Mitochondrial Chaperones in the Brain: Safeguarding Brain Health and Metabolism?

Loss of mitochondrial protease ClpP protects mice from diet‐induced obesity and insulin resistance

(2018) Shylesh Bhaskaran et al.   EMBO REPORTS

CLPP deficiency protects against metabolic syndrome but hinders adaptive thermogenesis

(2018) Christina Becker et al.   EMBO REPORTS

Hippocampal insulin resistance links maternal obesity with impaired neuronal plasticity in adult offspring

(2018) Lisa Schmitz et al.   PSYCHONEUROENDOCRINOLOGY

Analysis of HSPA8 and HSPA9 mRNA Expression and Promoter Methylation in the Brain and Blood of Alzheimer's Disease Patients

(2018) Patricia Natalia Silva et al.   JOURNAL OF ALZHEIMERS DISEASE

A homozygous missense mutation in ERAL1, encoding a mitochondrial rRNA chaperone, causes Perrault syndrome

(2017) Iliana A. Chatzispyrou et al.   HUMAN MOLECULAR GENETICS

The association between insulin resistance and depression in the Korean general population

(2017) Jae-Hon Lee et al.   JOURNAL OF AFFECTIVE DISORDERS

Mitostasis in Neurons: Maintaining Mitochondria in an Extended Cellular Architecture

(2017) Thomas Misgeld et al.   NEURON

Mitochondrial dysfunction in glial cells: Implications for neuronal homeostasis and survival

(2017) Jordan Rose et al.   TOXICOLOGY

SGLT2-inhibitor and DPP-4 inhibitor improve brain function via attenuating mitochondrial dysfunction, insulin resistance, inflammation, and apoptosis in HFD-induced obese rats

(2017) Piangkwan Sa-nguanmoo et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Activation of the mitochondrial unfolded protein response promotes longevity and dopamine neuron survival in Parkinson’s disease models

(2017) Jason F. Cooper et al.   Scientific Reports

Dynamin-Related Protein 1-Dependent Mitochondrial Fission Changes in the Dorsal Vagal Complex Regulate Insulin Action

(2017) Beatrice M. Filippi et al.   Cell Reports

Cellular Regulation of Amyloid Formation in Aging and Disease

(2017) Esther Stroo et al.   Frontiers in Neuroscience

European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)

(2017) Javier Egea et al.   Redox Biology

Mitochondrial contribution to lipofuscin formation

(2017) Jeannette König et al.   Redox Biology

Happily (n)ever after: Aging in the context of oxidative stress, proteostasis loss and cellular senescence

(2017) Annika Höhn et al.   Redox Biology

Brain Insulin-Like Growth Factor and Neurotrophin Resistance in Parkinson's Disease and Dementia with Lewy Bodies: Potential Role of Manganese Neurotoxicity

(2017) Ming Tong et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondrial Stress Induces Chromatin Reorganization to Promote Longevity and UPR mt

(2016) Ye Tian et al.   CELL

Lipid Biosynthesis Coordinates a Mitochondrial-to-Cytosolic Stress Response

(2016) Hyun-Eui Kim et al.   CELL

Mitochondrial Dysfunction and Biogenesis in Neurodegenerative diseases: Pathogenesis and Treatment

(2016) Mojtaba Golpich et al.   CNS Neuroscience & Therapeutics

Metabolic regulation of mitochondrial dynamics

(2016) Prashant Mishra et al.   JOURNAL OF CELL BIOLOGY

A Mutation in the Flavin Adenine Dinucleotide-Dependent Oxidoreductase FOXRED1 Results in Cell-Type-Specific Assembly Defects in Oxidative Phosphorylation Complexes I and II

(2016) Olga Zurita Rendón et al.   MOLECULAR AND CELLULAR BIOLOGY

Modulation of Molecular Chaperones in Huntington’s Disease and Other Polyglutamine Disorders

(2016) Sara D. Reis et al.   MOLECULAR NEUROBIOLOGY

Maintenance and propagation of a deleterious mitochondrial genome by the mitochondrial unfolded protein response

(2016) Yi-Fan Lin et al.   NATURE

Dysregulation of autophagy and mitochondrial function in Parkinson’s disease

(2016) Bao Wang et al.   Translational Neurodegeneration

CLPB Variants Associated with Autosomal-Recessive Mitochondrial Disorder with Cataract, Neutropenia, Epilepsy, and Methylglutaconic Aciduria

