Fatty Acid Synthase induced S6Kinase facilitates USP11-eIF4B complex formation for sustained oncogenic translation in DLBCL

Mutations of CREBBP and SOCS1 are independent prognostic factors in diffuse large B cell lymphoma: mutational analysis of the SAKK 38/07 prospective clinical trial cohort

(2017) Darius Juskevicius et al.   Journal of Hematology & Oncology

Regulation of XIAP Turnover Reveals a Role for USP11 in Promotion of Tumorigenesis

(2017) Zhuan Zhou et al.   EBioMedicine

Translational control by mTOR-independent routes: how eIF6 organizes metabolism

(2016) A. Miluzio et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Differential Regulation of the Melanoma Proteome by eIF4A1 and eIF4E

(2016) Cailin E. Joyce et al.   CANCER RESEARCH

miR-146b-5p within BCR-ABL1-Positive Microvesicles Promotes Leukemic Transformation of Hematopoietic Cells

(2016) H.-M. Zhang et al.   CANCER RESEARCH

Migration and epithelial-to-mesenchymal transition of lung cancer can be targeted via translation initiation factors eIF4E and eIF4GI

(2016) Oshrat Attar-Schneider et al.   LABORATORY INVESTIGATION

Mitotic MELK-eIF4B signaling controls protein synthesis and tumor cell survival

(2016) Yubao Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FASN regulates cellular response to genotoxic treatments by increasing PARP-1 expression and DNA repair activity via NF-κB and SP1

(2016) Xi Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

miR-150 exerts antileukemia activity in vitro and in vivo through regulating genes in multiple pathways

(2016) Zhi Hong Fang et al.   Cell Death & Disease

Lipid metabolic reprogramming in cancer cells

(2016) S Beloribi-Djefaflia et al.   Oncogenesis

Combinatorial targeting of nuclear export and translation of RNA inhibits aggressive B-cell lymphomas

(2015) B. Culjkovic-Kraljacic et al.   BLOOD

Evolution of the highly networked deubiquitinating enzymes USP4, USP15, and USP11

(2015) Caitlyn Vlasschaert et al.   BMC EVOLUTIONARY BIOLOGY

The Circadian Protein BMAL1 Regulates Translation in Response to S6K1-Mediated Phosphorylation

(2015) Jonathan O. Lipton et al.   CELL

Molecular Pathways: Fatty Acid Synthase

(2015) S. F. Jones et al.   CLINICAL CANCER RESEARCH

DUSP4 deficiency caused by promoter hypermethylation drives JNK signaling and tumor cell survival in diffuse large B cell lymphoma

(2015) Corina A. Schmid et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Targeting the translation machinery in cancer

(2015) Mamatha Bhat et al.   NATURE REVIEWS DRUG DISCOVERY

Deubiquitinase inhibition as a cancer therapeutic strategy

(2015) Padraig D'Arcy et al.   PHARMACOLOGY & THERAPEUTICS

Intracellular activation of EGFR by fatty acid synthase dependent palmitoylation

(2015) Lakshmi Reddy Bollu et al.   Oncotarget

SOCS1 Mutation Subtypes Predict Divergent Outcomes in Diffuse Large B-Cell Lymphoma (DLBCL) Patients

(2015) Birgit Schif et al.   Oncotarget

Inhibiting CARD11 translation during BCR activation by targeting the eIF4A RNA helicase

(2014) J. J. Steinhardt et al.   BLOOD

Abrogating phosphorylation of eIF4B is required for EGFR and mTOR inhibitor synergy in triple-negative breast cancer

(2014) Julie M. Madden et al.   BREAST CANCER RESEARCH AND TREATMENT

The mTORC1/S6K1 Pathway Regulates Glutamine Metabolism through the eIF4B-Dependent Control of c-Myc Translation

(2014) Alfredo Csibi et al.   CURRENT BIOLOGY

Targeting the B-cell receptor signaling pathway in B lymphoid malignancies

(2014) Maike Buchner et al.   CURRENT OPINION IN HEMATOLOGY

The Pim-1 Protein Kinase Is an Important Regulator of MET Receptor Tyrosine Kinase Levels and Signaling

(2014) B. Cen et al.   MOLECULAR AND CELLULAR BIOLOGY

Integrative Functional Genomics of Hepatitis C Virus Infection Identifies Host Dependencies in Complete Viral Replication Cycle

(2014) Qisheng Li et al.   PLoS Pathogens

Is Cancer a Metabolic Disease?

