(−)-Englerin A is a Potent and Selective Activator of TRPC4 and TRPC5 Calcium Channels

Biology-Oriented Synthesis: Harnessing the Power of Evolution

(2014) Hilde van Hattum et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nature's contribution to today's pharmacopeia

(2014) Lin Tao et al.   NATURE BIOTECHNOLOGY

A Short Enantioselective Total Synthesis of (−)-Englerin A

(2013) Martin Zahel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

In pursuit of small molecule chemistry for calcium-permeable non-selective TRPC channels - mirage or pot of gold?

(2013) Robin S Bon et al.   BRITISH JOURNAL OF PHARMACOLOGY

Englerin A Stimulates PKCθ to Inhibit Insulin Signaling and to Simultaneously Activate HSF1: Pharmacologically Induced Synthetic Lethality

(2013) Carole Sourbier et al.   CANCER CELL

Characteristics of Transient Receptor Potential Canonical Calcium-Permeable Channels and Their Relevance to Vascular Physiology and Disease

(2013) David J. Beech   CIRCULATION JOURNAL

Conserved Gating Elements in TRPC4 and TRPC5 Channels

(2013) Andreas Beck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Renal cancer-selective Englerin A induces multiple mechanisms of cell death and autophagy

(2013) Richard T Williams et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Isoform- and receptor-specific channel property of canonical transient receptor potential (TRPC)1/4 channels

(2013) Jinsung Kim et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Renal cancer biomarkers: the promise of personalized care

(2012) Naveen S Vasudev et al.   BMC Medicine

Renal cancer: Oxygen meets metabolism

(2012) Volker H. Haase   EXPERIMENTAL CELL RESEARCH

Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

(2012) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Englerin A Selectively Induces Necrosis in Human Renal Cancer Cells

(2012) Florian J. Sulzmaier et al.   PLoS One

Concepts in Advanced Renal Carcinoma

(2012) Peg Esper   Seminars in Oncology Nursing

Total Synthesis and Biological Evaluation of (−)-Englerin A and B: Synthesis of Analogues with Improved Activity Profile

(2011) Lea Radtke et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biology-Oriented Synthesis

(2011) Stefan Wetzel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chemical Synthesis of the Englerins

(2011) Rebecca H. Pouwer et al.   Chemistry-An Asian Journal

Corrigendum to “The Epidemiology of Renal Cell Carcinoma” [Eur Urol 2011;60:615–21]

(2011) Börje Ljungberg et al.   EUROPEAN UROLOGY

Identification of ML204, a Novel Potent Antagonist That Selectively Modulates Native TRPC4/C5 Ion Channels

(2011) Melissa Miller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Brief Synthesis of (−)-Englerin A

(2011) Zhenwu Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Transient receptor potential channels as therapeutic targets

(2011) Magdalene M. Moran et al.   NATURE REVIEWS DRUG DISCOVERY

Bioactivity-Guided Navigation of Chemical Space

(2010) Robin S. Bon et al.   ACCOUNTS OF CHEMICAL RESEARCH

Enantioselective Synthesis of (−)-Englerins A and B

(2010) Kian Molawi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric, Protecting-Group-Free Total Synthesis of (−)-Englerin A

(2010) Qianghui Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Synthesis of Englerin A

(2010) K. C. Nicolaou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Formal Synthesis of (−)-Englerin A via a Rh-Catalyzed [4 + 3] Cycloaddition Reaction

(2010) Jing Xu et al.   ORGANIC LETTERS

Total Synthesis and Absolute Configuration of the Guaiane Sesquiterpene Englerin A

(2009) Matthieu Willot et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Physiology and pathophysiology of canonical transient receptor potential channels

(2009) Joel Abramowitz et al.   FASEB JOURNAL

Biology-inspired synthesis of compound libraries

(2008) M. Kaiser et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

TRPs in Our Senses

(2008) Nils Damann et al.   CURRENT BIOLOGY

TRPC channel activation by extracellular thioredoxin

(2008) Shang-Zhong Xu et al.   NATURE

Englerin A, a Selective Inhibitor of Renal Cancer Cell Growth, fromPhyllanthus engleri

(2008) Ranjala Ratnayake et al.   ORGANIC LETTERS