Article
Oncology
Adam Brufsky, Xianchen Liu, Benjamin Li, Lynn Mcroy, Connie Chen, Rachel M. Layman, Hope S. Rugo
Summary: A retrospective study showed that the combination of cyclin-dependent kinase 4/6 inhibitor and endocrine therapy was associated with prolonged overall survival and real-world progression-free survival in patients with hormone receptor-positive/human epidermal growth factor 2-negative metastatic breast cancer with lung and/or liver metastases.
Article
Oncology
Bhanu Prakash Lalkota, B. J. Srinivasa, Mani V. Swamy, Diganta Hazarika, B. M. Jeet, K. Jyothi, Mithua Ghosh, Suhail M. Sayeed, Mohammad Nasiruddin, Radheshyam Naik
Summary: This study found that p53 gene mutation and high ki67 may have a significant impact on overall survival in breast cancer patients, with p53 mutated patients having a poorer prognosis.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2023)
Article
Multidisciplinary Sciences
Xiaodong Wang, Ying Chen, Yunshu Gao, Huiqing Zhang, Zehui Guan, Zhou Dong, Yuxuan Zheng, Jiarui Jiang, Haoqing Yang, Liming Wang, Xianming Huang, Lirong Ai, Wenlong Yu, Hongwei Li, Changsheng Dong, Zhou Zhou, Xiyang Liu, Guanzhen Yu
Summary: The study proposes a deep-learning framework to analyze lymph node whole-slide images, identifying lymph nodes and tumor regions, and revealing the importance of the tumor-area-to-MLN-area ratio (T/MLN) in predicting the prognosis of gastric cancer patients.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Xinyi Liu, Enming Zhang, Suxing Wang, Yixiao Shen, Kaiwen Xi, Qiong Fang
Summary: Visceral obesity is associated with a higher risk of disease recurrence, while sarcopenia is significantly correlated with recurrence and overall mortality among Chinese women with breast cancer. Body composition assessment could serve as a simple and effective approach in breast cancer management.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Maral Jamshidi, Rainer Fagerholm, Taru A. Muranen, Sippy Kaur, Swapnil Potdar, Sofia Khan, Eliisa Netti, John-Patrick Mpindi, Bhagwan Yadav, Johanna Kiiski, Kristiina Aittomaki, Paivi Heikkila, Jani Saarela, Ralf Butzow, Carl Blomqvist, Heli Nevanlinna
Summary: A comprehensive study on the role of the miR-30 family in breast cancer revealed that high miR-30d expression is associated with improved survival in aggressive tumor phenotypes. Drug sensitivity analysis showed that ectopic expression of miR-30 family members sensitized breast cancer cell lines to treatment. Pathway analysis suggested that the miR-30 family may inhibit pathways contributing to EMT and metastasis in breast cancer.
Article
Pharmacology & Pharmacy
Selase Ativui, Cynthia A. Danquah, Paul Poku Sampene Ossei, Michael Ofori
Summary: This study demonstrated that palmatine has the potential to improve hypoxemia, ameliorate metastasis-associated lung injury, decrease lung MTA1 expression, and increase p53 expression in the treatment of lung metastasis from triple negative breast cancer.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Health Care Sciences & Services
Jeong Won Lee, Sung Yong Kim, Sun Wook Han, Jong Eun Lee, Sung Hoon Hong, Sang Mi Lee, In Young Jo
Summary: This study found that textural parameters of peritumoral breast AT based on FDG PET/CT can predict axillary lymph node metastasis in breast cancer patients, with GLCM entropy showing the highest predictive value.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Cell Biology
Zhaoze Guo, Han Zhang, Yiming Fu, Junjie Kuang, Bei Zhao, LanFang Zhang, Jie Lin, Shuhui Lin, Dehua Wu, Guozhu Xie
Summary: Cancer-associated fibroblasts (CAFs) are the most common stromal cells in breast cancer, and they play a role in disease progression and chemoresistance. This study found that CAF-derived conditioned media can promote breast cancer cell growth and radioresistance. The secretion of interleukin 6 (IL-6) by CAFs activates the STAT3 signaling pathway, leading to the growth and radioresistance of breast cancer cells. Inhibition of STAT3 or neutralizing IL-6 can block the effects induced by CAFs. In mouse models, the IL-6 receptor monoclonal antibody tocilizumab can reverse CAF-induced growth and radioresistance. Additionally, poor response to radiotherapy in breast cancer is associated with the expression of IL-6 and p-STAT3. These findings highlight the importance of the IL-6/STAT3 signaling pathway as a potential therapeutic target in breast cancer radiotherapy.
