Substrate-assisted mechanism of RNP disruption by the spliceosomal Brr2 RNA helicase

Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 Å resolution

(2016) Thi Hoang Duong Nguyen et al.   NATURE

Molecular architecture of the human U4/U6.U5 tri-snRNP

(2016) D. E. Agafonov et al.   SCIENCE

The 3.8 A structure of the U4/U6.U5 tri-snRNP: Insights into spliceosome assembly and catalysis

(2016) R. Wan et al.   SCIENCE

SnapShot: Spliceosome Dynamics II

(2015) Markus C. Wahl et al.   CELL

The large N-terminal region of the Brr2 RNA helicase guides productive spliceosome activation

(2015) Eva Absmeier et al.   GENES & DEVELOPMENT

Assembly and dynamics of the U4/U6 di-snRNP by single-molecule FRET

(2015) John W. Hardin et al.   NUCLEIC ACIDS RESEARCH

Structural requirements for protein-catalyzed annealing of U4 and U6 RNAs during di-snRNP assembly

(2015) Allison L. Didychuk et al.   NUCLEIC ACIDS RESEARCH

NUFIP and the HSP90/R2TP chaperone bind the SMN complex and facilitate assembly of U4-specific proteins

(2015) Jonathan Bizarro et al.   NUCLEIC ACIDS RESEARCH

Spliceosome assembly in the absence of stable U4/U6 RNA pairing

(2015) Jordan E. Burke et al.   RNA

Structural basis of pre-mRNA splicing

(2015) Jing Hang et al.   SCIENCE

A composite double-/single-stranded RNA-binding region in protein Prp3 supports tri-snRNP stability and splicing

(2015) Sunbin Liu et al.   eLife

Core structure of the U6 small nuclear ribonucleoprotein at 1.7-Å resolution

(2014) Eric J Montemayor et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Novel regulatory principles of the spliceosomal Brr2 RNA helicase and links to retinal disease in humans

(2014) Sina Mozaffari-Jovin et al.   RNA Biology

Crystal structures of the Lsm complex bound to the 3′ end sequence of U6 small nuclear RNA

(2013) Lijun Zhou et al.   NATURE

Inhibition of RNA Helicase Brr2 by the C-Terminal Tail of the Spliceosomal Protein Prp8

(2013) S. Mozaffari-Jovin et al.   SCIENCE

Structural Basis of Brr2-Prp8 Interactions and Implications for U5 snRNP Biogenesis and the Spliceosome Active Site

(2013) Thi Hoang Duong Nguyen et al.   STRUCTURE

Brr2p-mediated conformational rearrangements in the spliceosome during activation and substrate repositioning

(2012) D. Hahn et al.   GENES & DEVELOPMENT

The Prp8 RNase H-like domain inhibits Brr2-mediated U4/U6 snRNA unwinding by blocking Brr2 loading onto the U4 snRNA

(2012) S. Mozaffari-Jovin et al.   GENES & DEVELOPMENT

Structural basis for functional cooperation between tandem helicase cassettes in Brr2-mediated remodeling of the spliceosome

(2012) K. F. Santos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Semiquantitative Proteomic Analysis of the Human Spliceosome via a Novel Two-Dimensional Gel Electrophoresis Method

(2011) D. E. Agafonov et al.   MOLECULAR AND CELLULAR BIOLOGY

Secondary structure of U6 small nuclear RNA: implications for spliceosome assembly

(2010) Elizabeth A. Dunn et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

RNA helicases at work: binding and rearranging

(2010) Eckhard Jankowsky   TRENDS IN BIOCHEMICAL SCIENCES

The Spliceosome: Design Principles of a Dynamic RNP Machine

(2009) Markus C. Wahl et al.   CELL

Deciphering the assembly pathway of Sm-class U snRNPs

(2008) Nils Neuenkirchen et al.   FEBS LETTERS

ATP-dependent unwinding of U4/U6 snRNAs by the Brr2 helicase requires the C terminus of Prp8

(2008) Corina Maeder et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY