Regulation ofAicdaexpression and AID activity

Viral Double-Stranded RNA Triggers Ig Class Switching by Activating Upper Respiratory Mucosa B Cells through an Innate TLR3 Pathway Involving BAFF

(2014) W. Xu et al.   JOURNAL OF IMMUNOLOGY

The role of activation-induced cytidine deaminase in lymphomagenesis

(2012) Xiwen Gu et al.   CURRENT OPINION IN HEMATOLOGY

Immune Cells Have Sex and So Should Journal Articles

(2012) Sabra L. Klein   ENDOCRINOLOGY

B cell TLRs and induction of immunoglobulin class-switch DNA recombination

(2012) Egest et al.   Frontiers in Bioscience-Landmark

Iron Inhibits Activation-induced Cytidine Deaminase Enzymatic Activity and Modulates Immunoglobulin Class Switch DNA Recombination

(2012) Guideng Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Histone Chaperone Spt6 Is Required for Activation-induced Cytidine Deaminase Target Determination through H3K4me3 Regulation

(2012) Nasim A. Begum et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A role for the RNA pol II–associated PAF complex in AID-induced immune diversification

(2012) Katharina L. Willmann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

BCL6 positively regulates AID and germinal center gene expression via repression of miR-155

(2012) Katia Basso et al.   JOURNAL OF EXPERIMENTAL MEDICINE

YY1 Controls Immunoglobulin Class Switch Recombination and Nuclear Activation-Induced Deaminase Levels

(2012) K. Zaprazna et al.   MOLECULAR AND CELLULAR BIOLOGY

MicroRNA profiling: approaches and considerations

(2012) Colin C. Pritchard et al.   NATURE REVIEWS GENETICS

The cytoplasmic AID complex

(2012) Julien Häsler et al.   SEMINARS IN IMMUNOLOGY

BCR-signalling synergizes with TLR-signalling for induction of AID and immunoglobulin class-switching through the non-canonical NF-κB pathway

(2012) Egest J. Pone et al.   Nature Communications

Rev1 Recruits Ung to Switch Regions and Enhances dU Glycosylation for Immunoglobulin Class Switch DNA Recombination

(2012) Hong Zan et al.   Cell Reports

Aberrant Expression and Mutation-Inducing Activity of AID in Human Lung Cancer

(2011) Kazuya Shinmura et al.   ANNALS OF SURGICAL ONCOLOGY

A BAFF/APRIL-dependent TLR3-stimulated pathway enhances the capacity of rheumatoid synovial fibroblasts to induce AID expression and Ig class-switching in B cells

(2011) M. Bombardieri et al.   ANNALS OF THE RHEUMATIC DISEASES

Immunoglobulin Responses at the Mucosal Interface

(2011) Andrea Cerutti et al.   Annual Review of Immunology

Inhibition of the catalytic function of activation-induced cytidine deaminase promotes apoptosis of germinal center B cells in BXD2 mice

(2011) Hui-Chen Hsu et al.   ARTHRITIS AND RHEUMATISM

AID dysregulation in lupus-prone MRL/Faslpr/lprmice increases class switch DNA recombination and promotes interchromosomalc-Myc/IgHloci translocations: Modulation by HoxC4

(2011) Clayton A. White et al.   AUTOIMMUNITY

Sex differences in spontaneous versus induced animal models of autoimmunity

(2011) Tai-Ping Lee et al.   AUTOIMMUNITY REVIEWS

Heme regulates B-cell differentiation, antibody class switch, and heme oxygenase-1 expression in B cells as a ligand of Bach2

(2011) M. Watanabe-Matsui et al.   BLOOD

Repression of human activation induced cytidine deaminase by miR-93 and miR-155

(2011) Glen M Borchert et al.   BMC CANCER

Translocation-Capture Sequencing Reveals the Extent and Nature of Chromosomal Rearrangements in B Lymphocytes

(2011) Isaac A. Klein et al.   CELL

Genome-wide Translocation Sequencing Reveals Mechanisms of Chromosome Breaks and Rearrangements in B Cells

(2011) Roberto Chiarle et al.   CELL

The RNA Exosome Targets the AID Cytidine Deaminase to Both Strands of Transcribed Duplex DNA Substrates

(2011) Uttiya Basu et al.   CELL

Optimal functional levels of activation-induced deaminase specifically require the Hsp40 DnaJa1

(2011) Alexandre Orthwein et al.   EMBO JOURNAL

Signaling by the tumor necrosis factor receptor superfamily in B-cell biology and disease

(2011) Robert C. Rickert et al.   IMMUNOLOGICAL REVIEWS

Epigenetic tethering of AID to the donor switch region during immunoglobulin class switch recombination

(2011) Beena Patricia Jeevan-Raj et al.   JOURNAL OF EXPERIMENTAL MEDICINE

REG-γ associates with and modulates the abundance of nuclear activation-induced deaminase

(2011) Yasuhiro Uchimura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Activation-Induced Cytidine Deaminase Induces Reproducible DNA Breaks at Many Non-Ig Loci in Activated B Cells

