Modeling Hemolytic-Uremic Syndrome: In-Depth Characterization of Distinct Murine Models Reflecting Different Features of Human Disease

In Vivo Tumor Targeting by the B-Subunit of Shiga Toxin

(2018) Thomas Viel et al.   Molecular Imaging

Streptococcus pneumoniae From Patients With Hemolytic Uremic Syndrome Binds Human Plasminogen via the Surface Protein PspC and Uses Plasmin to Damage Human Endothelial Cells

(2017) Christian Meinel et al.   JOURNAL OF INFECTIOUS DISEASES

Haemolytic uraemic syndrome

(2017) Fadi Fakhouri et al.   LANCET

Comparison of clinical and immunological findings in gnotobiotic piglets infected with Escherichia coli O104:H4 outbreak strain and EHEC O157:H7

(2017) Bettina Wöchtl et al.   Gut Pathogens

Development of a Mouse Model of Shiga Toxin 2 (Stx2) Intoxication for Testing Therapeutic Agents Against Hemolytic Uremic Syndrome (HUS)

(2016) Maria Mejias et al.   CURRENT PHARMACEUTICAL DESIGN

Early Terminal Complement Blockade and C6 Deficiency Are Protective in EnterohemorrhagicEscherichia coli–Infected Mice

(2016) Ida Arvidsson et al.   JOURNAL OF IMMUNOLOGY

Decreased Neutrophil Extracellular Trap Degradation in Shiga Toxin-Associated Haemolytic Uraemic Syndrome

(2016) Jonatan Leffler et al.   Journal of Innate Immunity

Men and mice: Relating their ages

(2016) Sulagna Dutta et al.   LIFE SCIENCES

Shiga toxin-producing escherichia coli infections in Norway, 1992–2012: characterization of isolates and identification of risk factors for haemolytic uremic syndrome

(2015) Lin T. Brandal et al.   BMC INFECTIOUS DISEASES

Mitochondria in the Regulation of Innate and Adaptive Immunity

(2015) Samuel E. Weinberg et al.   IMMUNITY

Shiga Toxin 2a–Induced Endothelial Injury in Hemolytic Uremic Syndrome: A Metabolomic Analysis

(2015) Christian Betzen et al.   JOURNAL OF INFECTIOUS DISEASES

Shiga Toxin 2-Induced Endoplasmic Reticulum Stress Is Minimized by Activated Protein C but Does Not Correlate with Lethal Kidney Injury

(2015) Caitlin Parello et al.   Toxins

Pro-Coagulant Endothelial Dysfunction Results from EHEC Shiga Toxins and Host Damage-Associated Molecular Patterns

(2015) Chad L. Mayer et al.   Frontiers in Immunology

Global Incidence of Human Shiga Toxin–Producing Escherichia coli Infections and Deaths: A Systematic Review and Knowledge Synthesis

(2014) Shannon E. Majowicz et al.   Foodborne Pathogens and Disease

Direct acute tubular damage contributes to Shigatoxin-mediated kidney failure

(2014) Stefan Porubsky et al.   JOURNAL OF PATHOLOGY

Shiga Toxin Promotes Podocyte Injury in Experimental Hemolytic Uremic Syndrome via Activation of the Alternative Pathway of Complement

(2014) M. Locatelli et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Hemoconcentration: a major risk factor for neurological involvement in hemolytic uremic syndrome

(2014) Gianluigi Ardissino et al.   PEDIATRIC NEPHROLOGY

Genetics of Atypical Hemolytic Uremic Syndrome (aHUS)

(2014) Marta Hidalgo et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Distinct Renal Pathology and a Chemotactic Phenotype after Enterohemorrhagic Escherichia coli Shiga Toxins in Non-Human Primate Models of Hemolytic Uremic Syndrome

(2013) Deborah J. Stearns-Kurosawa et al.   AMERICAN JOURNAL OF PATHOLOGY

Oral Intoxication of Mice with Shiga Toxin Type 2a (Stx2a) and Protection by Anti-Stx2a Monoclonal Antibody 11E10

(2013) L. M. Russo et al.   INFECTION AND IMMUNITY

Terminal Complement Inhibitor Eculizumab in Atypical Hemolytic–Uremic Syndrome

(2013) C.M. Legendre et al.   NEW ENGLAND JOURNAL OF MEDICINE

Serum neutrophil gelatinase-associated lipocalin (NGAL) in patients with Shiga toxin mediated haemolytic uraemic syndrome (STEC-HUS)

(2013) Jan Beneke et al.   THROMBOSIS AND HAEMOSTASIS

The CXCR4/CXCR7/SDF-1 pathway contributes to the pathogenesis of Shiga toxin–associated hemolytic uremic syndrome in humans and mice

(2012) Tania N. Petruzziello-Pellegrini et al.   JOURNAL OF CLINICAL INVESTIGATION

Shiga Toxins and the Pathophysiology of Hemolytic Uremic Syndrome in Humans and Animals

(2012) Chad L. Mayer et al.   Toxins

Mouse Models ofEscherichia coliO157:H7 Infection and Shiga Toxin Injection

(2011) Krystle L. Mohawk et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Alternative Pathway Activation of Complement by Shiga Toxin Promotes Exuberant C3a Formation That Triggers Microvascular Thrombosis

(2011) M. Morigi et al.   JOURNAL OF IMMUNOLOGY

Epidemic Profile of Shiga-Toxin–ProducingEscherichia coliO104:H4 Outbreak in Germany

(2011) Christina Frank et al.   NEW ENGLAND JOURNAL OF MEDICINE

Characterization of Stx2 Tubular Response in a Rat Experimental Model of Hemolytic Uremic Syndrome

(2010) F. Ochoa et al.   AMERICAN JOURNAL OF NEPHROLOGY

Distinct Physiologic and Inflammatory Responses Elicited in Baboons after Challenge with Shiga Toxin Type 1 or 2 from Enterohemorrhagic Escherichia coli

(2010) D. J. Stearns-Kurosawa et al.   INFECTION AND IMMUNITY

Ingested Shiga Toxin 2 (Stx2) Causes Histopathological Changes in Kidney, Spleen, and Thymus Tissues and Mortality in Mice

(2010) Reuven Rasooly et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

A Central Role for Free Heme in the Pathogenesis of Severe Sepsis

(2010) R. Larsen et al.   Science Translational Medicine

Alternative Pathway of Complement in Children with Diarrhea-Associated Hemolytic Uremic Syndrome

(2009) J. M. Thurman et al.   Clinical Journal of the American Society of Nephrology

Shiga Toxin 2 Targets the Murine Renal Collecting Duct Epithelium

(2009) M. A. Psotka et al.   INFECTION AND IMMUNITY

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Mouse Model of Hemolytic-Uremic Syndrome Caused by Endotoxin-Free Shiga Toxin 2 (Stx2) and Protection from Lethal Outcome by Anti-Stx2 Antibody

(2008) K. A. D. Sauter et al.   INFECTION AND IMMUNITY

Intravenous Shiga toxin 2 promotes enteritis and renal injury characterized by polymorphonuclear leukocyte infiltration and thrombosis in Dutch Belted rabbits

(2008) Alexis García et al.   MICROBES AND INFECTION