Review
Immunology
Wenyuan Li, Yao Wang
Summary: Eukaryotic cells form stress granules (SGs) in response to external pressure such as heat shock, oxidative stress, nutrient deficiencies, or infections, which play important roles in gene expression and cellular homeostasis. Pathogen invasion induces SGs formation by leveraging the host cell translation machinery. The host cell suspends translation to resist pathogen invasion, leading to the formation of SGs. This article reviews the production and function of SGs, the interaction between SGs and pathogens, and the relationship between SGs and pathogen-induced innate immunity to guide further research into strategies against infection and inflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Xiaowu Bai, Weixin Liu, Hongxia Chen, Tao Zuo, Xiaojian Wu
Summary: By analyzing RNA-seq data from patients with IBD (including CD and UC) and healthy individuals, this study revealed increased numbers of immune cells in different intestinal regions and disease-specific immune features in CD and UC. These findings provide important insights into the pathogenesis of IBD and serve as a valuable resource for future targeted studies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Liangfei Niu, Geyang Luo, Rui Liang, Chenli Qiu, Jianwei Yang, Lingling Xie, Kaile Zhang, Yu Tian, Decheng Wang, Shu Song, Howard E. Takiff, Ka-Wing Wong, Xiaoyong Fan, Qian Gao, Bo Yan
Summary: This study reveals the important role of nlrc3-like in the regulation of macrophage homeostasis, early bacterial burden control, and inflammation response. Overexpression or deficiency of nlrc3-like leads to abnormal inflammation response and bacterial burden, highlighting the importance of balanced innate immune response during mycobacterial infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yuri Haneishi, Yuma Furuya, Mayu Hasegawa, Antonio Picarelli, Mauro Rossi, Junki Miyamoto
Summary: Inflammatory bowel disease (IBD) is a rapidly increasing inflammatory disease of the gastrointestinal tract worldwide. Recent research suggests that factors such as genetics, environment, microbiota, and immune responses are involved in its development, but the underlying causes are unclear. Dysbiosis of gut microbiota, particularly a decrease in specific genera, has been identified as a possible trigger for IBD. Improving gut microbiota and identifying specific bacterial species are crucial for understanding and treating IBD and autoimmune diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Matthew Luzentales-Simpson, Yvonne C. F. Pang, Ada Zhang, James A. Sousa, Laura M. Sly
Summary: Inflammatory bowel diseases are characterized by chronic inflammation along the gastrointestinal tract due to excessive leukocyte infiltration. Current treatments include aminosalicylates, corticosteroids, immunosuppressants, and biologics such as anti-TNF antibodies, although some patients may become unresponsive to anti-TNF therapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Nuno-Valerio Silva, Diogo Carregosa, Catarina Goncalves, Otilia V. Vieira, Claudia Nunes dos Santos, Antonio Jacinto, Carolina Lage Crespo
Summary: Inflammatory bowel diseases with chronic immune cell infiltration in the gastrointestinal tract are common and challenging to treat. To address this, a dietary cholesterol-based in vivo assay using transgenic zebrafish models was developed for screening immune-modulatory therapeutics. This method is simple, cost-effective, and highly physiological, allowing for the identification of novel lead molecules with immune modulatory action on intestinal inflammation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Fisheries
Ming Xian Chang, Fan Xiong, Xiao Man Wu, Yi Wei Hu
Summary: NLR proteins are immune sensors that recognize pathogen patterns, with different species having varying numbers of NLRs. The zebrafish genome contains almost 400 NLR proteins. These proteins can positively or negatively regulate immune responses and inflammatory signaling cascades.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
J. Zeller, B. Bogner, J. D. McFadyen, J. Kiefer, D. Braig, G. Pietersz, G. Krippner, T. L. Nero, C. J. Morton, K. S. Cheung Tung Shing, M. W. Parker, K. Peter, S. U. Eisenhardt
Summary: C-reactive protein (CRP) is not only a marker of inflammation and predictor of cardiovascular risk, but also a direct pathogenic pro-inflammatory mediator in atherosclerosis and cardiovascular diseases. The different conformations of the CRP system can aggravate tissue injury in pathological conditions, and studying the structural changes of CRP could be a novel therapeutic target for cardiovascular diseases and excessive inflammation.
PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Immunology
Diana Coman, Isabelle Coales, Luke B. Roberts, Joana F. Neves
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the intestine with a complex etiology involving genetics, gut microbiome, environment, and immune system. Recent research has suggested that innate lymphoid cells (ILCs) may play a significant role in the dysregulation of intestinal immunity observed in IBD. Despite being rare in the intestine, helper-like ILCs may contribute to the exacerbation of IBD pathology.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Akihiro Nishiguchi, Tetsushi Taguchi
Summary: The study reports the discovery of a compound, bOEI, which has both anti-inflammatory properties and biocompatibility. It suppresses inflammatory responses by scavenging reactive oxygen species and inhibiting nuclear factor kappa-B, and its conjugate with hyaluronic acid enhances anti-inflammatory functions. In a murine ulcerative colitis model, this polyamine-conjugated biopolymer shows therapeutic potential by suppressing pro-inflammatory cytokine production.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Cell Biology
Rirong Chen, Yizhe Tie, Jinyu Lu, Li Li, Zhirong Zeng, Minhu Chen, Shenghong Zhang
Summary: Inflammatory bowel disease (IBD) is a chronic recurrent gastrointestinal inflammatory disease that poses a heavy burden to the global healthcare system. The tripartite motif (TRIM) family proteins play important roles in the pathogenesis of IBD and provide novel therapeutic targets. However, the exact mechanisms of TRIM proteins in IBD pathogenesis and IBD-related carcinogenesis are still unknown and require further research.
CELL PROLIFERATION
(2022)
Review
Immunology
Gael Galli, Maya Saleh
Summary: Macrophages play crucial roles in tissue homeostasis, inflammation, and host defense by recognizing microbial or danger signals and eliciting immune responses. The interaction between cellular metabolism and macrophage innate immunity involves metabolic adaptations that modulate immune signaling and macrophage function. Intracellular bacterial pathogens can exploit macrophage metabolic pathways to evade immune defenses. This review highlights recent evidence on host-bacterial immunometabolic interactions.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Neurosciences
Staley A. Brod
Summary: Systemic inflammation may increase the risk of organ-related diseases, including Alzheimer's disease (AD). In AD, there are high levels of pro-inflammatory cytokines IL-1 and IL-6. Targeting inflammation with anti-inflammatory measures, such as oral type I interferon, could potentially slow down cognitive decline in AD patients.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Review
Immunology
Tamisa Seeko Bandeira Honda, John Ku, Hans-Joachim Anders
Summary: The NLRP3 inflammasome plays a crucial role in monocytes, macrophages, and neutrophils, but is absent in non-immune cells according to most published evidence. However, an increasing number of studies have reported the presence and functionality of the NLRP3 inflammasome in almost every cell type.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Elsa Anes, David Pires, Manoj Mandal, Jose Miguel Azevedo-Pereira
Summary: This review highlights the spatial localization of cathepsins and their implications in immune activation and resolution pathways during infection.
FRONTIERS IN IMMUNOLOGY
(2022)