CELL DEATH DISCOVERY
(2023)
Article
Biochemistry & Molecular Biology
Akane Sugimura-Nagata, Akira Koshino, Kazuhiro Nagao, Aya Nagano, Masayuki Komura, Akane Ueki, Masahide Ebi, Naotaka Ogasawara, Toyonori Tsuzuki, Kenji Kasai, Satoru Takahashi, Kunio Kasugai, Shingo Inaguma
Summary: Dysregulation of mitochondrial quality control is associated with cancer and degenerative diseases. SPATA18 is a p53-inducible protein that plays a role in mitochondrial quality control and tumor suppression. This study found that high expression of SPATA18 in colorectal cancer cells is associated with smaller tumor size, better histological differentiation, absence of lymph node metastasis, and improved survival. SPATA18 expression was not correlated with p53 immunoreactivity or KRAS/BRAF mutation status. SPATA18 immunohistochemistry can be used as a prognostic marker in colorectal cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Ziqi Yu, Xue Dong, Mei Song, Aizhang Xu, Qing He, Huilin Li, Wen Ouyang, Lotfi Chouchane, Xiaojing Ma
Summary: This study demonstrates the important role of UBR5 in driving breast cancer metastasis by regulating the CDC73 and p53 pathways, affecting tumor cell apoptosis and proliferation. It provides a potential target for cancer therapy.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Lina Marie, Dina Braik, Nayef Abdel-Razeq, Hala Abu-Fares, Ahmad Al-Thunaibat, Hikmat Abdel-Razeq
Summary: Breast cancer with de novo bone-only metastasis has distinct clinical features and prognosis compared to subsequent bone-only metastasis. Patients with de novo bone-only metastasis have shorter overall survival.
CANCER MANAGEMENT AND RESEARCH
(2022)
Article
Oncology
Hanne Lefrere, Kat Moore, Giuseppe Floris, Joyce Sanders, Iris M. Seignette, Tycho Bismeijer, Dennis Peters, Annegien Broeks, Erik Hooijberg, Kristel Van Calsteren, Patrick Neven, Ellen Warner, Fedro Alessandro Peccatori, Sibylle Loibl, Charlotte Maggen, Sileny N. Han, Katarzyna J. Jerzak, Daniela Annibali, Diether Lambrechts, Karin E. de Visser, Lodewyk Wessels, Liesbeth Lenaerts, Frederic Amant
Summary: Patients with postweaning postpartum breast cancer (PP-BCPW) have a poor prognosis compared with other types of breast cancer. This study found that PP-BCPW patients with low expression of immunoglobulin genes but high infiltration of plasma B cells have an increased risk of metastasis and death.
CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Yu Xiong, Xia Shi, Qi Hu, Xingwei Wu, Enwu Long, Yuan Bian
Summary: A nomogram and risk stratification system were successfully developed to predict overall survival in patients with breast cancer liver metastasis, showing improvements in discrimination and calibration compared to the AJCC-TNM staging system. This system can assist clinicians in individualizing treatment strategies for BCLM patients and accurately predict their survival outcomes.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Huizi Lei, Pei Yuan, Changyuan Guo, Jianming Ying
Summary: The aim of this study was to develop and validate a nomogram for predicting positive non-sentinel lymph nodes (non-SLNs) in Chinese breast cancer patients. The nomogram was constructed based on pathological features and performed favorably in predicting non-SLN metastasis. The Memorial Sloan-Kettering Cancer Center (MSKCC) nomogram also showed accuracy in predicting non-SLN metastasis in Chinese patients with known ER status.
