Article
Biochemistry & Molecular Biology
Shoko Ueda, Jun Ito, Norihiro Harada, Sonoko Harada, Hitoshi Sasano, Yuuki Sandhu, Yuki Tanabe, Sumiko Abe, Satomi Shiota, Yuzo Kodama, Tetsutaro Nagaoka, Fumihiko Makino, Asako Chiba, Hisaya Akiba, Ryo Atsuta, Sachiko Miyake, Kazuhisa Takahashi
Summary: This study investigated the efficacy of sublingual immunotherapy (SLIT) in asthmatic patients with seasonal allergic rhinitis (SAR-JCP) and found that SLIT not only significantly improved allergic rhinitis and asthma symptoms, but also improved airway resistance. Moreover, the reduction in peripheral blood gamma delta T cells after SLIT was associated with the improvement of asthma symptoms.
Article
Cell Biology
Waka Ishida, Tatsuma Kishimoto, Fumio Takaiwa, Ken Fukuda
Summary: Oral administration of transgenic rice seeds expressing a hypoallergenic Bet v 1 derivative showed prophylactic and therapeutic effects in reducing allergic birch pollen conjunctivitis in mice. The treatment resulted in improved clinical scores, reduced eosinophil numbers, and modulation of IL-4 and IFN-gamma production.
Article
Otorhinolaryngology
Tatsuya Fujii, Yoshiaki Kitamura, Seiichiro Kamimura, Keisuke Ishitani, Noriaki Takeda
Summary: This study found that dual sublingual immunotherapy (SLIT) effectively suppressed nasal symptoms in patients with allergic rhinitis (AR) sensitized to both Japanese cedar pollen (JCP) and house dust mite (HDM). Dual-SLIT was more effective in suppressing nasal obstruction during the peak pollen period (PPP) compared to mono-SLIT with JCP.
LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY
(2022)
Article
Allergy
Mari Takei, Charles Nin, Tomona Iizuka, Marine Pawlikowski, Marie-Ange Selva, Yannick Chantran, Yurie Nakajima, Jingkang Zheng, Tomoyasu Aizawa, Motohiro Ebisawa, Helene Senechal, Pascal Poncet
Summary: The Capsicum genus belongs to the Solanaceae family and is rarely associated with allergies. Cross-reactivities have been reported with other allergens such as latex. Only two allergens from Capsicum have been referenced in the World Health Organization/International Union of Immunological Societies allergen data bank.
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Nanae Nagata, Tomoka Suzuki, Shinya Takenouchi, Koji Kobayashi, Takahisa Murata
Summary: The eicosapentaenoic acid metabolite (+/-)5(6)-dihydroxy-8Z,11Z,14Z,17Z-eicosatetraenoic acid ((+/-)5(6)-DiHETE) has potential therapeutic effects on allergic conjunctivitis (AC).
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Ophthalmology
Hiroshi Fujishima, Tomoko Hasunuma, Tetsuya Kawakita, Takuro Sekiya, Paul Gomes, David A. Hollander
Summary: The study demonstrates that once-daily Alcaftadine 0.25% is safe and effective in preventing signs and symptoms of Japanese cedar-pollen allergic conjunctivitis, with significant relief of ocular itching, reduction in conjunctival hyperemia, and good tolerability among most subjects.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2021)
Article
Biochemistry & Molecular Biology
Takashi Kanno, Changmin Kim, Daisuke Yamanaka, Ken-ichi Ishibashi, Hiroshi Tanaka, Naohito Ohno, Yoshiyuki Adachi
Summary: The study found that components in Japanese cedar pollen may lead to false positives when testing for deep mycosis. Care should be taken to consider the possibility of contamination from Japanese cedar pollen when conducting tests.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Allergy
Syuji Yonekura, Minoru Gotoh, Shinya Kaneko, Yuriko Maekawa, Kimihiro Okubo, Yoshitaka Okamoto
Summary: Japanese cedar pollen SLIT tablets demonstrated sustained clinical efficacy over 5 years, with the AA group showing the largest relative reduction in total nasal symptom and medication score. The treatment also exhibited disease-modifying effects for at least 2 years post-cessation.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Allergy
Riccardo Asero, Renato Ariano, Arianna Aruanno, Claudio Barzaghi, Paolo Borrelli, Moira Busa, Giorgio Celi, Massimo Cinquini, Gabriele Cortellini, Francesca D'Auria, Marco De Carli, Camilla Di Paolo, Giulia Garzi, Fabio Lodi Rizzini, Monica Magnani, Giuseppina Manzotti, Alessandro Marra, Stefano Miceli Sopo, Francesco Murzilli, Eleonora Nucera, Elena Pinter, Valerio Pravettoni, Federica Rivolta, Angela Rizzi, Nicoletta Saporiti, Enrico Scala, Danilo Villalta, Mona-Rita Yacoub, Giuliana Zisa
Summary: The study found that systemic reactions induced by PR-10 and profilin are facilitated by PPI, ingestion of large amounts of unprocessed foods, and fasting. Soybean beverages represent a risk for PR-10 hypersensitive patients.
