Review
Immunology
Johan Ronnelid, Carl Turesson, Alf Kastbom
Summary: Measurement of autoantibodies like RF and ACPA is crucial in the diagnosis and treatment of RA, but lack of harmonization between different commercial tests poses a challenge. It is recommended that all RF and ACPA tests should have a diagnostic specificity of 98-99%, and the introduction of test result-specific likelihood ratios can provide more precise information for clinical decision-making. Detection of autoantibodies can also be used to predict future arthritis development and prognosis in at-risk patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Adil Ahmed Ali, Khalid Eltahir Khalid, Somaya Elhaj Mohammed, Mohammed Salman Akhtar, Osman Khalafalla Saeed
Summary: The aim of this study was to determine the frequency of HLA class II alleles and haplotypes in Sudanese patients with Rheumatoid Arthritis (RA). The study found that HLA-DRB1*04 and *10 alleles were more common in RA patients, while HLA-DRB1*07 allele was significantly less common. HLA-DQB1*03 allele was strongly associated with RA risk, whereas HLA-DQB1*02 and *06 showed protective effects against RA. Several specific HLA haplotypes were also found to be significantly associated with RA risk or protection.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Twana Alkasalias, Juan Zhang, Harsha Madapura, Basile Dalarun, Oscar Bedoya Reina, Rolf Lewensohn, Kristina Viktorsson, Abbas Salihi, Suhas Darekar, Sonia Lain
Summary: This study aims to explore strategies to protect activated T cells from DHODH inhibitors and identify cancer types hypersensitive to these inhibitors. The findings suggest that selecting patients with low-CDA expressing cancers in combination with strategies to increase cytidine or the cytidine/uridine ratio in the extracellular environment can improve the therapeutic index of DHODH inhibitors.
CELL DEATH DISCOVERY
(2022)
Article
Medicine, General & Internal
Miriam Fabiola Ayon-Perez, Jonathan Joseph Topete-Cordoba, Juan Manuel Agraz-Cibrian, Liliana Ortiz-Martinez, Ma De Jesus Duran-Avelar, Alejandro Vazquez-Reyes, Norberto Vibanco-Perez, Jorge Gutierrez-Franco, Jose Francisco Zambrano-Zaragoza
Summary: Rheumatoid arthritis is an autoimmune disease characterized by inflammation in joints, with the NFkB gene polymorphism rs28362491 showing associations with antibody levels and health assessment index in patients, though no significant risk or protective association was identified.
Article
Immunology
Seyed Askar Roghani, Ramin Lotfi, Masood Ghasemzade Soroush, Ali Khorasanizadeh, Parisa Feizollahi, Shirin Assar, Parviz Soufivand, Mehran Pournazari, Zahra Mohammadi Kish, Mahdi Taghadosi
Summary: The gene expression of CCR6 and ROR gamma t is increased in peripheral blood leukocytes of new case RA patients, and it is positively correlated with disease activity and antibody levels.
IMMUNITY INFLAMMATION AND DISEASE
(2023)
Article
Medicine, General & Internal
Vincent Ricchiuti, Kelly Y. Chun, Jane M. Yang, Mary Ann Aure, Luis Gomez, Gary L. Norman, Michael Mahler
Summary: Anti-carbamylated protein (CarP) antibodies can serve as novel markers for the diagnosis and prognosis of rheumatoid arthritis. The study found that anti-CarP antibodies can be detected in both anti-cyclic citrullinated peptide (CCP), rheumatoid factor (RF), and 14-3-3 eta-positive and negative patients, potentially identifying specific subsets of patients.
Article
Biochemistry & Molecular Biology
Guo-Zheng Pang, Ya-Hui Zhao, Yuan-Xian Wang, Shao-Qin Rong, Hai Gao, Dan Zhou
Summary: Oxidized methylcytidines 5-hydroxymethyl-20deoxycytidine (5hmdC) and 5-formy-20deoxycytidine (5fdC) are deaminated by cytidine deaminase (CDA) into genome-toxic variants of uridine, triggering DNA damage and cell death. Our study found that cancer cells infected with mycoplasma exhibited increased sensitivity to 5hmdC and 5fdC, independent of CDA expression. Biochemical assays showed that mycoplasma CDA was capable of deaminating 5hmdC and 5fdC, and administration of Tetrahydrouridine (THU) attenuated the effect, suggesting that intratumoral microbes could enhance the tumor-killing effect of oxidized methylcytidines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Takashi Iizuka, Kousho Wakae, Masanori Ono, Takuma Suzuki, Yasunari Mizumoto, Kouichi Kitamura, Shin-ichi Horike, Masamichi Muramatsu, Hiroshi Fujiwara
Summary: The study revealed that AID plays a significant role in regulating the expression of GDF-9 and SCF in the ovary, possibly through a GDF-9 and SCF feedback system to modulate communication between oocytes and granulosa cells.
SCIENTIFIC REPORTS
(2021)
Article
Rheumatology
Dina Anas Abdel Hai Hussin, Reham M. Shaat, Shereen Salah Metwally, Manal Awad
Summary: The study results indicate that serum levels of 14-3-3 eta are significantly elevated in rheumatoid arthritis patients, serving as a valuable marker for diagnosis. Additionally, serum 14-3-3 eta may also have prognostic value in RA patients.