(2011) Ori Staszewski et al.   MOLECULAR CELL

The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells

(2011) Wataru Ise et al.   NATURE IMMUNOLOGY

Hierarchies of NF-κB target-gene regulation

(2011) Stephen T Smale   NATURE IMMUNOLOGY

NF-κB is 25

(2011) David Baltimore   NATURE IMMUNOLOGY

Crosstalk in NF-κB signaling pathways

(2011) Andrea Oeckinghaus et al.   NATURE IMMUNOLOGY

The Pathogenesis of Rheumatoid Arthritis

(2011) Iain B. McInnes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Activation-Induced Cytidine Deaminase Expression in CD4+ T Cells is Associated with a Unique IL-10-Producing Subset that Increases with Age

(2011) Hongyan Qin et al.   PLoS One

Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation

(2011) I.-m. Okazaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation-induced cytidine deaminase mediates central tolerance in B cells

(2011) M. Kuraoka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation-induced cytidine deaminase (AID) is required for B-cell tolerance in humans

(2011) G. Meyers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytoplasmic activation-induced cytidine deaminase (AID) exists in stoichiometric complex with translation elongation factor 1  (eEF1A)

(2011) J. Hasler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complex regulation and function of activation-induced cytidine deaminase

(2011) Janet Stavnezer   TRENDS IN IMMUNOLOGY

Adaptive Immune Regulation in the Gut: T Cell–Dependent and T Cell–Independent IgA Synthesis

(2010) Sidonia Fagarasan et al.   Annual Review of Immunology

Activation-Induced Cytidine Deaminase Targets DNA at Sites of RNA Polymerase II Stalling by Interaction with Spt5

(2010) Rushad Pavri et al.   CELL

Non-canonical NF-κB signaling pathway

(2010) Shao-Cong Sun   CELL RESEARCH

Helicobacter pylori-induced activation-induced cytidine deaminase expression and carcinogenesis

(2010) Hiroyuki Marusawa et al.   CURRENT OPINION IN IMMUNOLOGY

Up-regulation of Activation-Induced Cytidine Deaminase Causes Genetic Aberrations at the CDKN2b-CDKN2a in Gastric Cancer

(2010) Yuko Matsumoto et al.   GASTROENTEROLOGY

Differential B-lymphocyte regulation by CD40 and its viral mimic, latent membrane protein 1

(2010) John P. Graham et al.   IMMUNOLOGICAL REVIEWS

Preventing AID, a physiological mutator, from deleterious activation: regulation of the genomic instability that is associated with antibody diversity

(2010) H. Nagaoka et al.   INTERNATIONAL IMMUNOLOGY

GANP-mediated Recruitment of Activation-induced Cytidine Deaminase to Cell Nuclei and to Immunoglobulin Variable Region DNA

(2010) Kazuhiko Maeda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Estrogen Receptors Bind to and Activate theHOXC4/HoxC4Promoter to Potentiate HoxC4-mediated Activation-induced Cytosine Deaminase Induction, Immunoglobulin Class Switch DNA Recombination, and Somatic Hypermutation

(2010) Thach Mai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of activation-induced deaminase stability and antibody gene diversification by Hsp90

(2010) Alexandre Orthwein et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Involvement of activation-induced cytidine deaminase in the development of colitis-associated colorectal cancers

(2010) Yoko Endo et al.   JOURNAL OF GASTROENTEROLOGY

The Xs and Y of immune responses to viral vaccines

(2010) Sabra L Klein et al.   LANCET INFECTIOUS DISEASES

The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88

(2010) Bing He et al.   NATURE IMMUNOLOGY

The splicing regulator PTBP2 interacts with the cytidine deaminase AID and promotes binding of AID to switch-region DNA

(2010) Urszula Nowak et al.   NATURE IMMUNOLOGY

Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes

(2010) Arito Yamane et al.   NATURE IMMUNOLOGY

Widespread genomic breaks generated by activation-induced cytidine deaminase are prevented by homologous recombination

(2010) Muneer G Hasham et al.   NATURE IMMUNOLOGY

14-3-3 adaptor proteins recruit AID to 5′-AGCT-3′–rich switch regions for class switch recombination

(2010) Zhenming Xu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Histone H2A and H2B Are Monoubiquitinated at AID-Targeted Loci

(2010) Glen M. Borchert et al.   PLoS One

The Interaction between AID and CIB1 Is Nonessential for Antibody Gene Diversification by Gene Conversion or Class Switch Recombination

(2010) Zachary L. Demorest et al.   PLoS One

A single-molecule characterization of p53 search on DNA

(2010) A. Tafvizi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone3 lysine4 trimethylation regulated by the facilitates chromatin transcription complex is critical for DNA cleavage in class switch recombination

(2010) A. Stanlie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lupus-prone MRL/faslpr/lprmice display increased AID expression and extensive DNA lesions, comprising deletions and insertions, in the immunoglobulin locus: Concurrent upregulation of somatic hypermutation and class switch DNA recombination