Article
Allergy
Tomonori Endo, Daiya Asaka, Tsuguhisa Nakayama, Shota Saito, Hiroki Kodama, Ryoto Mitsuyoshi, Shinya Takaishi, Naoki Sugimoto, Sachiko Omae, Hidenori Takagi, Yuhya Wakasa, Kenjiro Ozawa, Makoto Takano, Fumio Takaiwa, Hiromi Kojima, Saburo Saito
Summary: Oral intake of transgenic rice significantly reduced allergen-specific T-cell responses in a dose-dependent manner, but did not improve medication scores or QOL symptom scores during the JC pollen season after 20 weeks of intake.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2021)
Review
Microbiology
Daiju Sakurai, Hiroki Ishii, Ayumi Shimamura, Daisuke Watanabe, Takaaki Yonaga, Tomokazu Matsuoka
Summary: The incidence of Japanese cedar pollinosis is increasing significantly in Japan. Allergen immunotherapy is the only fundamental treatment that modifies the natural course of allergic rhinitis and provides long-term remission. Sublingual immunotherapy has been developed and proven to have long-term efficacy and safety.
Article
Environmental Sciences
Weixuan Sheng, Aizhu Liu, Hong Peng, Jia Wang, Lei Guan
Summary: This study investigated the correlation between atmospheric pollen concentration and daily visits for allergic conjunctivitis. The results showed a moderate positive correlation between pollen concentration and visits for allergic conjunctivitis. Elevated concentrations of pollen increased the risk of allergic conjunctivitis, with a time lag effect.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Plant Sciences
Hiroyuki Kakui, Eriko Tsurisaki, Rei Shibata, Yoshinari Moriguchi
Summary: Genetic variation, male strobilus weight, and pollen size are the main factors affecting the pollen number in Japanese cedar. The pollen numbers vary significantly among different clones, with environmental conditions having a less significant impact. Understanding these factors will aid in breeding strategies to combat pollinosis.
Review
Allergy
Dai Miyazaki, Atsuki Fukushima, Eiichi Uchio, Jun Shoji, Kenichi Namba, Nobuyuki Ebihara, Etsuko Takamura, Ken Fukuda, Akira Matsuda, Shigeki Okamoto, Kazumi Fukagawa, Hiroshi Fujishima, Shigeaki Ohno, Yuichi Ohashi
Summary: This article summarizes the third edition of the Japanese guidelines for allergic conjunctival diseases, outlining the diagnosis, pathogenesis, and treatment of ACD, with a focus on the use of steroids and immunosuppressive drugs. This knowledge will assist healthcare providers and patients in making informed decisions regarding treatment.
ALLERGOLOGY INTERNATIONAL
(2022)
Article
Allergy
Yasuyuki Nomura, Kimihiro Okubo, Tadashi Nakamura, Seiji Sawaki, Hideto Kitagou, Norio Idei, Shinya Kaneko, Satoko Kobayashi, Yusuke Tanaka, Yoshitaka Okamoto
Summary: This study found that long-term use of JC pollen SLIT drops can continuously improve nasal and ocular symptoms in patients with JC pollinosis, and reduce the frequency of rescue medication use. The research also showed that the efficacy of JC pollen SLIT drops can persist for 2 years after treatment cessation.
ALLERGOLOGY INTERNATIONAL
(2021)
Article
Ophthalmology
Koji Sugioka, Ken Fukuda, Teruo Nishida, Shunji Kusaka
Summary: The cornea is a unique tissue lacking blood vessels, receiving nutrients and oxygen through diffusion from aqueous humor and limbal vessels, and relying on mechanisms such as the fibrinolytic system for healing and defense. Fibrinolytic factors play a crucial role in the biological defense of the cornea.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Ophthalmology
Ken Fukuda, Tomoka Mizobuchi, Tatsuma Kishimoto, Yusaku Miura, Takashi Nishiuchi, Kazuyuki Yoshida, Atsuki Fukushima
Summary: In this study, evaluation of intraocular inflammation in Japanese patients with cat-scratch disease revealed that white retinal or retinochoroidal foci were the most common manifestations in the posterior segment of the eye, suggesting a possible diagnosis of the disease. Symptoms such as high fever, decreased visual acuity, retinitis, and macular star may also be associated with ocular complications of cat-scratch disease.
