Integrin-based diffusion barrier separates membrane domains enabling the formation of microbiostatic frustrated phagosomes

pH of endophagosomes controls association of their membranes with Vps34 and PtdIns(3)P levels

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LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formation

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Integrins Form an Expanding Diffusional Barrier that Coordinates Phagocytosis

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LC3-associated phagocytosis: a crucial mechanism for antifungal host defence againstAspergillus fumigatus

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Dectin-1 Controls TLR9 Trafficking to Phagosomes Containing β-1,3 Glucan

(2016) Nida S. Khan et al.   JOURNAL OF IMMUNOLOGY

The Tyrosine Kinase Pyk2 Contributes to Complement-Mediated Phagocytosis in Murine Macrophages

(2016) Christoph Paone et al.   Journal of Innate Immunity

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(2016) Lars P. Erwig et al.   NATURE REVIEWS MICROBIOLOGY

Gliotoxin Suppresses Macrophage Immune Function by Subverting Phosphatidylinositol 3,4,5-Trisphosphate Homeostasis

(2016) Daniel Schlam et al.   mBio

Functional Genomic Analysis of Candida albicans Adherence Reveals a Key Role for the Arp2/3 Complex in Cell Wall Remodelling and Biofilm Formation

(2016) Jason A. Lee et al.   PLoS Genetics

Roles of Autophagy and Autophagy-Related Proteins in Antifungal Immunity

(2016) Masashi Kanayama et al.   Frontiers in Immunology

Novel Role of Src in Priming Pyk2 Phosphorylation

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Phosphoinositides in phagocytosis and macropinocytosis

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Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins

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Global analysis of fungal morphology exposes mechanisms of host cell escape

(2015) Teresa R. O’Meara et al.   Nature Communications

Salmonella Disrupts Host Endocytic Trafficking by SopD2-Mediated Inhibition of Rab7

(2015) Vanessa M. D’Costa et al.   Cell Reports

CR3 and Dectin-1 Collaborate in Macrophage Cytokine Response through Association on Lipid Rafts and Activation of Syk-JNK-AP-1 Pathway

(2015) Juin-Hua Huang et al.   PLoS Pathogens

Disruption of Sphingolipid Biosynthesis Blocks Phagocytosis of Candida albicans

(2015) Fikadu G. Tafesse et al.   PLoS Pathogens

Bordetella adenylate cyclase toxin is a unique ligand of the integrin complement receptor 3

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Candida albicans Targets a Lipid Raft/Dectin-1 Platform to Enter Human Monocytes and Induce Antigen Specific T Cell Responses

(2015) Valeria de Turris et al.   PLoS One

The Induction of Inflammation by Dectin-1 In Vivo Is Dependent on Myeloid Cell Programming and the Progression of Phagocytosis

(2014) M. Rosas et al.   JOURNAL OF IMMUNOLOGY

Neutrophils sense microbe size and selectively release neutrophil extracellular traps in response to large pathogens

(2014) Nora Branzk et al.   NATURE IMMUNOLOGY

Candida albicans Hypha Formation and Mannan Masking of β-Glucan Inhibit Macrophage Phagosome Maturation

(2014) Judith M. Bain et al.   mBio

Fungal Chitin Dampens Inflammation through IL-10 Induction Mediated by NOD2 and TLR9 Activation

(2014) Jeanette Wagener et al.   PLoS Pathogens

Hiding in Plain Sight: Interplay between Staphylococcal Biofilms and Host Immunity

(2014) Tyler D. Scherr et al.   Frontiers in Immunology

The large ectodomains of CD45 and CD148 regulate their segregation from and inhibition of ligated T-cell receptor

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Dectin-1 Activation Controls Maturation of β-1,3-Glucan-containing Phagosomes

(2013) Michael K. Mansour et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Filamentous morphology of bacteria delays the timing of phagosome morphogenesis in macrophages

(2013) Akriti Prashar et al.   JOURNAL OF CELL BIOLOGY

Bruton's Tyrosine Kinase (BTK) and Vav1 Contribute to Dectin1-Dependent Phagocytosis of Candida albicans in Macrophages

(2013) Karin Strijbis et al.   PLoS Pathogens

NADPH Oxidase-Driven Phagocyte Recruitment Controls Candida albicans Filamentous Growth and Prevents Mortality

(2013) Kimberly M. Brothers et al.   PLoS Pathogens

Differential Adaptation of Candida albicans In Vivo Modulates Immune Recognition by Dectin-1

(2013) Mohlopheni J. Marakalala et al.   PLoS Pathogens

Lifetime of Major Histocompatibility Complex Class-I Membrane Clusters Is Controlled by the Actin Cytoskeleton

(2012) Yael Lavi et al.   BIOPHYSICAL JOURNAL

C-type lectin receptors orchestrate antifungal immunity

(2012) Sarah E Hardison et al.   NATURE IMMUNOLOGY

Hidden Killers: Human Fungal Infections

(2012) G. D. Brown et al.   Science Translational Medicine

Thinking outside the cell: how cadherins drive adhesion

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Stage Specific Assessment of Candida albicans Phagocytosis by Macrophages Identifies Cell Wall Composition and Morphogenesis as Key Determinants

