Cytochrome c oxidase deficiency accelerates mitochondrial apoptosis by activating ceramide synthase 6

Role of Apoptosis in disease

(2016) B. Favaloro et al.   Aging-US

Obesity-Induced CerS6-Dependent C16:0 Ceramide Production Promotes Weight Gain and Glucose Intolerance

(2014) Sarah M. Turpin et al.   Cell Metabolism

CerS2 Haploinsufficiency Inhibits β-Oxidation and Confers Susceptibility to Diet-Induced Steatohepatitis and Insulin Resistance

(2014) Suryaprakash Raichur et al.   Cell Metabolism

BID-dependent release of mitochondrial SMAC dampens XIAP-mediated immunity against Shigella

(2014) M. Andree et al.   EMBO JOURNAL

Sphingolipid metabolites in inflammatory disease

(2014) Michael Maceyka et al.   NATURE

Targeting the mitochondrial apoptotic pathway: a preferred approach in hematologic malignancies?

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Ceramide synthases as potential targets for therapeutic intervention in human diseases

(2013) Joo-Won Park et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Ubiquitin C-Terminal Hydrolase-L1 Potentiates Cancer Chemosensitivity by Stabilizing NOXA

(2013) Kerstin Brinkmann et al.   Cell Reports

Ceramide synthases at the centre of sphingolipid metabolism and biology

(2012) Thomas D. Mullen et al.   BIOCHEMICAL JOURNAL

B-cell receptor triggers drug sensitivity of primary CLL cells by controlling glucosylation of ceramides

(2012) J. Schwamb et al.   BLOOD

Sphingolipid Metabolism Cooperates with BAK and BAX to Promote the Mitochondrial Pathway of Apoptosis

(2012) Jerry E. Chipuk et al.   CELL

Nonsense mutations in the COX1 subunit impair the stability of respiratory chain complexes rather than their assembly

(2012) Hue-Tran Hornig-Do et al.   EMBO JOURNAL

A defect in the mitochondrial complex III, but not complex IV, triggers early ROS-dependent damage in defined brain regions

(2012) Francisca Diaz et al.   HUMAN MOLECULAR GENETICS

Physiological Roles of Mitochondrial Reactive Oxygen Species

(2012) Laura A. Sena et al.   MOLECULAR CELL

The role of mitochondrial OXPHOS dysfunction in the development of neurologic diseases

(2012) M.E. Breuer et al.   NEUROBIOLOGY OF DISEASE

Mechanisms of mitochondrial diseases

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Mitochondrial Ceramide-Rich Macrodomains Functionalize Bax upon Irradiation

(2011) Hyunmi Lee et al.   PLoS One

Apoptosis-induced changes in mitochondrial lipids

(2010) Massimo Crimi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Elevated XIAP expression alone does not confer chemoresistance

(2010) J M Seeger et al.   BRITISH JOURNAL OF CANCER

The BCL-2 Protein BAK Is Required for Long-chain Ceramide Generation during Apoptosis

(2010) Leah J. Siskind et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Developmentally Regulated Ceramide Synthase 6 Increases Mitochondrial Ca2+Loading Capacity and Promotes Apoptosis

(2010) Sergei A. Novgorodov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways

(2009) Can E. Senkal et al.   FASEB JOURNAL

The pathophysiology of mitochondrial disease as modeled in the mouse

(2009) D. C. Wallace et al.   GENES & DEVELOPMENT

Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase-3 in colon cancer cells

(2009) S White-Gilbertson et al.   ONCOGENE

Ceramide Generated by Sphingomyelin Hydrolysis and the Salvage Pathway Is Involved in Hypoxia/Reoxygenation-induced Bax Redistribution to Mitochondria in NT-2 Cells

(2008) Junfei Jin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantitative analysis of sphingolipids for lipidomics using triple quadrupole and quadrupole linear ion trap mass spectrometers

(2008) Rebecca L. Shaner et al.   JOURNAL OF LIPID RESEARCH

Lack of Pathology in a Triple Transgenic Mouse Model of Alzheimer's Disease after Overexpression of the Anti-Apoptotic Protein Bcl-2

(2008) T. T. Rohn et al.   JOURNAL OF NEUROSCIENCE

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY