The life of U6 small nuclear RNA, from cradle to grave

PARN Modulates Y RNA Stability and Its 3′-End Formation

(2017) Siddharth Shukla et al.   MOLECULAR AND CELLULAR BIOLOGY

Structure of a spliceosome remodelled for exon ligation

(2017) Sebastian M. Fica et al.   NATURE

Cryo-EM structure of a human spliceosome activated for step 2 of splicing

(2017) Karl Bertram et al.   NATURE

Mechanistic insights into precursor messenger RNA splicing by the spliceosome

(2017) Yigong Shi   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Substoichiometric ribose methylations in spliceosomal snRNAs

(2017) Nicolai Krogh et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Yeast Prp2 liberates the 5′ splice site and the branch site adenosine for catalysis of pre-mRNA splicing

(2017) Penghui Bao et al.   RNA

Usb1 controls U6 snRNP assembly through evolutionarily divergent cyclic phosphodiesterase activities

(2017) Allison L. Didychuk et al.   Nature Communications

Crystal structures of U6 snRNA-specific terminal uridylyltransferase

(2017) Seisuke Yamashita et al.   Nature Communications

Structure and conformational plasticity of the U6 small nuclear ribonucleoprotein core

(2017) Eric J. Montemayor et al.   Acta Crystallographica Section D-Structural Biology

Group II Intron Self-Splicing

(2016) Anna Marie Pyle   Annual Review of Biophysics

Functions and regulation of the Brr2 RNA helicase during splicing

(2016) Eva Absmeier et al.   CELL CYCLE

Pseudouridines in U2 snRNA stimulate the ATPase activity of Prp5 during spliceosome assembly

(2016) Guowei Wu et al.   EMBO JOURNAL

Structural Basis of the Recruitment of Ubiquitin-specific Protease USP15 by Spliceosome Recycling Factor SART3

(2016) Qi Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Analysis of Multi-Helical RNAs by NMR–SAXS/WAXS: Application to the U4/U6 di-snRNA

(2016) Gabriel Cornilescu et al.   JOURNAL OF MOLECULAR BIOLOGY

Decoding the principles underlying the frequency of association with nucleoli for RNA polymerase III–transcribed genes in budding yeast

(2016) Praveen Belagal et al.   MOLECULAR BIOLOGY OF THE CELL

Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 Å resolution

(2016) Thi Hoang Duong Nguyen et al.   NATURE

Cryo-EM structure of the spliceosome immediately after branching

(2016) Wojciech P. Galej et al.   NATURE

A multi-step model for facilitated unwinding of the yeast U4/U6 RNA duplex

(2016) Margaret L. Rodgers et al.   NUCLEIC ACIDS RESEARCH

Structural basis for recruiting and shuttling of the spliceosomal deubiquitinase USP4 by SART3

(2016) Joon Kyu Park et al.   NUCLEIC ACIDS RESEARCH

Substrate-assisted mechanism of RNP disruption by the spliceosomal Brr2 RNA helicase

(2016) Matthias Theuser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

U6 snRNA intron insertion occurred multiple times during fungi evolution

(2016) Sebastian Canzler et al.   RNA Biology

Molecular architecture of the human U4/U6.U5 tri-snRNP

(2016) D. E. Agafonov et al.   SCIENCE

The 3.8 A structure of the U4/U6.U5 tri-snRNP: Insights into spliceosome assembly and catalysis

(2016) R. Wan et al.   SCIENCE

Structure of a yeast catalytic step I spliceosome at 3.4 A resolution

(2016) R. Wan et al.   SCIENCE

Structure of a yeast step II catalytically activated spliceosome

(2016) Chuangye Yan et al.   SCIENCE

Molecular architecture of the Saccharomyces cerevisiae activated spliceosome

(2016) R. Rauhut et al.   SCIENCE

Structure of a yeast activated spliceosome at 3.5 A resolution

(2016) C. Yan et al.   SCIENCE

The target of the DEAH-box NTP triphosphatase Prp43 in Saccharomyces cerevisiae spliceosomes is the U2 snRNP-intron interaction

(2016) Jean-Baptiste Fourmann et al.   eLife

U6atac snRNA stem-loop interacts with U12 p65 RNA binding protein and is functionally interchangeable with the U12 apical stem-loop III

(2016) Jagjit Singh et al.   Scientific Reports

Human Mpn1 promotes post-transcriptional processing and stability of U6atac

(2015) Vadim Shchepachev et al.   FEBS LETTERS

The large N-terminal region of the Brr2 RNA helicase guides productive spliceosome activation

(2015) Eva Absmeier et al.   GENES & DEVELOPMENT

Structure and Thermodynamics of N6-Methyladenosine in RNA: A Spring-Loaded Base Modification

(2015) Caroline Roost et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

U6 snRNA Pseudogenes: Markers of Retrotransposition Dynamics in Mammals

(2015) Aurélien J. Doucet et al.   MOLECULAR BIOLOGY AND EVOLUTION

Mechanism of Transcription Termination by RNA Polymerase III Utilizes a Non-template Strand Sequence-Specific Signal Element