(2009) Hong Zan et al.   AUTOIMMUNITY

Imatinib Resistance and Progression of CML to Blast Crisis: Somatic Hypermutation AIDing the Way

(2009) Matthew P. Strout et al.   CANCER CELL

The B Cell Mutator AID Promotes B Lymphoid Blast Crisis and Drug Resistance in Chronic Myeloid Leukemia

(2009) Lars Klemm et al.   CANCER CELL

The roles of TLRs, RLRs and NLRs in pathogen recognition

(2009) T. Kawai et al.   INTERNATIONAL IMMUNOLOGY

Immunoglobulin switch μ sequence causes RNA polymerase II accumulation and reduces dA hypermutation

(2009) Deepa Rajagopal et al.   JOURNAL OF EXPERIMENTAL MEDICINE

S region sequence, RNA polymerase II, and histone modifications create chromatin accessibility during class switch recombination

(2009) Lili Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The activation-induced cytidine deaminase (AID) efficiently targets DNA in nucleosomes but only during transcription

(2009) Hong Ming Shen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Estrogen directly activates AID transcription and function

(2009) Siim Pauklin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

AID Produces DNA Double-Strand Breaks in Non-Ig Genes and Mature B Cell Lymphomas with Reciprocal Chromosome Translocations

(2009) Davide F. Robbiani et al.   MOLECULAR CELL

HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutation

(2009) Seok-Rae Park et al.   NATURE IMMUNOLOGY

A coming-of-age story: activation-induced cytidine deaminase turns 10

(2009) Rebecca K Delker et al.   NATURE IMMUNOLOGY

Specific recruitment of protein kinase A to the immunoglobulin locus regulates class-switch recombination

(2009) Bao Q Vuong et al.   NATURE IMMUNOLOGY

B cell–specific and stimulation-responsive enhancers derepress Aicda by overcoming the effects of silencers

(2009) Thinh Huy Tran et al.   NATURE IMMUNOLOGY

Increased Expression of Activation-Induced Cytidine Deaminase is Associated with Anti-CCP and Rheumatoid Factor in Rheumatoid Arthritis

(2009) X. Xu et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

How Location Governs Toll-Like Receptor Signaling

(2009) Akanksha Chaturvedi et al.   TRAFFIC

Estradiol improves genital herpes vaccine efficacy in mice

(2009) Jeffry W. Pennock et al.   VACCINE

Sex Differences in Autoimmune Disease from a Pathological Perspective

(2008) DeLisa Fairweather et al.   AMERICAN JOURNAL OF PATHOLOGY

AID Is Required for the Chromosomal Breaks in c-myc that Lead to c-myc/IgH Translocations

(2008) Davide F. Robbiani et al.   CELL

Evidence for a Pathogenic Determinant in HIV-1 Nef Involved in B Cell Dysfunction in HIV/AIDS

(2008) Simon Swingler et al.   Cell Host & Microbe

The B Cell Receptor Governs the Subcellular Location of Toll-like Receptor 9 Leading to Hyperresponses to DNA-Containing Antigens

(2008) Akanksha Chaturvedi et al.   IMMUNITY

MicroRNA-155 Is a Negative Regulator of Activation-Induced Cytidine Deaminase

(2008) Grace Teng et al.   IMMUNITY

MicroRNA-155 Suppresses Activation-Induced Cytidine Deaminase-Mediated Myc-Igh Translocation

(2008) Yair Dorsett et al.   IMMUNITY

Restricting activation-induced cytidine deaminase tumorigenic activity in B lymphocytes

(2008) Rafael Casellas et al.   IMMUNOLOGY

Activation-induced deaminase heterozygous MRL/lpr mice are delayed in the production of high-affinity pathogenic antibodies and in the development of lupus nephritis

(2008) Chuancang Jiang et al.   IMMUNOLOGY

AID expression levels determine the extent ofcMyconcogenic translocations and the incidence of B cell tumor development

(2008) Makiko Takizawa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

miR-181b negatively regulates activation-induced cytidine deaminase in B cells

(2008) Virginia G. de Yébenes et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Proteasomal degradation restricts the nuclear lifespan of AID

(2008) Said Aoufouchi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hormonal regulation of B-cell function and systemic lupus erythematosus

(2008) JFG Cohen-Solal et al.   LUPUS

Interaction between Antibody-Diversification Enzyme AID and Spliceosome-Associated Factor CTNNBL1

(2008) Silvestro G. Conticello et al.   MOLECULAR CELL

Two levels of protection for the B cell genome during somatic hypermutation

(2008) Man Liu et al.   NATURE

Haploinsufficiency of Activation-Induced Deaminase for Antibody Diversification and Chromosome Translocations both In Vitro and In Vivo

(2008) Isora V. Sernández et al.   PLoS One

Induction of IgG3 to LPS via Toll-Like Receptor 4 Co-Stimulation

(2008) Francisco J. Quintana et al.   PLoS One