Overnutrition Determines LPS Regulation of Mycotoxin Induced Neurotoxicity in Neurodegenerative Diseases

Energy intake is associated with endotoxemia in apparently healthy men

(2018) Jacques Amar et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Histidine 14 Modulates Membrane Binding and Neurotoxicity of the Alzheimer's Disease Amyloid-β Peptide

(2017) Danielle G. Smith et al.   JOURNAL OF ALZHEIMERS DISEASE

Molecular dynamics simulations of GPCR–cholesterol interaction: An emerging paradigm

(2015) Durba Sengupta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Fungal and mycotoxin contamination of coffee beans in Benguet province, Philippines

(2015) Audrey Glenn L. Culliao et al.   Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment

Posttranslational modification and mutation of histidine 50 trigger alpha synuclein aggregation and toxicity

(2015) Wei Xiang et al.   Molecular Neurodegeneration

Distribution of the LDL receptor within clathrin-coated pits and caveolae in rat and human liver

(2014) Soumya Ivaturi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hypercholesterolaemia-induced oxidative stress at the blood–brain barrier

(2014) Irundika H.K. Dias et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Oxysterol Mixture in Hypercholesterolemia-Relevant Proportion Causes Oxidative Stress-Dependent Eryptosis

(2014) Luisa Tesoriere et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Filamentous Fungi and Mycotoxins in Cheese: A Review

(2014) Nolwenn Hymery et al.   COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY

Cholesterol in brain disease: sometimes determinant and frequently implicated

(2014) M. G. Martin et al.   EMBO REPORTS

Inducible nitric oxide synthase is key to peroxynitrite-mediated, LPS-induced protein radical formation in murine microglial BV2 cells

(2014) Ashutosh Kumar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Neurotoxic effects of ochratoxin A on the subventricular zone of adult mouse brain

(2014) Sara Paradells et al.   JOURNAL OF APPLIED TOXICOLOGY

Oxidative Stress-induced Inhibition of Sirt1 by Caveolin-1 Promotes p53-dependent Premature Senescence and Stimulates the Secretion of Interleukin 6 (IL-6)

(2014) Daniela Volonte et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Redox-resistant Sirtuin-1 Mutant Protects against Hepatic Metabolic and Oxidant Stress

(2014) Di Shao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Involvement of Lipids in Alzheimer's Disease

(2014) Wei Ling Florence Lim et al.   Journal of Genetics and Genomics

Selenium supplementation shows protective effects against patulin-induced brain damage in mice via increases in GSH-related enzyme activity and expression

(2014) Erqun Song et al.   LIFE SCIENCES

SIRT1 in Neurodevelopment and Brain Senescence

(2014) A. Zara Herskovits et al.   NEURON

Cysteine inhibits the fibrillisation and cytotoxicity of amyloid-β 40 and 42: implications for the contribution of the thiophilic interaction

(2014) Eisuke Takai et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Cholesterol-Induced Non-Alcoholic Fatty Liver Disease and Atherosclerosis Aggravated by Systemic Inflammation

(2014) Eung Ju Kim et al.   PLoS One

Role of caveolin-1 in the biology of the blood-brain barrier

(2014) Yong-Lin Zhao et al.   REVIEWS IN THE NEUROSCIENCES

Regulation of platelet plug formation by phosphoinositide metabolism

(2013) S. H. Min et al.   BLOOD

Fusaric acid, a mycotoxin, and its influence on blood coagulation and platelet function

(2013) Sannaningaiah Devaraja et al.   BLOOD COAGULATION & FIBRINOLYSIS

The multiple roles of histidine in protein interactions

(2013) Si-Ming Liao et al.   Chemistry Central Journal

Obesity and NAFLD

(2013) Ajay Duseja et al.   Clinics in Liver Disease

Gut-liver Axis and Microbiota in NAFLD: Insight Pathophysiology for Novel Therapeutic Target

(2013) Luca Miele et al.   CURRENT PHARMACEUTICAL DESIGN

Difference in LDL Receptor Feedback Regulation in Macrophages and Vascular Smooth Muscle Cells: Foam Cell Transformation Under Inflammatory Stress

(2013) Qiang Ye et al.   INFLAMMATION

Obesity in Aging Exacerbates Blood-Brain Barrier Disruption, Neuroinflammation, and Oxidative Stress in the Mouse Hippocampus: Effects on Expression of Genes Involved in Beta-Amyloid Generation and Alzheimer's Disease

(2013) Z. Tucsek et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Proteome-wide mapping of cholesterol-interacting proteins in mammalian cells

(2013) Jonathan J Hulce et al.   NATURE METHODS

Increased Amyloid-β Peptide-Induced Memory Deficits in Phospholipid Transfer Protein (PLTP) Gene Knockout Mice