(2015) Aneeshkumar G. Arimbasseri et al.   MOLECULAR CELL

The architecture of the spliceosomal U4/U6.U5 tri-snRNP

(2015) Thi Hoang Duong Nguyen et al.   NATURE

Assembly and dynamics of the U4/U6 di-snRNP by single-molecule FRET

(2015) John W. Hardin et al.   NUCLEIC ACIDS RESEARCH

The ribonucleotidyl transferase USIP-1 acts with SART3 to promote U6 snRNA recycling

(2015) Stefan Rüegger et al.   NUCLEIC ACIDS RESEARCH

Structural requirements for protein-catalyzed annealing of U4 and U6 RNAs during di-snRNP assembly

(2015) Allison L. Didychuk et al.   NUCLEIC ACIDS RESEARCH

Dramatically reduced spliceosome inCyanidioschyzon merolae

(2015) Martha R. Stark et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spliceosome assembly in the absence of stable U4/U6 RNA pairing

(2015) Jordan E. Burke et al.   RNA

Structure of a yeast spliceosome at 3.6-angstrom resolution

(2015) Chuangye Yan et al.   SCIENCE

The exosome controls alternative splicing by mediating the gene expression and assembly of the spliceosome complex

(2015) Lin Zhang et al.   Scientific Reports

SART3-Dependent Accumulation of Incomplete Spliceosomal snRNPs in Cajal Bodies

(2015) Ivan Novotný et al.   Cell Reports

A composite double-/single-stranded RNA-binding region in protein Prp3 supports tri-snRNP stability and splicing

(2015) Sunbin Liu et al.   eLife

Crystal structure and biochemical analysis of the heptameric Lsm1-7 complex

(2014) Lijun Zhou et al.   CELL RESEARCH

A day in the life of the spliceosome

(2014) A. Gregory Matera et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The dynamic epitranscriptome: N6-methyladenosine and gene expression control

(2014) Kate D. Meyer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Core structure of the U6 small nuclear ribonucleoprotein at 1.7-Å resolution

(2014) Eric J Montemayor et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Evidence for a group II intron–like catalytic triplex in the spliceosome

(2014) Sebastian M Fica et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Pseudouridine Residue in the Spliceosome Core Is Part of the Filamentous Growth Program in Yeast

(2014) Anindita Basak et al.   Cell Reports

Dissection of the factor requirements for spliceosome disassembly and the elucidation of its dissociation products using a purified splicing system

(2013) J.-B. Fourmann et al.   GENES & DEVELOPMENT

Sad1 Counteracts Brr2-Mediated Dissociation of U4/U6.U5 in Tri-snRNP Homeostasis

(2013) Y.-H. Huang et al.   MOLECULAR AND CELLULAR BIOLOGY

RNA catalyses nuclear pre-mRNA splicing

(2013) Sebastian M. Fica et al.   NATURE

Crystal structures of the Lsm complex bound to the 3′ end sequence of U6 small nuclear RNA

(2013) Lijun Zhou et al.   NATURE

Cotranscriptional recruitment of yeast TRAMP complex to intronic sequences promotes optimal pre-mRNA splicing

(2013) Ka-Yiu Edwin Kong et al.   NUCLEIC ACIDS RESEARCH

Splicing proofreading at 5′ splice sites by ATPase Prp28p

(2013) Fei Yang et al.   NUCLEIC ACIDS RESEARCH

microRNA-122 Abundance in Hepatocellular Carcinoma and Non-Tumor Liver Tissue from Japanese Patients with Persistent HCV versus HBV Infection

(2013) Carolyn Spaniel et al.   PLoS One

Single-molecule colocalization FRET evidence that spliceosome activation precedes stable approach of 5' splice site and branch site

(2013) D. J. Crawford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Archaeal and eukaryotic homologs of Hfq

(2013) Cameron Mura et al.   RNA Biology

Inhibition of RNA Helicase Brr2 by the C-Terminal Tail of the Spliceosomal Protein Prp8

(2013) S. Mozaffari-Jovin et al.   SCIENCE

Architecture of the Lsm1-7-Pat1 Complex: A Conserved Assembly in Eukaryotic mRNA Turnover

(2013) Humayun Sharif et al.   Cell Reports

Alternative Spliceosome Assembly Pathways Revealed by Single-Molecule Fluorescence Microscopy

(2013) Inna Shcherbakova et al.   Cell Reports

U6 RNA biogenesis and disease association

(2013) Seweryn Mroczek et al.   Wiley Interdisciplinary Reviews-RNA

Minor introns are embedded molecular switches regulated by highly unstable U6atac snRNA

(2013) Ihab Younis et al.   eLife

Transcription termination by the eukaryotic RNA polymerase III

(2012) Aneeshkumar G. Arimbasseri et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Aberrant 3' oligoadenylation of spliceosomal U6 small nuclear RNA in poikiloderma with neutropenia

(2012) C. Hilcenko et al.   BLOOD

Visualizing Group II Intron Catalysis through the Stages of Splicing

(2012) Marco Marcia et al.   CELL

Negative regulation of human U6 snRNA promoter by p38 kinase through Oct-1

(2012) Bor-Ruei Lin et al.   GENE

C16orf57, a gene mutated in poikiloderma with neutropenia, encodes a putative phosphodiesterase responsible for the U6 snRNA 3' end modification

