Journal
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
Volume 172, Issue -, Pages 166-175Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jsbmb.2017.07.001
Keywords
Endocrine resistance; Hormone receptor; Estrogen receptor; Breast cancer
Funding
- Ministry of Science and Technology, Taiwan [MOST 104-2628-B-075-001-MY3]
- Ministry of Health and Welfare, Executive Yuan, Taiwan [MOHW106-TDU-B-211-144-003]
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Endocrine resistance remains a challenge and an unmet need for managing hormone receptor-positive breast cancer. The mechanisms of endocrine resistance are multifaceted and are likely to evolve over time following various single or combination therapies. The purpose of this review article is to provide general understanding of molecular basis of endocrine resistance of breast cancer and to offer comprehensive review on current treatment options and potential new treatment strategies for endocrine resistant breast cancers. Last but not the least, we discuss current challenges and future directions for management of endocrine resistant breast cancers.
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