cells in the mouse for cancer gene identification

(2009) D LARGAESPADA   METHODS

What have worm models told us about the mechanisms of neuronal dysfunction in human neurodegenerative diseases?

(2009) Dawn Teschendorf et al.   Molecular Neurodegeneration

The Pharmacological Chaperone 1-Deoxygalactonojirimycin Reduces Tissue Globotriaosylceramide Levels in a Mouse Model of Fabry Disease

(2009) Richie Khanna et al.   MOLECULAR THERAPY

Temporally-Controlled Site-Specific Recombination in Zebrafish

(2009) Stefan Hans et al.   PLoS One

Optimized Gal4 genetics for permanent gene expression mapping in zebrafish

(2009) M. Distel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration

(2009) I. Wegorzewska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear DNA Damage as a Direct Cause of Aging

(2009) Benjamin P. Best   REJUVENATION RESEARCH

Cognition in Mouse Models of Schizophrenia Susceptibility Genes

(2009) P. A. Arguello et al.   SCHIZOPHRENIA BULLETIN

A Genetic Defect Caused by a Triplet Repeat Expansion in Arabidopsis thaliana

(2009) S. Sureshkumar et al.   SCIENCE

DNA Binding Made Easy

(2009) D. F. Voytas et al.   SCIENCE

Breaking the Code of DNA Binding Specificity of TAL-Type III Effectors

(2009) J. Boch et al.   SCIENCE

A Simple Cipher Governs DNA Recognition by TAL Effectors

(2009) M. J. Moscou et al.   SCIENCE

Knockout Rats via Embryo Microinjection of Zinc-Finger Nucleases

(2009) Aron M. Geurts et al.   SCIENCE

Hemizygous minipigs produced by random gene insertion and handmade cloning express the Alzheimer’s disease-causing dominant mutation APPsw

(2009) Peter M. Kragh et al.   TRANSGENIC RESEARCH

Zinc-finger nucleases: a powerful tool for genetic engineering of animals

(2009) Séverine Rémy et al.   TRANSGENIC RESEARCH

Lafora disease: insights into neurodegeneration from plant metabolism

(2009) Matthew S. Gentry et al.   TRENDS IN BIOCHEMICAL SCIENCES

A Primer for Morpholino Use in Zebrafish

(2009) Brent R. Bill et al.   Zebrafish

DrosophilaModels of Neurodegenerative Diseases

(2008) Bingwei Lu et al.   Annual Review of Pathology-Mechanisms of Disease

Development of transgenic rats producing human β-amyloid precursor protein as a model for Alzheimer's disease: Transgene and endogenous APP genes are regulated tissue-specifically

(2008) Cansu Agca et al.   BMC NEUROSCIENCE

Mifepristone-inducible LexPR system to drive and control gene expression in transgenic zebrafish

(2008) Alexander Emelyanov et al.   DEVELOPMENTAL BIOLOGY

Generation of oocyte-specifically expressed cre transgenic zebrafish for female germline excision of loxp-flanked transgene

(2008) Xingjun Liu et al.   DEVELOPMENTAL DYNAMICS

The IRG mouse: A two-color fluorescent reporter for assessing Cre-mediated recombination and imaging complex cellular relationships in situ

(2008) Rita De Gasperi et al.   GENESIS

ADrosophilaModel for Amyotrophic Lateral Sclerosis Reveals Motor Neuron Damage by Human SOD1

(2008) Melanie R. Watson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ablation of Proliferating Microglia Does Not Affect Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis Caused by Mutant Superoxide Dismutase

(2008) G. Gowing et al.   JOURNAL OF NEUROSCIENCE

Full-Length Human Mutant Huntingtin with a Stable Polyglutamine Repeat Can Elicit Progressive and Selective Neuropathogenesis in BACHD Mice

(2008) M. Gray et al.   JOURNAL OF NEUROSCIENCE

Depletion of 26S Proteasomes in Mouse Brain Neurons Causes Neurodegeneration and Lewy-Like Inclusions Resembling Human Pale Bodies

(2008) L. Bedford et al.   JOURNAL OF NEUROSCIENCE

Towards a transgenic model of Huntington’s disease in a non-human primate

(2008) Shang-Hsun Yang et al.   NATURE

Novel targets for Huntington's disease in an mTOR-independent autophagy pathway

(2008) Andrea Williams et al.   Nature Chemical Biology

Animal models of Alzheimer's disease and frontotemporal dementia

(2008) Jürgen Götz et al.   NATURE REVIEWS NEUROSCIENCE

A transgenic rat that develops Alzheimer's disease-like amyloid pathology, deficits in synaptic plasticity and cognitive impairment

(2008) Li Liu et al.   NEUROBIOLOGY OF DISEASE

Neurotoxic effects induced by the Drosophila amyloid-β peptide suggest a conserved toxic function

(2008) Katia Carmine-Simmen et al.   NEUROBIOLOGY OF DISEASE

Aβ42 Mutants with Different Aggregation Profiles Induce Distinct Pathologies in Drosophila

(2008) Koichi Iijima et al.   PLoS One

MAO-B Elevation in Mouse Brain Astrocytes Results in Parkinson's Pathology

(2008) Jyothi K. Mallajosyula et al.   PLoS One

Genetic dissection of neural circuits by Tol2 transposon-mediated Gal4 gene and enhancer trapping in zebrafish

(2008) K. Asakawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficient gene targeting in Drosophila by direct embryo injection with zinc-finger nucleases

(2008) K. J. Beumer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chromosomal transposition of PiggyBac in mouse embryonic stem cells

(2008) W. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Zinc Finger–Based Knockout Punches for Zebrafish Genes

(2008) Stephen C. Ekker   Zebrafish

Gal4/UAS Transgenic Tools and Their Application to Zebrafish

(2008) Marnie E. Halpern et al.   Zebrafish

Gene Activation Using FLP Recombinase in C. elegans

(2008) M. Wayne Davis et al.   PLoS Genetics

Vector-free DNA constructs improve transgene expression in C. elegans

(2007) John F Etchberger et al.   NATURE METHODS

A transgenic rat model of Alzheimer's disease with extracellular Aβ deposition

(2007) Dorothy G. Flood et al.   NEUROBIOLOGY OF AGING