Molecular farming on rescue of pharma industry for next generations

Potential and Emerging Treatment Options for Ebola Virus Disease

(2014) Bryan M. Bishop   ANNALS OF PHARMACOTHERAPY

Plant Molecular Pharming for the Treatment of Chronic and Infectious Diseases

(2014) Eva Stoger et al.   Annual Review of Plant Biology

Developing inexpensive malaria vaccines from plants and algae

(2014) James A. Gregory et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Plant-based vaccines for Alzheimer's disease: an overview

(2014) Sergio Rosales-Mendoza et al.   Expert Review of Vaccines

Next-generation therapeutics

(2014) Ernesto Andrianantoandro   TRENDS IN BIOTECHNOLOGY

Plant-based vaccines against viruses

(2014) Edward P Rybicki   Virology Journal

Plant Virus Expression Vector Development: New Perspectives

(2014) Kathleen Hefferon   Biomed Research International

Soybean Seeds: A Practical Host for the Production of Functional Subunit Vaccines

(2014) Laura C. Hudson et al.   Biomed Research International

The use of rice seeds to produce human pharmaceuticals for oral therapy

(2013) Yuhya Wakasa et al.   Biotechnology Journal

Seeds as a Production System for Molecular Pharming Applications: Status and Prospects

(2013) Maite Sabalza et al.   CURRENT PHARMACEUTICAL DESIGN

Molecular Farming of Pharmaceutical Proteins Using Plant Suspension Cell and Tissue Cultures

(2013) Stefan Schillberg et al.   CURRENT PHARMACEUTICAL DESIGN

Hybrid Viral Vectors for Vaccine and Antibody Production in Plants

(2013) Vidadi Yusibov et al.   CURRENT PHARMACEUTICAL DESIGN

GoldenBraid 2.0: A Comprehensive DNA Assembly Framework for Plant Synthetic Biology

(2013) A. Sarrion-Perdigones et al.   PLANT PHYSIOLOGY

Immunogenic properties of a lettuce-derived C4(V3)6 multiepitopic HIV protein

(2013) Dania O. Govea-Alonso et al.   PLANTA

Protection of Recombinant Mammalian Antibodies from Development-Dependent Proteolysis in Leaves of Nicotiana benthamiana

(2013) Stéphanie Robert et al.   PLoS One

Optimization of protein purification and characterization using Thermofluor screens

(2013) Stephane Boivin et al.   PROTEIN EXPRESSION AND PURIFICATION

Proteolysis of recombinant proteins in bioengineered plant cells

(2013) Priyen Pillay et al.   Bioengineered

Production platforms for biotherapeutic glycoproteins. Occurrence, impact, and challenges of non-human sialylation

(2012) Darius Ghaderi et al.   Biotechnology & Genetic Engineering Reviews

The use of plants for the production of therapeutic human peptides

(2012) Chiara Lico et al.   PLANT CELL REPORTS

Functional characterization of the recombinant HIV-neutralizing monoclonal antibody 2F5 produced in maize seeds

(2012) M. Sabalza et al.   PLANT MOLECULAR BIOLOGY

Production of unique immunotoxin cancer therapeutics in algal chloroplasts

(2012) M. Tran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GMP issues for recombinant plant-derived pharmaceutical proteins

(2011) Rainer Fischer et al.   BIOTECHNOLOGY ADVANCES

Expression of biologically active human insulin-like growth factor 1 in Arabidopsis thaliana seeds via oleosin fusion technology

(2011) Wei Li et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Plant-made pharmaceuticals: Leading products and production platforms

(2011) Matthew Paul et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Hairy roots cultures from different Solanaceous species have varying capacities to produce E. coli B-subunit heat-labile toxin antigen

(2011) Giorgio De Guzman et al.   BIOTECHNOLOGY LETTERS

Glucose lowering effect of transgenic human insulin-like growth factor-I from rice: in vitro and in vivo studies

(2011) Stanley CK Cheung et al.   BMC BIOTECHNOLOGY

Review Soybeans as bioreactors for biopharmaceuticals and industrial proteins

(2011) G.R. Vianna et al.   GENETICS AND MOLECULAR RESEARCH

Production of active human glucocerebrosidase in seeds of Arabidopsis thaliana complex-glycan-deficient (cgl) plants

