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Pharmacology & Pharmacy
Hawa Nordin Siti, Juriyati Jalil, Ahmad Yusof Asmadi, Yusof Kamisah
Summary: The study found that Parkia speciosa empty pod extract can protect against angiotensin II-induced cardiomyocyte hypertrophy by modulating the Ang II/reactive oxygen species/nitric oxide axis and mitogen-activated protein kinase signaling pathway, potentially through a mechanism distinct from valsartan.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Isabelle Hernandez, Audrey Chissey, Jean Guibourdenche, Roger Atasoy, Xavier Coumoul, Thierry Fournier, Jean-Louis Beaudeux, Amal Zerrad-Saadi
Summary: The study demonstrates the involvement of NADPH oxidase in the secretion of sFlt-1 and PlGF in first trimester chorionic villi, and indicates the participation of p38 MAPK pathway in sFlt-1 production and Nox activation. Additionally, the research highlights the major role of placental NADPH oxidase in mediating the signal transduction cascade of sFlt-1 production, as well as the involvement of p38 activation in first trimester placental Nox activity.
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Oncology
Jiao Chen, Xiang Xue, Jianqin Cai, Ling Jia, Baodi Sun, Wei Zhao
Summary: The study showed that taurine alleviated sepsis-induced lung injury by suppressing the inflammatory response and oxidative stress, as well as inhibiting the activation of the p38/MAPK signaling pathway. Therefore, the p38/MAPK signaling pathway may serve as a potential therapeutic target for the treatment of sepsis-induced ALI.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Cell Biology
Tao Zhou, Suining Li, Liehong Yang, Daokang Xiang
Summary: The study demonstrates that miR-363-3p negatively regulates NOX4 in coronary arterial endothelial cells (CAECs) through blocking the p38 MAPK signaling pathway, leading to reduced inflammation, oxidative stress, and apoptosis while improving cell viability. This protective mechanism of miR-363-3p against coronary heart disease (CHD) suggests it as a potential therapeutic target for CHD.
Article
Cell Biology
Yuliya Filina, Aida Gabdoulkhakova, Albert Rizvanov, Valentina Safronova
Summary: Phagocytes' functional activity and inflammation's development and resolution are determined by formylpeptide receptors (FPRs) signaling. Research has shown that different types of formylpeptide receptors, FPR1 and FPR2, activate distinct patterns of MAP kinase activity, with JNK involved in both Fpr1 and Fpr2 mediated activation of ROS production, while p38 MAPK and ERK are only involved in Fpr1 induced ROS generation.
CELLULAR SIGNALLING
(2022)
Article
Pharmacology & Pharmacy
Wael A. Alanazi, Hussain N. Alhamami, Metab Alharbi, Khalid Alhazzani, Abdulrahman S. Alanazi, Sary Alsanea, Nemat Ali, Abdullah F. Alasmari, Ahmed Z. Alanazi, Moureq R. Alotaibi, Mohammed Alswayyed
Summary: This study investigated the mechanisms of gefitinib-induced cardiac hypertrophy by studying the roles of AngII, oxidative stress, and MAPK pathway. The findings demonstrated that valsartan protected the heart and attenuated gefitinib-induced cardiac hypertrophy by adjusting AngII-induced NADPH oxidase and JNK/p38-MAPK pathway.
SAUDI PHARMACEUTICAL JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Yi Wen, Hansen Chen, Lu Zhang, Meiling Wu, Feng Zhang, Dan Yang, Jiangang Shen, Jianping Chen
Summary: 18-beta-glycyrrhetinic acid can promote the production of ROS and RNS through activating NADPH oxidases and iNOS, decreasing GSH and GPX activity, subsequently exacerbating lipid peroxidation and triggering ferroptosis in triple-negative breast cancer cells.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Oncology
Serina Cheung, Pallavi Jain, Jonathan So, Saeid Shahidi, Stephen Chung, Marianne Koritzinsky
Summary: Targeting the p38 MAPK protein kinase can inhibit growth and survival of castration-resistant prostate cancer cells, regardless of oxygen levels, and may prolong the survival of tumor-bearing mice. This demonstrates the potential of p38 MAPK inhibition as a therapeutic strategy for disrupting AR signaling in the heterogeneous CRPC tumor microenvironment.
