The Roles of p53 in Mitochondrial Dynamics and Cancer Metabolism: The Pendulum between Survival and Death in Breast Cancer?

Emerging Roles of p53 Family Members in Glucose Metabolism

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The p53 Tumor Suppressor in the Control of Metabolism and Ferroptosis

(2018) Keerthana Gnanapradeepan et al.   Frontiers in Endocrinology

Good Guy or Bad Guy? The Duality of Wild-Type p53 in Hormone-Dependent Breast Cancer Origin, Treatment, and Recurrence

(2018) Eileen McGowan et al.   Cancers

Signaling Pathways Regulating Redox Balance in Cancer Metabolism

(2018) Maria Chiara De Santis et al.   Frontiers in Oncology

Mitochondrial network complexity emerges from fission/fusion dynamics

(2018) Nahuel Zamponi et al.   Scientific Reports

Induction of ferroptosis and mitochondrial dysfunction by oxidative stress in PC12 cells

(2018) Chuanhong Wu et al.   Scientific Reports

Treatment for the endocrine resistant breast cancer: Current options and future perspectives

(2017) Chun-Yu Liu et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Annual Report to the Nation on the Status of Cancer, 1975–2014, Featuring Survival

(2017) Ahmedin Jemal et al.   JNCI-Journal of the National Cancer Institute

Gain of function in the mouse model of a recurrent mutation p53N236S promotes the formation of double minute chromosomes and the oncogenic potential of p19ARF

(2017) Lanjun Zhao et al.   MOLECULAR CARCINOGENESIS

Mutant p53 oncogenic functions in cancer stem cells are regulated by WIP through YAP/TAZ

(2017) M Escoll et al.   ONCOGENE

Deciphering metabolic rewiring in breast cancer subtypes

(2017) Martin P. Ogrodzinski et al.   Translational Research

Fueling the Cell Division Cycle

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Annual Report to the Nation on the Status of Cancer, 1975–2014, Featuring Survival

(2017) Ahmedin Jemal et al.   JNCI-Journal of the National Cancer Institute

Annexin/S100A Protein Family Regulation through p14ARF-p53 Activation: A Role in Cell Survival and Predicting Treatment Outcomes in Breast Cancer

(2017) Diana Hatoum et al.   PLoS One

Incidence and Mortality and Epidemiology of Breast Cancer in the World

(2016) Mahshid Ghoncheh et al.   Asian Pacific Journal of Cancer Prevention

The p53 family orchestrates the regulation of metabolism: physiological regulation and implications for cancer therapy

(2016) Marco Napoli et al.   BRITISH JOURNAL OF CANCER

Endocrine treatment in breast cancer: Cure, resistance and beyond

(2016) Konstantinos Tryfonidis et al.   CANCER TREATMENT REVIEWS

Reexamining cancer metabolism: lactate production for carcinogenesis could be the purpose and explanation of the Warburg Effect

(2016) Iñigo San-Millán et al.   CARCINOGENESIS

Cancer therapy in the necroptosis era

(2016) Z Su et al.   CELL DEATH AND DIFFERENTIATION

Ferroptosis: process and function

(2016) Y Xie et al.   CELL DEATH AND DIFFERENTIATION

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

Cancer metabolism: a therapeutic perspective

(2016) Ubaldo E. Martinez-Outschoorn et al.   Nature Reviews Clinical Oncology

p53 coordinates base excision repair to prevent genomic instability

(2016) Mattia Poletto et al.   NUCLEIC ACIDS RESEARCH

Expanding the view of breast cancer metabolism: Promising molecular targets and therapeutic opportunities

(2016) John P. Harrelson et al.   PHARMACOLOGY & THERAPEUTICS

Mitochondrial Dynamics and Metabolic Regulation

(2016) Timothy Wai et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

On metabolic reprogramming and tumor biology: A comprehensive survey of metabolism in breast cancer

(2016) Judith Penkert et al.   Oncotarget

Lipid metabolic reprogramming in cancer cells

(2016) S Beloribi-Djefaflia et al.   Oncogenesis

Clinical Overview of MDM2/X-Targeted Therapies

(2016) Andrew Burgess et al.   Frontiers in Oncology

Effect of p53 on mitochondrial morphology, import, and assembly in skeletal muscle

(2015) Ayesha Saleem et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Tailoring therapies—improving the management of early breast cancer: St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2015

(2015) A. S. Coates et al.   ANNALS OF ONCOLOGY

Programmed Necrosis in the Cross Talk of Cell Death and Inflammation

(2015) Francis Ka-Ming Chan et al.   Annual Review of Immunology

Tumor suppressor p53 and its mutants in cancer metabolism

(2015) Juan Liu et al.   CANCER LETTERS

Ferroptosis in p53-dependent oncosuppression and organismal homeostasis

(2015) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Endocrine resistance in breast cancer – An overview and update

(2015) Robert Clarke et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Metabolic pathways promoting cancer cell survival and growth

(2015) Lindsey K. Boroughs et al.   NATURE CELL BIOLOGY

p53 in survival, death and metabolic health: a lifeguard with a licence to kill

(2015) Flore Kruiswijk et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Recent Advances in the Use of Metformin: Can Treating Diabetes Prevent Breast Cancer?

