Cotranscriptional recruitment of yeast TRAMP complex to intronic sequences promotes optimal pre-mRNA splicing

Transcriptome-wide Analysis of Exosome Targets

(2012) Claudia Schneider et al.   MOLECULAR CELL

Extensive Degradation of RNA Precursors by the Exosome in Wild-Type Cells

(2012) Rajani Kanth Gudipati et al.   MOLECULAR CELL

Air2p is critical for the assembly and RNA-binding of the TRAMP complex and the KOW domain of Mtr4p is crucial for exosome activation

(2012) Peter Holub et al.   NUCLEIC ACIDS RESEARCH

The THO complex cooperates with the nuclear RNA surveillance machinery to control small nucleolar RNA expression

(2012) Marc Larochelle et al.   NUCLEIC ACIDS RESEARCH

RNA unwinding by the Trf4/Air2/Mtr4 polyadenylation (TRAMP) complex

(2012) H. Jia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tri-snRNP-associated proteins interact with subunits of the TRAMP and nuclear exosome complexes, linking RNA decay and pre-mRNA splicing

(2012) Anita Nag et al.   RNA Biology

Rrp6 is recruited to transcribed genes and accompanies the spliced mRNA to the nuclear pore

(2012) V. Hessle et al.   RNA

Air proteins control differential TRAMP substrate specificity for nuclear RNA surveillance

(2012) K. Schmidt et al.   RNA

The RNA Helicase Mtr4p Modulates Polyadenylation in the TRAMP Complex

(2011) Huijue Jia et al.   CELL

The nuclear RNA polymerase II surveillance system targets polymerase III transcripts

(2011) Wiebke Wlotzka et al.   EMBO JOURNAL

The multifunctional Ccr4–Not complex directly promotes transcription elongation

(2011) Jennifer A. Kruk et al.   GENES & DEVELOPMENT

Air1 Zinc Knuckles 4 and 5 and a Conserved IWRXY Motif Are Critical for the Function and Integrity of the Trf4/5-Air1/2-Mtr4 Polyadenylation (TRAMP) RNA Quality Control Complex

(2011) Milo B. Fasken et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Pre-mRNA Degradation Pathway that Selectively Targets Intron-Containing Genes Requires the Nuclear Poly(A)-Binding Protein

(2011) Caroline Lemieux et al.   MOLECULAR CELL

Interaction Profiling Identifies the Human Nuclear Exosome Targeting Complex

(2011) Michal Lubas et al.   MOLECULAR CELL

Dynamic histone acetylation is critical for cotranscriptional spliceosome assembly and spliceosomal rearrangements

(2011) Felizza Q. Gunderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome Instability and Transcription Elongation Impairment in Human Cells Depleted of THO/TREX

(2011) María S. Domínguez-Sánchez et al.   PLoS Genetics

Leo1 Subunit of the Yeast Paf1 Complex Binds RNA and Contributes to Complex Recruitment

(2010) Jessica L. Dermody et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Yeast arginine methyltransferase Hmt1p regulates transcription elongation and termination by methylating Npl3p

(2010) Chi-Ming Wong et al.   NUCLEIC ACIDS RESEARCH

The Genetic Landscape of a Cell

(2010) M. Costanzo et al.   SCIENCE

The Many Pathways of RNA Degradation

(2009) Jonathan Houseley et al.   CELL

The Spliceosome: Design Principles of a Dynamic RNP Machine

(2009) Markus C. Wahl et al.   CELL

TRAMP Complex Enhances RNA Degradation by the Nuclear Exosome Component Rrp6

(2009) Kevin P. Callahan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Exosome Associates Cotranscriptionally with the Nascent Pre-mRNP through Interactions with Heterogeneous Nuclear Ribonucleoproteins

(2009) Viktoria Hessle et al.   MOLECULAR BIOLOGY OF THE CELL

“Cotranscriptionality”: The Transcription Elongation Complex as a Nexus for Nuclear Transactions

(2009) Roberto Perales et al.   MOLECULAR CELL

Bidirectional promoters generate pervasive transcription in yeast

(2009) Zhenyu Xu et al.   NATURE

Widespread bidirectional promoters are the major source of cryptic transcripts in yeast

(2009) Helen Neil et al.   NATURE

The N-terminal PIN domain of the exosome subunit Rrp44 harbors endonuclease activity and tethers Rrp44 to the yeast core exosome

(2009) Claudia Schneider et al.   NUCLEIC ACIDS RESEARCH

The CCR4-NOT Complex Physically and Functionally Interacts with TRAMP and the Nuclear Exosome

(2009) Nowel Azzouz et al.   PLoS One

Nonsense-mediated mRNA decay mutes the splicing defects of spliceosome component mutations

(2009) T. Kawashima et al.   RNA

Loss of Yeast Peroxiredoxin Tsa1p Induces Genome Instability through Activation of the DNA Damage Checkpoint and Elevation of dNTP Levels

(2009) Hei-Man Vincent Tang et al.   PLoS Genetics

Distinct Roles of Non-Canonical Poly(A) Polymerases in RNA Metabolism

(2009) Salvatore San Paolo et al.   PLoS Genetics

Acetylation by the Transcriptional Coactivator Gcn5 Plays a Novel Role in Co-Transcriptional Spliceosome Assembly

(2009) Felizza Q. Gunderson et al.   PLoS Genetics

Widespread Impact of Nonsense-Mediated mRNA Decay on the Yeast Intronome

(2008) Shakir Sayani et al.   MOLECULAR CELL

Endonucleolytic RNA cleavage by a eukaryotic exosome

(2008) Alice Lebreton et al.   NATURE

Unphosphorylated SR-Like Protein Npl3 Stimulates RNA Polymerase II Elongation

(2008) Jessica L. Dermody et al.   PLoS One

The exosome: a multipurpose RNA-decay machine

(2008) Manfred Schmid et al.   TRENDS IN BIOCHEMICAL SCIENCES

A vector system for efficient and economical switching of C-terminal epitope tags inSaccharomyces cerevisiae

(2008) Min-Kyung Sung et al.   YEAST