JAPANESE JOURNAL OF OPHTHALMOLOGY
(2021)
Letter
Ophthalmology
Isana Nakajima, Yoshinori Taniguchi, Tomoka Mizobuchi, Tatsuma Kishimoto, Atsuki Fukushima, Ken Fukuda
Summary: This case report highlights the use of color Doppler ultrasonography and MRI in diagnosing optic neuropathy, demonstrating their utility as rapid, convenient, and noninvasive tools for differential diagnosis.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2022)
Editorial Material
Ophthalmology
Ken Fukuda, Yusaku Miura, Mitsuko Iguchi
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Letter
Rheumatology
Isana Nakajima, Yoshinori Taniguchi, Hideki Tsuji, Tomoka Mizobuchi, Ken Fukuda
Article
Medicine, General & Internal
Yusaku Miura, Ken Fukuda
Summary: This study compared the clinical outcomes of ab interno microhook trabeculotomy (mu LOT) before and after cataract surgery, and found that performing mu LOT before cataract surgery may reduce the risk of postoperative hyphema with niveau formation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Editorial Material
Ophthalmology
Minori Kumada, Tamaki Sumi, Mitsuko Iguchi, Naoyuki Yamada, Ken Fukuda, Kenji Yamashiro
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Tatsuma Kishimoto, Waka Ishida, Isana Nakajima, Osamu Taguchi, Koji Sugioka, Shunji Kusaka, Ken Fukuda
Summary: Mast cells and conjunctival fibroblasts play important roles in conjunctival wound healing and allergic ocular inflammation. Mast cells can accelerate the contraction of collagen gel by increasing the release and activation of metalloproteinases (MMPs) in conjunctival fibroblasts, potentially contributing to conjunctival scar formation after glaucoma filtering surgery.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Tatsuma Kishimoto, Waka Ishida, Isana Nakajima, Ken Fukuda, Kenji Yamashiro
Summary: Dry eye disease (DED) and allergic conjunctivitis have interactions and can exacerbate each other in mice, leading to ocular surface epithelial damage and aggravated allergic signs and symptoms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Ophthalmology
Tomoka Mizobuchi, Takashi Nishiuchi, Yusaku Miura, Ken Fukuda
Summary: Coats disease is a retinal vascular disorder characterized by aneurysms and telangiectasias. This case report describes an unusual case of spontaneous peeling of preretinal macular fibrosis in a patient with untreated Coats disease.
Review
Cell Biology
Ken Fukuda, Waka Ishida, Tatsuma Kishimoto, Isana Nakajima, Yusaku Miura, Tamaki Sumi, Kenji Yamashiro
Summary: Severe ocular allergic diseases can cause damage to ocular tissues and inflammation, leading to visual impairments. Research has shown that damage-associated molecular patterns (DAMPs/alarmins) play a critical role in the pathogenesis of these diseases and may be a potential therapeutic target.
Review
Allergy
Dai Miyazaki, Atsuki Fukushima, Eiichi Uchio, Jun Shoji, Kenichi Namba, Nobuyuki Ebihara, Etsuko Takamura, Ken Fukuda, Akira Matsuda, Shigeki Okamoto, Kazumi Fukagawa, Hiroshi Fujishima, Shigeaki Ohno, Yuichi Ohashi
Summary: This article summarizes the third edition of the Japanese guidelines for allergic conjunctival diseases, outlining the diagnosis, pathogenesis, and treatment of ACD, with a focus on the use of steroids and immunosuppressive drugs. This knowledge will assist healthcare providers and patients in making informed decisions regarding treatment.
ALLERGOLOGY INTERNATIONAL
(2022)
Review
Allergy
Ken Fukuda, Tatsuma Kishimoto, Tamaki Sumi, Kenji Yamashiro, Nobuyuki Ebihara
Summary: The use of biologics targeting specific antibodies and receptors has significantly improved the treatment outcomes in allergic diseases. However, these drugs have not been approved for ocular allergic diseases. While some studies have reported beneficial effects, adverse ocular symptoms have also been observed. Different biologics may have specific effects on different ocular allergies, and allergists must fully understand the effects of each drug on the eye. This review outlines the potential therapeutic and adverse effects of various biologics on allergic diseases of the eye.
ALLERGOLOGY INTERNATIONAL
(2023)
Review
Biochemistry & Molecular Biology
Teruo Nishida, Koji Sugioka, Ken Fukuda, Junko Murakami
Summary: The shape and transparency of the cornea are crucial for vision clarity, but its susceptibility to pathogenic microorganisms can lead to bacterial keratitis and potentially corneal ulcers. Timely diagnosis and treatment are essential for successful management of bacterial keratitis, as progression to corneal ulcer can cause collagen degradation and serious complications. In corneal ulcer, corneal fibroblasts play a central role in collagen destruction, with a cascade of reactions involving uPA, plasmin, MMPs, interleukin-8, and ICAM-1 contributing to tissue damage and inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Tadahiro Nasukawa, Ryosuke Sugimoto, Jumpei Uchiyama, Iyo Takemura-Uchiyama, Hironobu Murakami, Ken Fukuda, Shigenobu Matsuzaki, Masahiro Sakaguchi
Summary: In this study, high-performance flow cytometry was used to analyze membrane vesicles (MVs) from Gram-positive bacteria, Staphylococcus aureus and Bacillus subtilis, showing that flow cytometric sorting provided higher purity and uniformity compared to gradient isolation alone. The MV purification method using flow cytometry should be useful for applications requiring very high purity of MV samples such as proteomic, metagenomic, or lipidomic studies.
RESEARCH IN MICROBIOLOGY
(2021)