(2012) Leanne E. Lewis et al.   PLoS Pathogens

The β-Glucan Receptor Dectin-1 Activates the Integrin Mac-1 in Neutrophils via Vav Protein Signaling to Promote Candida albicans Clearance

(2011) Xun Li et al.   Cell Host & Microbe

Phagosomal proteolysis in dendritic cells is modulated by NADPH oxidase in a pH-independent manner

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Polarized Secretion of Lysosomes at the B Cell Synapse Couples Antigen Extraction to Processing and Presentation

(2011) Maria-Isabel Yuseff et al.   IMMUNITY

The Interaction between Candida krusei and Murine Macrophages Results in Multiple Outcomes, Including Intracellular Survival and Escape from Killing

(2011) Rocío García-Rodas et al.   INFECTION AND IMMUNITY

Lectin Site Ligation of CR3 Induces Conformational Changes and Signaling

(2011) Xian M. O'Brien et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Staphylococcus aureus Biofilms Prevent Macrophage Phagocytosis and Attenuate Inflammation In Vivo

(2011) L. R. Thurlow et al.   JOURNAL OF IMMUNOLOGY

Fitness and Virulence Costs of Candida albicans FKS1 Hot Spot Mutations Associated With Echinocandin Resistance

(2011) Ronen Ben-Ami et al.   JOURNAL OF INFECTIOUS DISEASES

Protein kinase Cδ is a critical component of Dectin-1 signaling in primary human monocytes

(2011) Deena H. Elsori et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Evidence for a fence that impedes the diffusion of phosphatidylinositol 4,5-bisphosphate out of the forming phagosomes of macrophages

(2011) Urszula Golebiewska et al.   MOLECULAR BIOLOGY OF THE CELL

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(2011) Helen S. Goodridge et al.   NATURE

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(2011) Peter E. Sudbery   NATURE REVIEWS MICROBIOLOGY

Candida albicans morphogenesis and host defence: discriminating invasion from colonization

(2011) Neil A. R. Gow et al.   NATURE REVIEWS MICROBIOLOGY

Fungal recognition is mediated by the association of dectin-1 and galectin-3 in macrophages

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Indirect Inhibition of Toll-like Receptor and Type I Interferon Responses by ITAM-Coupled Receptors and Integrins

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Contribution of Candida albicans Cell Wall Components to Recognition by and Escape from Murine Macrophages

(2010) C. G. J. McKenzie et al.   INFECTION AND IMMUNITY

The L412F variant of Toll-like receptor 3 (TLR3) is associated with cutaneous candidiasis, increased susceptibility to cytomegalovirus, and autoimmunity

(2010) Amit Nahum et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Class I and class III phosphoinositide 3-kinases are required for actin polymerization that propels phagosomes

(2010) Michal Bohdanowicz et al.   JOURNAL OF CELL BIOLOGY

Pyk2 Is Required for Neutrophil Degranulation and Host Defense Responses to Bacterial Infection

(2010) L. A. Kamen et al.   JOURNAL OF IMMUNOLOGY

Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b

(2010) Chaofeng Han et al.   NATURE IMMUNOLOGY

The final steps of integrin activation: the end game

(2010) Sanford J. Shattil et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Asbestos, carbon nanotubes and the pleural mesothelium: a review and the hypothesis regarding the role of long fibre retention in the parietal pleura, inflammation and mesothelioma

(2010) Ken Donaldson et al.   Particle and Fibre Toxicology

Self-organizing actin waves as planar phagocytic cup structures

(2010) Guenther Gerisch et al.   Cell Adhesion & Migration

Candida albicansinternalization by host cells is mediated by a clathrin-dependent mechanism

(2009) Emilia Moreno-Ruiz et al.   CELLULAR MICROBIOLOGY

Influence of Mannan and Glucan on Complement Activation and C3 Binding by Candida albicans

(2009) G. M. Boxx et al.   INFECTION AND IMMUNITY

Activated Dectin-1 Localizes to Lipid Raft Microdomains for Signaling and Activation of Phagocytosis and Cytokine Production in Dendritic Cells

(2009) Shengli Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NADPH oxidase controls phagosomal pH and antigen cross-presentation in human dendritic cells

(2008) A. R. Mantegazza et al.   BLOOD

Dectin-1 synergizes with TLR2 and TLR4 for cytokine production in human primary monocytes and macrophages

(2008) Gerben Ferwerda et al.   CELLULAR MICROBIOLOGY

Specificity of Interactions between mDia Isoforms and Rho Proteins

(2008) Michael Lammers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Paxillin comes of age

(2008) N. O. Deakin et al.   JOURNAL OF CELL SCIENCE

Integrin-dependent phagocytosis - spreading from microadhesion to new concepts

(2008) A. G. Dupuy et al.   JOURNAL OF CELL SCIENCE

Actin and Phosphoinositide Recruitment to Fully Formed Candida albicans Phagosomes in Mouse Macrophages

(2008) Sigrid E.M. Heinsbroek et al.   Journal of Innate Immunity

Lifeact: a versatile marker to visualize F-actin

(2008) Julia Riedl et al.   NATURE METHODS

An integrated model of the recognition of Candida albicans by the innate immune system

(2007) Mihai G. Netea et al.   NATURE REVIEWS MICROBIOLOGY