Intrathecal heat shock protein 60 mediates neurodegeneration and demyelination in the CNS through a TLR4- and MyD88-dependent pathway

Intrathecal delivery of protein therapeutics to the brain: A critical reassessment

(2014) Pericles Calias et al.   PHARMACOLOGY & THERAPEUTICS

Superiority of Preventive Antibiotic Treatment Compared with Standard Treatment of Poststroke Pneumonia in Experimental Stroke: A Bed to Bench Approach

(2013) Susann Hetze et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

SARM Is Required for Neuronal Injury and Cytokine Production in Response to Central Nervous System Viral Infection

(2013) Y.-J. Hou et al.   JOURNAL OF IMMUNOLOGY

Signaling via TLR2 and TLR4 Directly Down-Regulates T Cell Effector Functions: The Regulatory Face of Danger Signals

(2013) Alexandra Zanin-Zhorov et al.   Frontiers in Immunology

Chemokines in CNS injury and repair

(2012) Anne Jaerve et al.   CELL AND TISSUE RESEARCH

Innate immunity in the central nervous system

(2012) Richard M. Ransohoff et al.   JOURNAL OF CLINICAL INVESTIGATION

Extracellularly Delivered Single-Stranded Viral RNA Causes Neurodegeneration Dependent on TLR7

(2012) S. M. Lehmann et al.   JOURNAL OF IMMUNOLOGY

An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration

(2012) Sabrina M Lehmann et al.   NATURE NEUROSCIENCE

Microglial LOX-1 reacts with extracellular HSP60 to bridge neuroinflammation and neurotoxicity

(2012) Dongmei Zhang et al.   NEUROCHEMISTRY INTERNATIONAL

Activation of toll-like receptor, RAGE and HMGB1 signalling in malformations of cortical development

(2011) E. Zurolo et al.   BRAIN

Molecular chaperones and protein-folding catalysts as intercellular signaling regulators in immunity and inflammation

(2010) Brian Henderson et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Gymnastics of Molecular Chaperones

(2010) Matthias P. Mayer   MOLECULAR CELL

Integrating the cell stress response: a new view of molecular chaperones as immunological and physiological homeostatic regulators

(2009) Brian Henderson   CELL BIOCHEMISTRY AND FUNCTION

Caught with their PAMPs down? The extracellular signalling actions of molecular chaperones are not due to microbial contaminants

(2009) Brian Henderson et al.   CELL STRESS & CHAPERONES

The surface-exposed chaperone, Hsp60, is an agonist of the microglial TREM2 receptor

(2009) Luisa Stefano et al.   JOURNAL OF NEUROCHEMISTRY

Real-Time Quantitative RT-PCR: Design, Calculations, and Statistics

(2009) I. Rieu et al.   PLANT CELL

Subcellular stress response and induction of molecular chaperones and folding proteins after transient global ischemia in rats

(2008) Jessie S. Truettner et al.   BRAIN RESEARCH

Upregulated Expression of Toll-Like Receptor 4 in Monocytes Correlates with Severity of Acute Cerebral Infarction

(2008) Qing-wu Yang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Blockade of LOX-1 Prevents Endotoxin-Induced Acute Lung Inflammation and Injury in Mice

(2008) Ping Zhang et al.   Journal of Innate Immunity

A Vicious Cycle Involving Release of Heat Shock Protein 60 from Injured Cells and Activation of Toll-Like Receptor 4 Mediates Neurodegeneration in the CNS

(2008) S. Lehnardt et al.   JOURNAL OF NEUROSCIENCE

Rapidly Increased Neuronal Mitochondrial Biogenesis After Hypoxic-Ischemic Brain Injury

(2008) Wei Yin et al.   STROKE

Toll-Like Receptor 4 Is Involved in Subacute Stress–Induced Neuroinflammation and in the Worsening of Experimental Stroke

(2008) Javier R. Caso et al.   STROKE