(2013) Catherine Desrumaux et al.   NEUROPSYCHOPHARMACOLOGY

Lipopolysaccharide-induced blood brain barrier permeability is enhanced by alpha-synuclein expression

(2013) Adam Jangula et al.   NEUROSCIENCE LETTERS

Bacterial Communities Associated with the Surfaces of Fresh Fruits and Vegetables

(2013) Jonathan W. Leff et al.   PLoS One

Influence of T-2 and HT-2 Toxin on the Blood-Brain Barrier In Vitro: New Experimental Hints for Neurotoxic Effects

(2013) Maria Weidner et al.   PLoS One

Electrostatics of cysteine residues in proteins: Parameterization and validation of a simple model

(2013) Freddie R. Salsbury et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

What are lipoproteins doing in the brain?

(2013) Hong Wang et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The role of Cysteine 6.47 in class A GPCRs

(2013) Mireia Olivella et al.   BMC STRUCTURAL BIOLOGY

From the Gut to the Brain: Journey and Pathophysiological Effects of the Food-Associated Trichothecene Mycotoxin Deoxynivalenol

(2013) Marc Maresca   Toxins

Producers and Important Dietary Sources of Ochratoxin A and Citrinin

(2013) Vladimir Ostry et al.   Toxins

How cholesterol interacts with membrane proteins: an exploration of cholesterol-binding sites including CRAC, CARC, and tilted domains

(2013) Jacques Fantini et al.   Frontiers in Physiology

The Effect of High-Fat Diet-Induced Pathophysiological Changes in the Gut on Obesity: What Should be the Ideal Treatment?

(2013) Chooi Y Lee   Clinical and Translational Gastroenterology

Oxysterols in the pathogenesis of major chronic diseases

(2013) Giuseppe Poli et al.   Redox Biology

A Key Role for Lysine Residues in Amyloid β-Protein Folding, Assembly, and Toxicity

(2012) Sharmistha Sinha et al.   ACS Chemical Neuroscience

Dysregulation of cholesterol balance in the brain: contribution to neurodegenerative diseases

(2012) J. E. Vance   Disease Models & Mechanisms

Intestinal microbiota determines development of non-alcoholic fatty liver disease in mice

(2012) Tiphaine Le Roy et al.   GUT

Low-density Lipoprotein Receptor Represents an Apolipoprotein E-independent Pathway of Aβ Uptake and Degradation by Astrocytes

(2012) Jacob M. Basak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipopolysaccharide impairs amyloid beta efflux from brain: altered vascular sequestration, cerebrospinal fluid reabsorption, peripheral clearance and transporter function at the blood–brain barrier

(2012) Michelle A Erickson et al.   Journal of Neuroinflammation

 -Amyloid Inhibits Protein Prenylation and Induces Cholesterol Sequestration by Impairing SREBP-2 Cleavage

(2012) A. Mohamed et al.   JOURNAL OF NEUROSCIENCE

Caveolin targeting to late endosome/lysosomal membranes is induced by perturbations of lysosomal pH and cholesterol content

(2012) Dorothy I. Mundy et al.   MOLECULAR BIOLOGY OF THE CELL

A neuroprotective role for sirtuin 1

(2012) Charlotte Harrison   NATURE REVIEWS DRUG DISCOVERY

Receptor-Independent Interaction of Bacterial Lipopolysaccharide with Lipid and Lymphocyte Membranes; the Role of Cholesterol

(2012) Filip Ciesielski et al.   PLoS One

High Fat Diet-Induced Gut Microbiota Exacerbates Inflammation and Obesity in Mice via the TLR4 Signaling Pathway

(2012) Kyung-Ah Kim et al.   PLoS One

Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood A  clearance in a mouse model of  -amyloidosis

(2012) J. M. Castellano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aflatoxin Biosynthesis: Current Frontiers

(2012) Ludmila V. Roze et al.   Annual Review of Food Science and Technology

Causative role of gut microbiota in non-alcoholic fatty liver disease pathogenesis

(2012) Anna Alisi et al.   Frontiers in Cellular and Infection Microbiology

Cholesterol and amyloid-beta: Evidence for a cross-talk between astrocytes and neuronal cells

(2011) Elisa Canepa et al.   Alzheimers & Dementia

Uncovering the intimate relationship between lipids, cholesterol and GPCR activation

(2011) Joanne Oates et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Plasma ochratoxin A levels, food consumption, and risk biomarkers of a representative sample of men and women from the Molise region in Italy

(2011) Romina di Giuseppe et al.   EUROPEAN JOURNAL OF NUTRITION

Function and regulation of ABCA1 - membrane meso-domain organization and reorganization