(2011) Xu He et al.   GLYCOBIOLOGY

Emerging antibody products and Nicotiana manufacturing

(2011) Kevin J. Whaley et al.   Human vaccines & immunotherapeutics

Clinical development of plant-produced recombinant pharmaceuticals: Vaccines, antibodies and beyond

(2011) Vidadi Yusibov et al.   Human vaccines & immunotherapeutics

Membrane-Based Inverse Transition Cycling: An Improved Means for Purifying Plant-Derived Recombinant Protein-Elastin-Like Polypeptide Fusions

(2011) Hoang Trong Phan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Improved expression and purification of recombinant human serum albumin from transgenic tobacco suspension culture

(2011) Qiao-Yang Sun et al.   JOURNAL OF BIOTECHNOLOGY

The development of a high-yield recombinant protein bioreactor through RNAi induced knockdown of ATP/ADP transporter in Solanum tuberosum

(2011) Reynald Tremblay et al.   JOURNAL OF BIOTECHNOLOGY

Extraction, purification and characterization of the plant-produced HPV16 subunit vaccine candidate E7 GGG

(2011) J.F. Buyel et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Plant production of anti-β-glucan antibodies for immunotherapy of fungal infections in humans

(2011) Cristina Capodicasa et al.   PLANT BIOTECHNOLOGY JOURNAL

Chloroplast biotechnology, genomics and evolution: current status, challenges and future directions

(2011) Jihong Liu Clarke et al.   PLANT MOLECULAR BIOLOGY

The Expression of a Xylanase Targeted to ER-Protein Bodies Provides a Simple Strategy to Produce Active Insoluble Enzyme Polymers in Tobacco Plants

(2011) Immaculada Llop-Tous et al.   PLoS One

A Cost-Effective ELP-Intein Coupling System for Recombinant Protein Purification from Plant Production Platform

(2011) Li Tian et al.   PLoS One

High-level recombinant protein expression in transgenic plants by using a double-inducible viral vector

(2011) S. Werner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-value products from transgenic maize

(2010) Shaista Naqvi et al.   BIOTECHNOLOGY ADVANCES

Advances in plant molecular farming

(2010) Olawole O. Obembe et al.   BIOTECHNOLOGY ADVANCES

Micro-algae come of age as a platform for recombinant protein production

(2010) Elizabeth Specht et al.   BIOTECHNOLOGY LETTERS

Effect of codon optimization and subcellular targeting on Toxoplasma gondii antigen SAG1 expression in tobacco leaves to use in subcutaneous and oral immunization in mice

(2010) Melina Laguía-Becher et al.   BMC BIOTECHNOLOGY

In PlantaProtein Sialylation through Overexpression of the Respective Mammalian Pathway

(2010) Alexandra Castilho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of a Cholera Toxin B Subunit-Neutralizing Epitope of the Porcine Epidemic Diarrhea Virus Fusion Gene in Transgenic Lettuce (Lactuca sativa L.)

(2010) Nguyen-Xuan Huy et al.   MOLECULAR BIOTECHNOLOGY

Production of the 42-kDa fragment of Plasmodium falciparum merozoite surface protein 1, a leading malaria vaccine antigen, in Arabidopsis thaliana seeds

(2010) On Sun Lau et al.   PLANT BIOTECHNOLOGY JOURNAL

Risk-managed production of bioactive recombinant proteins using a novel plant virus vector with a helper plant to complement viral systemic movement

(2010) Noriho Fukuzawa et al.   PLANT BIOTECHNOLOGY JOURNAL

Plant-specific glycosylation patterns in the context of therapeutic protein production

(2010) Véronique Gomord et al.   PLANT BIOTECHNOLOGY JOURNAL

Seed-based expression systems for plant molecular farming

(2010) Joseph Boothe et al.   PLANT BIOTECHNOLOGY JOURNAL

Production of therapeutic proteins in algae, analysis of expression of seven human proteins in the chloroplast of Chlamydomonas reinhardtii

(2010) Beth A. Rasala et al.   PLANT BIOTECHNOLOGY JOURNAL

Success stories in molecular farming-a brief overview

(2010) Loïc Faye et al.   PLANT BIOTECHNOLOGY JOURNAL

Low-cost production of proinsulin in tobacco and lettuce chloroplasts for injectable or oral delivery of functional insulin and C-peptide

(2010) Diane Boyhan et al.   PLANT BIOTECHNOLOGY JOURNAL

The production of hemagglutinin-based virus-like particles in plants: a rapid, efficient and safe response to pandemic influenza

