Streptococcus pneumoniae From Patients With Hemolytic Uremic Syndrome Binds Human Plasminogen via the Surface Protein PspC and Uses Plasmin to Damage Human Endothelial Cells

Pneumococcal Adhesins PavB and PspC Are Important for the Interplay with Human Thrombospondin-1

(2015) Ulrike Binsker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of DGK  induces endothelial cell activation and death independently of complement activation

(2014) S. Bruneau et al.   BLOOD

Tuf of Streptococcus pneumoniae is a surface displayed human complement regulator binding protein

(2014) Sarbani Mohan et al.   MOLECULAR IMMUNOLOGY

Hemolytic uremic syndrome

(2013) Michel Baum   CURRENT OPINION IN PEDIATRICS

Update on Streptococcus pneumoniae associated hemolytic uremic syndrome

(2013) Joann M. Spinale et al.   CURRENT OPINION IN PEDIATRICS

Streptococcus pneumoniaeEndopeptidase O (PepO) Is a Multifunctional Plasminogen- and Fibronectin-binding Protein, Facilitating Evasion of Innate Immunity and Invasion of Host Cells

(2013) Vaibhav Agarwal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comprehensive Genetic Analysis of Complement and Coagulation Genes in Atypical Hemolytic Uremic Syndrome

(2013) F. Bu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Does dysregulated complement activation contribute to haemolytic uraemic syndrome secondary to Streptococcus pneumoniae?

(2013) Rodney D. Gilbert et al.   MEDICAL HYPOTHESES

Human complement control and complement evasion by pathogenic microbes – Tipping the balance

(2013) Peter F. Zipfel et al.   MOLECULAR IMMUNOLOGY

DGKE and atypical HUS

(2013) Susan E Quaggin   NATURE GENETICS

Glomerular endothelium: A porous sieve and formidable barrier

(2012) Marya Obeidat et al.   EXPERIMENTAL CELL RESEARCH

Streptococcus pneumoniae Capsular Serotype Invasiveness Correlates with the Degree of Factor H Binding and Opsonization with C3b/iC3b

(2012) Catherine Hyams et al.   INFECTION AND IMMUNITY

Plasminogen Is a Complement Inhibitor

(2012) Diana Barthel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel developments in thrombotic microangiopathies: is there a common link between hemolytic uremic syndrome and thrombotic thrombocytic purpura?

(2011) Peter F. Zipfel et al.   PEDIATRIC NEPHROLOGY

Complement Regulator Factor H Mediates a Two-step Uptake ofStreptococcus pneumoniaeby Human Cells

(2010) Vaibhav Agarwal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DEAP-HUS: Deficiency of CFHR plasma proteins and autoantibody-positive form of hemolytic uremic syndrome

(2010) Peter F. Zipfel et al.   PEDIATRIC NEPHROLOGY

Association of factor H autoantibodies with deletions of CFHR1, CFHR3, CFHR4, and with mutations in CFH, CFI, CD46, and C3 in patients with atypical hemolytic uremic syndrome

(2009) I. Moore et al.   BLOOD

The Effects of PspC on Complement-Mediated Immunity to Streptococcus pneumoniae Vary with Strain Background and Capsular Serotype

(2009) J. Yuste et al.   INFECTION AND IMMUNITY

Clinical Isolates of Streptococcus pneumoniae Bind the Complement Inhibitor C4b-Binding Protein in a PspC Allele-Dependent Fashion

(2009) A. Dieudonne-Vatran et al.   JOURNAL OF IMMUNOLOGY

Complement evasion strategies of pathogens—Acquisition of inhibitors and beyond

(2009) Anna M. Blom et al.   MOLECULAR IMMUNOLOGY

Thrombomodulin Mutations in Atypical Hemolytic–Uremic Syndrome

(2009) Mieke Delvaeye et al.   NEW ENGLAND JOURNAL OF MEDICINE

The complement fitness Factor H: Role in human diseases and for immune escape of pathogens, like pneumococci

(2008) Peter F. Zipfel et al.   VACCINE