FRONTIERS IN ONCOLOGY
(2023)
Article
Chemistry, Medicinal
Dipti Kanabar, Mimansa Goyal, Emma Kane, Tejashri Chavan, Abbas Kabir, Xuechun Wang, Snehal Shukla, Joseph Almasri, Sona Goswami, Gizem Osman, Marino Kokolis, Donald E. Spratt, Vivek Gupta, Aaron Muth
Summary: This study reports the structure-based design of small molecules that can bind to Gankyrin and inhibit its overexpression in breast and lung cancers, showing potential therapeutic value.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jing-Jing Liu, Zun Wang, Li-Ming Nie, Yuan-Yuan Zhu, Ge Li, Lin-Ling Lin, Min Chen, Guo-Jun Zhang
Summary: The use of cRGD-MNPs for photoacoustic imaging demonstrated excellent tumor targeting with low toxicity, showing great potential for accurate tumor localization and surgical guidance in breast cancer treatment.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Chemistry, Multidisciplinary
Rui-Qin Yang, Pei-Yuan Wang, Kang-Liang Lou, Yong-Ying Dang, Hai-Na Tian, Yang Li, Yi-Yang Gao, Wen-He Huang, Yong-Qu Zhang, Xiao-Long Liu, Guo-Jun Zhang
Summary: A biodegradable cyclic RGD pentapeptide/hollow virus-like gadolinium-based indocyanine green nanoprobe is developed for fluorescence image-guided surgery and radiotherapy in breast cancer, showing improved efficacy and diagnostic accuracy, and providing a basis for developing precision treatment strategies.
Meeting Abstract
Oncology
Chen Wei-Ling, Yong-Qu Zhang, Wen-He Huang, Min Chen, Yao-Chen Li, Guo-Jun Zhang
Meeting Abstract
Oncology
Yuan-Yuan Zhu, Yong-Qu Zhang, Zun Wang, Min Chen, Guo-Jun Zhang
Article
Nanoscience & Nanotechnology
Rui-Qin Yang, Min Chen, Qiang Zhang, Yi-Yang Gao, Kang-Liang Lou, Tong-Tong Lin, Wen-He Huang, Yun-Zhu Zeng, Yong-Qu Zhang, Yong-Ying Dang, Lei Ren, Guo-Jun Zhang
Summary: In this study, a novel near-infrared fluorescent probe based on HBc VLP was developed and its potential for surgical navigation in breast cancer was demonstrated through preclinical experiments. The probe exhibited outstanding targeting ability both in vitro and in vivo, enabling more complete tumor resection, improved survival rate, and differentiation between benign and malignant breast tissues. Additionally, the design of the probe reduced immune response.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Review
Oncology
Wan-Ling Liu, Yong-Qu Zhang, Liang-Tao Li, Yuan-Yuan Zhu, Zi-He Ming, Wei-Ling Chen, Rui-Qin Yang, Rong-Hui Li, Min Chen, Guo-Jun Zhang
Summary: This narrative review summarizes the preclinical and clinical application of molecular imaging technology in guiding immune checkpoint therapy (ICT) and explores the future opportunities and practical difficulties of these innovations.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Kang-Liang Lou, Pei-Yuan Wang, Rui-Qin Yang, Yi-Yang Gao, Hai-Na Tian, Yong-Ying Dang, Yang Li, Wen-He Huang, Min Chen, Xiao-Long Liu, Guo-Jun Zhang
Summary: Near-infrared fluorescence imaging integrated into surgical procedures can guide tumor resection with higher contrast and deeper tissue penetration in the second near-infrared (NIR-II) region. By using erbium-based rare-earth nanoparticles (ErNPs) with superior optical property in NIR-IIb region, enhanced tumor visualization can be achieved, leading to more complete tumor resection and better identification of malignant lesions.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Yong-Qu Zhang, Wan-Ling Liu, Xiang-Jie Luo, Jun-Peng Shi, Yun-Zhu Zeng, Wei-Ling Chen, Wen-He Huang, Yuan-Yuan Zhu, Wen-Liang Gao, Rong-Hui Li, Zi-He Ming, Li-Xin Zhang, Rui-Qin Yang, Jia-Zheng Wang, Guo-Jun Zhang
Summary: A novel self-assembled multifunctional nanoprobe (NPs-Bev) is developed to improve the efficacy of fluorescence-image-guided breast-conserving surgery (BCS) and radiation therapy (RT) for breast cancer treatment. The NPs can accurately discriminate between benign and malignant mammary tissue, and induce more reactive oxygen species under X-ray radiation therapy, leading to increased sensitivity and reduced tumor progression in mice. The NPs, composed of clinically safe reagents, provide a solid precision therapy platform for breast cancer treatment.