(2010) Marc-André D’Aoust et al.   PLANT BIOTECHNOLOGY JOURNAL

High-level expression of human interferon alpha-2b in transgenic carrot (Daucus carota L.) plants

(2010) Yu. Luchakivskaya et al.   PLANT CELL REPORTS

Expression of an immunogenic F1-V fusion protein in lettuce as a plant-based vaccine against plague

(2010) Sergio Rosales-Mendoza et al.   PLANTA

Accumulation of functional recombinant human coagulation factor IX in transgenic soybean seeds

(2010) Nicolau B. Cunha et al.   TRANSGENIC RESEARCH

Plants as bioreactors for the production of vaccine antigens

(2009) Siddharth Tiwari et al.   BIOTECHNOLOGY ADVANCES

Plants as bioreactors: Recent developments and emerging opportunities

(2009) Arun K. Sharma et al.   BIOTECHNOLOGY ADVANCES

Foreign protein production using plant cell and organ cultures: Advantages and limitations

(2009) Sharon M.-H. Shih et al.   BIOTECHNOLOGY ADVANCES

Inducible gene expression systems and plant biotechnology

(2009) Giandomenico Corrado et al.   BIOTECHNOLOGY ADVANCES

Barley as a green factory for the production of functional Flt3 ligand

(2009) Lýður S. Erlendsson et al.   Biotechnology Journal

Genetically modified plants for non-food or non-feed purposes: Straightforward screening for their appearance in food and feed

(2009) A. Alderborn et al.   FOOD AND CHEMICAL TOXICOLOGY

Influence of elastin-like peptide fusions on the quantity and quality of a tobacco-derived human immunodeficiency virus-neutralizing antibody

(2009) Doreen M. Floss et al.   PLANT BIOTECHNOLOGY JOURNAL

A soybean (Glycine max) polyubiquitin promoter gives strong constitutive expression in transgenic soybean

(2009) Carlos M. Hernandez-Garcia et al.   PLANT CELL REPORTS

Optimization of ELP-intein mediated protein purification by salt substitution

(2009) Baley A. Fong et al.   PROTEIN EXPRESSION AND PURIFICATION

Different subcellular localization and glycosylation for a functional antibody expressed in Nicotiana tabacum plants and suspension cells

(2009) Benoit De Muynck et al.   TRANSGENIC RESEARCH

Stable production of peptide antigens in transgenic tobacco chloroplasts by fusion to the p53 tetramerisation domain

(2009) Susana M. Ortigosa et al.   TRANSGENIC RESEARCH

A novel expression platform for the production of diabetes-associated autoantigen human glutamic acid decarboxylase (hGAD65)

(2008) Xiaofeng Wang et al.   BMC BIOTECHNOLOGY

Plant Molecular Farming: Opportunities and Challenges

(2008) Pervin Basaran et al.   CRITICAL REVIEWS IN BIOTECHNOLOGY

Down-regulated expression of plant-specific glycoepitopes in alfalfa

(2008) Christophe Sourrouille et al.   PLANT BIOTECHNOLOGY JOURNAL

Expression of rat β(1,4)-N-acetylglucosaminyltransferase III inNicotiana tabacumremodels the plant-specificN-glycosylation

(2008) Alexander D. Frey et al.   PLANT BIOTECHNOLOGY JOURNAL

Exhaustion of the chloroplast protein synthesis capacity by massive expression of a highly stable protein antibiotic

(2008) Melanie Oey et al.   PLANT JOURNAL

Improvement of recombinant hGM-CSF production by suppression of cysteine proteinase gene expression using RNA interference in a transgenic rice culture

(2008) Nan-Sun Kim et al.   PLANT MOLECULAR BIOLOGY

Maize plants: An ideal production platform for effective and safe molecular pharming

(2008) Koreen Ramessar et al.   PLANT SCIENCE

Co-expression of proteinase inhibitor enhances recombinant human granulocyte–macrophage colony stimulating factor production in transgenic rice cell suspension culture

(2008) Tae-Geum Kim et al.   PROTEIN EXPRESSION AND PURIFICATION

Is the Drought Over for Pharming?

(2008) J. Kaiser   SCIENCE

Recombinant antibody 2G12 produced in maize endosperm efficiently neutralizes HIV-1 and contains predominantly single-GlcNAc N-glycans

(2007) Thomas Rademacher et al.   PLANT BIOTECHNOLOGY JOURNAL