(2015) Carol Saunders et al.   AMERICAN JOURNAL OF HUMAN GENETICS

CLPB Mutations Cause 3-Methylglutaconic Aciduria, Progressive Brain Atrophy, Intellectual Disability, Congenital Neutropenia, Cataracts, Movement Disorder

(2015) Saskia B. Wortmann et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The Biology of Proteostasis in Aging and Disease

(2015) Johnathan Labbadia et al.   Annual Review of Biochemistry

ClpX stimulates the mitochondrial unfolded protein response (UPRmt) in mammalian cells

(2015) Natalie Al-Furoukh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondrial ClpX Activates a Key Enzyme for Heme Biosynthesis and Erythropoiesis

(2015) Julia R. Kardon et al.   CELL

Increased Oxidative Stress and Mitochondrial Dysfunction in Zucker Diabetic Rat Liver and Brain

(2015) Haider Raza et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Reduced levels of Hspa9 attenuate Stat5 activation in mouse B cells

(2015) Kilannin Krysiak et al.   EXPERIMENTAL HEMATOLOGY

Mitochondrial Heat Shock Protein (Hsp) 70 and Hsp10 Cooperate in the Formation of Hsp60 Complexes

(2015) Lena Böttinger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intrathecal heat shock protein 60 mediates neurodegeneration and demyelination in the CNS through a TLR4- and MyD88-dependent pathway

(2015) Karen Rosenberger et al.   Molecular Neurodegeneration

Dysregulation of parkin in the substantia nigra of db/db and high-fat diet mice

(2015) R. Khang et al.   NEUROSCIENCE

Insulin resistance in brain alters dopamine turnover and causes behavioral disorders

(2015) Andre Kleinridders et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease

(2015) Brent J. Ryan et al.   TRENDS IN BIOCHEMICAL SCIENCES

Type 2 diabetes as a protein misfolding disease

(2015) Abhisek Mukherjee et al.   TRENDS IN MOLECULAR MEDICINE

Cytochrome c oxidase deficiency accelerates mitochondrial apoptosis by activating ceramide synthase 6

(2015) S Schüll et al.   Cell Death & Disease

Absence of BiP Co-chaperone DNAJC3 Causes Diabetes Mellitus and Multisystemic Neurodegeneration

(2014) Matthis Synofzik et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Obesity-Induced CerS6-Dependent C16:0 Ceramide Production Promotes Weight Gain and Glucose Intolerance

(2014) Sarah M. Turpin et al.   Cell Metabolism

Protein Misfolding and Aggregation in Alzheimer’s Disease and Type 2 Diabetes Mellitus

(2014) Ghulam Ashraf et al.   CNS & Neurological Disorders-Drug Targets

Insulin Action in Brain Regulates Systemic Metabolism and Brain Function

(2014) A. Kleinridders et al.   DIABETES

Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Integrity Is Required for Insulin Signaling and Is Implicated in Hepatic Insulin Resistance

(2014) E. Tubbs et al.   DIABETES

Heat shock protein 60: an endogenous inducer of dopaminergic cell death in Parkinson disease

(2014) Carmen Noelker et al.   Journal of Neuroinflammation

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Metabolism Regulates the Spontaneous Firing of Substantia Nigra Pars Reticulata Neurons via K ATP and Nonselective Cation Channels

(2014) Andrew Lutas et al.   JOURNAL OF NEUROSCIENCE

Loss of Mitochondrial Fission Depletes Axonal Mitochondria in Midbrain Dopamine Neurons

(2014) A. Berthet et al.   JOURNAL OF NEUROSCIENCE

Essential Role of TID1 in Maintaining Mitochondrial Membrane Potential Homogeneity and Mitochondrial DNA Integrity

(2014) A. C.-H. Ng et al.   MOLECULAR AND CELLULAR BIOLOGY

A Computational Model of Motor Neuron Degeneration

(2014) Gwendal Le Masson et al.   NEURON

Diabetes Mellitus and the Risk of Alzheimer’s Disease: A Nationwide Population-Based Study

(2014) Chin-Chou Huang et al.   PLoS One

Insulin Receptor Signaling in Normal and Insulin-Resistant States

(2014) J. Boucher et al.   Cold Spring Harbor Perspectives in Biology

Mitochondrial proteolytic stress induced by loss of mortalin function is rescued by Parkin and PINK1

(2014) L F Burbulla et al.   Cell Death & Disease

Deletion of the Mitochondrial Chaperone TRAP-1 Uncovers Global Reprogramming of Metabolic Networks

