Glyco-engineering in plants to produce human-like N-glycan structures

Branched N-glycans and their implications for cell adhesion, signaling and clinical applications for cancer biomarkers and in therapeutics

(2012) Naoyuki Taniguchi et al.   BMB Reports

Production of Plant Made Pharmaceuticals: From Plant Host to Functional Protein

(2012) B. Nagels et al.   CRITICAL REVIEWS IN PLANT SCIENCES

Moss-based production of asialo-erythropoietin devoid of Lewis A and other plant-typical carbohydrate determinants

(2012) Juliana Parsons et al.   PLANT BIOTECHNOLOGY JOURNAL

Controlled-release interferon alpha 2b, a new member of the interferon family for the treatment of chronic hepatitis C

(2011) Peter LM Jansen et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

N-Glycosylation engineering of plants for the biosynthesis of glycoproteins with bisected and branched complex N-glycans

(2011) Alexandra Castilho et al.   GLYCOBIOLOGY

β-N-Acetylhexosaminidases HEXO1 and HEXO3 Are Responsible for the Formation of PaucimannosidicN-Glycans inArabidopsis thaliana

(2011) Eva Liebminger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sub-Compartmental Organization of Golgi-Resident N-Glycan Processing Enzymes in Plants

(2011) Jennifer Schoberer et al.   Molecular Plant

What's fueling the biotech engine—2010 to 2011

(2011) Saurabh Aggarwal   NATURE BIOTECHNOLOGY

Glycoproteins are species-specific markers and major IgE reactants in grass pollens

(2011) Hélène Manduzio et al.   PLANT BIOTECHNOLOGY JOURNAL

Production of recombinant human granulocyte macrophage-colony stimulating factor in rice cell suspension culture with a human-like N-glycan structure

(2011) Yun-Ji Shin et al.   PLANT BIOTECHNOLOGY JOURNAL

Production of Complex Multiantennary N-Glycans in Nicotiana benthamiana Plants

(2011) B. Nagels et al.   PLANT PHYSIOLOGY

Expression of Antibody Fragments with a Controlled N-Glycosylation Pattern and Induction of Endoplasmic Reticulum-Derived Vesicles in Seeds of Arabidopsis

(2011) A. Loos et al.   PLANT PHYSIOLOGY

Rapid High Yield Production of Different Glycoforms of Ebola Virus Monoclonal Antibody

(2011) Alexandra Castilho et al.   PLoS One

Enhanced potency of a fucose-free monoclonal antibody being developed as an Ebola virus immunoprotectant

(2011) L. Zeitlin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

N-Glycosylation engineering of lepidopteran insect cells by the introduction of the  1,4-N-acetylglucosaminyltransferase III gene

(2010) T. Okada et al.   GLYCOBIOLOGY

In PlantaProtein Sialylation through Overexpression of the Respective Mammalian Pathway

(2010) Alexandra Castilho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reduction of N-linked xylose and fucose by expression of rat β1,4-N-acetylglucosaminyltransferase III in tobacco BY-2 cells depends on Golgi enzyme localization domain and genetic elements used for expression

(2010) Saskia R. Karg et al.   JOURNAL OF BIOTECHNOLOGY

Fc-Glycosylation Influences Fc  Receptor Binding and Cell-Mediated Anti-HIV Activity of Monoclonal Antibody 2G12

(2010) D. N. Forthal et al.   JOURNAL OF IMMUNOLOGY

Biopharmaceutical benchmarks 2010

(2010) Gary Walsh   NATURE BIOTECHNOLOGY

Development trends for human monoclonal antibody therapeutics

(2010) Aaron L. Nelson et al.   NATURE REVIEWS DRUG DISCOVERY

Production of pharmaceutical-grade recombinant aprotinin and a monoclonal antibody product using plant-based transient expression systems

(2010) Gregory P. Pogue et al.   PLANT BIOTECHNOLOGY JOURNAL

The production of hemagglutinin-based virus-like particles in plants: a rapid, efficient and safe response to pandemic influenza

(2010) Marc-André D’Aoust et al.   PLANT BIOTECHNOLOGY JOURNAL

Synthesis of Lewis X epitopes on plant N-glycans

(2009) Gerard J.A. Rouwendal et al.   CARBOHYDRATE RESEARCH

N-glycosylation Engineering of Biopharmaceutical Expression Systems

(2009) P. Jacobs et al.   CURRENT MOLECULAR MEDICINE

Improved Virus Neutralization by Plant-produced Anti-HIV Antibodies with a Homogeneous β1,4-GalactosylatedN-Glycan Profile

(2009) Richard Strasser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The repertoire of glycan determinants in the human glycome

(2009) Richard D. Cummings   Molecular BioSystems

Glycosylation as a strategy to improve antibody-based therapeutics

(2009) Roy Jefferis   NATURE REVIEWS DRUG DISCOVERY

Transient co-expression for fast and high-yield production of antibodies with human-likeN-glycans in plants

(2009) Louis-P. Vézina et al.   PLANT BIOTECHNOLOGY JOURNAL

pEAQ: versatile expression vectors for easy and quick transient expression of heterologous proteins in plants

(2009) Frank Sainsbury et al.   PLANT BIOTECHNOLOGY JOURNAL

A CMP-sialic acid transporter cloned from Arabidopsis thaliana

(2008) Hans Bakker et al.   CARBOHYDRATE RESEARCH

Cetuximab-Induced Anaphylaxis and IgE Specific for Galactose-α-1,3-Galactose

(2008) Christine H. Chung et al.   NEW ENGLAND JOURNAL OF MEDICINE

Down-regulated expression of plant-specific glycoepitopes in alfalfa

(2008) Christophe Sourrouille et al.   PLANT BIOTECHNOLOGY JOURNAL

Biochemical and functional characterization of anti-HIV antibody-ELP fusion proteins from transgenic plants

(2008) Doreen M. Floss et al.   PLANT BIOTECHNOLOGY JOURNAL

Generation of glyco-engineered Nicotiana benthamiana for the production of monoclonal antibodies with a homogeneous human-like N-glycan structure

(2008) Richard Strasser et al.   PLANT BIOTECHNOLOGY JOURNAL

Expression of rat β(1,4)-N-acetylglucosaminyltransferase III inNicotiana tabacumremodels the plant-specificN-glycosylation

(2008) Alexander D. Frey et al.   PLANT BIOTECHNOLOGY JOURNAL

Construction of a Functional CMP-Sialic Acid Biosynthesis Pathway in Arabidopsis

(2008) A. Castilho et al.   PLANT PHYSIOLOGY

Analysis of immunoglobulin glycosylation by LC-ESI-MS of glycopeptides and oligosaccharides

(2008) Johannes Stadlmann et al.   PROTEOMICS

Recapitulation of IVIG Anti-Inflammatory Activity with a Recombinant IgG Fc

(2008) R. M. Anthony et al.   SCIENCE

Intermediate Organelles of the Plant Secretory Pathway: Identity and Function

(2008) Ombretta Foresti et al.   TRAFFIC