Ubiquitin Hydrolase UCH-L1 Destabilizes mTOR Complex 1 by Antagonizing DDB1-CUL4-Mediated Ubiquitination of Raptor
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Title
Ubiquitin Hydrolase UCH-L1 Destabilizes mTOR Complex 1 by Antagonizing DDB1-CUL4-Mediated Ubiquitination of Raptor
Authors
Keywords
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Journal
MOLECULAR AND CELLULAR BIOLOGY
Volume 33, Issue 6, Pages 1188-1197
Publisher
American Society for Microbiology
Online
2013-01-09
DOI
10.1128/mcb.01389-12
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- (2011) E. Liu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The therapeutic potential of deubiquitinating enzyme inhibitors
- (2010) Frédéric Colland BIOCHEMICAL SOCIETY TRANSACTIONS
- Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids
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- mTORC1 signaling requires proteasomal function and the involvement of CUL4-DDB1 ubiquitin E3 ligase
- (2010) Papia Ghosh et al. CELL CYCLE
- mTOR-Dependent Regulation of PHLPP Expression Controls the Rapamycin Sensitivity in Cancer Cells
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- The de-ubiquitinase UCH-L1 is an oncogene that drives the development of lymphoma in vivo by deregulating PHLPP1 and Akt signaling
- (2010) S Hussain et al. LEUKEMIA
- mTOR: from growth signal integration to cancer, diabetes and ageing
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- Association Between the Ubiquitin Carboxyl-Terminal Esterase L1 Gene (UCHL1) S18Y Variant and Parkinson's Disease: A HuGE Review and Meta-Analysis
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- Therapeutic targeting of mTOR in tuberous sclerosis
- (2009) Julian R. Sampson BIOCHEMICAL SOCIETY TRANSACTIONS
- TORC-Specific Phosphorylation of Mammalian Target of Rapamycin (mTOR): Phospho-Ser2481 Is a Marker for Intact mTOR Signaling Complex 2
- (2009) J. Copp et al. CANCER RESEARCH
- mTOR Ser-2481 Autophosphorylation Monitors mTORC-specific Catalytic Activity and Clarifies Rapamycin Mechanism of Action
- (2009) Ghada A. Soliman et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss
- (2009) Luke S Tain et al. NATURE NEUROSCIENCE
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- (2008) B.J. Walters et al. MOLECULAR AND CELLULAR NEUROSCIENCE
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- The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1
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