(2015) Diana Hatoum et al.   Biomed Research International

Nutlin-3a: A Potential Therapeutic Opportunity for TP53 Wild-Type Ovarian Carcinomas

(2015) Erin K. Crane et al.   PLoS One

Regulation of glucose metabolism by p53: Emerging new roles for the tumor suppressor

(2015) Esha Madan et al.   Oncotarget

A dual role of p53 in the control of autophagy

(2014) Ezgi Tasdemir et al.   Autophagy

Trends in 5-year survival rates among breast cancer patients by hormone receptor status and stage

(2014) Lu Chen et al.   BREAST CANCER RESEARCH AND TREATMENT

Doxorubicin and 5-fluorouracil induced accumulation and transcriptional activity of p53 are independent of the phosphorylation at serine 15 in MCF-7 breast cancer cells

(2014) Matthew T Balmer et al.   CANCER BIOLOGY & THERAPY

Mitochondrial metabolism directs stemness and differentiation in P19 embryonal carcinoma stem cells

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IAPP-driven metabolic reprogramming induces regression of p53-deficient tumours in vivo

(2014) Avinashnarayan Venkatanarayan et al.   NATURE

Drugging the p53 pathway: understanding the route to clinical efficacy

(2014) Kian Hoe Khoo et al.   NATURE REVIEWS DRUG DISCOVERY

Molecular mechanisms of regulated necrosis

(2014) Lorenzo Galluzzi et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Integrative investigation on breast cancer in ER, PR and HER2-defined subgroups using mRNA and miRNA expression profiling

(2014) Xiaofeng Dai et al.   Scientific Reports

Molecular mechanism and physiological role of active–deactive transition of mitochondrial complex I

(2013) Marion Babot et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Trastuzumab for patients with HER2 positive breast cancer: Delivery, duration and combination therapies

(2013) Ana Catarina Pinto et al.   BREAST

p53 in breast cancer subtypes and new insights into response to chemotherapy

(2013) Philippe Bertheau et al.   BREAST

The relative mRNA expression of p53 isoforms in breast cancer is associated with clinical features and outcome

(2013) Kelly A. Avery-Kiejda et al.   CARCINOGENESIS

p63 regulates glutaminase 2 expression

(2013) Giacobbe Arianna et al.   CELL CYCLE

Metabolic Regulation by p53 Family Members

(2013) Celia R. Berkers et al.   Cell Metabolism

Cellular Fatty Acid Metabolism and Cancer

(2013) Erin Currie et al.   Cell Metabolism

TAp73 enhances the pentose phosphate pathway and supports cell proliferation

(2013) Wenjing Du et al.   NATURE CELL BIOLOGY

Senescence and aging: the critical roles of p53

(2013) A Rufini et al.   ONCOGENE

Regulation of Mitochondrial Morphogenesis by Annexin A6

(2013) Marcin Chlystun et al.   PLoS One

The Emerging Role of p53 in Exercise Metabolism

(2013) Jonathan D. Bartlett et al.   SPORTS MEDICINE

The impact of p53 in predicting clinical outcome of breast cancer patients with visceral metastasis

(2013) P. Yang et al.   Scientific Reports

Bioenergetic role of mitochondrial fusion and fission

(2012) Benedikt Westermann   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Expression of glucose transporters in cancers

(2012) Leszek Szablewski   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Tumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and Senescence

(2012) Tongyuan Li et al.   CELL

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

 Np63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation

(2012) R.-A. Romano et al.   DEVELOPMENT

TAp73 depletion accelerates aging through metabolic dysregulation

(2012) A. Rufini et al.   GENES & DEVELOPMENT

Mutant p53: one name, many proteins

(2012) W. A. Freed-Pastor et al.   GENES & DEVELOPMENT

Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells

(2012) Oliver D. K. Maddocks et al.   NATURE

p53 mutations in cancer

(2012) Patricia A. J. Muller et al.   NATURE CELL BIOLOGY

Multitasking p53 promotes necrosis

(2012) Kim Baumann   NATURE REVIEWS MOLECULAR CELL BIOLOGY

p14ARF Post-Transcriptional Regulation of Nuclear Cyclin D1 in MCF-7 Breast Cancer Cells: Discrimination between a Good and Bad Prognosis?