Editorial Material
Oncology
Weiling Chen, Guimei Wang, Guojun Zhang
CANCER BIOLOGY & MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Min Wei, Jingwen Bai, Xiao Shen, Kangliang Lou, Yiyang Gao, Ruichan Lv, Peiyuan Wang, Xiaolong Liu, Guojun Zhang
Summary: A nanoprobe is designed to address the challenges in accurate margin assessments and enhance radiotherapy in breast cancer. The nanoprobe targets tumor cells efficiently, allows for precise surgery under NIR-II fluorescence imaging, and boosts radiation sensitivity by disrupting intracellular ROS homeostasis.
Review
Biochemistry & Molecular Biology
Xue Zhao, Jing-Wen Bai, Qiu Guo, Ke Ren, Guo-Jun Zhang
Summary: Deep learning, a powerful data-driven machine learning technique in AI, has shown remarkable advances in data extraction and analysis for medical imaging, particularly in breast MRI. This review summarizes the current applications of DL models in breast MRI, including advanced learning approaches and methods for data normalization and breast and lesion segmentation. DL-based breast MRI models have been proven useful in various clinical aspects, such as breast cancer diagnosis, molecular and histopathological type classification, prediction of chemotherapy response, and lymph node metastasis prediction. Further improvements in data acquisition and preprocessing, exploration of additional DL techniques, and wider clinical applications are needed for future studies.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Article
Cell Biology
Yuzhu Qi, Meifang Li, Shaozhong Li, De Zeng, Yingsheng Xiao, Jiwei Li, Qianqian Ye, Edwin Bremer, Guo-jun Zhang
Summary: This study explored the molecular mechanisms of chemoresistance in triple-negative breast cancer (TNBC) and found that Notch1 and CD73 were associated with poor clinical outcome in cisplatin-treated patients. Further experiments revealed that Notch1 regulated CD73 expression by directly binding to the CD73 promoter. These findings suggest that CD73 is a direct downstream target of Notch1 in mediating cisplatin resistance in TNBC.
CELL DEATH DISCOVERY
(2023)
Review
Biochemistry & Molecular Biology
Jing-Wen Bai, Si-Qi Qiu, Guo-Jun Zhang
Summary: Targeted anticancer drugs interfere with specific signaling pathways to block cancer cell growth. However, the assessment of their efficacy using the RECIST system, based on tumor size changes, is sometimes inaccurate. Therefore, innovative molecular imaging techniques are gaining importance in evaluating targeted therapy.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Correction
Multidisciplinary Sciences
Jiwei Li, Jing Wu, Qiuyue Long, Yan'an Wu, Xiaoyi Hu, Yukun He, Mingzheng Jiang, Jia Li, Lili Zhao, Shuoqi Yang, Xiaoyong Chen, Minghui Wang, Jianshi Zheng, Fangfang Wu, Ruiliang Wu, Lihong Ren, Liang Bu, Houzhao Wang, Ke Li, Lijuan Fu, Guojun Zhang, Yali Zheng, Zhancheng Gao
Article
Medicine, Research & Experimental
Yi-Yang Gao, Rui-Qin Yang, Kang-Liang Lou, Yong-Ying Dang, Yuan-Yuan Dong, Yue-Yang He, Wen-He Huang, Min Chen, Guo-Jun Zhang
Summary: A novel fluorescent probe CPP30-Lipo/CDKACT4 was developed to monitor CDK4 activity and the therapeutic response of its inhibitor in breast cancer. It demonstrated good optical stability and targetability. The probe successfully monitored CDK4 activity and therapeutic response in living cells and in vivo, providing a new strategy for evaluating antitumor therapeutic efficacy and drug development in a clinical context.
