Shiga Toxins and the Pathophysiology of Hemolytic Uremic Syndrome in Humans and Animals

Mechanistic View of Risk Factors for Venous Thromboembolism

(2012) Pieter H. Reitsma et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Therapeutic concentrations of antibiotics inhibit Shiga toxin release from enterohemorrhagic E. coli O104:H4 from the 2011 German outbreak

(2012) Diana Corogeanu et al.   BMC MICROBIOLOGY

The neurological syndrome in adults during the 2011 northern German E. coli serotype O104:H4 outbreak

(2012) Tim Magnus et al.   BRAIN

Risk Factors for the Hemolytic Uremic Syndrome in Children Infected With Escherichia coli O157:H7: A Multivariable Analysis

(2012) C. S. Wong et al.   CLINICAL INFECTIOUS DISEASES

E. coli O104:H4 German outbreak: a missed opportunity

(2012) Piero Ruggenenti et al.   Nature Reviews Nephrology

Isolation and Characterization of Intestinal Epithelial Cells from Normal and SIV-Infected Rhesus Macaques

(2012) Diganta Pan et al.   PLoS One

Manganese Blocks Intracellular Trafficking of Shiga Toxin and Protects Against Shiga Toxicosis

(2012) S. Mukhopadhyay et al.   SCIENCE

The Role and Source of Tumor Necrosis Factor-α in Hemorrhage-Induced Priming for Septic Lung Injury

(2012) Joanne Lomas-Neira et al.   SHOCK

Gut-origin sepsis: Evolution of a concept

(2012) Edwin A. Deitch   SURGEON-JOURNAL OF THE ROYAL COLLEGES OF SURGEONS OF EDINBURGH AND IRELAND

Validation of treatment strategies for enterohaemorrhagic Escherichia coli O104:H4 induced haemolytic uraemic syndrome: case-control study

(2012) J. Menne et al.   BMJ-British Medical Journal

Shiga Toxin 1 Induces on Lipopolysaccharide-Treated Astrocytes the Release of Tumor Necrosis Factor-alpha that Alter Brain-Like Endothelium Integrity

(2012) Verónica I. Landoni et al.   PLoS Pathogens

The Interactions of Human Neutrophils with Shiga Toxins and Related Plant Toxins: Danger or Safety?

(2012) Maurizio Brigotti   Toxins

The Pathogenesis of Sepsis

(2011) Deborah J. Stearns-Kurosawa et al.   Annual Review of Pathology-Mechanisms of Disease

Complement activation on platelet-leukocyte complexes and microparticles in enterohemorrhagic Escherichia coli-induced hemolytic uremic syndrome

(2011) A.-l. Stahl et al.   BLOOD

Factors Associated with Sporadic Verotoxigenic Escherichia coli Infection in Children with Diarrhea from the Central Eastern Area of Argentina

(2011) Mariana Alejandra Rivero et al.   Foodborne Pathogens and Disease

Molecular Mechanisms That Mediate Colonization of Shiga Toxin-Producing Escherichia coli Strains

(2011) Mauricio J. Farfan et al.   INFECTION AND IMMUNITY

Mouse Models ofEscherichia coliO157:H7 Infection and Shiga Toxin Injection

(2011) Krystle L. Mohawk et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Alternative Pathway Activation of Complement by Shiga Toxin Promotes Exuberant C3a Formation That Triggers Microvascular Thrombosis

(2011) M. Morigi et al.   JOURNAL OF IMMUNOLOGY

Treatment of severe neurological deficits with IgG depletion through immunoadsorption in patients with Escherichia coli O104:H4-associated haemolytic uraemic syndrome: a prospective trial

(2011) Andreas Greinacher et al.   LANCET

Characterisation of the Escherichia coli strain associated with an outbreak of haemolytic uraemic syndrome in Germany, 2011: a microbiological study

(2011) Martina Bielaszewska et al.   LANCET INFECTIOUS DISEASES

Eculizumab in Severe Shiga-Toxin–Associated HUS

(2011) Anne-Laure Lapeyraque et al.   NEW ENGLAND JOURNAL OF MEDICINE

Epidemic Profile of Shiga-Toxin–ProducingEscherichia coliO104:H4 Outbreak in Germany

(2011) Christina Frank et al.   NEW ENGLAND JOURNAL OF MEDICINE

German Outbreak ofEscherichia coliO104:H4 Associated with Sprouts

(2011) Udo Buchholz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Atypical hemolytic uremic syndrome

(2011) Chantal Loirat et al.   Orphanet Journal of Rare Diseases

Streptococcus pneumoniae-associated Hemolytic Uremic Syndrome Among Children in North America

(2011) Ritu Banerjee et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Rescue from lethal Shiga toxin 2-induced renal failure with a cell-permeable peptide

(2011) Deborah J. Stearns-Kurosawa et al.   PEDIATRIC NEPHROLOGY

Shiga toxin B subunits induce VWF secretion by human endothelial cells and thrombotic microangiopathy in ADAMTS13-deficient mice

