Multifarious roles of sialic acids in immunity

Polysialic Acid, a Glycan with Highly Restricted Expression, Is Found on Human and Murine Leukocytes and Modulates Immune Responses

(2014) P. M. Drake et al.   JOURNAL OF IMMUNOLOGY

Crystallographic determination of the disease-associated T1184R variant of complement regulator factor H

(2011) Hugh P. Morgan et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Siglec-15, a member of the sialic acid-binding lectin, is a novel regulator for osteoclast differentiation

(2011) Yoshiharu Hiruma et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeting Siglecs—A novel pharmacological strategy for immuno- and glycotherapy

(2011) Camilla Jandus et al.   BIOCHEMICAL PHARMACOLOGY

Supramolecular Complexing of Membane Siglec CD22 Mediated by a Polyvalent Heterobifunctional Ligand that Templates on IgM

(2011) Lina Cui et al.   BIOCONJUGATE CHEMISTRY

Detection of anti-Siglec-14 alloantibodies in blood components implicated in nonhaemolytic transfusion reactions

(2011) Kazuta Yasui et al.   BRITISH JOURNAL OF HAEMATOLOGY

High-Affinity Ligands of Siglec Receptors and their Therapeutic Potentials

(2011) S. Magesh et al.   CURRENT MEDICINAL CHEMISTRY

Polysialic acid is required for neuropilin-2a/b-mediated control of CCL21-driven chemotaxis of mature dendritic cells and for their migration in vivo

(2011) Angela Rey-Gallardo et al.   GLYCOBIOLOGY

Letter to the Glyco-Forum: Since there are PAMPs and DAMPs, there must be SAMPs? Glycan "self-associated molecular patterns" dampen innate immunity, but pathogens can mimic them

(2011) A. Varki   GLYCOBIOLOGY

Meningococcal Group W-135 and Y Capsular Polysaccharides Paradoxically Enhance Activation of the Alternative Pathway of Complement

(2011) Sanjay Ram et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Characterization of the Interaction between SialylatedNeisseria gonorrhoeaeand Factor H

(2011) Jutamas Shaughnessy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Galectin-8-N-domain Recognition Mechanism for Sialylated and Sulfated Glycans

(2011) Hiroko Ideo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Investigations on the pattern recognition molecule M-ficolin: quantitative aspects of bacterial binding and leukocyte association

(2011) Troels R. Kjaer et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Endogenous PMN sialidase activity exposes activation epitope on CD11b/CD18 which enhances its binding interaction with ICAM-1

(2011) Chiguang Feng et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Intravenous gammaglobulin suppresses inflammation through a novel TH2 pathway

(2011) Robert M. Anthony et al.   NATURE

Targeting the GD3 acetylation pathway selectively induces apoptosis in glioblastoma

(2011) Suzanne M. Birks et al.   NEURO-ONCOLOGY

Dual interaction of factor H with C3d and glycosaminoglycans in host-nonhost discrimination by complement

(2011) T. Kajander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sexual selection by female immunity against paternal antigens can fix loss of function alleles

(2011) D. Ghaderi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Potential Targeting of Siglecs, Mast Cell Inhibitory Receptors, in Interstitial Cystitis

(2011) Chang-Shin Park et al.   International Neurourology Journal

O-Acetylation of sialic acid on Group BStreptococcusinhibits neutrophil suppression and virulence

(2010) Shannon Weiman et al.   BIOCHEMICAL JOURNAL

The human Cas1 protein: A sialic acid-specific O-acetyltransferase?

(2010) S. Arming et al.   GLYCOBIOLOGY

Ganglioside DSGb5, preferred ligand for Siglec-7, inhibits NK cell cytotoxicity against renal cell carcinoma cells

(2010) Y. Kawasaki et al.   GLYCOBIOLOGY

Evolution of CD33-related siglecs: regulating host immune functions and escaping pathogen exploitation?

(2010) Huan Cao et al.   IMMUNOLOGY

Role for Hepatic and Circulatory ST6Gal-1 Sialyltransferase in Regulating Myelopoiesis

(2010) Mark B. Jones et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Emerging Role of α2,6-Sialic Acid as a Negative Regulator of Galectin Binding and Function

(2010) Ya Zhuo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

X-ray Structures of Human Galectin-9 C-terminal Domain in Complexes with a Biantennary Oligosaccharide and Sialyllactose

(2010) Hiromi Yoshida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell Death Modulation by Intravenous Immunoglobulin

(2010) Stephan von Gunten et al.   JOURNAL OF CLINICAL IMMUNOLOGY

A Novel Role for the IgG Fc Glycan: The Anti-inflammatory Activity of Sialylated IgG Fcs

(2010) Robert M. Anthony et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Novel mechanism for the generation of human xeno-autoantibodies against the nonhuman sialic acidN-glycolylneuraminic acid

(2010) Rachel E. Taylor et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tethering of Ficolin-1 to cell surfaces through recognition of sialic acid by the fibrinogen-like domain

(2010) Christian Honoré et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Attachment of Mouse Hepatitis Virus to O-Acetylated Sialic Acid Is Mediated by Hemagglutinin-Esterase and Not by the Spike Protein

(2010) M. A. Langereis et al.   JOURNAL OF VIROLOGY

Functionally defective germline variants of sialic acid acetylesterase in autoimmunity

(2010) Ira Surolia et al.   NATURE

Uniquely human evolution of sialic acid genetics and biology

(2010) A. Varki   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of Complement Factor H in Age-related Macular Degeneration: A Review