(2013) Hilary A. Coller   AMERICAN JOURNAL OF PATHOLOGY

eIF4B Phosphorylation by Pim Kinases Plays a Critical Role in Cellular Transformation by Abl Oncogenes

(2013) J. Yang et al.   CANCER RESEARCH

Emerging Role of the Ubiquitin-proteasome System as Drug Targets

(2013) Gozde Kar et al.   CURRENT PHARMACEUTICAL DESIGN

A role for eukaryotic initiation factor 4B overexpression in the pathogenesis of diffuse large B-cell lymphoma

(2013) E Horvilleur et al.   LEUKEMIA

Ubiquitin Hydrolase UCH-L1 Destabilizes mTOR Complex 1 by Antagonizing DDB1-CUL4-Mediated Ubiquitination of Raptor

(2013) Sajjad Hussain et al.   MOLECULAR AND CELLULAR BIOLOGY

Mitoxantrone Targets Human Ubiquitin-Specific Peptidase 11 (USP11) and Is a Potent Inhibitor of Pancreatic Cancer Cell Survival

(2013) Richard A. Burkhart et al.   MOLECULAR CANCER RESEARCH

A20 (TNFAIP3) Deletion in Epstein-Barr Virus-Associated Lymphoproliferative Disorders/Lymphomas

(2013) Midori Ando et al.   PLoS One

PTEN loss defines a PI3K/AKT pathway-dependent germinal center subtype of diffuse large B-cell lymphoma

(2013) M. Pfeifer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modifying chemotherapy response by targeted inhibition of eukaryotic initiation factor 4A

(2013) R Cencic et al.   Blood Cancer Journal

MYC, Metabolism, Cell Growth, and Tumorigenesis

(2013) C. V. Dang   Cold Spring Harbor Perspectives in Medicine

Treatment challenges in the management of relapsed or refractory non-Hodgkin’s lymphoma – novel and emerging therapies

(2013) Mark Chao   Cancer Management and Research

The ubiquitin-specific protease USP2a enhances tumor progression by targeting cyclin A1 in bladder cancer

(2012) Jayoung Kim et al.   CELL CYCLE

A high-throughput approach for measuring temporal changes in the interactome

(2012) Anders R Kristensen et al.   NATURE METHODS

USP11 augments TGF  signalling by deubiquitylating ALK5

(2012) M. A. Al-Salihi et al.   Open Biology

ATM regulates a DNA damage response posttranscriptional RNA operon in lymphocytes

(2011) K. Mazan-Mamczarz et al.   BLOOD

Targeting the translational machinery as a novel treatment strategy for hematologic malignancies

(2010) P. R. Hagner et al.   BLOOD

BLIMP1 Is a Tumor Suppressor Gene Frequently Disrupted in Activated B Cell-like Diffuse Large B Cell Lymphoma

(2010) Jonathan Mandelbaum et al.   CANCER CELL

eIF4B controls survival and proliferation and is regulated by proto-oncogenic signaling pathways

(2010) David Shahbazian et al.   CELL CYCLE

Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor

(2010) Goedele N Maertens et al.   EMBO JOURNAL

Sensitivity to Poly(ADP-ribose) Polymerase (PARP) Inhibition Identifies Ubiquitin-specific Peptidase 11 (USP11) as a Regulator of DNA Double-strand Break Repair

(2010) Timothy D. Wiltshire et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ribavirin as an anti-cancer therapy: acute myeloid leukemia and beyond?

(2010) Katherine L. B. Borden et al.   LEUKEMIA & LYMPHOMA

Inhibition of Fatty Acid Synthase Suppresses c-Met Receptor Kinase and Induces Apoptosis in Diffuse Large B-Cell Lymphoma

(2010) S. Uddin et al.   MOLECULAR CANCER THERAPEUTICS

TNFAIP3/A20 functions as a novel tumor suppressor gene in several subtypes of non-Hodgkin lymphomas

(2009) K. Honma et al.   BLOOD

Defining the Human Deubiquitinating Enzyme Interaction Landscape

(2009) Mathew E. Sowa et al.   CELL

USP11 negatively regulates TNFα-induced NF-κB activation by targeting on IκBα

(2009) Wenjing Sun et al.   CELLULAR SIGNALLING

SUnSET, a nonradioactive method to monitor protein synthesis

(2009) Enrico K Schmidt et al.   NATURE METHODS

Fatty Acid Synthase Gene Is Up-regulated by Hypoxia via Activation of Akt and Sterol Regulatory Element Binding Protein-1

(2008) E. Furuta et al.   CANCER RESEARCH