(2012) S. Mroczek et al.   GENES & DEVELOPMENT

The Prp8 RNase H-like domain inhibits Brr2-mediated U4/U6 snRNA unwinding by blocking Brr2 loading onto the U4 snRNA

(2012) S. Mozaffari-Jovin et al.   GENES & DEVELOPMENT

Transcriptome-wide Analysis of Exosome Targets

(2012) Claudia Schneider et al.   MOLECULAR CELL

Tri-snRNP-associated proteins interact with subunits of the TRAMP and nuclear exosome complexes, linking RNA decay and pre-mRNA splicing

(2012) Anita Nag et al.   RNA Biology

The spliceosome: a flexible, reversible macromolecular machine

(2012) Aaron A. Hoskins et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mpn1, Mutated in Poikiloderma with Neutropenia Protein 1, Is a Conserved 3′-to-5′ RNA Exonuclease Processing U6 Small Nuclear RNA

(2012) Vadim Shchepachev et al.   Cell Reports

The Bin3 RNA methyltransferase targets 7SK RNA to control transcription and translation

(2012) Michael S. Cosgrove et al.   Wiley Interdisciplinary Reviews-RNA

A novel occluded RNA recognition motif in Prp24 unwinds the U6 RNA internal stem loop

(2011) Stephen Martin-Tumasz et al.   NUCLEIC ACIDS RESEARCH

Nhp6: A small but powerful effector of chromatin structure in Saccharomyces cerevisiae

(2010) David J. Stillman   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

In vivo kinetics of U4/U6·U5 tri-snRNP formation in Cajal bodies

(2010) Ivan Novotný et al.   MOLECULAR BIOLOGY OF THE CELL

Exon Definition Complexes Contain the Tri-snRNP and Can Be Directly Converted into B-like Precatalytic Splicing Complexes

(2010) Marc Schneider et al.   MOLECULAR CELL

Pol II and its associated epigenetic marks are present at Pol III–transcribed noncoding RNA genes

(2010) Artem Barski et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Conformational dynamics of single pre-mRNA molecules during in vitro splicing

(2010) John Abelson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human RNA polymerase III transcriptomes and relationships to Pol II promoter chromatin and enhancer-binding factors

(2010) Andrew J Oler et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Close association of RNA polymerase II and many transcription factors with Pol III genes

(2010) Debasish Raha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spliceosome Structure and Function

(2010) C. L. Will et al.   Cold Spring Harbor Perspectives in Biology

The Spliceosome: Design Principles of a Dynamic RNP Machine

(2009) Markus C. Wahl et al.   CELL

Analysis of Lsm1p and Lsm8p domains in the cellular localization of Lsm complexes in budding yeast

(2009) Martin A. M. Reijns et al.   FEBS Journal

Minimum-Energy Path for a U6 RNA Conformational Change Involving Protonation, Base-Pair Rearrangement and Base Flipping

(2009) Vincenzo Venditti et al.   JOURNAL OF MOLECULAR BIOLOGY

The conserved 3' end domain of U6atac snRNA can direct U6 snRNA to the minor spliceosome

(2009) R. C. Dietrich et al.   RNA

Evidence that U2/U6 helix I promotes both catalytic steps of pre-mRNA splicing and rearranges in between these steps

(2009) M. A. Mefford et al.   RNA

Visual Analysis of the Yeast 5S rRNA Gene Transcriptome: Regulation and Role of La Protein

(2008) S. L. French et al.   MOLECULAR AND CELLULAR BIOLOGY

Chromatin Structure and Expression of a Gene Transcribed by RNA Polymerase III Are Independent of H2A.Z Deposition

(2008) A. G. Arimbasseri et al.   MOLECULAR AND CELLULAR BIOLOGY

Spliceosomal Small Nuclear Ribonucleoprotein Particles Repeatedly Cycle through Cajal Bodies

(2008) David Staněk et al.   MOLECULAR BIOLOGY OF THE CELL

Transcription Termination and RNA Degradation Contribute to Silencing of RNA Polymerase II Transcription within Heterochromatin

(2008) Lidia Vasiljeva et al.   MOLECULAR CELL

ATP-dependent unwinding of U4/U6 snRNAs by the Brr2 helicase requires the C terminus of Prp8

(2008) Corina Maeder et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Minor spliceosome components are predominantly localized in the nucleus

(2008) H. K. J. Pessa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

3'-cyclic phosphorylation of U6 snRNA leads to recruitment of recycling factor p110 through LSm proteins

(2008) K. Licht et al.   RNA

Competition between the Rex1 exonuclease and the La protein affects both Trf4p-mediated RNA quality control and pre-tRNA maturation

(2008) L. A. Copela et al.   RNA

High-Quality Binary Protein Interaction Map of the Yeast Interactome Network

(2008) H. Yu et al.   SCIENCE

Both Catalytic Steps of Nuclear Pre-mRNA Splicing Are Reversible

(2008) C.-K. Tseng et al.   SCIENCE