(2010) J. Huang et al.   BLOOD

The complement system

(2010) J. Vidya Sarma et al.   CELL AND TISSUE RESEARCH

Relative Role of Genetic Complement Abnormalities in Sporadic and Familial aHUS and Their Impact on Clinical Phenotype

(2010) M. Noris et al.   Clinical Journal of the American Society of Nephrology

Regulation of inflammation by the protein C system

(2010) Hartmut Weiler   CRITICAL CARE MEDICINE

Distinct Physiologic and Inflammatory Responses Elicited in Baboons after Challenge with Shiga Toxin Type 1 or 2 from Enterohemorrhagic Escherichia coli

(2010) D. J. Stearns-Kurosawa et al.   INFECTION AND IMMUNITY

Pathophysiology of thrombotic thrombocytopenic purpura

(2010) Han-Mou Tsai   INTERNATIONAL JOURNAL OF HEMATOLOGY

Clinical Relevance of Shiga Toxin Concentrations in the Blood of Patients With Hemolytic Uremic Syndrome

(2010) Maurizio Brigotti et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Genetics and complement in atypical HUS

(2010) David Kavanagh et al.   PEDIATRIC NEPHROLOGY

Shiga toxin-associated hemolytic uremic syndrome: pathophysiology of endothelial dysfunction

(2010) Carla Zoja et al.   PEDIATRIC NEPHROLOGY

Escherichia coli Shiga Toxin Mechanisms of Action in Renal Disease

(2010) Tom G. Obrig   Toxins

Hemolytic Uremic Syndrome and Death in Persons withEscherichia coliO157:H7 Infection, Foodborne Diseases Active Surveillance Network Sites, 2000–2006

(2009) L. Hannah Gould et al.   CLINICAL INFECTIOUS DISEASES

Alternative Pathway of Complement in Children with Diarrhea-Associated Hemolytic Uremic Syndrome

(2009) J. M. Thurman et al.   Clinical Journal of the American Society of Nephrology

Soluble thrombomodulin: A sign of bad times*

(2009) Shinichiro Kurosawa et al.   CRITICAL CARE MEDICINE

Serum thrombomodulin level relates to the clinical course of disseminated intravascular coagulation, multiorgan dysfunction syndrome, and mortality in patients with sepsis*

(2009) Shu-Min Lin et al.   CRITICAL CARE MEDICINE

Shiga Toxin 1-Induced Inflammatory Response in Lipopolysaccharide-Sensitized Astrocytes Is Mediated by Endogenous Tumor Necrosis Factor Alpha

(2009) V. I. Landoni et al.   INFECTION AND IMMUNITY

Shiga Toxin Activates Complement and Binds Factor H: Evidence for an Active Role of Complement in Hemolytic Uremic Syndrome

(2009) Dorothea Orth et al.   JOURNAL OF IMMUNOLOGY

Eculizumab for Atypical Hemolytic–Uremic Syndrome

(2009) Jens Nürnberger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Eculizumab for Congenital Atypical Hemolytic–Uremic Syndrome

(2009) Ralph A. Gruppo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Thrombomodulin Mutations in Atypical Hemolytic–Uremic Syndrome

(2009) Mieke Delvaeye et al.   NEW ENGLAND JOURNAL OF MEDICINE

Macropinocytosis in Shiga toxin 1 uptake by human intestinal epithelial cells and transcellular transcytosis

(2008) Irina Malyukova et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Mutations in complement C3 predispose to development of atypical hemolytic uremic syndrome

(2008) V. Fremeaux-Bacchi et al.   BLOOD

Subtilase cytotoxin activates PERK, IRE1 and ATF6 endoplasmic reticulum stress-signalling pathways

(2008) Jennifer J. Wolfson et al.   CELLULAR MICROBIOLOGY

Shiga toxin 1 induces apoptosis through the endoplasmic reticulum stress response in human monocytic cells

(2008) Sang-Yun Lee et al.   CELLULAR MICROBIOLOGY

Renal damage and death in weaned mice after oral infection with Shiga toxin 2-producingEscherichia colistrains

(2008) R. J. F. Brando et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Mouse Model of Hemolytic-Uremic Syndrome Caused by Endotoxin-Free Shiga Toxin 2 (Stx2) and Protection from Lethal Outcome by Anti-Stx2 Antibody

(2008) K. A. D. Sauter et al.   INFECTION AND IMMUNITY

Liver-Kidney Transplantation to Cure Atypical Hemolytic Uremic Syndrome

(2008) J. M. Saland et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Development of an experimental hemolytic uremic syndrome in rats

(2008) Elsa Zotta et al.   PEDIATRIC NEPHROLOGY

Duration of oliguria and anuria as predictors of chronic renal-related sequelae in post-diarrheal hemolytic uremic syndrome

(2008) Robert S. Oakes et al.   PEDIATRIC NEPHROLOGY

Membrane cofactor protein mutations in atypical hemolytic uremic syndrome (aHUS), fatal Stx-HUS, C3 glomerulonephritis, and the HELLP syndrome

(2007) C. J. Fang et al.   BLOOD