(2014) Sofia Lisanti et al.   Cell Reports

Molecular Chaperone Functions in Protein Folding and Proteostasis

(2013) Yujin E. Kim et al.   Annual Review of Biochemistry

The accumulation of misfolded proteins in the mitochondrial matrix is sensed by PINK1 to induce PARK2/Parkin-mediated mitophagy of polarized mitochondria

(2013) Seok Min Jin et al.   Autophagy

Mitochondrial Dynamics Controlled by Mitofusins Regulate Agrp Neuronal Activity and Diet-Induced Obesity

(2013) Marcelo O. Dietrich et al.   CELL

Mitofusin 2 in POMC Neurons Connects ER Stress with Leptin Resistance and Energy Imbalance

(2013) Marc Schneeberger et al.   CELL

Inflammatory response of microglial BV-2 cells includes a glycolytic shift and is modulated by mitochondrial glucose-regulated protein 75/mortalin

(2013) Ludmila A. Voloboueva et al.   FEBS LETTERS

TRAP1 rescues PINK1 loss-of-function phenotypes

(2013) Li Zhang et al.   HUMAN MOLECULAR GENETICS

Leptin regulation of Hsp60 impacts hypothalamic insulin signaling

(2013) André Kleinridders et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitonuclear protein imbalance as a conserved longevity mechanism

(2013) Riekelt H. Houtkooper et al.   NATURE

Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis

(2013) S. Yoshida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Shared dysregulated pathways lead to Parkinson's disease and diabetes

(2013) Jose A. Santiago et al.   TRENDS IN MOLECULAR MEDICINE

Drosophila Trap1 protects against mitochondrial dysfunction in a PINK1/parkin model of Parkinson’s disease

(2013) A C Costa et al.   Cell Death & Disease

Metabolic Alterations Induced by Sucrose Intake and Alzheimer’s Disease Promote Similar Brain Mitochondrial Abnormalities

(2012) Cristina Carvalho et al.   DIABETES

SIRT3 Functions in the Nucleus in the Control of Stress-Related Gene Expression

(2012) T. Iwahara et al.   MOLECULAR AND CELLULAR BIOLOGY

TRAP1 Controls Mitochondrial Fusion/Fission Balance through Drp1 and Mff Expression

(2012) Hironori Takamura et al.   PLoS One

Loss of Prohibitin Membrane Scaffolds Impairs Mitochondrial Architecture and Leads to Tau Hyperphosphorylation and Neurodegeneration

(2012) Carsten Merkwirth et al.   PLoS Genetics

The Mitochondrial Chaperone Protein TRAP1 Mitigates α-Synuclein Toxicity

(2012) Erin K. Butler et al.   PLoS Genetics

Cellular Links between Neuronal Activity and Energy Homeostasis

(2012) Pavan K. Shetty et al.   Frontiers in Pharmacology

Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling

(2011) Jisun Lee et al.   BIOCHEMICAL JOURNAL

TRAP-1, the mitochondrial Hsp90

(2011) Dario C. Altieri et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Brain Energy Metabolism: Focus on Astrocyte-Neuron Metabolic Cooperation

(2011) Mireille Bélanger et al.   Cell Metabolism

Mitochondrial stress: A bridge between mitochondrial dysfunction and metabolic diseases?

(2011) Fang Hu et al.   CELLULAR SIGNALLING

Stimulatory Effect of Insulin on Glucose Uptake by Muscle Involves the Central Nervous System in Insulin-Sensitive Mice

(2011) C. P. Coomans et al.   DIABETES

Diabetes and the Risk of Developing Parkinson's Disease in Denmark

(2011) E. Schernhammer et al.   DIABETES CARE

Novel variant Pro143Ala in HTRA2 contributes to Parkinson’s disease by inducing hyperphosphorylation of HTRA2 protein in mitochondria

(2011) Chin-Hsien Lin et al.   HUMAN GENETICS

Higher levels of heat shock proteins in longer-lived mammals and birds

(2011) Kurtis D. Salway et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Neuronal circuitry regulates the response of Caenorhabditis elegans to misfolded proteins

(2011) V. Prahlad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial protein quality control during biogenesis and aging

(2011) Brooke M. Baker et al.   TRENDS IN BIOCHEMICAL SCIENCES

Quality Control of Mitochondrial Proteostasis

(2011) M. J. Baker et al.   Cold Spring Harbor Perspectives in Biology

Familial longevity is marked by enhanced insulin sensitivity

(2010) Carolien A. Wijsman et al.   AGING CELL

Somatic Mitochondrial DNA Mutations in Mammalian Aging

(2010) Nils-Göran Larsson   Annual Review of Biochemistry

Human ERAL1 is a mitochondrial RNA chaperone involved in the assembly of the 28S small mitochondrial ribosomal subunit