CLINICAL RHEUMATOLOGY
(2021)
Article
Rheumatology
Laura C. Cappelli, Clifton O. Bingham, Patrick M. Forde, Valsamo Anagnostou, Julie Brahmer, Evan J. Lipson, Jennifer Mammen, Megan Schollenberger, Ami A. Shah, Erika Darrah
Summary: Anti-RA33 antibodies are present in a subset of patients with ICI-induced IA, but absent in other patients treated with immune checkpoint inhibitors. Anti-RA33 antibodies may be a biomarker for developing inflammatory arthritis.
Article
Biochemistry & Molecular Biology
Haejeong Heo, Jong-Hwan Kim, Hyun Jung Lim, Jeong-Hwan Kim, Miso Kim, Jaemoon Koh, Joo-Young Im, Bo-Kyung Kim, Misun Won, Ji-Hwan Park, Yang-Ji Shin, Mi Ran Yun, Byoung Chul Cho, Yong Sung Kim, Seon-Young Kim, Mirang Kim
Summary: Targeting cytidine deaminase metabolism represents a potential new therapeutic strategy for overcoming ALK inhibitor resistance in non-small-cell lung cancer.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Sameh S. Gad, Ahmed M. Fayez, Mahmoud Abdelaziz, Doaa Abou El-ezz
Summary: The study explored the potential beneficial effects of zinc oxide nanoparticles on rheumatoid arthritis. Results showed that the nanoparticles attenuated inflammatory mediators and autoimmunity in rats. The findings emphasize the potential for using nanoparticles in combination with existing treatments for improved control of RA.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Karim Samy El-Said, Amira Atta, Maysa A. Mobasher, Mousa O. Germoush, Tarek M. Mohamed, Maha M. Salem
Summary: The study evaluated the inhibitory effect of quercetin on ADA enzyme activity, as well as its combination effect with methotrexate in treating inflammation. The findings showed that quercetin inhibited ADA activity in joint tissues and exhibited anti-inflammatory effects in a rat RA model. Furthermore, quercetin enhanced the efficacy of methotrexate and reduced its toxic effects.
MOLECULAR MEDICINE
(2022)
Article
Rheumatology
Mehran Pournazari, Parisa Feizollahi, Seyed Askar Roghani, Shirin Assar, Parviz Soufivand, Bijan Soleymani, Fariborz Bahrehmand, Zahra Mohammadi Kish, Mahdi Taghadosi
Summary: The study revealed that the plasma levels of CCL20 are elevated in newly diagnosed RA patients, with a significant positive correlation with rheumatoid factor, anti-citrullinated peptide antibodies, ESR, and DAS-28.
CLINICAL RHEUMATOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Baole Qu, Yun Zhao, Lili An, Haiying Hang
Summary: This study demonstrates that adenine deaminase (ADA) can efficiently induce random A/T to G/C mutations on the target gene in CHO cell display, and can be applied in affinity maturation to improve antibody affinity. The combined use of ADA and activation-induced cytidine deaminase (AID) provides more mutant types, offering an opportunity to acquire new mutants with higher affinities than those obtained by only using AID.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Immunology
Hilal Uensal, Canan Caka, Hacer Neslihan Bildik, Saliha Esenboga, Alphan Kupesiz, Baris Kuskonmaz, Duygu Uckan Cetinkaya, Mirjam van Der Burg, Ilhan Tezcan, Deniz Cagdas
Summary: The study investigated the demographic, clinical, laboratory, follow-up, and treatment characteristics of 21 patients with Major Histocompatibility Complex Class II (MHC-II) deficiency. It was found that patients with Bare Lymphocyte Syndrome (BLS) exhibited clinical findings similar to severe combined immunodeficiency (SCID), and the flow cytometric MHC-II expression study played a crucial role in the diagnosis, differential diagnosis, early hematopoietic stem cell transplantation (HSCT), and post-HSCT follow-up.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2024)
Article
Immunology
Axel Rosell, Cecilia Karlstrom, Joakim S. Dahlin, Daryl Boey, Monika Klimkowska, Kajsa Ax, Charlotte Thalin, Johanna Ungerstedt
Summary: There is no evidence of global increase in neutrophil extracellular trap release in patients with systemic mastocytosis.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2024)
Article
Immunology
Charles W. Armitage, Connor P. O'Meara, Emily R. Bryan, Avinash Kollipara, Logan K. Trim, Danica Hickey, Alison J. Carey, Wilhelmina M. Huston, Gavin Donnelly, Anusch Yazdani, Richard S. Blumberg, Kenneth W. Beagley
Summary: This study demonstrates that IgG seroconversion during male infection can amplify female immunopathology and infertility. IgG transcytosis through the FcRn receptor allows Chlamydia to cross the epithelial barrier and be phagocytosed by antigen-presenting cells. This leads to increased pro-inflammatory signaling and T cell proliferation, resulting in more severe pathology and infertility in female mice.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2024)
Article
Immunology
Fatma Gonca Kocanci, Azize Yasemin Goksu Erol, Fatma Yildiz, Hamiyet Eciroglu
Summary: Calcineurin inhibitors, such as pimecrolimus, have been found to have preventive effects against neuroinflammation and apoptotic pathways, which are underlying mechanisms in neurodegenerative diseases. This study demonstrated that pimecrolimus exerts neuroprotective effects by inhibiting inflammation and oxidative stress, making it a potential treatment option for neurodegenerative diseases.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2024)