FASN regulates cellular response to genotoxic treatments by increasing PARP-1 expression and DNA repair activity via NF-κB and SP1

A Small Molecule Compound Targeting STAT3 DNA-Binding Domain Inhibits Cancer Cell Proliferation, Migration, and Invasion

(2014) Wei Huang et al.   ACS Chemical Biology

A novel crosstalk between BRCA1 and poly (ADP-ribose) polymerase 1 in breast cancer

(2014) Da Li et al.   CELL CYCLE

PARG is dispensable for recovery from transient replicative stress but required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress

(2014) Giuditta Illuzzi et al.   NUCLEIC ACIDS RESEARCH

PARP1-Driven Poly-ADP-Ribosylation Regulates BRCA1 Function in Homologous Recombination-Mediated DNA Repair

(2014) Y. Hu et al.   Cancer Discovery

Cisplatin Resistance Associated with PARP Hyperactivation

(2013) J. Michels et al.   CANCER RESEARCH

Fatty acid synthase plays a role in cancer metabolism beyond providing fatty acids for phospholipid synthesis or sustaining elevations in glycolytic activity

(2013) Kathryn E. Hopperton et al.   EXPERIMENTAL CELL RESEARCH

Identification and Functional Characterization of a Ku-binding Motif in Aprataxin Polynucleotide Kinase/Phosphatase-like Factor (APLF)

(2013) Purnata Shirodkar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fatty acid synthase causes drug resistance by inhibiting TNF-α and ceramide production

(2013) Hailan Liu et al.   JOURNAL OF LIPID RESEARCH

Role of poly(ADP-ribose) polymerase-1 in the removal of UV-induced DNA lesions by nucleotide excision repair

(2013) M. Robu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

APLF promotes the assembly and activity of non-homologous end joining protein complexes

(2012) Gabrielle J Grundy et al.   EMBO JOURNAL

On PAR with PARP: cellular stress signaling through poly(ADP-ribose) and PARP-1

(2012) X. Luo et al.   GENES & DEVELOPMENT

Quantitative Live Cell Imaging Reveals a Gradual Shift between DNA Repair Mechanisms and a Maximal Use of HR in Mid S Phase

(2012) Ketki Karanam et al.   MOLECULAR CELL

Nasopharyngeal carcinoma in Indonesia: epidemiology, incidence,signs, and symptoms at presentation

(2012) Marlinda Adham et al.   Chinese Journal of Cancer

Factors determining DNA double-strand break repair pathway choice in G2 phase

(2011) Atsushi Shibata et al.   EMBO JOURNAL

PARP regulates nonhomologous end joining through retention of Ku at double-strand breaks

(2011) C. Anne-Marie Couto et al.   JOURNAL OF CELL BIOLOGY

Role of eIF3a in regulating cisplatin sensitivity and in translational control of nucleotide excision repair of nasopharyngeal carcinoma

(2011) R-Y Liu et al.   ONCOGENE

Role of 14-3-3σ in poor prognosis and in radiation and drug resistance of human pancreatic cancers

(2010) Zhaomin Li et al.   BMC CANCER

Histone  H2AX and Poly(ADP-Ribose) as Clinical Pharmacodynamic Biomarkers

(2010) C. E. Redon et al.   CLINICAL CANCER RESEARCH

PARP1 suppresses homologous recombination events in mice in vivo

(2010) A. Claybon et al.   NUCLEIC ACIDS RESEARCH

PARP1 ADP-ribosylates lysine residues of the core histone tails

(2010) Simon Messner et al.   NUCLEIC ACIDS RESEARCH

Toward a unified nomenclature for mammalian ADP-ribosyltransferases

(2010) Michael O. Hottiger et al.   TRENDS IN BIOCHEMICAL SCIENCES

Poly(ADP-Ribose) Polymerase-1 and DNA-Dependent Protein Kinase Have Equivalent Roles in Double Strand Break Repair Following Ionizing Radiation

(2009) Jody Mitchell et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Parp1 Localizes within the Dnmt1 Promoter and Protects Its Unmethylated State by Its Enzymatic Activity

(2009) Michele Zampieri et al.   PLoS One

Regulation of NF- B by NSD1/FBXL11-dependent reversible lysine methylation of p65

(2009) T. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Poly(ADP-ribose) Polymerase-1 Down-regulates BRCA2 Expression through theBRCA2Promoter

(2008) Jinhua Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A new mechanism of drug resistance in breast cancer cells: fatty acid synthase overexpression-mediated palmitate overproduction

(2008) H. Liu et al.   MOLECULAR CANCER THERAPEUTICS

Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins

(2008) Ivan Ahel et al.   NATURE