(2010) Sven Dennerlein et al.   BIOCHEMICAL JOURNAL

Oxidative stress and the etiology of insulin resistance and type 2 diabetes

(2010) Erik J. Henriksen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative stress, insulin signaling, and diabetes

(2010) Justin L. Rains et al.   FREE RADICAL BIOLOGY AND MEDICINE

Characterization of the human HSC20, an unusual DnaJ type III protein, involved in iron–sulfur cluster biogenesis

(2010) Helge Uhrigshardt et al.   HUMAN MOLECULAR GENETICS

Disease-causing mutations in Parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy

(2010) Joo-Yong Lee et al.   JOURNAL OF CELL BIOLOGY

The mitochondrial UPR - protecting organelle protein homeostasis

(2010) C. M. Haynes et al.   JOURNAL OF CELL SCIENCE

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

(2010) Mikko Taipale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ERAL1 is associated with mitochondrial ribosome and elimination of ERAL1 leads to mitochondrial dysfunction and growth retardation

(2010) Takeshi Uchiumi et al.   NUCLEIC ACIDS RESEARCH

Hypothalamic and pituitary c-Jun N-terminal kinase 1 signaling coordinately regulates glucose metabolism

(2010) B. F. Belgardt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exercise training and experimental diabetes modulate heat shock protein response in brain

(2010) Z. Lappalainen et al.   SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS

The impact of dietary energy intake on cognitive aging

(2010) Mattson   Frontiers in Aging Neuroscience

Brain mitochondrial dysfunction in aging, neurodegeneration and Parkinson's disease

(2010) Ana Navarro   Frontiers in Aging Neuroscience

Mitochondria in Huntington's disease

(2009) Maria Damiano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Role of mitochondrial dysfunction in the pathogenesis of Huntington's disease

(2009) Rodrigo A. Quintanilla et al.   BRAIN RESEARCH BULLETIN

Oxidative Stress and Insulin Resistance: The Coronary Artery Risk Development in Young Adults study

(2009) K. Park et al.   DIABETES CARE

Knockdown of Human COX17 Affects Assembly and Supramolecular Organization of Cytochrome c Oxidase

(2009) C. Oswald et al.   JOURNAL OF MOLECULAR BIOLOGY

Mutational screening of the mortalin gene (HSPA9) in Parkinson’s disease

(2009) Lorena De Mena et al.   JOURNAL OF NEURAL TRANSMISSION

Mitochondrial Dynamics in Mammalian Health and Disease

(2009) Marc Liesa et al.   PHYSIOLOGICAL REVIEWS

Mitochondrial Hsp60 Chaperonopathy Causes an Autosomal-Recessive Neurodegenerative Disorder Linked to Brain Hypomyelination and Leukodystrophy

(2008) Daniella Magen et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Time course of high-fat diet-induced reductions in adipose tissue mitochondrial proteins: potential mechanisms and the relationship to glucose intolerance

(2008) Lindsey N. Sutherland et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Measures of striatal insulin resistance in a 6-hydroxydopamine model of Parkinson's disease

(2008) J.K. Morris et al.   BRAIN RESEARCH

Mitochondrial dysfunction triggered by loss of HtrA2 results in the activation of a brain-specific transcriptional stress response

(2008) N Moisoi et al.   CELL DEATH AND DIFFERENTIATION

Quality control of mitochondria: protection against neurodegeneration and ageing

(2008) Takashi Tatsuta et al.   EMBO JOURNAL

Brain mitochondrial dysfunction in aging

(2008) Alberto Boveris et al.   IUBMB LIFE

Central insulin action regulates peripheral glucose and fat metabolism in mice

(2008) Linda Koch et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial Dysfunction in SOD1G93A-Bearing Astrocytes Promotes Motor Neuron Degeneration: Prevention by Mitochondrial-Targeted Antioxidants

(2008) P. Cassina et al.   JOURNAL OF NEUROSCIENCE

Decreased expression of the mitochondrial matrix proteases Lon and ClpP in cells from a patient with hereditary spastic paraplegia (SPG13)

(2008) J. Hansen et al.   NEUROSCIENCE

Regulation of the Cellular Heat Shock Response in Caenorhabditis elegans by Thermosensory Neurons

(2008) V. Prahlad et al.   SCIENCE

Hippocampal hypometabolism predicts cognitive decline from normal aging

(2007) Lisa Mosconi et al.   NEUROBIOLOGY OF AGING