(2012) Eileen M. McGowan et al.   PLoS One

Estrogen receptor prevents p53-dependent apoptosis in breast cancer

(2012) S. T. Bailey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

Mitochondria and autophagy: Critical interplay between the two homeostats

(2011) Koji Okamoto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Necroptosis: An emerging form of programmed cell death

(2011) Wei Wu et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Regulatory role of p53 in cancer metabolism via SCO2 and TIGAR in human breast cancer

(2011) Kyu Yeoun Won et al.   HUMAN PATHOLOGY

The cell cycle and cancer

(2011) Gareth H Williams et al.   JOURNAL OF PATHOLOGY

Targeted nutlin-3a loaded nanoparticles inhibiting p53–MDM2 interaction: novel strategy for breast cancer therapy

(2011) Manasi Das et al.   Nanomedicine

The p53 family: guardians of maternal reproduction

(2011) Arnold J. Levine et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Triple-Negative Breast Cancer: An Unmet Medical Need

(2011) C. A. Hudis et al.   ONCOLOGIST

Evaluation of Cell Cycle Arrest in Estrogen Responsive MCF-7 Breast Cancer Cells: Pitfalls of the MTS Assay

(2011) Eileen M. McGowan et al.   PLoS One

Mitofusin-2 is a novel direct target of p53

(2010) Weilin Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

New insights into p53 activation

(2010) Christopher L Brooks et al.   CELL RESEARCH

Autophagy regulation by p53

(2010) Maria Chiara Maiuri et al.   CURRENT OPINION IN CELL BIOLOGY

Warburg tumours and the mechanisms of mitochondrial tumour suppressor genes. Barking up the right tree?

(2010) Jean-Pierre Bayley et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

New insights into the role of mitochondria in aging: mitochondrial dynamics and more

(2010) A. Y. Seo et al.   JOURNAL OF CELL SCIENCE

Issues and updates: evaluating estrogen receptor-α, progesterone receptor and HER2 in breast cancer

(2010) D Craig Allred   MODERN PATHOLOGY

Mitochondrial fusion and fission in cell life and death

(2010) Benedikt Westermann   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanisms of estrogen receptor antagonism toward p53 and its implications in breast cancer therapeutic response and stem cell regulation

(2010) S. D. Konduri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

(2010) W. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy and Metabolism

(2010) J. D. Rabinowitz et al.   SCIENCE

The Control of the Metabolic Switch in Cancers by Oncogenes and Tumor Suppressor Genes

(2010) A. J. Levine et al.   SCIENCE

Functions of p53 in metabolism and invasion:

(2009) Karen H. Vousden   BIOCHEMICAL SOCIETY TRANSACTIONS

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

p53 Regulates Hematopoietic Stem Cell Quiescence

(2009) Yan Liu et al.   Cell Stem Cell

Tumor suppressors and cell metabolism: a recipe for cancer growth

(2009) R. G. Jones et al.   GENES & DEVELOPMENT

Cytoplasmic functions of the tumour suppressor p53

(2009) Douglas R. Green et al.   NATURE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

p63 and p73 Transcriptionally Regulate Genes Involved in DNA Repair

(2009) Yu-Li Lin et al.   PLoS Genetics

Cancer Cell Metabolism: Warburg and Beyond

(2008) Peggy P. Hsu et al.   CELL

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

(2008) Ralph J. DeBerardinis et al.   Cell Metabolism

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

p53: The Janus of autophagy?

(2008) Beth Levine et al.   NATURE CELL BIOLOGY

Regulation of autophagy by cytoplasmic p53

(2008) Ezgi Tasdemir et al.   NATURE CELL BIOLOGY

Transcriptional control of human p53-regulated genes

(2008) Todd Riley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TP53 Status and Response to Chemotherapy in Breast Cancer

(2008) Philippe Bertheau et al.   PATHOBIOLOGY

Role of p53 in mitochondrial biogenesis and apoptosis in skeletal muscle

(2008) Ayesha Saleem et al.   PHYSIOLOGICAL GENOMICS

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

(2008) D. W. Parsons et al.   SCIENCE

Homeostatic functions of the p53 tumor suppressor: Regulation of energy metabolism and antioxidant defense

(2008) Ivan A. Olovnikov et al.   SEMINARS IN CANCER BIOLOGY