(2010) Larry A. Donoso et al.   SURVEY OF OPHTHALMOLOGY

Basic and Clinical Immunology of Siglecs

(2009) Stephan von Gunten et al.   Annals of the New York Academy of Sciences

Sialic acids in T cell development and function

(2009) Shuguang Bi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Human sialidase inhibitors: Design, synthesis, and biological evaluation of 4-acetamido-5-acylamido-2-fluoro benzoic acids

(2009) Sadagopan Magesh et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response

(2009) A. F. Carlin et al.   BLOOD

Low incidence of N-glycolylneuraminic acid in birds and reptiles and its absence in the platypus

(2009) Roland Schauer et al.   CARBOHYDRATE RESEARCH

Neu1 desialylation of sialyl α-2,3-linked β-galactosyl residues of TOLL-like receptor 4 is essential for receptor activation and cellular signaling

(2009) Schammim Ray Amith et al.   CELLULAR SIGNALLING

Intravenous immunoglobulins - understanding properties and mechanisms

(2009) A. Durandy et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Sialic acids as regulators of molecular and cellular interactions

(2009) Roland Schauer   CURRENT OPINION IN STRUCTURAL BIOLOGY

Sialic acids acquired byPseudomonas aeruginosaare involved in reduced complement deposition and siglec mediated host-cell recognition

(2009) Biswajit Khatua et al.   FEBS LETTERS

Siglec-7 mediates nonapoptotic cell death independently of its immunoreceptor tyrosine-based inhibitory motifs in monocytic cell line U937

(2009) Motoaki Mitsuki et al.   GLYCOBIOLOGY

The CMP-legionaminic acid pathway in Campylobacter: Biosynthesis involving novel GDP-linked precursors

(2009) Ian C Schoenhofen et al.   GLYCOBIOLOGY

Metabolic glycoengineering: Sialic acid and beyond

(2009) Jian Du et al.   GLYCOBIOLOGY

Natural ligands for CD33-related Siglecs?

(2009) A. Varki   GLYCOBIOLOGY

Dependence of pathogen molecule-induced Toll-like receptor activation and cell function on Neu1 sialidase

(2009) Schammim Ray Amith et al.   GLYCOCONJUGATE JOURNAL

Comparative genomics indicates the mammalian CD33rSiglec locus evolved by an ancient large-scale inverse duplication and suggests all Siglecs share a common ancestral region

(2009) Huan Cao et al.   IMMUNOGENETICS

CD22 and Siglec-G: B-cell inhibitory receptors with distinct functions

(2009) Lars Nitschke   IMMUNOLOGICAL REVIEWS

Regulation of Phagocytosis in Macrophages by Neuraminidase 1

(2009) Volkan Seyrantepe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Carbohydrate Recognition Properties of Human Ficolins

(2009) Evelyne Gout et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sialoadhesin-Positive Macrophages Bind Regulatory T Cells, Negatively Controlling Their Expansion and Autoimmune Disease Progression

(2009) Chuan Wu et al.   JOURNAL OF IMMUNOLOGY

Sialic Acid: A Preventable Signal for Pneumococcal Biofilm Formation, Colonization, and Invasion of the Host

(2009) Claudia Trappetti et al.   JOURNAL OF INFECTIOUS DISEASES

Interaction of Polysialic Acid with CCL21 Regulates the Migratory Capacity of Human Dendritic Cells

(2009) Marieke Bax et al.   PLoS One

Polysialic acid governs T-cell development by regulating progenitor access to the thymus

(2009) P. M. Drake et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innovations in host and microbial sialic acid biosynthesis revealed by phylogenomic prediction of nonulosonic acid structure

(2009) A. L. Lewis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD24-Siglec G/10 discriminates danger- from pathogen-associated molecular patterns

(2009) Yang Liu et al.   TRENDS IN IMMUNOLOGY

Esterases and autoimmunity: the sialic acid acetylesterase pathway and the regulation of peripheral B cell tolerance

(2009) Shiv Pillai et al.   TRENDS IN IMMUNOLOGY

Siglecs as targets for therapy in immune-cell-mediated disease

(2009) Mary K. O’Reilly et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Neuraminidase-1, a Subunit of the Cell Surface Elastin Receptor, Desialylates and Functionally Inactivates Adjacent Receptors Interacting with the Mitogenic Growth Factors PDGF-BB and IGF-2

(2008) Aleksander Hinek et al.   AMERICAN JOURNAL OF PATHOLOGY

Siglecs as positive and negative regulators of the immune system: Figure 1

(2008) Paul R. Crocker et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

SIGLEC16encodes a DAP12-associated receptor expressed in macrophages that evolved from its inhibitory counterpartSIGLEC11and has functional and non-functional alleles in humans

(2008) Huan Cao et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Variation in use of erythrocyte invasion pathways by Plasmodium falciparum mediates evasion of human inhibitory antibodies

(2008) Kristina E.M. Persson et al.   JOURNAL OF CLINICAL INVESTIGATION

B cell antigen receptor signal strength and peripheral B cell development are regulated by a 9-O-acetyl sialic acid esterase

(2008) Annaiah Cariappa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Sialoside Analogue Arrays for Rapid Identification of High Affinity Siglec Ligands

(2008) Ola Blixt et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxin

(2008) Emma Byres et al.   NATURE

The Ashwell receptor mitigates the lethal coagulopathy of sepsis

(2008) Prabhjit K Grewal et al.   NATURE MEDICINE

Sialoadhesin Expressed on IFN-Induced Monocytes Binds HIV-1 and Enhances Infectivity

(2008) Hans Rempel et al.   PLoS One

Polysialic acid in the plasticity of the developing and adult vertebrate nervous system

(2007) Urs Rutishauser   NATURE REVIEWS NEUROSCIENCE