Article
Biochemistry & Molecular Biology
Plamena R. Angelova, Isabella Myers, Andrey Y. Abramov
Summary: A study found that carbon monoxide (CO) poisoning is a major cause of toxic mortality and morbidity. Reactive oxygen species were found to be generated in response to toxic doses of CO exposure, leading to lipid peroxidation and a decrease in GSH. Inhibition of different phases of reactive oxygen species generation protected cells against CO-induced oxidative stress and cell death, with the most significant effect observed during NADPH oxidase inhibition.
Article
Immunology
Ming Li, Yabing Gao, Zhenglei Wang, Binfeng Wu, Jinqiu Zhang, Yuanyuan Xu, Xiangan Han, Vanhnaseng Phouthapane, Jinfeng Miao
Summary: This study investigated the molecular mechanisms of S. uberis-induced NETs formation and the regulatory role of taurine. The results showed that taurine can protect mammary epithelial cells and barriers from damage by reducing S. uberis-induced NETs.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Payel Dey, Soumyajit Biswas, Rima Das, Sandipan Chatterjee, Utpal Ghosh
Summary: This study explores the synergistic anticancer activities of olaparib combined with a p38 MAPK inhibitor, SB203580, on non-small cell lung carcinoma A549 cells. The results demonstrate that while olaparib and SB203580 individually reduce cell viability in a dose-dependent manner, their combination synergistically reduces cell viability. The combination treatment enhances the anticancer potential of olaparib by increasing DNA damage-induced apoptosis and inhibiting telomerase activity.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Geriatrics & Gerontology
Ji Yun Park, Haneur Lee, Eun Seon Song, Yun Haeng Lee, Myeong Uk Kuk, Gahyun Ko, Hyung Wook Kwon, Youngjoo Byun, Joon Tae Park
Summary: This study reveals a novel mechanism in which modulation of p38 MAPK activity leads to the improvement of senescence through functional restoration of lysosomes and mitochondria.
REJUVENATION RESEARCH
(2022)
Article
Medicine, Research & Experimental
Seung Hoon Lee, Gun-Woo Won, Seung-Hyeon Choi, Mi-Yoon Kim, Cheong-Hae Oh, Jong-Tae Park, Jong-Il Park
Summary: Inotodiol has the potential to prevent oxidative stress-induced skin aging by inhibiting the MAPK-NOX5 and NF-kappa B signaling pathways, protecting human dermal fibroblasts.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Santosh Kumar, Shubhankar Suman, Bo-Hyun Moon, Albert J. Fornace Jr, Kamal Datta
Summary: This study reveals that radiation exposure induces long-term oxidative stress in colonic epithelial cells, which is associated with colon carcinogenesis. The NADPH oxidase pathway may play a critical role in propagating this oxidative stress after radiation exposure.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Immunology
Ershun Zhou, Zhikai Wu, Xingyi Zhu, Peixuan Li, Jingjing Wang, Zhengtao Yang
Summary: This study investigated the role of histamine on bovine NET formation and its preliminary molecular mechanisms. The results showed that histamine triggered dose-dependent NET release and elevated ROS production, phosphorylated ERK and p38 proteins in PMNs. Inhibition of NADPH oxidase, ERK, and p38 pathways reduced histamine-induced NET formation, revealing potential molecular mechanisms behind this process.
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hui-Ting Huang, Shun-Fen Tzeng
Summary: Our study demonstrates the role of interleukin-33 (IL-33) in a demyelinating mouse model induced by cuprizone (CPZ), showing that IL-33 can alleviate the reduction of APC+ OLs and the decline of IL-33 levels in the corpus callosum, and promote the expression of myelin basic protein (MBP).
NEUROCHEMISTRY INTERNATIONAL
(2024)