(2011) Kohjiro Nagao et al.   FEBS Journal

Mechanisms of Mycotoxin-Induced Neurotoxicity through Oxidative Stress-Associated Pathways

(2011) Kunio Doi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Role of Caveolin-1 in Blood–Brain Barrier Disruption Induced by Focused Ultrasound Combined with Microbubbles

(2011) Jinmu Deng et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Exacerbation of CNS inflammation and neurodegeneration by systemic LPS treatment is independent of circulating IL-1β and IL-6

(2011) Carol L Murray et al.   Journal of Neuroinflammation

The role of G protein-coupled receptors in the pathology of Alzheimer's disease

(2011) Amantha Thathiah et al.   NATURE REVIEWS NEUROSCIENCE

Caveolin-1 interacts with alpha-synuclein and mediates toxic actions of cellular alpha-synuclein overexpression

(2011) Alexandra Madeira et al.   NEUROCHEMISTRY INTERNATIONAL

Promotion of β-amyloid production by C-reactive protein and its implications in the early pathogenesis of Alzheimer’s disease

(2011) Bing-Tian Bi et al.   NEUROCHEMISTRY INTERNATIONAL

Astrocytes are important mediators of Aβ-induced neurotoxicity and tau phosphorylation in primary culture

(2011) C J Garwood et al.   Cell Death & Disease

In vivo direct patulin-induced fluidization of the plasma membrane of fission yeast Schizosaccharomyces pombe

(2010) Eszter Horváth et al.   FOOD AND CHEMICAL TOXICOLOGY

Phagocytosis and LPS alter the maturation state of β-amyloid precursor protein and induce different Aβ peptide release signatures in human mononuclear phagocytes

(2010) Philipp Spitzer et al.   Journal of Neuroinflammation

Loss of Caveolin-1 Accelerates Neurodegeneration and Aging

(2010) Brian P. Head et al.   PLoS One

Impact of mycotoxins on humans and animals

(2010) Mohamed E. Zain   Journal of Saudi Chemical Society

Mycotoxins and human disease: a largely ignored global health issue

(2009) C. P. Wild et al.   CARCINOGENESIS

Clearance of Amyloid-β Peptide Across the Blood-Brain Barrier: Implication for Therapies in Alzheimers Disease

(2009) R. Deane et al.   CNS & Neurological Disorders-Drug Targets

Influence of Hypercholesterolemia and Hypertension on the Integrity of the Blood–Brain Barrier in Rats

(2009) Rivaze Kalayci et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Formation of Two Intramolecular Disulfide Bonds Is Necessary for ApoA-I-dependent Cholesterol Efflux Mediated by ABCA1

(2009) Masako Hozoji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

G Protein-Coupled Receptors, Cholinergic Dysfunction, and A  Toxicity in Alzheimer's Disease

(2009) A. Thathiah et al.   Science Signaling

The mycotoxin Deoxynivalenol inhibits the cell surface expression of activation markers in human macrophages

(2009) Yann J. Waché et al.   TOXICOLOGY

Cholesterol-induced stimulation of platelet aggregation is prevented by a hempseed-enriched dietThis article is one of a selection of papers published in the special issue Bridging the Gap: Where Progress in Cardiovascular and Neurophysiologic Research Meet.

(2008) M.A. Prociuk et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Impact of mycotoxins on human health in developing countries

(2008) G. S. Shephard   Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment

An Amphipathic Helical Region of the N-terminal Barrel of Phospholipid Transfer Protein Is Critical for ABCA1-dependent Cholesterol Efflux

(2008) John F. Oram et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of lipid-bound apoA-I cysteine mutants on lipopolysaccharide-induced endotoxemia in mice

(2008) Yunlong Wang et al.   JOURNAL OF LIPID RESEARCH

Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation

(2008) Jae Lee et al.   Journal of Neuroinflammation

Brain cholesterol metabolism and neurologic disease

(2008) E. E. Benarroch   NEUROLOGY

LDL Receptor-Related Protein 1: Unique Tissue-Specific Functions Revealed by Selective Gene Knockout Studies

(2008) Anna P. Lillis et al.   PHYSIOLOGICAL REVIEWS

Opposing Effects of Sirtuins on Neuronal Survival: SIRT1-Mediated Neuroprotection Is Independent of Its Deacetylase Activity

(2008) Jason A. Pfister et al.   PLoS One

SIRT1 and neuronal diseases

(2007) Bor Luen Tang et al.   MOLECULAR ASPECTS OF MEDICINE

Activation of p38 MAPK induced peroxynitrite generation in LPS plus IFN-γ-stimulated rat primary astrocytes via activation of iNOS and NADPH oxidase

(2007) Byoung Kwon Yoo et al.   NEUROCHEMISTRY INTERNATIONAL